Search Result

Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

aortic cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Androgen Receptor (2) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (1) AP-1 (1) Apoptosis (6) Bacterial (1) Biochemical Assay Reagents (1) ClpP (1) COX (2) Drug Derivative (2) Endogenous Metabolite (10) Endothelin Receptor (1) ERK (1) FAK (2) Ferroptosis (1) Fluorescent Dye (2) Glucosylceramide Synthase (GCS) (1) HIF/HIF Prolyl-Hydroxylase (1) Insulin Receptor (1) Interleukin Related (1) JNK (3) MMP (1) Monoamine Oxidase (2) NF-κB (2) P2Y Receptor (1) p38 MAPK (3) Parasite (2) Phosphodiesterase (PDE) (1) Phospholipase (1) PKC (1) Prostaglandin Receptor (1) Reactive Oxygen Species (1) Sirtuin (1) Vasopressin Receptor (2) VEGFR (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (13) Endocrinology (2) Infection (2) Inflammation/Immunology (6) Metabolic Disease (12) Neurological Disease (3)

By Targets:

Akt (2)

Androgen Receptor (2)

Angiotensin Receptor (1)

Angiotensin-converting Enzyme (ACE) (1)

AP-1 (1)

Apoptosis (6)

Bacterial (1)

Biochemical Assay Reagents (1)

ClpP (1)

COX (2)

Drug Derivative (2)

Endogenous Metabolite (10)

Endothelin Receptor (1)

ERK (1)

FAK (2)

Ferroptosis (1)

Fluorescent Dye (2)

Glucosylceramide Synthase (GCS) (1)

HIF/HIF Prolyl-Hydroxylase (1)

Insulin Receptor (1)

Interleukin Related (1)

JNK (3)

MMP (1)

Monoamine Oxidase (2)

NF-κB (2)

P2Y Receptor (1)

p38 MAPK (3)

Parasite (2)

Phosphodiesterase (PDE) (1)

Phospholipase (1)

PKC (1)

Prostaglandin Receptor (1)

Reactive Oxygen Species (1)

Sirtuin (1)

Vasopressin Receptor (2)

VEGFR (2)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (16)

Cardiovascular Disease (13)

Endocrinology (2)

Infection (2)

Inflammation/Immunology (6)

Metabolic Disease (12)

Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126410

Petunidin chloride 1 Publications Verification	FAK	Metabolic Disease
Petunidin chloride is an O-methylated anthocyanidin derived from delphinidin. Petunidin chloride binds with and suppresses the activity of focal adhesion kinase and to inhibit platelet-derived growth factor-induced aortic smooth muscle cell migration, which may confer a protective effect against atherosclerosis.

HY-15778A

AVE 0991 sodium salt Maximum Cited Publications 13 Publications Verification	Angiotensin Receptor	Cardiovascular Disease Endocrinology
AVE 0991 sodium salt is a nonpeptide and orally active Ang-(1-7) receptor Mas agonist. AVE 0991 competes for high-affinity binding of [ ¹²⁵I]-Ang-(1-7) to bovine aortic endothelial cell membranes with IC₅₀ of 21 nM .

HY-P0049

Argipressin 10+ Cited Publications Arg8-vasopressin; AVP	Vasopressin Receptor	Neurological Disease Cancer
Argipressin (Arg8-vasopressin) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a K_d value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1.

HY-120986

(S)-Bromoenol lactone (S)-BEL; (S,E)-Bromoenol lactone	Phospholipase	Inflammation/Immunology
(S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A₂β (iPLA₂β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC₅₀ of 2 µM .

HY-N3063

Pimaric acid	Apoptosis MMP NF-κB p38 MAPK	Cardiovascular Disease Cancer
Pimaric acid is a resin acid that has been found in A. cordata and various pines. Pimaric acid exerts anticancer effects via endoplasmic reticulum stress, caspase-dependent apoptosis, cell cycle arrest, and inhibition of cell migration in human ovarian cancer cells. Pimaric acid reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs) .

HY-161290

PDE5-IN-12	Phosphodiesterase (PDE)	Cardiovascular Disease
PDE5-IN-12 (compound 4h) is a potent phosphodiesterase-5 (PDE-5) inhibitor with an IC₅₀ of 22 nM. PDE5-IN-12 shows anti-proliferative effects against the aortic cell line .

HY-116392A

(−)-L-threo-PDMP hydrochloride	Glucosylceramide Synthase (GCS)	Cancer
(−)-L-threo-PDMP hydrochloride is the hydrochloride form of (−)-L-threo-PDMP. L-threo-PDMP is a glucosylceramide synthase (GCS) inhibitor. L-threo-PDMP stimulates the proliferation of cultured aortic smooth muscle cells, and that increases the level of LacCer in B16 melanoma cells .

HY-A0117

Temocaprilat Temocapril diacid; Temocaprilate; RS 5139	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Temocaprilat (Temocapril diacid) is an inhibitor of angiotensin-converting enzyme (ACE). Temocaprilat alleviates the inhibitory effect of high glucose on the proliferation of aortic endothelial cells. Temocaprilat has potential applications in hypertension and vascular inflammation .

HY-D2376

BH-Vis	Fluorescent Dye	Cancer
BH-Vis is a two-photon fluorescent probe that inhibits cell plasma membrane (CPM). BH-Vis has great potential to accurately identify pyroptosis at the cellular level during AAA development in the mouse abdominal aortic aneurysm AAA model .

HY-W539944

Argipressin acetate Arg8-vasopressin acetate; AVP acetate	Vasopressin Receptor Apoptosis	Neurological Disease Cancer
Argipressin (Arg8-vasopressin) (acetate) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a K_d value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1 .

HY-126410R

Petunidin chloride (Standard)	FAK	Metabolic Disease
Petunidin (chloride) (Standard) is the analytical standard of Petunidin (chloride). This product is intended for research and analytical applications. Petunidin chloride is an O-methylated anthocyanidin derived from delphinidin. Petunidin chloride binds with and suppresses the activity of focal adhesion kinase and to inhibit platelet-derived growth factor-induced aortic smooth muscle cell migration, which may confer a protective effect against atherosclerosis.

HY-W706672

Propane-1,2,3-triyl tritricosanoate Glycerol Tritricosanoate; TG(23:0/23:0/23:0); Tritricosanoin	Endogenous Metabolite	Metabolic Disease
1,2,3-Tritricosanoyl glycerol is a triacylglycerol that contains tricosanoic acid (HY-W009081) at the sn-1, sn-2, and sn-3 positions. It has been used as an internal standard for the quantification of fatty acids in the triglyceride component of human aortic endothelial cells (HAECs) grown in media supplemented with stearic and/or oleic acid.

HY-115381

Lipoxin A5	Endogenous Metabolite	Cardiovascular Disease
Lipoxin A5 is an eicosapentaenoic acid derived from pig white blood cells. Lipoxin A5 slowly contracted the guinea pig lung parenchymal strips with a contractile force similar to that of LXA4 and LXB4.2, but LXA5 did not have the vasodilating effect on the aortic smooth muscle shown by LXA4 and LXB4.2 .

HY-118829

3,4-Methylenedioxy PV9 hydrochloride	Drug Derivative	Neurological Disease
3,4-Methylenedioxy PV9 hydrochloride is a Cathinone derivative. 3,4-Methylenedioxy PV9 hydrochloride shows toxicity against BEAS-2B, human aortic endothelia, HASM, SK-N-SH, A172, HepG2, MKN45, and DLD1cells (LC₅₀=12.8-67.5 μM) .

HY-15404

Darusentan Lu-135252	Endothelin Receptor	Cardiovascular Disease Endocrinology
Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) receptor antagonist, which binds with a K_i of 1.4 nM to the ET-A receptor and a K_i of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors . Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a K_i of 13 nM .

HY-120485

Raxofelast IRFI-016	p38 MAPK ERK PKC	Cardiovascular Disease
Raxofelast (IRFI-016) is an antioxidant agent in various models of ischemia-reperfusion injury. Raxofelast has antiproliferative activity in H₂O₂-stimulated rat aortic smooth muscle cells. Raxofelast attenuates the activation of mitogen-activating protein kinase (MAPK), ERK kinase 1, 2 (MEK1,2) and protein kinase C (PKC) without affecting Ras expression .

HY-116307

2-Thio-UTP	P2Y Receptor	Cardiovascular Disease
2-Thio-UTP is a selective P2Y₂ inhibitor with an EC₅₀ value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) .

HY-N0194

Asiatic acid 3 Publications Verification	Apoptosis Parasite	Inflammation/Immunology Cancer
Asiatic acid, a pentacyclic triterpene found in Centella asiatica (Centella asiatica), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model .

HY-130502

5β,6β-epoxycholestanol Cholesterol 5beta,6beta-epoxide	Biochemical Assay Reagents	Others
5β,6β-epoxycholestanol is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. Induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. Cholesterol 5beta,6beta-epoxide has been found in human fatty streaks and advanced atherosclerotic lesions, but not in normal aortic tissue .

HY-Y0337A

L-Cysteine hydrochloride 5+ Cited Publications	Endogenous Metabolite	Metabolic Disease Cancer
L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) .

HY-N0194R

Asiatic acid (Standard)	Apoptosis Parasite	Inflammation/Immunology Cancer
Asiatic acid (Standard) is the analytical standard of Asiatic acid. This product is intended for research and analytical applications. Asiatic acid, a pentacyclic triterpene found in Centella asiatica (Centella asiatica), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model .

HY-N2673

5-Heptadecylresorcinol 5-n-Heptadecylresorcinol; AR-C17	Sirtuin	Cardiovascular Disease Metabolic Disease
5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector. 5-Heptadecylresorcinol improves mitochondrial function via sirtuin3 signaling pathway, thus alleviates endothelial cell damage and apoptosis. 5-Heptadecylresorcinol induces sirtuin3-mediated autophagy. 5-Heptadecylresorcinol reduces the atherosclerotic plaques in the aortic root region of mice heart. 5-Heptadecylresorcinol can be used for research of atherosclerosis prevention and obesity .

HY-16768

Fevipiprant 1 Publications Verification QAW039; NVP-QAW039	Prostaglandin Receptor	Cardiovascular Disease
Fevipiprant (QAW039, NVP-QAW039) is s an orally active, selective, reversible prostaglandin D2 (DP2) receptor antagonist with an K_d value of 1.14 nM. Fevipiprant has the potential for the research of bronchial asthma .

HY-N6031

Dendrophenol Moscatilin	NF-κB Apoptosis COX HIF/HIF Prolyl-Hydroxylase Wnt β-catenin JNK	Cardiovascular Disease Inflammation/Immunology Cancer
Dendrophenol (Moscatilin) is a NF-κB inhibitor that inhibits inflammation. Dendrophenol exerts potent cytotoxic effect against tumor cells and induces cell cycle arrest and apoptosis. Dendrophenol has antitumor activity. In addition, Dendrophenol can inhibit vascular calcification .

HY-W706672R

Propane-1,2,3-triyl tritricosanoate (Standard)	Endogenous Metabolite	Metabolic Disease
Propane-1,2,3-triyl tritricosanoate (Standard) is the analytical standard of Propane-1,2,3-triyl tritricosanoate. This product is intended for research and analytical applications. 1,2,3-Tritricosanoyl glycerol is a triacylglycerol that contains tricosanoic acid (HY-W009081) at the sn-1, sn-2, and sn-3 positions. It has been used as an internal standard for the quantification of fatty acids in the triglyceride component of human aortic endothelial cells (HAECs) grown in media supplemented with stearic and/or oleic acid.

HY-113438

15(S)-HPETE	AP-1 JNK	Inflammation/Immunology
15(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A41 or reduced to 15(S)-HETE by peroxidases.2,1 15(S)-HpETE mediates a number of biological functions including the induction of c-fos and c-jun, and activation of AP-1.3 15(S)-HpETE inhibits prostacyclin synthesis in porcine aortic microsomes and bovine endothelial cells, and can cause the suicide inactivation of porcine 12-LO.

HY-Y0337AR

L-Cysteine (hydrochloride) (Standard)	Endogenous Metabolite	Metabolic Disease Cancer
L-Cysteine (hydrochloride) (Standard) is the analytical standard of L-Cysteine (hydrochloride). This product is intended for research and analytical applications. L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) [4].

HY-117991

DW10075	VEGFR	Cancer
DW10075 is a highly selective and orally active VEGFR inhibitor targeting the VEGF/VEGFR pathway. DW10075 selectively inhibits VEGFR-1, VEGFR-2, and VEGFR-3, but has no effect on FGFR and PDGFR. DW10075 inhibits VEGF-induced HUVEC proliferation, migration, and tube formation. And DW10075 inhibits angiogenesis in both the rat aortic ring model and the chick chorionic membrane model. DW10075 also exhibits antiproliferative activity against human cancer cell lines, with IC₅₀s of 2.2 μM and 22.2 μM against U87-MG human glioblastoma cells and A375 melanoma cells, respectively. In the nude mouse U87-MG xenograft tumor model, DW10075 (po) significantly inhibits tumor growth and reduces the expression of CD31 and Ki67 in tumor tissues.

HY-W342441

Monosialoganglioside GM3 (bovine)	VEGFR Akt Ferroptosis Insulin Receptor	Metabolic Disease Cancer
Monosialoganglioside GM3 (bovine) is a monosialoganglioside and an inhibitor of VEGFR2 and Akt. At a concentration of 20 μM, Monosialoganglioside GM3 inhibits angiogenesis and reduces the proliferation and migration of human umbilical vein endothelial cells (HUVECs) by inhibiting VEGFR2 and Akt phosphorylation. Ganglioside GM3 also inhibits ferroptosis, providing protective effects during the formation of abdominal aortic aneurysms. Additionally, Monosialoganglioside GM3 (bovine) acts as an inhibitor of insulin signaling, inducing the dissociation of the insulin receptor (IR)-Caveolin-1 complex from lipid microdomains and causing insulin resistance in adipocytes. Monosialoganglioside GM3 (bovine) can be used in cancer and metabolic disease research .

HY-D1635

Sulfo-NHS-LC-LC-Biotin Biotin-XX-SSE	Fluorescent Dye	Infection
Sulfo-NHS-LC-LC-Biotin (Biotin-XX-SSE), a biotin reagent, is used to label the proteins exposed to the external leaflet of intact exosomes and contains a larger spacer arm between the biotin and amine reactive linker. The size of this linker helps to overcome steric hindrance and increases labeling efficiency at the crowded exosome surface .

HY-Y1750

β-Aminopropionitrile 3 Publications Verification BAPN	Monoamine Oxidase Endogenous Metabolite	Metabolic Disease Cancer
β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes .

HY-Y1750A

β-Aminopropionitrile hydrochloride BAPN hydrochloride	Monoamine Oxidase Endogenous Metabolite	Metabolic Disease Cancer
β-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes .

HY-76779

4-(Chloromethyl)-7-hydroxycoumarin	Drug Derivative	Cancer
4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII .

HY-N1181

Tamarixetin 1 Publications Verification 4'-O-Methyl Quercetin	Endogenous Metabolite ClpP Bacterial Apoptosis Akt Interleukin Related COX JNK p38 MAPK Reactive Oxygen Species	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC₅₀ of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways .

HY-N6660

Trisdecanoin Tricaprin; Glyceryl tridecanoate	Endogenous Metabolite Androgen Receptor	Cardiovascular Disease Metabolic Disease
Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics .

HY-N6660R

Trisdecanoin (Standard)	Endogenous Metabolite Androgen Receptor	Metabolic Disease
Trisdecanoin (Standard) is the analytical standard of Trisdecanoin. This product is intended for research and analytical applications. Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics .

Cat. No.	Product Name	Type