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Results for "

VCP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	p97 (12) ADC Linker (3) Adenosine Receptor (1) Drug-Linker Conjugates for ADC (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (12) Inflammation/Immunology (1) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: p97

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-157508

VCP Activator 1 1 Publications Verification	p97	Others
VCP Activator 1 is a *VCP* activator that dose-dependently stimulates VCP ATPase activity. VCP Activator 1 binds an allosteric pocket near the C-terminus. In addition, VCP Activator 1 binding site can also be occupied by a phenylalanine residue in the VCP C-terminal tail .

HY-128870

*Mal-PEG2-VCP-Eribulin*	Drug-Linker Conjugates for ADC	Cancer
Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin (HY-13442). Eribulin is a mechanistically unique microtubule inhibitor and Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Mal-PEG2-VCP-Eribulin is an Eribulin-based agent for antibody conjugates .

HY-130084

*Mal-PEG2-VCP-NB*	ADC Linker	Cancer
Mal-PEG2-VCP-NB is a claevable ADC linker containing a Maleimide group, 2-unit PEG and a VCP NB.

HY-128871

VCP-Eribulin	Drug-Linker Conjugates for ADC	Cancer
VCP-Eribulin consists the ADCs linker (VCP) and Eribulin . Eribulin is a mechanistically unique microtubule inhibitor for cancer . VCP-Eribulin is an Eribulin-based agent for antibody conjugates .

HY-113608

VCP171	Adenosine Receptor	Neurological Disease
VCP171 is a potent adenosine A1 receptor (A1R) positive allosteric modulator (PAM). VCP171 is effective at decreasing excitatory synaptic currents in Lamina II of neuropathic pain model. VCP171 can be used for researching neuropathic pain .

HY-139606

VCP/p97 inhibitor-1	p97	Cancer
VCP/p97 inhibitor-1 is a potent inhibitor of *VCP/p97* (also called Cdc48, CDC-. 48, or Ter94) with an IC₅₀ of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS) .

HY-RS15622

Vcp Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Vcp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vcp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vcp Mouse Pre-designed siRNA Set A Vcp Mouse Pre-designed siRNA Set A

HY-RS15623

Vcp Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Vcp Rat Pre-designed siRNA Set A contains three designed siRNAs for Vcp gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vcp Rat Pre-designed siRNA Set A Vcp Rat Pre-designed siRNA Set A

HY-RS15621

VCP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
VCP Human Pre-designed siRNA Set A contains three designed siRNAs for VCP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

VCP Human Pre-designed siRNA Set A VCP Human Pre-designed siRNA Set A

HY-160981

*Mal-PEG4-VCP-NB*	ADC Linker	Cancer
Mal-PEG4-VCP-NB (Compound 17) is a degradable ADC linker containing a maleimide group, 4 PEG units and VCP NB .

HY-160982

*Mal-PEG3-VCP-NB*	ADC Linker	Cancer
Mal-PEG3-VCP-NB (Compund 25c) is a degradable ADC linker containing a maleimide group, 3-unit PEG and VCP NB .

HY-124776

NPD8733	p97	Cancer
NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. NPD8733 specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family. NPD8733 has the potential for the research of cancer diseases .

HY-12861

CB-5083 Maximum Cited Publications 28 Publications Verification	p97	Cancer
CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase/VCP. CB-5083 selectively inhibits p97 through its D2 site with the IC₅₀ of 11 nM .

HY-15714

NMS-859	p97	Cancer
NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC₅₀s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.

HY-15713

NMS-873 10+ Cited Publications	p97	Cancer
NMS-873 is a potent, selective allosteric *VCP/p97* inhibitor with an IC₅₀ value of 30 nM.

HY-168325

UP12	p97	Neurological Disease
UP12 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC₅₀ of 1.24 μM .

HY-168324

UP158	p97	Others
UP158 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC₅₀ of 2.57 μM .

HY-138233

KUS121	p97	Neurological Disease Inflammation/Immunology
KUS121, a *valosin-containing protein (VCP, p97)* modulator with significant neuroprotective effects, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress .

HY-168323

UP163	p97	Others
UP163 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC₅₀ of 9.0 μM. UP163 reduces MG-132 (HY-13259)-induced TDP-43 aggregates .

HY-148122

NW 1028	p97	Cancer
NW 1028 is a potent *VCP/p97* inhibitor. NW 1028 targets the ND1L domain of p97 and inhibits the degradation of a p97-dependent reporter. NW 1028 has good binding affinity with K_d values of 100 and 285 nM for ND1L and full length p97, respectively. NW 1028 has the function of regulating the mitotic spindle of cells .

HY-123872

MSC1094308	p97	Cancer
MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC₅₀ values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively . MSC1094308 inhibits the D2 ATPase activity by binding to a agentable hotspot of p97. MSC1094308 can be used in study of cancer .

Species:	Human (4)
Tag:	His (3) Tag Free (1)
Source:	HEK293 (1) Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71420

	VCP Protein, Human (His) Transitional Endoplasmic Reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 Subunit; Valosin-Containing Protein; VCP	Human	E. coli
	VCP proteins are indispensable for Golgi stack dynamics, coordinating fragmentation during mitosis and postmitotic reorganization. It actively promotes the formation of the transitional endoplasmic reticulum (tER), enables ATP-dependent vesicle budding, and enables membrane transfer to the Golgi apparatus. VCP Protein, Human (His) is the recombinant human-derived VCP protein, expressed by E. coli , with C-6*His labeled tag. The total length of VCP Protein, Human (His) is 588 a.a., with molecular weight of ~75.0 kDa.

HY-P701436

	VCPIP1 Protein, Human (Sf9) VCPIP1; Deubiquitinating protein VCPIP1; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135; VCP/p47 complex-interacting 135-kDa protein	Human	Sf9 insect cells
	The VCPIP1 protein is a multifunctional deubiquitinating enzyme that plays a crucial role in a variety of cellular processes. It is an integral component of DNA repair and postmitotic Golgi and endoplasmic reticulum reassembly, promoting VCP-mediated Golgi stacking and tER formation. VCPIP1 Protein, Human (Sf9) is the recombinant human-derived VCPIP1 protein, expressed by Sf9 insect cells , with tag free. The total length of VCPIP1 Protein, Human (Sf9) is 1222 a.a., .

HY-P701435

	VCPIP1 Protein, Human (Sf9, His) VCPIP1; Deubiquitinating protein VCPIP1; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135; VCP/p47 complex-interacting 135-kDa protein	Human	Sf9 insect cells
	The VCPIP1 protein is a multifunctional deubiquitinating enzyme that plays a crucial role in a variety of cellular processes. It is an integral component of DNA repair and postmitotic Golgi and endoplasmic reticulum reassembly, promoting VCP-mediated Golgi stacking and tER formation. VCPIP1 Protein, Human (Sf9, His) is the recombinant human-derived VCPIP1 protein, expressed by Sf9 insect cells , with C-8*His labeled tag. The total length of VCPIP1 Protein, Human (Sf9, His) is 1222 a.a., .

HY-P7818

	CPVL Protein, Human (HEK293, His) rHuProbable serine carboxypeptidase CPVL, His; Probable serine carboxypeptidase CPVL; Carboxypeptidase vitellogenic-like; Vitellogenic carboxypeptidase-like protein; VCP-like protein; CPVL	Human	HEK293
	CPVL protein, a serine carboxypeptidase, may be involved in the digestion of phagocytic granules in lysosomes and in the inflammatory protease cascade. CPVL protein, a potential biomarker, may promote glioma progression by inhibiting STAT1 phosphorylation. CPVL Protein, Human (HEK293, His) is the recombinant human-derived CPVL protein, expressed by HEK293 , with C-6*His labeled tag.

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HY-P82630

	VCP Antibody (YA2375) 15S Mg(2+) ATPase p97 subunit; ALS14; ATPase p97; CDC48; IBMPFD; p97; TER ATPase; TERA; VCP; Yeast Cdc48p homolog	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	VCP Antibody (YA2375) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2375), targeting VCP, with a predicted molecular weight of 89 kDa (observed band size: 89 kDa). VCP Antibody (YA2375) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

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Vcp Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Vcp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vcp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vcp Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Vcp Rat Pre-designed siRNA Set A contains three designed siRNAs for Vcp gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

VCP Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
VCP Human Pre-designed siRNA Set A contains three designed siRNAs for VCP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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