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Results for "

degranulation inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Apoptosis (2) Bacterial (2) Calmodulin (2) Caspase (1) Complement System (1) Drug Metabolite (2) Endogenous Metabolite (2) Fc Receptor (FcR) (1) Influenza Virus (1) Leukotriene Receptor (1) Mas-related G-protein-coupled Receptor (MRGPR) (4) MDM-2/p53 (1) MMP (1) NF-κB (1) p38 MAPK (1) Parasite (2) Phosphodiesterase (PDE) (1) PI3K (2) PKC (2) SOD (1) Syk (1) TNF Receptor (4) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Infection (8) Inflammation/Immunology (20) Metabolic Disease (1) Neurological Disease (2)

By Targets:

Antibiotic (2)

Apoptosis (2)

Bacterial (2)

Calmodulin (2)

Caspase (1)

Complement System (1)

Drug Metabolite (2)

Endogenous Metabolite (2)

Fc Receptor (FcR) (1)

Influenza Virus (1)

Leukotriene Receptor (1)

Mas-related G-protein-coupled Receptor (MRGPR) (4)

MDM-2/p53 (1)

MMP (1)

NF-κB (1)

p38 MAPK (1)

Parasite (2)

Phosphodiesterase (PDE) (1)

PI3K (2)

PKC (2)

SOD (1)

Syk (1)

TNF Receptor (4)

Toll-like Receptor (TLR) (1)

By Research Areas:

Cancer (2)

Cardiovascular Disease (1)

Infection (8)

Inflammation/Immunology (20)

Metabolic Disease (1)

Neurological Disease (2)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N4207

Cnidicin	Others	Others
Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells .

HY-N1336

Rubianthraquinone	Others	Others
Rubianthraquinone is a anthraquinone, that can be isolated from the roots of Rubia yunnanensis. Rubianthraquinone inhibits NO production and degranulation .

HY-124146

BI1002494	Syk	Inflammation/Immunology
BI1002494 is an orally active, potent, and selective spleen tyrosine kinase (SYK) inhibitor. BI 1002494 exhibits an IC₅₀ of 115 nM in inhibiting high-affinity IgE receptor-mediated mast cell and basophil degranulation. BI1002494 can be utilized in immunology reesearch .

HY-N14981

Eurocidin E	Antibiotic	Infection Inflammation/Immunology
Eurocidin E is an antibiotic. Eurocidin E can inhibit the degranulation and the release of histamine in rat mast cells .

HY-N14978

Eurocidin D	Antibiotic	Infection Inflammation/Immunology
Eurocidin D is a cyclic peptide antibiotic. Eurocidin D can inhibit the degranulation of rat mast cells .

HY-145891

B10-S	Others	Inflammation/Immunology
B10-S is a potent anti-allergic agent. B10-S can inhibit the degranulation of LAD2 induced by substance P .

HY-106306

Laprafylline S 9795	Phosphodiesterase (PDE)	Cardiovascular Disease
Laprafylline (S 9795), a xanthine derivative, is a bronchodilator. Laprafylline has potent anti-bronchoconstrictive effects, inhibiting action on mast cell degranulation and phosphodiesterase (PDE) activity (IC₅₀ of 6 μM) .

HY-N4207R

Cnidicin (Standard)	Others	Others
Cnidicin (Standard) is the analytical standard of Cnidicin. This product is intended for research and analytical applications. Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells .

HY-145893

MrgprX2 antagonist-7	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
MrgprX2 antagonist-7 (compound 10) is an anti-allergic agent. MrgprX2 antagonist-7 shows excellent anti-allergy effects and can inhibit mast cell degranulation .

HY-145892

MrgprX2 antagonist-6	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
MrgprX2 antagonist-6 (compound 9) is an anti-allergic agent. MrgprX2 antagonist-6 shows excellent anti-allergy effects and can inhibit mast cell degranulation .

HY-N15423

Acrophylline	Others	Inflammation/Immunology
Acrophylline is an antiallergic compound. Acrophylline inhibits mast cell degranulation. Acrophylline reduces the plasma leakage in mouse ear in a passive cutaneous anaphylactic (PCA) reaction. Acrophylline is an alkaloid can be isolated from acronychia haplophylla .

HY-169851

JANEX-1-M	Drug Metabolite	Others
JANEX-1-M is a metabolite of JANEX-1 (HY-15508). JANEX-1 is a JAK3 specific inhibitor, which can effectively inhibit mast cell degranulation and the release of pro-inflammatory mediators .

HY-N8593

Undecane	TNF Receptor	Infection
Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α ^[

HY-122295

Dehydroleucodine	Apoptosis	Inflammation/Immunology Cancer
Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects .

HY-N2344

Procyanidin A1 1 Publications Verification Proanthocyanidin A1	PKC	Inflammation/Immunology
Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca ²⁺ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects .

HY-124257

(R)-Citronellol D-Citronellol; (R)-(+)-β-Citronellol	Endogenous Metabolite	Inflammation/Immunology
(R)-Citronellol (D-Citronellol) is an alcoholic monoterpene found in geranium essential oil. (R)-Citronellol inhibits degranulation of mast cells and does not affect caffeine bitterness perception. (R)-Citronellol can be used in decorative cosmetics, toiletries as well as in non-cosmetic products .

HY-N0078

Ginkgolic Acid (C13:0) Ginkgolic acid (13:0); Ginkgoneolic Acid; 6-Tridecylsalicylic acid	Bacterial PI3K Parasite	Infection Inflammation/Immunology
Ginkgolic Acid (C13:0) (Ginkgoneolic Acid) is an anti-cariogenic agent and a PI3Kδ inhibitor (IC₅₀: 2.49 μM). Ginkgolic Acid (C13:0) exhibits antibacterial and anti-parasitic activities. Ginkgolic Acid (C13:0) can also inhibit mast cell degranulation (IC₅₀: 2.40 μM) .

HY-N2095

Atractylone Atractylon	Influenza Virus	Infection Inflammation/Immunology
Atractylone (Atractylon) is a sesquiterpenoid extracted from Atractylodis Rhizoma. Atractylone (Atractylon) alleviates influenza A virus (IAV)-induced lung injury via regulating the TLR7 signaling pathway, and acts as a promising agent for IAV treatment. Atractylone (Atractylon) inhibits the degranulation of mast cell and exhibits potential for the treatment of mast cell-mediated allergic reactions .

HY-N8593S

Undecane-d24	TNF Receptor	Infection
Undecane-d₂₄ is the deuterium labeled Undecane[1]. Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α[2].

HY-N8593R

Undecane (Standard)	TNF Receptor	Infection
Undecane (Standard) is the analytical standard of Undecane. This product is intended for research and analytical applications. Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α[

HY-P1076

CALP2	Calmodulin	Inflammation/Immunology
CALP2 is a calmodulin (CaM) antagonist ( (K_d of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca ²⁺-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca ²⁺ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages .

HY-N2344R

Procyanidin A1 (Standard)	PKC	Inflammation/Immunology
Procyanidin A1 (Standard) is the analytical standard of Procyanidin A1. This product is intended for research and analytical applications. Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects .

HY-P1076A

CALP2 TFA	Calmodulin	Inflammation/Immunology
CALP2 TFA is a calmodulin (CaM) antagonist (K_d of 7.9 µM) with high affinity for binding to the CaM EF-hand/Ca ²⁺-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca ²⁺ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages .

HY-160901

CP-289,503	Complement System	Inflammation/Immunology
CP-289,503 is an inhibitor of the complement C5a receptor with an IC50 of 1 μM. C5a acts as an activator of leukocytes and phagocytes during complement system activation. The C5a receptor can bind to C5a, which can stimulate the upregulation of cell surface integrins and degranulation of inflammatory cells, leading to endothelial cell damage. C5a receptor inhibitors can block C5a signaling and inhibit a variety of inflammatory diseases .

HY-158990

GE1111	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
GE1111 is the antagonist for mas-related G protein-coupled receptor X2 (MRGPRX2) with an IC₅₀ of 9.42 μM. GE1111 inhibits mast cell degranulation with an IC₅₀ of 4.7 μM. GE1111 exhibits anti-allergic and anti-inflammatory effects in C48/80 (HY-130592)-induced systemic allergic reaction model .

HY-113483

20-Carboxy-Leukotriene B4 20-COOH LTB4	Drug Metabolite Leukotriene Receptor	Metabolic Disease
20-Carboxy-Leukotriene B4 (20-COOH LTB4) is a metabolite of Leukotriene B4 (LTB4; HY-107608). 20-Carboxy-Leukotriene B4 binds to the BLT1 receptor with high affinity. 20-Carboxy-Leukotriene B4 inhibits LTB4-mediated neutrophil responses (migration, degranulation, leukotriene biosynthesis) .

HY-111198

YM-355179 fumarate	Endogenous Metabolite	Inflammation/Immunology
YM-355179 fumarate is a newly synthesized selective CCR3 antagonist with the potential to inhibit eosinophil-related allergic inflammatory diseases. YM-355179 can effectively inhibit the binding of CCL11 and CCL5 to CCR3-expressing cells, with IC₅₀ values of 7.6 nM and 24 nM respectively. In functional experiments, YM-355179 can inhibit CCL11-induced intracellular Ca(2+) influx, chemotaxis and eosinophil degranulation, IC₅₀ The values are 8.0 nM, 24 nM and 29 nM respectively .

HY-158316

BTL-MK	Fc Receptor (FcR)	Others
BTL-MK (Compound 19) an orally active antiallergic agent, that inhibits degranulation of mast cells with an IC₅₀ of 6.7 μM, through binding to the inhibitory receptor FcγRIIB. BTL-MK improves the metaboilic stability in human liver microsomes. BTL-MK ameliorates the allergic response in Ovalbumins (HY-W250978)-induced food allergy mice model. BTL-MK exhibits a good pharmacokinetic character with metabolic stability .

HY-120149

Inotodiol	Toll-like Receptor (TLR) MDM-2/p53 MMP Caspase SOD p38 MAPK NF-κB Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Inotodiol activates p53 signaling pathway, inhibits MMP-2/9, and exhibits antitumor activity in cancer cell HeLa. Inotodiol inhibits the generation of ROS and exhibits antioxidant and neuroprotective effects. Inotodiol inhibits the activation of MAPK and NF-κB signaling pathway, and exhibits anti-inflammatory activity. Inotodiol inhibits TLR-4 mediated TNF-α production (IC₅₀s in BMMC and BMDM is 0.7 μM and 3.0 μM), inhibits the degranulation in mast cell, exhibits anti-allergic activity. Inotodiol is orally active .

HY-N0078R

Ginkgolic Acid (C13:0) (Standard) Ginkgolic acid (13:0) (Standard); Ginkgoneolic Acid (Standard); 6-Tridecylsalicylic acid (Standard)	Bacterial PI3K Parasite	Infection Inflammation/Immunology
Ginkgolic Acid (C13:0) (Standard) is the analytical standard of Ginkgolic Acid (C13:0) (HY-N0078). This product is intended for research and analytical applications. Ginkgolic Acid (C13:0) (Ginkgoneolic Acid) is an anti-cariogenic agent and a PI3Kδ inhibitor (IC₅₀: 2.49 μM). Ginkgolic Acid (C13:0) exhibits antibacterial and anti-parasitic activities. Ginkgolic Acid (C13:0) can also inhibit mast cell degranulation (IC₅₀: 2.40 μM) .

HY-172458

Z-3578	Mas-related G-protein-coupled Receptor (MRGPR) TNF Receptor	Neurological Disease
Z-3578 is a small-molecule antagonist targeting MrgX2 (Mas-related G protein-coupled receptor X2) with significant anti-pseudoallergic activity and a K_D value of 729 nM. Z-3578 effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, suppressing the release of β-hexosaminidase with IC₅₀ values of 4.90 µM and 6.18 µM, respectively. It also markedly reduces the release of histamine and TNF-α, along with intracellular calcium flux. In a murine pseudoallergy model, Z-3578 significantly alleviates paw swelling and dye extravasation and lowers serum histamine levels, indicating potent in vivo anti-allergic effects. Z-3578 holds promise as a lead compound for the treatment of allergic diseases, especially pseudoallergic reactions .

Cat. No.	Product Name	Target	Research Area