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adenosine receptors (AR)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (74) Apoptosis (1) Aurora Kinase (1) Biochemical Assay Reagents (1) Carbonic Anhydrase (1) CD20 (1) Dopamine Receptor (1) Endogenous Metabolite (12) G protein-coupled Bile Acid Receptor 1 (1) HDAC (1) Influenza Virus (1) Isotope-Labeled Compounds (7) PARP (1)
By Research Areas:	Cancer (24) Cardiovascular Disease (4) Infection (2) Inflammation/Immunology (29) Neurological Disease (33)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Adenosine Kinase Adenosine Receptor Adenosine Deaminase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147907

Adenosine receptor inhibitor 1	Adenosine Receptor	Neurological Disease Inflammation/Immunology Cancer
Adenosine receptor inhibitor 1 is a potent and selective **adenosine receptor (AR) inhibitor with K_i** values of >1000, 68.5, >1000, >1000 nM for A₁AR, A_2AAR, A_2BAR, A₃AR, respectively. Adenosine receptor inhibitor 1 shows antinociceptive activity, anti-inflammatory effect and peripheral analgesic effect. Adenosine receptor inhibitor 1 has the potential for the research of cancer or neurodegenerative diseases .

HY-101854

N6-(2-Phenylethyl)adenosine N6-Phenethyladenosine; N6-Phenylethyladenosine	Adenosine Receptor	Inflammation/Immunology Cancer
N6-(2-Phenylethyl)adenosine (N6-Phenethyladenosine), an adenosine derivative, is a potent **adenosine receptors (AR) agonist with K_i** values of 11.8 nM, 30.1 nM, 0.63 nM for rat A₁AR, human A₁AR and hA₃AR, respectively .

HY-111809

N6-Ethyladenosine	Adenosine Receptor	Others
N6-Ethyladenosine is an adenosine derivative, acts as a **Adenosine receptor agonist, with K_i*s of 4.9 and 4.7 nM for hA₁AR* and hA₃AR, respectively .

HY-101980

Imaradenant 3 Publications Verification HTL1071; AZD4635	Adenosine Receptor	Cancer
AZD4635 (HTL1071) is a potent, selective and orally active **adenosine A2A receptor** (A2AR) antagonist. AZD4635 binds to human A2AR with a K_i of 1.7 nM and shows >30-fold selectivity over other adenosine receptors .

HY-120652

A3AR antagonist 3	Adenosine Receptor	Inflammation/Immunology
A3AR antagonist 3 (compound 21) is a selective A3 adenosine receptor (A3AR) antagonist with a K_i of 37 nM. A3AR antagonist 3 shows >60-fold selectivity in comparison to A1 and A2A adenosine receptors .

HY-162851

Adenosine receptor agonist 1	Adenosine Receptor	Others
Adenosine receptor agonist 1 (compound 6m) is an A3 adenosine receptor (AR) partial agonist with K_i value of 6.7 nM .

HY-147908

Adenosine receptor inhibitor 2	Adenosine Receptor	Inflammation/Immunology
Adenosine receptor inhibitor 2 (compound 14b) is a potent AR (adenosine receptor) inhibitor. Adenosine receptor inhibitor 2 shows dual affinity toward A₁/A_2A ARs with higher affinity for the A₁- than the A_2AAR. Adenosine receptor inhibitor 2 has K_i values of 52.2 nM for the *A₁AR* and 167 nM for the A_2AAR .

HY-151899

A3AR modulator 1	Adenosine Receptor	Inflammation/Immunology
A3AR modulator 1 (MRS8054) is an orally active A3 adenosine receptor (A3AR) (Adenosine Receptor) positive allosteric modulator (PAM). A3AR modulator 1 greatly enhances Cl-IB-MECA-stimulated [ ³⁵S]GTPγS binding E_max .

HY-136702

L-97-1	Adenosine Receptor	Inflammation/Immunology
L-97-1 is a A1 adenosine receptor (A1AR) antagonist. L-97-1 is a water-soluble small molecule compound with high affinity and high selectivity against human A1 adenosine receptors. L-97-1 works by blocking A1 adenosine receptors. In patients with asthma, adenosine is an important signaling molecule capable of causing bronchoconstriction by activating *A1AR. L-97-1 reduces airway hyperreactivity (BHR) by competitively binding to A1AR, thereby alleviating or blocking adenosine*-induced bronchoconstriction and inflammation .

HY-139694

hA3AR agonist 1	Adenosine Receptor	Others
hA3AR agonist 1 is a potent human A₃ adenosine receptor (hA₃AR) agonist with a K_i value of 2.40 nM.

HY-103183

CV1808 2-Phenylaminoadenosine	Adenosine Receptor Endogenous Metabolite	Inflammation/Immunology
CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with K_is of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively .

HY-124259

I-AB-MECA	Adenosine Receptor	Others
I-AB-MECA is an important radioligand for the study of A₃ adenosine receptors (A₃AR) .

HY-146457

A3AR antagonist 1	Adenosine Receptor	Inflammation/Immunology
A3AR antagonist 1 (compound 17) is a potent and selective human A₃ adenosine receptor (AR) antagonist, with an K_i of 4.63 nM. A3AR antagonist 1 shows no affinity for the rat A₃ AR even at high concentrations .

HY-120090

MRS1177	Adenosine Receptor	Inflammation/Immunology
MRS1177 is a potent and selective human Adenosine A3 receptor *(hA₃AR)* antagonist, with a K_i of 0.3 nM.

HY-N0138

Theobromine 1 Publications Verification 3,7-Dimethylxanthine	Adenosine Receptor Endogenous Metabolite	Neurological Disease
Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.

HY-118678

MRS1186	Adenosine Receptor	Inflammation/Immunology
MRS1186 is a potent and selective human Adenosine A3 receptor *(hA₃AR)* antagonist, with a K_i of 7.66 nM.

HY-116042

FSCPX	Adenosine Receptor	Cardiovascular Disease
FSCPX is a potent and selective irreversible antagonist of A₁ adenosine receptor (A₁AR), with low nanomolar potency for binding to the A₁AR. FSCPX could modify the effect of NBTI, a nucleoside transport inhibitor, by reducing the interstitial adenosine level in the guinea pig atrium .

HY-153333

A1/A3 AR antagonist 3	Adenosine Receptor	Cardiovascular Disease
A1/A3 AR antagonist 3 is an A₁R/A₃R dual antagonist with high affinity at low-micromolar to low-nanomolar. A1/A3 AR antagonist 3 can be used for the research of chronic heart diseases .

HY-147544

A1AR antagonist 5	Adenosine Receptor	Neurological Disease
A1AR antagonist 5 (compound 20) is a potent and selective *A1AR* (A1 adenosine receptor) antagonist, with a pIC₅₀ of 5.83 and a pK_i of 6.11 .

HY-147543

A1AR antagonist 4	Adenosine Receptor	Neurological Disease
A1AR antagonist 4 (compound 22) is a potent and selective *A1AR* (A1 adenosine receptor) antagonist, with a pIC₅₀ of 5.51 and a pK_i of 6.29 .

HY-147545

A1AR antagonist 6	Adenosine Receptor	Neurological Disease
A1AR antagonist 6 (compound 15) is a potent and selective *A1AR* (A1 adenosine receptor) antagonist, with a pIC₅₀ of 6.38 and a pK_i of 7.13 .

HY-125602

MNI-444	Adenosine Receptor	Neurological Disease
MNI-444 is a BBB-penetrable ligand of **adenosine 2A receptor** (A2AR). A2AR is a potential non-dopaminergic target for the research of Parkinson’s disease .

HY-103162

ANR94	Adenosine Receptor	Neurological Disease
ANR94 is a potent and selective adenosine A_2A receptor (AA_2AR) antagonist with an K_i of 46 nM for hAA_2AR. ANR94 has the potential for the research of Parkinson's disease .

HY-161718

MRS8028	Adenosine Receptor	Inflammation/Immunology
MRS8028 is an agonist for A3 adenosine receptor (A3AR), which binds hA3AR with K_i of 2.44 nM. MRS8028 is potential for ameliorating ischemia and inflammatory diseases .

HY-158180

A3AR agonist 4	Adenosine Receptor	Inflammation/Immunology
A3AR agonist 4 is an A3 adenosine receptor (A3AR) agonist (K_i: 1.24 nM for hA3AR). A3AR agonist 4 inhibits cAMP production with an EC₅₀ of 0.17 nM. A3AR agonist 4 can be used for research of inflammation and pain .

HY-147541

A2A/A3 AR antagonist-1	Adenosine Receptor	Inflammation/Immunology
A2A/A3 AR antagonist-1 (compound 23) is a dual A_2A/A₃ adenosine receptor (AR) fluorescent ligand, with K_is of 90 nM and 31.8 nM for hA_2A AR and hA₃ AR, respectively .

HY-167905

ATL444	Adenosine Receptor	Neurological Disease
ATL444 is a **adenosine receptor antagonist, with K_i** values of 7.0, 2.5, 61.8, >1000 nM for rA₁AR, rA_2AAR, rA_2BAR, rA₃AR, respectively .

HY-141865

Adenosine receptor antagonist 1	Adenosine Receptor	Cancer
Adenosine receptor antagonist 1 is a *A2aR*-selective antagonist with an IC₅₀ of 0.29 nM and displays 14-fold more selective for *A2aR* than A2bR.

HY-144672

A2A receptor antagonist 2	Adenosine Receptor	Inflammation/Immunology Cancer
A2A receptor antagonist 2 (Compound 57) is a potent, highly selective **adenosine A_2A receptor** (A_2AR) antagonist with an IC₅₀ of 8.3 nM .

HY-12099

A3AR antagonist 2	Adenosine Receptor	Inflammation/Immunology
A3AR antagonist 2 (compound 18) is a potent Human A3 adenosine receptor antagonist with an K_i value of 4.54 nM .

HY-158179

A3AR agonist 3	Adenosine Receptor	Neurological Disease
A3AR agonist 3 (Compound 15A) is a A3 adenosine receptor (A3AR) agonist, with K_i and EC₅₀ values of 2.27 and 0.20 nM for hA3 and cAMP, respectivelly. A3AR agonist 3 can be used for the research of neuroinflammation .

HY-158181

A3AR agonist 5	Adenosine Receptor	Inflammation/Immunology
A3AR agonist 5 (Compound 6b) is a A3 adenosine receptor (A3AR) activator, with EC₅₀ and K_i values of 0.14 nM and 6.36 nM for cAMP and hA3, respectively. A3AR agonist 5 can be used in pain and inflammatory research .

HY-161810

MRS8247	Adenosine Receptor	Others
MRS8247 is a positive allosteric modulator (PAM) of the A3 adenosine receptor (A3AR) that can also slow the dissociation rate of agonists .

HY-19532

ZM241385 5+ Cited Publications	Adenosine Receptor	Neurological Disease Cancer
ZM241385 is a potent, high affinity and selective adenosine A_2a receptor (A_2AR) antagonist with a K_i value of 1.4 nM .

HY-164621

A3AR antagonist 5	Adenosine Receptor	Others
A3AR antagonist 5 (Compound 16) is a selective antagonist for human adenosine A3 receptor with an affinity pC of 4.542 μM .

HY-144116

A1AR antagonist 2	Adenosine Receptor	Neurological Disease
A1AR antagonist 2 (compound 18h) is a potent A₁ adenosine receptor (AR) antagonist with K_is of 1.49, 10.2, and 50.1 nM for hA₁, hA_2A and hA_2B, respectively .

HY-144115

A1AR antagonist 1	Adenosine Receptor	Neurological Disease
A1AR antagonist 1 (compound 18g) is a potent A₁ adenosine receptor (AR) antagonist with K_is of 2.08, 6.91, and 31.2 nM for hA1, hA2A and hA2B, respectively .

HY-101978

Ciforadenant 5 Publications Verification CPI-444; V81444	Adenosine Receptor	Cancer
Ciforadenant (CPI-444) is a potent, orally active and selective **adenosine A2A receptor** (A2AR) antagonist, which induces antitumor responses .

HY-110202

MRS5698	Adenosine Receptor	Neurological Disease Inflammation/Immunology
MRS5698 is a selective G_i protein-coupled A₃ adenosine receptor (A₃AR) agonist, with K_is of approximately 3 nM for human and mouse A₃AR, respectively. MRS5698 can be used for the research of pain and psoriasis .

HY-N0092

Inosine Maximum Cited Publications 9 Publications Verification	Adenosine Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-N0138S

Theobromine-d6 3,7-Dimethylxanthine-d₆	Isotope-Labeled Compounds Adenosine Receptor Endogenous Metabolite	Neurological Disease
Theobromine-d₆ is the deuterium labeled Theobromine. Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.

HY-N0138S1

Theobromine-d3 3,7-Dimethylxanthine-d₃	Adenosine Receptor Endogenous Metabolite	Neurological Disease
Theobromine-d₃ is the deuterium labeled Theobromine. Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.

HY-129393

Etrumadenant 5+ Cited Publications AB928	Adenosine Receptor	Inflammation/Immunology Cancer
Etrumadenant (AB928) is an orally bioavailable, selective dual adenosine receptor *(A2aR/A2bR)* antagonist. Etrumadenant relieves adenosine-mediated immune suppression. Etrumadenant has immunomodulatory and antitumor activities .

HY-146456

A1AR antagonist 3	Adenosine Receptor	Neurological Disease
A1AR antagonist 3 (compound 13) is a selective adenosine 1 (A1) receptor antagonist with K_is of 9.69 nM and 0.529 nM for human A1 and rat A1, respectively. A1AR antagonist 3 can be used for researching neurological diseases .

HY-N0138R

Theobromine (Standard)	Adenosine Receptor Endogenous Metabolite	Neurological Disease
Theobromine (Standard) is the analytical standard of Theobromine. This product is intended for research and analytical applications. Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.

HY-103169

SCH442416 2 Publications Verification	Adenosine Receptor	Neurological Disease
SCH442416 is a potent, selective and brain-penetrant antagonist of **adenosine A_2A receptor (A_2AR), with K_i*s of 0.048 and 0.5 nM for human and rat A_2AR* respectively. SCH442416 displays more than 23000-fold selectivity over A₁R, A_2BR, and A₃R (K_i=1111, 10000, and 10000 nM, respectively). SCH442416 can be used for imaging of adenosine A_2A receptors in rat and primate brain .

HY-W004425

DMPX 3,7-Dimethyl-1-propargylxanthine	Adenosine Receptor	Neurological Disease
DMPX (3,7-Dimethyl-1-propargylxanthine) is a BBB-penatrable caffeine analogue. DMPX is A₂ selective adenosine receptor (AR) antagonist that strongly and selectively blocks hypothermia and behavioral inhibition induced by A₂ adenosine receptor agonists such as NECA (HY-103173). DMPX can be used in the study of Parkinson's disease and other diseases .

HY-N0092S1

Inosine-13C	Adenosine Receptor Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Inosine- ¹³C is the ¹³C labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-145308

Heterobivalent ligand-1	Adenosine Receptor Dopamine Receptor	Neurological Disease
Heterobivalent ligand-1 (compound 26) is a heterobivalent ligand for the Adenosine A 2A-dopamine D 2 receptor heteromer (K_DB1 A_2AR=2.1 nM, K_DB1 D₂R= 0.13 nM) .

HY-12365

Namodenoson 2 Publications Verification CF-102; 2-Cl-IB-MECA	Adenosine Receptor	Cancer
Namodenoson (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (K_i=0.33 nM). Namodenoson displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively .

Cat. No.	Product Name	Target	Research Area

HY-P99483

Blontuvetmab AT 004; VT 007	CD20 Adenosine Receptor	Cancer
Blontuvetmab (AT 004) is a caninized CD20 monoclonal antibody and is also a potent, selective, highly potent antagonist of A2aR receptor. Blontuvetmab behaves as Nociceptin (HY-P0183)/Orphanin (HY-P0183) FQ receptor (NOP) agonists displaying weak NOP affinity. Blontuvetmab inhibits 5'-N-Ethylcarboxamidoadenosine (NECA)-mediated A2aR activation and significantly reverses the ability of adenosine to suppress CD8 T cell activation, increasing levels of cytokines such as IFN-γ. Blontuvetmab Blontuvetmab can be used for the research of Canine B-cell lymphoma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-103183

CV1808 2-Phenylaminoadenosine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Adenosine Receptor Endogenous Metabolite
CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with K_is of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively .

HY-N0138

Theobromine 1 Publications Verification 3,7-Dimethylxanthine	Alkaloids Structural Classification Microorganisms Neurological Disease Classification of Application Fields Cocoa beans Other Alkaloids Sterculiaceae Source classification Plants Endogenous metabolite Disease Research Fields	Adenosine Receptor Endogenous Metabolite
Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.

HY-N0092

Inosine 5+ Cited Publications	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Adenosine Receptor Endogenous Metabolite
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-N0092R

Inosine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Adenosine Receptor Endogenous Metabolite
Inosine (Standard) is the analytical standard of Inosine. This product is intended for research and analytical applications. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors . In Vitro:Inosine dose-dependently stimulates cAMP production mediated through the A_2AR . Inosine dose-dependently induces hA_2AR-mediated ERK1/2 phosphorylation . Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes . In Vivo:Inosine (10-100 mg/kg; i.p.) exhibits antinociceptive effect in mice .

HY-N0138R

Theobromine (Standard)	Alkaloids Structural Classification Microorganisms Cocoa beans Other Alkaloids Sterculiaceae Source classification Plants Endogenous metabolite	Adenosine Receptor Endogenous Metabolite
Theobromine (Standard) is the analytical standard of Theobromine. This product is intended for research and analytical applications. Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.

Cat. No.	Product Name	Chemical Structure

HY-N0138S

Theobromine-d6
Theobromine-d₆ is the deuterium labeled Theobromine. Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.

HY-N0138S1

Theobromine-d3
Theobromine-d₃ is the deuterium labeled Theobromine. Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.

HY-N0092S

Inosine-2,8-d2
Inosine-2,8-d₂ is the deuterium labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors .

HY-N0092S2

Inosine-13C5
Inosine- ¹³C₅ is the ¹³C₅ labeled Inosine (HY-N0092). Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-N0092S1

Inosine-13C
Inosine- ¹³C is the ¹³C labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-19532S

ZM241385-d7
ZM241385-d7 is a deuterated form of ZM241385 (HY-19532). ZM241385 is a potent, high affinity and selective adenosine A_2a receptor (A_2AR) antagonist with a K_i value of 1.4 nM .

HY-N0092S4

Inosine-13C3
Inosine-13C3 is a ¹³C-labeled Inosine that can be used in pharmacokinetic studies of Inosine. Inosine is an agonist of adenosine receptors A₁R and *A_2AR* with anti-inflammatory immunomodulatory, antinociceptive and neuroprotective effects .

HY-N0092S3

Inosine-13C10,15N4
Inosine-13C10,15N4 is ¹³C and ¹⁵N labeled Inosine (HY-N0092). Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

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adenosine receptors (AR)

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Natural
Products