Dendrophenol (Synonyms: Moscatilin)

Cat. No.: HY-N6031 Purity: 99.63%: FAQs
Data Sheet SDS COA Handling Instructions

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Dendrophenol (Moscatilin) acts as a NF-κB inhibitor. Antineoplastic activity.

For research use only. We do not sell to patients.

Dendrophenol Chemical Structure

CAS No. : 108853-14-1

Size	Price	Stock	Quantity
1 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

Biological Activity
Purity & Documentation
References
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Description

Dendrophenol (Moscatilin) acts as a NF-κB inhibitor^[1]. Antineoplastic activity^[1].

IC₅₀ & Target^[1]

NF-κB

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.1 μM Compound: 23MST; MST	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 31047774]
FaDu	IC₅₀	2.55 μM Compound: 1	Cytotoxicity against human FaDu cells assessed as cell viability incubated for 24 hrs by CCK-8 assay Cytotoxicity against human FaDu cells assessed as cell viability incubated for 24 hrs by CCK-8 assay	[PMID: 32711292]
HCCLM3	IC₅₀	2.092 μM Compound: 24	Antiproliferative activity against human HCCLM3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HCCLM3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 34931827]
HCT-116	IC₅₀	2.29 μM Compound: 23MST; MST	Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 31047774]
HepG2	IC₅₀	3.02 μM Compound: 24	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 34931827]
HepG2	IC₅₀	3.76 μM Compound: 23MST; MST	Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 31047774]
MDA-MB-231	IC₅₀	0.082 μM Compound: 23MST; MST	Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay	[PMID: 31047774]
MKN-45	IC₅₀	3.51 μM Compound: 23MST; MST	Antiproliferative activity against human MKN45 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MKN45 cells incubated for 72 hrs by MTT assay	[PMID: 31047774]
N2a	IC₅₀	> 20 μM Compound: Mos	Cytotoxicity against mouse Neuro2a cells assessed as reduction in cell viability after 12 hrs by MTT assay Cytotoxicity against mouse Neuro2a cells assessed as reduction in cell viability after 12 hrs by MTT assay	[PMID: 31291099]
N2a	IC₅₀	> 20 μM Compound: Mos	Cytotoxicity against mouse Neuro2a cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against mouse Neuro2a cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 31291099]
Platelet	IC₅₀	61.8 μM Compound: 1	Antiplatelet activity against washed rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins by turbidimetric method Antiplatelet activity against washed rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins by turbidimetric method	[PMID: 7798962]
RAW264.7	IC₅₀	4.4 μM Compound: 1	Cytotoxicity against mouse RAW264.7 cells assessed as decrease in cell proliferation rate after 24 hrs by MTS assay Cytotoxicity against mouse RAW264.7 cells assessed as decrease in cell proliferation rate after 24 hrs by MTS assay	[PMID: 27777005]
SH-SY5Y	IC₅₀	> 20 μM Compound: Mos	Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 12 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 12 hrs by MTT assay	[PMID: 31291099]
SH-SY5Y	IC₅₀	> 20 μM Compound: Mos	Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 31291099]

Molecular Weight

304.34

Formula

C₁₇H₂₀O₅

CAS No.

108853-14-1

Appearance

Solid

Color

White to off-white

SMILES

COC1=C(O)C=CC(CCC2=CC(OC)=C(O)C(OC)=C2)=C1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 61 mg/mL (200.43 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2858 mL	16.4290 mL	32.8580 mL
5 mM	0.6572 mL	3.2858 mL	6.5716 mL
10 mM	0.3286 mL	1.6429 mL	3.2858 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.63%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (248 KB) HNMR (234 KB) RP-HPLC (265 KB)

Handling Instructions (2659 KB)

References

[1]. Yang H, et al. Targeting tumor proteasome with traditional Chinese medicine. Curr Drug Discov Technol. 2010 Mar;7(1):46-53. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2858 mL	16.4290 mL	32.8580 mL	82.1450 mL
	5 mM	0.6572 mL	3.2858 mL	6.5716 mL	16.4290 mL
	10 mM	0.3286 mL	1.6429 mL	3.2858 mL	8.2145 mL
	15 mM	0.2191 mL	1.0953 mL	2.1905 mL	5.4763 mL
	20 mM	0.1643 mL	0.8214 mL	1.6429 mL	4.1072 mL
	25 mM	0.1314 mL	0.6572 mL	1.3143 mL	3.2858 mL
	30 mM	0.1095 mL	0.5476 mL	1.0953 mL	2.7382 mL
	40 mM	0.0821 mL	0.4107 mL	0.8214 mL	2.0536 mL
	50 mM	0.0657 mL	0.3286 mL	0.6572 mL	1.6429 mL
	60 mM	0.0548 mL	0.2738 mL	0.5476 mL	1.3691 mL
	80 mM	0.0411 mL	0.2054 mL	0.4107 mL	1.0268 mL
	100 mM	0.0329 mL	0.1643 mL	0.3286 mL	0.8214 mL

Dendrophenol Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dendrophenol108853-14-1MoscatilinNF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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Dendrophenol (Synonyms: Moscatilin)

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Dendrophenol Related Antibodies

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Biological Activity

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References

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Complete Stock Solution Preparation Table

Dendrophenol Related Classifications

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