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Results for "

antibiofilm

" in MedChemExpress (MCE) Product Catalog:

64

Inhibitors & Agonists

8

Peptides

9

Natural
Products

3

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-170520
    Antibiofilm agent-14

    		Bacterial Infection
    Antibiofilm agent-14 (compound 11) is an antibiofilm agent. Antibiofilm agent-14 has antifungal activity against C.albicans SC5314 with MIC of 50 μM .
    Antibiofilm agent-14
  • HY-164123
    Antibiofilm agent-9

    		Bacterial Infection
    Antibiofilm agent-9 (Compound 4) is a pyrrolomycin derivative with antibacterial activity. Antibiofilm agent-9 inhibits Bacillus anthracis with MIC of 0.031 μg/mL. Antibiofilm agent-9 exhibits antibiofilm activity with 84% biofilm inhibition (24 h, 8.0 μg/mL). Antibiofilm agent-9 exhibits a good pharmacokinetic characters in mouse model .
    Antibiofilm agent-9
  • HY-168900
    Antibiofilm agent-16

    		Bacterial Infection
    Antibiofilm agent-15 (Compound 17) is an antibacterial agent. Antibiofilm agent-15 inhibits biofilm formation in Gram-positive and Gram-negative bacteria .
    Antibiofilm agent-16
  • HY-161279
    Antibiofilm agent-5

    		Bacterial Lactate Dehydrogenase Reactive Oxygen Species Infection
    Antibiofilm agent-5 (compound 6c) is a multitargeting antibacterial agent with potent antibiofilm activity. Antibiofilm agent-5 could induce metabolic dysfunction by deactivating lactate dehydrogenase and promote the accumulation of reactive oxygen species to decrease the reduced glutathione and ultimately cause oxidative damage in bacteria. Antibiofilm agent-5 can be used for the research of refractory biofilm-intensified bacterial infections .
    Antibiofilm agent-5
  • HY-164369
    Antibiofilm agent-10

    		Bacterial Infection
    Antibiofilm agent-10 is an antibiofilm agent, which reduces bacterial levels and improves wound healing in recalcitrant pressure ulcers (PUs) in combination with negative pressure wound therapy (NPWT). Antibiofilm agent-10 enhances pathogen killing efficacy of antimicrobials .
    Antibiofilm agent-10
  • HY-168258
    Antibiofilm agent-13

    		Bacterial Infection
    Antibiofilm agent-13 (compound 14b) is a potent antibacterial agent that displays a broad-spectrum antimicrobial activity. Antibiofilm agent-13 could disintegrate the integrity of bacterial cell membranes by destroying transmembrane potential and enhancing membrane permeability, and causing the generation of intracellular ROS and the leakage of DNA and proteins, ultimately leading to bacterial death. Antibiofilm agent-13 inhibits both Gram-positive bacteria (MIC of 0.5-1 μg/mL) and Gram-negative bacteria (MIC of 1-32 μg/mL) .
    Antibiofilm agent-13
  • HY-161086
    Antibiofilm agent-4

    		Bacterial Infection
    Antibiofilm agent-4 (compound 4p) is a LasR inhibitor. Antibiofilm agent-4 shows the best antibiofilm and anti-QS properties .
    Antibiofilm agent-4
  • HY-168063
    Antibiofilm agent-11

    		Bacterial Infection
    Antibiofilm agent-11 (compound C12) is a xanthone derivative with anti-biofilm activity .
    Antibiofilm agent-11
  • HY-163481
    Antibiofilm agent-6

    		Bacterial Infection
    Antibiofilm agent-6 (Compound 26c) is a quorum sensing inhibitor with strong antibiofilm effects that can inhibit the fluorescence intensity of PAO1-lasB-gfp and PAO1-pqsA-gfp in a concentration-dependent manner. Antibiofilm agent-6 can inhibit the production of pyocyanin and rhamnolipid. Antibiofilm agent-6 aids helps ciprofloxacin (HY-B0356) effectively eliminate the living bacteria in a mouse model infected with P. aeruginosa PAO1 .
    Antibiofilm agent-6
  • HY-168077
    Antibiofilm agent-12

    		Fungal Infection
    Antibiofilm agent-12 (Compound C13) is an antifungal agent that belongs to the class of carbazate derivatives. Antibiofilm agent-12 exhibits significant antifungal activity against Candida auris, with a MIC90 of 237.9 μM. By inhibiting the drug efflux pump activity of Candida auris and promoting ergosterol depletion, Antibiofilm agent-12 hinders biofilm formation and reduces the metabolic flexibility of Candida auris. Additionally, Antibiofilm agent-12 demonstrates antifungal activity in a Candida auris-infected C. elegans model .
    Antibiofilm agent-12
  • HY-156439
    Antibiofilm agent-2

    		Bacterial Infection
    Antibiofilm agent-2 (compound 4T) is a potent biofilm inhibitor with an IC50 of 3.6 μM. Antibiofilm agent-2 inhibits the quorum sensing system and iron homeostasis as antibacterial synergists against Pseudomonas aeruginosa .
    Antibiofilm agent-2
  • HY-158401
    Antibiofilm agent-7

    		Bacterial Infection
    Antibiofilm agent-7 (Compound 9) exhibits potent antibiofilm activity with IC50 of 60, 133.32, and 19.67 µg/mL against S. aureus, E. coli, and methicillin-resistant S. aureus (MRSA), respectively. Antibiofilm agent-7 has antibacterial activity for S. aureus, E. coli, C. albicans, and MRSA, with MIC values of 4.88, 78.13, 9.77 and 39.06 µg/mL, respectively .
    Antibiofilm agent-7
  • HY-161685
    Antibiofilm agent-8

    		Bacterial Reactive Oxygen Species Endogenous Metabolite Infection
    Antibiofilm agent-8 (compound Ru2) enhances antimicrobial activity on visible-light exposure (400-700 nm, 10 J cm-2). Antibiofilm agent-8 generates of oxidative stress via NADH oxidation and ROS generation and compromises bacterial wall .
    Antibiofilm agent-8
  • HY-155461
    Antibiofilm agent-3

    		Bacterial Infection
    Antibiofilm agent-3 (compound 3b) is a tetracarboxamide antibacterial agent that effectively inhibits the plant bacterial pathogen Xanthomonas citri (Xanthomonas citri ssp. citri, Xcc) (MIC=500 μg/ mL). Antibiofilm agent-3 inhibits biofilm formation by Xcc with IC50=15.37 μg/mL .
    Antibiofilm agent-3
  • HY-168928
    Antibiofilm agent prodrug 1

    		Bacterial Infection
    Antibiofilm agent prodrug 1 (Compound 5c) exhibits antibacterial activity through inhibition of biofilm formation and iron uptake. Antibiofilm agent prodrug 1 inhibits P. aeruginosa PAO1 with a MIC of 1.07 μM. Antibiofilm agent prodrug 1 exhibits anti-infectious efficacy in C. elegans with improved survival rate .
    Antibiofilm agent prodrug 1
  • HY-155333
    Antibiofilm agent-1

    		Bacterial Infection
    Antibiofilm agent-1 is an antibacterial agent that inhibits growth of Gram-positive pathogens (WO2017011725A1; compound 17) .
    Antibiofilm agent-1
  • HY-146067
    β-Nor-lapachone

    		Fungal Reactive Oxygen Species Infection
    β-Nor-lapachone is a Candida glabrata antibiofilm agent. β-Nor-lapachone can stimulate ROS production, inhibits efflux activity, adhesion, biofilm formation and the metabolism of mature biofilms of Candida glabrata. β-Nor-lapachone has antifungal activity .
    β-Nor-lapachone
  • HY-Y1718
    Tridecanoic acid
    1 Publications Verification

    N-Tridecanoic acid

    		 Endogenous Metabolite Bacterial Infection Metabolic Disease
    Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation .
    Tridecanoic acid
  • HY-Y1718R
    Tridecanoic acid (Standard)

    		Endogenous Metabolite Bacterial Infection Metabolic Disease
    Tridecanoic acid (Standard) is the analytical standard of Tridecanoic acid. This product is intended for research and analytical applications. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation .
    Tridecanoic acid (Standard)
  • HY-108547
    Alexidine dihydrochloride
    1 Publications Verification

    		 Fungal Apoptosis Infection Cancer
    Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens .
    Alexidine dihydrochloride
  • HY-147866
    Antibacterial agent 110

    		Bacterial DNA/RNA Synthesis ROS Kinase Infection
    Antibacterial agent 110 (Compound 4e) is a potent antibacterial agent with a MIC value of 1 μg/mL against P. aeruginosa. Antibacterial agent 110 possesses favorable antibiofilm activity and can destroy cell membranes. Antibacterial agent 110 causes metabolic arrest and intracellular oxidative stress, and obstructs DNA replication .
    Antibacterial agent 110
  • HY-168873
    Anti-MRSA agent 23

    		Bacterial Infection
    Anti-MRSA agent 23 (compound 11) is a potent anti-methicillin-resistant Staphylococcus aureus agent. Anti-MRSA agent 23 shows antibacterial and antibiofilm activities. Anti-MRSA agent 23 accelerates the reconstruction and healing of MRSA-infected cutaneous wounds by decreasing bacterial loads, attenuating inflammation, and promoting angiogenesis .
    Anti-MRSA agent 23
  • HY-157143
    Antibacterial agent 164

    		Bacterial Infection
    Antibacterial agent 164 (compound 2a) is an antibacterial and antibiofilm agent. Antibacterial agent 164 inhibits S. aureus and B. subtilis (MIC of 0.09 mM), and also exhibits strong anti-B. Subtilis biofilm formation .
    Antibacterial agent 164
  • HY-N11722
    Panduratin A

    		PPAR Apoptosis Bacterial Infection Inflammation/Immunology Cancer
    Panduratin A, a natural chalcone compound, is a PPAR-α/δ activator. Panduratin A induces apoptosis, and promotes cell cycle arrest at G0/G1 phase in multiple hematologic malignant cell lines. Panduratin A has anticancer, antioxidant, anti-inflammatory, antibacterial, and antibiofilm activities .
    Panduratin A
  • HY-P5924A
    D-K6L9

    		Bacterial Infection
    D-K6L9 shows antimicrobial and antibiofilm activities against P. aeruginosa from cystic fibrosis patients. D-K6L9 is stable and resistant to degradation by cystic fibrosis sputum proteases and will not induce bacterial resistance .
    D-K6L9
  • HY-P5924
    L-K6L9

    		Bacterial Infection
    L-K6L9 shows antimicrobial and antibiofilm activities against P. aeruginosa from cystic fibrosis patients. L-K6L9 is stable and resistant to degradation by cystic fibrosis sputum proteases and will not induce bacterial resistance .
    L-K6L9
  • HY-B1474
    Alexidine

    		Fungal Infection Cancer
    Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis .
    Alexidine
  • HY-N10755A
    (±)-ε-Viniferin

    		Cytochrome P450 Bacterial Infection
    (±)-ε-Viniferin is a racemate of ε-Viniferin (HY-N3841). (±)-ε-Viniferin exhibits P450 inhibitory antioxidants, as well as hepato-protective and antimicrobial activities. (±)-ε-Viniferin has antibacterial and antibiofilm activity against Gram-positive bacteria Streptococcus pneumoniae with a MIC of 20 μM .
    (±)-ε-Viniferin
  • HY-W062216
    2-Aminoimidazole

    		Bacterial Arginase Infection
    2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a Ki of 3.6 mM .
    2-Aminoimidazole
  • HY-172109
    DNA Gyrase-IN-15

    		DNA/RNA Synthesis Infection
    DNA Gyrase-IN-15 (Compound 11) is an antimicrobial agent and inhibitor of DHPS and DNA gyrase, with IC50s of 1.73 and 0.07 µM, respectively. DNA Gyrase-IN-15 shows antimicrobial activity against Enterococcus faecalis (MIC of 15.62 µg/mL), Acinetobacter baumannii, Enterobacter species (MIC of 7.81 µg/mL), Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus. DNA Gyrase-IN-15 also shows antibiofilm activity against Enterococcus faecalis .
    DNA Gyrase-IN-15
  • HY-147531
    Antibacterial agent 106

    		Bacterial Infection
    Antibacterial agent 106 (compound 8) is an orally active and potent antibacterial agent with antibiofilm activity. Antibacterial agent 106 shows potent antibacterial effect against multi-agent resistant (MDR)-Gram positive pathogens. Antibacterial agent 106 is highly effective in clearing 99.7% of the intracellular methicillin-resistant S. aureus (MRSA) harbored inside macrophages . Antibacterial agent 106 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Antibacterial agent 106
  • HY-163203
    DDC18-8A

    		Bacterial Infection
    DDC18-8A is an amphiphilic dendrimer that exhibits high antibacterial and antibiofilm efficacy .
    DDC18-8A
  • HY-P10233
    SAAP 148

    		Bacterial Infection
    SAAP 148 is an antimicrobial and antibiofilm agent, and exhibits inhibitory efficacy against antibiotic-resistant pathogens, with LC50 of 0.8-12.8 μM .
    SAAP 148
  • HY-P10361
    Temporin-GHc

    		Bacterial Antibiotic Inflammation/Immunology
    Temporin-GHc has an antibacterial activity with MBIC50 value of 6 μM and antibiofilm activity with MBEC50 value of 25 μM at 24 h .
    Temporin-GHc
  • HY-169191
    Quorum sensing-IN-8

    		Bacterial Infection
    Quorum sensing-IN-8 (compound 5e) has anti-biofilm activity. Quorum sensing-IN-8 can be used for the study of antimicrobial resistance .
    Quorum sensing-IN-8
  • HY-P10233A
    SAAP 148 TFA

    		Bacterial Infection
    SAAP 148 TFA is an antimicrobial and antibiofilm agent, and exhibits inhibitory efficacy against antibiotic-resistant pathogens, with LC50 of 0.8-12.8 μM .
    SAAP 148 TFA
  • HY-W041080
    3,5-Di-tert-butylphenol

    		Fungal Reactive Oxygen Species Infection
    3,5-Di-tert-butylphenol is an volatile organic compound with anti-biofilm and antifungal activities. 3,5-Di-tert-butylphenol induces accumulation of reactive oxygen species (ROS).
    3,5-Di-tert-butylphenol
  • HY-17594
    Oxyclozanide
    1 Publications Verification

    		 Oxidative Phosphorylation Parasite Bacterial Fungal Infection
    Oxyclozanide is an orally active salicylanilide anthelmintic agent that mainly acts by uncoupling oxidative phosphorylation in flukes. Oxyclozanide shows good anti-adenovirus, anti-biofilm, antifungal, and antibacterial activity .
    Oxyclozanide
  • HY-N6931
    Usaramine

    		Bacterial Infection
    Usaramine is a pyrrolizidine alkaloid isolated from seeds of Crolatalaria pallida. Usaramine demonstrates a highlighted antibiofilm activity against Staphylococcus epidermidis by reducing more than 50% of biofilm formation without killing the bacteria .
    Usaramine
  • HY-E70127
    Serratiopeptidase

    Brasan; Dasen

    		 SARS-CoV Infection
    Serratiopeptidase is an anti-inflammatory agent. Serratiopeptidase has anti-inflammatory, anti-biofilm, mucolytic, fibrinolytic, and wound-healing properties. Serratiopeptidase can be used for combat COVID-19-induced respiratory syndrome research .
    Serratiopeptidase
  • HY-155546
    Antimicrobial agent-22

    		Bacterial Infection
    Antimicrobial agent-22 (THI 6c) is a multi-target broad-spectrum antibacterial agent. Antimicrobial agent-22 has low cytotoxicity, hemolytic property, rapid bactericidal ability and good anti-biofilm activity .
    Antimicrobial agent-22
  • HY-157482
    EBP-59

    		Bacterial Infection
    EBP-59 is a bacterial inhibitor with antibiofilm activity against Gram-positive bacteria. EBP-59 is effective against Staphylococcus aureus and MRSA (methicillin–resistant staphylococcus aureus). EBP-59 can be used to study bacterial infections .
    EBP-59
  • HY-17594R
    Oxyclozanide (Standard)

    		Oxidative Phosphorylation Parasite Bacterial Fungal Infection
    Oxyclozanide (Standard) is the analytical standard of Oxyclozanide. This product is intended for research and analytical applications. Oxyclozanide is an orally active salicylanilide anthelmintic agent that mainly acts by uncoupling oxidative phosphorylation in flukes. Oxyclozanide shows good anti-adenovirus, anti-biofilm, antifungal, and antibacterial activity .
    Oxyclozanide (Standard)
  • HY-B1159
    Nitroxoline

    8-Hydroxy-5-nitroquinoline; 5-Nitro-8-quinolinol

    		 Bacterial Antibiotic Apoptosis Autophagy Infection Cancer
    Nitroxoline (8-Hydroxy-5-nitroquinoline), an antibiotic, is an orally active antibiofilm agent. Nitroxoline reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Nitroxoline can be used for the urinary tract infections and cancer research .
    Nitroxoline
  • HY-N6931R
    Usaramine (Standard)

    		Bacterial Infection
    Usaramine (Standard) is the analytical standard of Usaramine. This product is intended for research and analytical applications. Usaramine is a pyrrolizidine alkaloid isolated from seeds of Crolatalaria pallida. Usaramine demonstrates a highlighted antibiofilm activity against Staphylococcus epidermidis by reducing more than 50% of biofilm formation without killing the bacteria .
    Usaramine (Standard)
  • HY-161069
    Anti-infective agent 8

    		Bacterial Infection
    Anti-infective agent 8 (compound 9d) is an antibacterial agent with an MIC of 0.5 μg/mL against Staphylococcus aureus and Mycobacterium tuberculosis H37Rv. Anti-infective agent 8 has anti-biofilm activity and significantly reduces Staphylococcus aureus biofilm formation .
    Anti-infective agent 8
  • HY-Y1718S1
    Tridecanoic acid-d25

    N-Tridecanoic acid-d25

    		 Endogenous Metabolite Bacterial Cancer
    Tridecanoic acid-d25 is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation[1].
    Tridecanoic acid-d25
  • HY-Y1718S
    Tridecanoic acid-d2

    N-Tridecanoic acid-d2

    		 Isotope-Labeled Compounds Endogenous Metabolite Bacterial Infection
    Tridecanoic acid-d2 is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation[1].
    Tridecanoic acid-d2
  • HY-Y1718S2
    Tridecanoic acid-d9

    N-Tridecanoic acid-d9

    		 Isotope-Labeled Compounds Endogenous Metabolite Bacterial Infection
    Tridecanoic acid-d9 is the deuterium labeled Tridecanoic acid. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation[1].
    Tridecanoic acid-d9
  • HY-162261
    Antibacterial agent 186

    		Bacterial Infection
    Antibacterial agent 186 (compound 25) is a potent antibacterial agent. Antibacterial agent 186 shows antibiofilm-forming properties against clinical Staphylococcus epidermidis strains and demonstrates the capacity to eliminate existing biofilm layers. Antibacterial agent 186 has the potential for the research of multidrug-resistant Staphylococcus epidermidis .
    Antibacterial agent 186

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