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Results for "

dimaleate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Adrenergic Receptor (1) Akt (2) Amyloid-β (1) Apoptosis (3) Autophagy (3) Bacterial (1) c-Met/HGFR (3) CaMK (1) Caspase (1) CDK (2) Dopamine Receptor (4) Drug Metabolite (1) EGFR (5) Endogenous Metabolite (1) Histamine Receptor (4) Influenza Virus (1) Interleukin Related (1) NADPH Oxidase (1) P-glycoprotein (1) p38 MAPK (2) SARS-CoV (2) Sodium Channel (1) STAT (1) Topoisomerase (2)
By Research Areas:	Cancer (13) Endocrinology (1) Infection (3) Inflammation/Immunology (4) Neurological Disease (9)

By Targets:

5-HT Receptor (2)

Adrenergic Receptor (1)

Akt (2)

Amyloid-β (1)

Apoptosis (3)

Autophagy (3)

Bacterial (1)

c-Met/HGFR (3)

CaMK (1)

Caspase (1)

CDK (2)

Dopamine Receptor (4)

Drug Metabolite (1)

EGFR (5)

Endogenous Metabolite (1)

Histamine Receptor (4)

Influenza Virus (1)

Interleukin Related (1)

NADPH Oxidase (1)

P-glycoprotein (1)

p38 MAPK (2)

SARS-CoV (2)

Sodium Channel (1)

STAT (1)

Topoisomerase (2)

By Research Areas:

Cancer (13)

Endocrinology (1)

Infection (3)

Inflammation/Immunology (4)

Neurological Disease (9)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101373A

Zolantidine dimaleate SKF 95282 dimaleate	Histamine Receptor	Neurological Disease
Zolantidine dimaleate (SKF 95282 dimaleate) is a potent, selective and cross the blood-brain barrier histamine H2 antagonist. Zolantidine dimaleate induces antinociception .

HY-101046

Azaperone dimaleate Quipazine dimaleate	5-HT Receptor SARS-CoV	Neurological Disease
Quipazine dimaleate is a 5-HT agonist with a K_i value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine dimaleate shows antiviral activity against SARS-CoV-2 with an EC₅₀ of 31.64 μM. Quipazine dimaleate behaves as a 5-HT3R antagonist in peripheral models. Quipazine dimaleate can be used for neurological disease research .

HY-104065B

Pyrotinib dimaleate 10+ Cited Publications SHR-1258 dimaleate	EGFR	Cancer
Pyrotinib dimaleate (SHR-1258 dimaleate) is a potent and selective EGFR/HER2 dual inhibitor with IC₅₀s of 13 and 38 nM, respectively .

HY-B1262

Acetophenazine dimaleate 1 Publications Verification	Dopamine Receptor	Neurological Disease
Acetophenazine dimaleate, a phenothiazine derivative, is an antipsychotic agent. Acetophenazine dimaleate primarily blocks dopamine D2 receptors in the brain. Acetophenazine dimaleate can be used for researching psychotic disorders such as schizophrenia and anxious depression .

HY-B0807A

Prochlorperazine dimaleate	NADPH Oxidase	Neurological Disease Inflammation/Immunology Cancer
Prochlorperazine dimaleate is a first-generation antipsychotic. Prochlorperazine dimaleate can be used in the research of chemotherapy-induced nausea and vomiting (CINV). Prochlorperazine dimaleate also possesses anticancer activity. Prochlorperazine dimaleate exhibits IC₅₀ values of 6.4 μM, 4.5 μM and 2.3 μM for NOX1, NOX2 and NOX5, respectively .

HY-133110

Afatinib N-Oxide	Drug Metabolite	Others
Afatinib N-Oxide is an impurity of Afatinib dimaleate in oxidative degradation. Afatinib dimaleate is an irreversible EGFR family inhibitor .

HY-B0532B

Trifluoperazine dimaleate	Dopamine Receptor Adrenergic Receptor P-glycoprotein CaMK Influenza Virus Autophagy	Infection Neurological Disease Cancer
Trifluoperazine dimaleate, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dimaleate is a potent α1-adrenergic receptor antagonist. Trifluoperazine dimaleate is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dimaleate is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dimaleate can be used for the research of schizophrenia. Trifluoperazine dimaleate acts as a reversible inhibitor of influenza virus morphogenesis .

HY-13559A

Atiprimod dimaleate Azaspirane dimaleate; SKF 106615-12 dimaleate; SKF 106615A12 dimaleate	Apoptosis Caspase STAT Interleukin Related
Atiprimod (Azaspirane) (dimaleate) is an anti-proliferative and anti-angiogenic agent that inhibits proliferation of cancer cell lines. Atiprimod (dimaleate) also induces Apoptosis and activates both caspase-9 and caspase-3 in T84 colon carcinoma cells. Atiprimod (dimaleate) inhibits both bFGF and VEGF induced proliferation and migration of human umbilical vein endothelial cells, resulting in disruption of cord formation. Atiprimod (dimaleate) reduces production of IL-6, VEGF and inhibits activation of Stat3 .

HY-104065BR

*Pyrotinib dimaleate* (Standard)**	EGFR	Cancer
Pyrotinib dimaleate (Standard) is the analytical standard of Pyrotinib dimaleate. This product is intended for research and analytical applications. Pyrotinib dimaleate (SHR-1258 dimaleate) is a potent and selective EGFR/HER2 dual inhibitor with IC₅₀s of 13 and 38 nM, respectively .

HY-119980A

Fluphenazine dimaleate	Dopamine Receptor Sodium Channel SARS-CoV	Infection Neurological Disease Cancer
Fluphenazine dimaleate is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dimaleate blocks neuronal voltage-gated sodium channels. Fluphenazine dimaleate acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dimaleate can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dimaleate can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2 .

HY-115371

Butaperazine dimaleate	Endogenous Metabolite	Neurological Disease
Butaperazine dimaleate is an antipsychotic compound with activity for the detection of vanadium (V). Butaperazine dimaleate can react with vanadium (V) in a phosphoric acid medium to form a red radical cation. The absorption spectrum of butaperazine dimaleate reaches a maximum at 513 nm, which conforms to Beer's law and corresponds to a concentration range of 0.25-5.0 μg/ml. Butaperazine dimaleate has a sensitivity value of 6.1 ng/cm2 and is suitable for the analysis of vanadium steel, minerals, biological samples, and soil samples .

HY-B1794A

Thiethylperazine dimaleate 1 Publications Verification	Dopamine Receptor Histamine Receptor Bacterial Amyloid-β	Infection Neurological Disease
Thiethylperazine dimaleate, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine dimaleate is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine dimaleate has anti-emetic, antipsychotic and antimicrobial effects .

HY-19017B

Fenclozine dimaleate	Others	Inflammation/Immunology
Fenclozine dimaleate is a non-steroidal antiinflammatory agent .

HY-101052

HTMT dimaleate	Histamine Receptor	Inflammation/Immunology
HTMT (dimaleate) is a potent histamine H1 and H2 receptor agonist. HTMT (dimaleate) is 4 x 10 ⁴ times more active than histamine in H2-mediated effects in natural suppressor cells .

HY-101049

CGS 12066 dimaleate	5-HT Receptor	Neurological Disease
CGS 12066 (dimaleate) dimaleate is a selective 5-HT_1B receptor agonist with an IC₅₀ of 51 nM .

HY-103443A

HKI-357 dimaleate	EGFR	Cancer
HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2 with IC₅₀s of 34 nM and 33 nM, respectively. HKI-357 dimaleate suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation .

HY-10261AR

*Afatinib (dimaleate) (Standard)*	EGFR Autophagy Apoptosis c-Met/HGFR Akt p38 MAPK	Cancer
Afatinib (dimaleate) (Standard) is the analytical standard of Afatinib (dimaleate). This product is intended for research and analytical applications. Afatinib (BIBW 2992) dimaleate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib dimaleate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .

HY-B0170A

Azatadine dimaleate Azatadine maleate	Histamine Receptor	Inflammation/Immunology Endocrinology
Azatadine dimaleate is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.

HY-160171A

CDK9-IN-31 dimaleate	CDK	Cancer
CDK9-IN-31 dimaleate (Compound Z1) is a CDK9 inhibitor that inhibits cancer cell growth. CDK9-IN-31 dimaleate has the potential to be developed as an anticancer agent .

HY-X0009A

JSH-009 dimaleate	CDK	Cancer
JSH-009 dimaleate (Compound 1) is a potent and highly selective CDK9 inhibitor with an IC₅₀ of 0.928 nM. JSH-009 can effectively inhibit the growth of subcutaneous tumor (cute myelogenous leukemia MV4-11) mice .

HY-10261A

Afatinib dimaleate Maximum Cited Publications 64 Publications Verification BIBW 2992MA2	EGFR Autophagy Apoptosis c-Met/HGFR Akt p38 MAPK	Cancer
Afatinib (BIBW 2992) dimaleate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC₅₀ values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR ^wt, EGFR ^L858R, EGFR ^L858R/T790M and HER2, respectively. Afatinib dimaleate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .

HY-152852A

Mefatinib Mifanertinib dimaleate	c-Met/HGFR	Cancer
Mefatinib is a potent tyrosine kinase inhibitor with antineoplastic activity .

HY-13727A

Pixantrone 3 Publications Verification BBR 2778	Topoisomerase	Cancer
Pixantrone (BBR 2778) dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity.

HY-13727AR

Pixantrone (Standard)	Topoisomerase	Cancer
Pixantrone (Standard) is the analytical standard of Pixantrone. This product is intended for research and analytical applications. Pixantrone (BBR 2778) dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity.

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dimaleate

Inhibitors & Agonists