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anti-fertility

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By Targets:	Akt (1) Apoptosis (5) Autophagy (5) Bacterial (1) Bcl-2 Family (2) Cytochrome P450 (2) EGFR (1) Estrogen Receptor/ERR (4) FAK (2) Fungal (2) GnRH Receptor (1) HBV (2) HSP (1) NF-κB (2) Parasite (2) Progesterone Receptor (4) Prostaglandin Receptor (1) TGF-beta/Smad (2) Wnt (2) β-catenin (2)
By Research Areas:	Cancer (8) Cardiovascular Disease (3) Endocrinology (13) Infection (5) Inflammation/Immunology (5) Metabolic Disease (4) Neurological Disease (4)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Peptides

Natural
Products

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-32736

Triptonide 3 Publications Verification NSC 165677; PG 492	Wnt β-catenin Apoptosis Autophagy	Inflammation/Immunology Cancer
Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC₅₀ of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects .

HY-N2181

Acetylshikonin 1 Publications Verification	Cytochrome P450 Apoptosis Bacterial Autophagy	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Acetylshikonin is an oral active anti-cancer, anti-inflammatory, antioxidant, anti-fertility, antibacterial, and neuroprotective agent. Acetylshikonin is a inhibitor of acetylcholinase (AChE) (IC₅₀=34.6 μM) and nonselective cytochrome P450. Acetylshikonin can induce Apoptosis and Autophagy in cancer cells. Acetylshikonin regulates blood glucose, liver fat metabolism, and renal fibrosis, and is used in the study of diabetes, diabetic nephropathy (DN), obesity, and nonalcoholic fatty liver disease (NAFLD) .

HY-N0587

Demethylzeylasteral 3 Publications Verification	Apoptosis TGF-beta/Smad Estrogen Receptor/ERR NF-κB FAK	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Demethylzeylasteral is an orally active triterpenoid compound isolated from Tripterygium wilfordii, which has functions such as anti-inflammatory, anti-tumor, anti fertility, estrogen metabolism regulation, immune suppression, and immune system regulation ^[1][2].

HY-N4088

Pseudolaric acid A-O-β-D-glucopyranoside	Fungal	Infection Endocrinology
Pseudolaric acid A-O-β-D-glucopyranoside, isolated from Cortex Pseudolaricis, demonstrates antifungal and antifertility activities .

HY-126476

Justicisaponin I	Others	Others
Justicisaponin I can be used as an anti-fertility agent. Justicisaponin I stabilizes the acrosome membrane of sperm, and inhibits the release of acid hydrolase and sperm proteins .

HY-32736R

Triptonide (Standard)	Wnt β-catenin Apoptosis Autophagy	Inflammation/Immunology Cancer
Triptonide (Standard) is the analytical standard of Triptonide. This product is intended for research and analytical applications. Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC₅₀ of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects .

HY-129638

L-10503	Others	Endocrinology
L-10503 is a non-hormonal non-prostaglandin antifertility compound .

HY-131729

16-Phenoxy tetranor Prostaglandin A2	Others	Cardiovascular Disease
16-Phenoxy tetranor Prostaglandin A2 is a metabolite of uprostone and an analog of the antifertility hormone PGF2α .

HY-N0587R

Demethylzeylasteral (Standard)	Apoptosis TGF-beta/Smad Estrogen Receptor/ERR NF-κB FAK	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Demethylzeylasteral (Standard) is the analytical standard of Demethylzeylasteral. This product is intended for research and analytical applications. Demethylzeylasteral is an orally active triterpenoid compound isolated from Tripterygium wilfordii, which has functions such as anti-inflammatory, anti-tumor, anti fertility, estrogen metabolism regulation, immune suppression, and immune system regulation .

HY-P2357

MI-1544	GnRH Receptor	Metabolic Disease
MI-1544 is a powerful GnRH antagonist. MI-1544 induces inhibitory effects on the pituitary LH release and on gonads. MI-1544 can be used for the research of antifertility effect .

HY-106299

Lilopristone ZK98734	Progesterone Receptor	Metabolic Disease
Lilopristone (ZK98734) is a progesterone antagonist with a potential to induce menstruation, inhibit nidation, and terminate pregnancy. Lilopristone blocks progesterone action at the endometrium as well as decreases progesterone bioavailability, and can be utilized in antifertility research .

HY-N1581

Quassin Nigakilactone D	Parasite	Infection Endocrinology
Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits *P. falciparum* with an IC₅₀ of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity .

HY-N4088R

Pseudolaric acid A-O-β-D-glucopyranoside (Standard)	Fungal	Infection Endocrinology
Pseudolaric acid A-O-β-D-glucopyranoside (Standard) is the analytical standard of Pseudolaric acid A-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Pseudolaric acid A-O-β-D-glucopyranoside, isolated from Cortex Pseudolaricis, demonstrates antifungal and antifertility activities .

HY-16508R

Ulipristal acetate (Standard)	Progesterone Receptor Autophagy	Endocrinology Cancer
Ulipristal acetate (Standard) is the analytical standard of Ulipristal acetate. This product is intended for research and analytical applications. Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma .

HY-16508

Ulipristal acetate 2 Publications Verification CDB-2914	Progesterone Receptor Autophagy	Endocrinology Cancer
Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma .

HY-14959

Ulipristal CDB-3236; Deacetyl CDB-2914	Progesterone Receptor	Endocrinology Cancer
Ulipristal (CDB 3236) is a selective progesterone receptor modulator (SPRM). Ulipristal binds to the progesteron receptor, thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system .

HY-B1192

Estradiol benzoate Maximum Cited Publications 13 Publications Verification β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate	Estrogen Receptor/ERR HBV Bcl-2 Family	Neurological Disease
Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .

HY-N1581R

Quassin (Standard)	Parasite	Infection Endocrinology
Quassin (Standard) is the analytical standard of Quassin. This product is intended for research and analytical applications. Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC₅₀ of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity .

HY-B1192R

Estradiol benzoate (Standard)	Estrogen Receptor/ERR HBV Bcl-2 Family	Neurological Disease
Estradiol benzoate (Standard) is the analytical standard of Estradiol benzoate. This product is intended for research and analytical applications. Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .

HY-136092

Androsta-1,4,6-triene-3,17-dione	Cytochrome P450	Neurological Disease Endocrinology
Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor with a K_i of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory .

HY-137355

15(S)-15-methyl Prostaglandin D2 15(S)-15-Methyl PGD2	Prostaglandin Receptor	Metabolic Disease
15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. In contrast to PGD2, 15(S)-15-methyl PGD2 induces vasoconstriction and increases systemic blood pressure with much reduced inhibitory activity on ADP-induced platelet aggregation. It also exhibits strong antifertility activity in hamsters (200-fold more potent than PGD2).

HY-123035

Gamendazole	HSP Akt EGFR	Endocrinology
Gamendazole, an indazole carboxylic acid (ICA), is an orally active, selective HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A) inhibitor. Gamendazole binds to the C-terminal nucleotide binding pocket of HSP90 and cause downregulation of clients AKT1 and ERBB2, but stabilizes the HSP90 heterocomplex. Gamendazole specifically inhibits the actin bundling function of EEF1A1, but does not bind to the nucleotide docking pocket nor inhibits the ribosome charging or protein translation functions of EEF1A1. Gamendazole, an antispermatogenic compound with antifertility effects, has the potential for reversible non-hormonal male contraceptive agent research .

Cat. No.	Product Name	Target	Research Area

HY-P2357

MI-1544	GnRH Receptor	Metabolic Disease
MI-1544 is a powerful GnRH antagonist. MI-1544 induces inhibitory effects on the pituitary LH release and on gonads. MI-1544 can be used for the research of antifertility effect .

Triptonide 3 Publications Verification NSC 165677; PG 492	Structural Classification Classification of Application Fields Terpenoids Source classification Celastraceae Diterpenoids Tripterygium wilfordii Hook. f. Plants Inflammation/Immunology Disease Research Fields	Wnt β-catenin Apoptosis Autophagy
Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC₅₀ of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects .

Acetylshikonin 1 Publications Verification	Quinones Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Boraginaceae Inflammation/Immunology Disease Research Fields	Cytochrome P450 Apoptosis Bacterial Autophagy
Acetylshikonin is an oral active anti-cancer, anti-inflammatory, antioxidant, anti-fertility, antibacterial, and neuroprotective agent. Acetylshikonin is a inhibitor of acetylcholinase (AChE) (IC₅₀=34.6 μM) and nonselective cytochrome P450. Acetylshikonin can induce Apoptosis and Autophagy in cancer cells. Acetylshikonin regulates blood glucose, liver fat metabolism, and renal fibrosis, and is used in the study of diabetes, diabetic nephropathy (DN), obesity, and nonalcoholic fatty liver disease (NAFLD) .

Demethylzeylasteral 3 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Celastraceae Tripterygium wilfordii Hook. f. Plants Inflammation/Immunology Disease Research Fields	Apoptosis TGF-beta/Smad Estrogen Receptor/ERR NF-κB FAK
Demethylzeylasteral is an orally active triterpenoid compound isolated from Tripterygium wilfordii, which has functions such as anti-inflammatory, anti-tumor, anti fertility, estrogen metabolism regulation, immune suppression, and immune system regulation ^[1][2].

Pseudolaric acid A-O-β-D-glucopyranoside	Structural Classification other families Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Endocrinology	Fungal
Pseudolaric acid A-O-β-D-glucopyranoside, isolated from Cortex Pseudolaricis, demonstrates antifungal and antifertility activities .

Quassin Nigakilactone D	Triterpenes Structural Classification Simaroubaceae Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Picrasma quassioides(D．Don)Benn． Endocrinology	Parasite
Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits *P. falciparum* with an IC₅₀ of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity .

Estradiol benzoate Maximum Cited Publications 13 Publications Verification β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate	Classification of Application Fields Disease Research Fields Cancer	Estrogen Receptor/ERR HBV Bcl-2 Family
Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .

Justicisaponin I	Justicia rotundifolia Nees Triterpenes Structural Classification Acanthaceae Terpenoids Source classification Plants	Others
Justicisaponin I can be used as an anti-fertility agent. Justicisaponin I stabilizes the acrosome membrane of sperm, and inhibits the release of acid hydrolase and sperm proteins .

Triptonide (Standard)	Structural Classification Terpenoids Source classification Celastraceae Diterpenoids Tripterygium wilfordii Hook. f. Plants	Wnt β-catenin Apoptosis Autophagy
Triptonide (Standard) is the analytical standard of Triptonide. This product is intended for research and analytical applications. Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC₅₀ of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects .

Demethylzeylasteral (Standard)	Triterpenes Structural Classification Terpenoids Source classification Celastraceae Tripterygium wilfordii Hook. f. Plants	Apoptosis TGF-beta/Smad Estrogen Receptor/ERR NF-κB FAK
Demethylzeylasteral (Standard) is the analytical standard of Demethylzeylasteral. This product is intended for research and analytical applications. Demethylzeylasteral is an orally active triterpenoid compound isolated from Tripterygium wilfordii, which has functions such as anti-inflammatory, anti-tumor, anti fertility, estrogen metabolism regulation, immune suppression, and immune system regulation .

Pseudolaric acid A-O-β-D-glucopyranoside (Standard)	Structural Classification other families Terpenoids Source classification Diterpenoids Plants	Fungal
Pseudolaric acid A-O-β-D-glucopyranoside (Standard) is the analytical standard of Pseudolaric acid A-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Pseudolaric acid A-O-β-D-glucopyranoside, isolated from Cortex Pseudolaricis, demonstrates antifungal and antifertility activities .

Quassin (Standard)	Triterpenes Structural Classification Simaroubaceae Terpenoids Source classification Plants Picrasma quassioides(D．Don)Benn．	Parasite
Quassin (Standard) is the analytical standard of Quassin. This product is intended for research and analytical applications. Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC₅₀ of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity .

Cat. No.	Product Name		Classification

HY-118950

J 628		Alkynes
J 628 is an estrogen derivative used to study antifertility effects after sexual intercourse in mice, rats, and rabbits .

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anti-fertility

Inhibitors & Agonists

Peptides

NaturalProducts

Click Chemistry

Natural
Products