Search Result

Results for "

anti-mutagenic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (2) Apoptosis (8) Bacterial (6) Biochemical Assay Reagents (2) Caspase (2) DNA/RNA Synthesis (3) EBV (2) Endogenous Metabolite (8) HBV (2) HIV (2) iGluR (1) Isotope-Labeled Compounds (1) JAK (2) Keap1-Nrf2 (2) MAGL (1) Reactive Oxygen Species (4) STAT (1) TNF Receptor (1) β-catenin (2)
By Research Areas:	Cancer (18) Cardiovascular Disease (2) Infection (6) Inflammation/Immunology (9) Metabolic Disease (1) Neurological Disease (5)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7015

Zerumbone 1 Publications Verification	EBV Caspase Apoptosis Bacterial	Infection Cancer
Zerumbone is an orally active natural cyclic sesquiterpene and can be isolated from Zingiber zerumbet. Zerumbone has anti-proliferative, anti-inflammation, anti-cancer, anti-bacterial and anti-mutagenic activity .

HY-N0790

Lupeol 3 Publications Verification Clerodol; Monogynol B; Fagarasterol	Androgen Receptor Apoptosis	Cancer
Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent androgen receptor (AR) inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC) .

HY-N0056

Isochlorogenic acid A 5+ Cited Publications 3,5-Dicaffeoylquinic acid; 3,5-CQA	Reactive Oxygen Species HBV Endogenous Metabolite HIV Bacterial	Neurological Disease Inflammation/Immunology
Isochlorogenic acid A (3,5-Dicaffeoylquinic acid) is a natural phenolic acid with anti-mutagenicity, anti-HBV, anti-HIV, anti-oxidant, anti-bacterial, and anti-inflammatoryy activities .

HY-105008

Secoisolariciresinol diglucoside 4 Publications Verification (S,S)-SDG; (S,S)-LGM2605	Others	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects .

HY-N0351S1

p-Coumaric acid-d6 trans-4-Hydroxycinnamic acid-d₆	Endogenous Metabolite	Cancer
p-Coumaric acid-d₆ is the deuterium labeled p-Coumaric acid (HY-N0351). p-Coumaric acid is the abundant isomer of cinnamic acid which has antitumor and anti-mutagenic activities[1][2].

HY-N0313

Euphol	MAGL Endogenous Metabolite	Inflammation/Immunology
Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC₅₀=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain .

HY-N7015R

Zerumbone (Standard)	EBV Caspase Apoptosis Bacterial	Infection
Zerumbone (Standard) is the analytical standard of Zerumbone. This product is intended for research and analytical applications. Zerumbone is an orally active natural cyclic sesquiterpene and can be isolated from Zingiber zerumbet. Zerumbone has anti-proliferative, anti-inflammation, anti-cancer, anti-bacterial and anti-mutagenic activity .

HY-N0351S

p-Coumaric acid-13C3	Endogenous Metabolite	Cancer
p-Coumaric acid- ¹³C₃ is the ¹³C-labeled p-Coumaric acid. p-Coumaric acid is the abundant isomer of cinnamic acid which has antitumor and anti-mutagenic activities.

HY-N0790R

Lupeol (Standard)	Androgen Receptor Apoptosis	Cancer
Lupeol (Standard) is the analytical standard of Lupeol. This product is intended for research and analytical applications. Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic?triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent?androgen receptor (AR)?inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC) .

HY-N0056R

Isochlorogenic acid A (Standard)	Reactive Oxygen Species HBV Endogenous Metabolite HIV Bacterial	Neurological Disease Inflammation/Immunology
Isochlorogenic acid A (Standard) is the analytical standard of Isochlorogenic acid A. This product is intended for research and analytical applications. Isochlorogenic acid A (3,5-Dicaffeoylquinic acid) is a natural phenolic acid with anti-mutagenicity, anti-HBV, anti-HIV, anti-oxidant, anti-bacterial, and anti-inflammatoryy activities .

HY-N1779

(E)-3,4-Dimethoxycinnamyl alcohol	Others	Infection
(E)-3,4-Dimethoxycinnamyl alcohol is an antimutagenic. (E)-3,4-Dimethoxycinnamyl alcohol has antimutagenic activity against furylfuramide, Trp-P-1, and activated Trp-P-1 .

HY-N0323

Bilirubin 2 Publications Verification	Endogenous Metabolite	Metabolic Disease
Bilirubin is a yellow breakdown product of heme catabolism . Bilirubin exhibits antioxidant and antimutagenic effects .

HY-119956

Biflorin	Apoptosis STAT	Infection Inflammation/Immunology Cancer
Biflorin has antimicrobial, antitumor, antiinflammatory and antimutagenic activities. Biflorin is found in the roots of Capraria biflora L .

HY-B0911

Chlorophyllin sodium copper salt 1 Publications Verification	Biochemical Assay Reagents	Cardiovascular Disease Cancer
Chlorophyllin sodium copper salt is an orally active green pigment, antioxidant and antimutagenic agent. Chlorophyllin sodium copper salt promotes hematopoiesis and thrombopoiesis .

HY-N9110

7,3′,4′-Tri-O-methyleriodictyol	Others	Others
7,3′,4′-Tri-O-methyleriodictyol is a flavonoid with an *antimutagenic* activity. 7,3′,4′-Tri-O-methyleriodictyol inhibits the furylfuramide-induced SOS response and has potency as bioantimutagens .

HY-W275553

4-Decanol	Others	Infection
4-Decanol is an antimutagenic compound, that can be isolated from mustard leaves. 4-Decanol inhibits mutagenic activities of $AFB_1$ and MNNG in Salmonella typhimurium TA100 .

HY-133621

9,10-Dichlorostearic acid	Others	Cancer
9,10-Dichlorostearic acid is a chlorinated stearic acid with antimutagenic properties. 9,10-Dichlorostearic acid can cause membrane damage by inducing leakage of adenosine triphosphate (ATP) from mammalian tumour cells in vitro .

HY-B0911R

Chlorophyllin sodium copper salt (Standard)	Biochemical Assay Reagents	Cancer
Chlorophyllin sodium copper salt (Standard) is the analytical standard of Chlorophyllin sodium copper salt. This product is intended for research and analytical applications. Chlorophyllin sodium copper salt is an orally active green pigment, antioxidant and antimutagenic agent. Chlorophyllin sodium copper salt promotes hematopoiesis and thrombopoiesis .

HY-W014118

α-Hexylcinnamaldehyde	Others	Cancer
α-Hexylcinnamaldehyde, a compound derived from Cinnamaldehyde. α-Hexylcinnamaldehyde has the potential antimutagenic and chemosensitizing properties. α-Hexylcinnamaldehyde is widely used as an ingredient in many personal care, and as an additive in food and the pharmaceutical industry .

HY-N4156

Pteropodine	Others	Others
Pteropodine (compound 3) is a monoterpenoid oxindole alkaloid that can be isolated from Hamelia patens. Pteropodine modulates the functions of M1 muscarinic and 5-HT2 receptors. Pteropodine has antioxidant and antimutagenic properties .

HY-N0527

Pentagalloylglucose Maximum Cited Publications 10 Publications Verification Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose	JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species	Neurological Disease Inflammation/Immunology Cancer
Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities .

HY-126383

Spilanthol	Bacterial	Infection Others Inflammation/Immunology Cancer
Spilanthol is an orally active analgesic, neuroprotective, antioxidant, antimutagenic, anti-cancer, anti-inflammatory, antimicrobial and insecticidal compound.pilanthol can induce cAMP to inhibit negative regulation of urinary concentration mechanism. Spilanthol can be use as diuretic research .

HY-N5054

(R)-5,7-Dimethoxyflavanone	TNF Receptor	Inflammation/Immunology
(R)-5,7-Dimethoxyflavanone shows potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. typhimurium TA100 and TA98 strains . And (R)-5,7-Dimethoxyflavanone significantly and dose-dependently inhibits the inflammatory mediato .

HY-N0527R

Pentagalloylglucose (Standard)	JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species	Neurological Disease Inflammation/Immunology Cancer
Pentagalloylglucose (Standard) is the analytical standard of Pentagalloylglucose. This product is intended for research and analytical applications. Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities .

HY-N0368S1

Linalool-13C3	Apoptosis Endogenous Metabolite iGluR Bacterial Isotope-Labeled Compounds	Cancer
Linalool- ¹³C₃ is ¹³C labeled α-Hexylcinnamaldehyde (HY-W014118). α-Hexylcinnamaldehyde, a compound derived from Cinnamaldehyde. α-Hexylcinnamaldehyde has the potential antimutagenic and chemosensitizing properties. α-Hexylcinnamaldehyde is widely used as an ingredient in many personal care, and as an additive in food and the pharmaceutical industry .

HY-W014118R

α-Hexylcinnamaldehyde (Standard)	Others	Cancer
α-Hexylcinnamaldehyde (Standard) is the analytical standard of α-Hexylcinnamaldehyde. This product is intended for research and analytical applications. α-Hexylcinnamaldehyde, a compound derived from Cinnamaldehyde. α-Hexylcinnamaldehyde has the potential antimutagenic and chemosensitizing properties. α-Hexylcinnamaldehyde is widely used as an ingredient in many personal care, and as an additive in food and the pharmaceutical industry .

HY-N3616

trans-Coniferyl aldehyde	DNA/RNA Synthesis Endogenous Metabolite	Cancer
trans-Coniferyl aldehyde (compound 2) is a natural compound isolated from the buds of clove (Syzygium aromaticum).trans-Coniferyl aldehyde suppresses 63% of the UV mutable gene expression at 1.20 μM, and with an ID₅₀ value of 0.76 μM,and has the antimutagenic activities against furylfuramide, Trp-P-1, and activated Trp-P-1 .

HY-135218

AV-153	DNA/RNA Synthesis	Cancer
AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 has anti-cancer activity .

HY-135218A

AV-153 free base 1 Publications Verification	DNA/RNA Synthesis	Cancer
AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity .

HY-N1959

Cannabisin A	Others	Others
Cannabisin A is a natural product in seeds in sprouts .

Cat. No.	Product Name

HY-L068

Flavonoids Library	516 compounds
Flavonoids are an important class of natural products; particularly, they belong to a class of plant secondary metabolites having a polyphenolic structure, widely found in fruits, vegetables and certain beverages. Flavonoids can be subdivided into different subgroups depending on the carbon of the C ring on which the B ring is attached and the degree of unsaturation and oxidation of the C ring. These subgroups are: flavones, flavonols, flavanones, flavanonols, flavanols or catechins, anthocyanins and chalcones. Flavonoids are now considered as an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal and cosmetic applications. This is attributed to their anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme function. Naturally occurring flavonoids are known to have biological activities for use as drugs, for example, in diseases like cancer, Alzheimer’s disease (AD), atherosclerosis, etc. MCE offers a unique collection of 516 natural flavonoid compounds which is a useful tool for drug discovery as an important source of lead compounds.

Flavonoids Library

516 compounds

Flavonoids are an important class of natural products; particularly, they belong to a class of plant secondary metabolites having a polyphenolic structure, widely found in fruits, vegetables and certain beverages. Flavonoids can be subdivided into different subgroups depending on the carbon of the C ring on which the B ring is attached and the degree of unsaturation and oxidation of the C ring. These subgroups are: flavones, flavonols, flavanones, flavanonols, flavanols or catechins, anthocyanins and chalcones. Flavonoids are now considered as an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal and cosmetic applications. This is attributed to their anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme function. Naturally occurring flavonoids are known to have biological activities for use as drugs, for example, in diseases like cancer, Alzheimer’s disease (AD), atherosclerosis, etc.

MCE offers a unique collection of 516 natural flavonoid compounds which is a useful tool for drug discovery as an important source of lead compounds.

Cat. No.	Product Name	Category	Target	Chemical Structure