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Results for "

estrogen metabolite

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Metabolite (15) Endogenous Metabolite (25) Estrogen Receptor/ERR (29) Adhesion G Protein-coupled Receptors (AGPCRs) (1) Androgen Receptor (1) Apoptosis (9) Bacterial (2) Cytochrome P450 (6) FKBP (3) Fluorescent Dye (3) Glucocorticoid Receptor (2) Insecticide (4) Isotope-Labeled Compounds (14) LDLR (1) LXR (2) Mitochondrial Metabolism (1) Necroptosis (3) Parasite (4) Photosensitizer (1) Potassium Channel (2) Progesterone Receptor (3) Reference Standards (6)
By Research Areas:	Cancer (26) Cardiovascular Disease (2) Endocrinology (26) Infection (6) Inflammation/Immunology (3) Metabolic Disease (16) Neurological Disease (4)

By Targets:

Drug Metabolite (15)

Endogenous Metabolite (25)

Estrogen Receptor/ERR (29)

Adhesion G Protein-coupled Receptors (AGPCRs) (1)

Androgen Receptor (1)

Apoptosis (9)

Bacterial (2)

Cytochrome P450 (6)

FKBP (3)

Fluorescent Dye (3)

Glucocorticoid Receptor (2)

Insecticide (4)

Isotope-Labeled Compounds (14)

LDLR (1)

LXR (2)

Mitochondrial Metabolism (1)

Necroptosis (3)

Parasite (4)

Photosensitizer (1)

Potassium Channel (2)

Progesterone Receptor (3)

Reference Standards (6)

By Research Areas:

Cancer (26)

Cardiovascular Disease (2)

Endocrinology (26)

Infection (6)

Inflammation/Immunology (3)

Metabolic Disease (16)

Neurological Disease (4)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Metabolite Endogenous Metabolite Estrogen Receptor/ERR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-129987

Estradiol 17-(β-D-Glucuronide) sodium	Endogenous Metabolite	Metabolic Disease Endocrinology
Estradiol 17-(β-D-Glucuronide) sodium, a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans .

HY-W353102

Estradiol 17-(β-D-Glucuronide)	Endogenous Metabolite	Metabolic Disease Endocrinology
Estradiol 17-(β-D-Glucuronide), a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans. Estradiol 17-(β-D-Glucuronide) is a high-affinity substrate for oatp organic anion transporter .

HY-B0652

Etonogestrel 3-Oxodesogestrel; 3-keto-Desogestrel	Drug Metabolite Estrogen Receptor/ERR Progesterone Receptor Endogenous Metabolite FKBP	Endocrinology
Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-W009300

4-Hydroxyestrone 1 Publications Verification 4-OHE1	Endogenous Metabolite	Neurological Disease
4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity .

HY-N6709

Zeranol α-Zearalanol	Estrogen Receptor/ERR	Endocrinology
Zeranol, a metabolite of the mycoestrogen zearalenone, is an estrogen receptor agonist. Zeranol is used as a growth promoter of livestock due to its strong estrogenic activity .

HY-18719A

Endoxifen Z-isomer hydrochloride 3 Publications Verification	Estrogen Receptor/ERR Potassium Channel	Cancer
Endoxifen Z-isomer hydrochloride is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα).

HY-113252

2-Methoxyestrone 3 Publications Verification	Endogenous Metabolite	Metabolic Disease
2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.

HY-W587691

16-Ketoestradiol 16-keto-17β-Estradiol	Endogenous Metabolite	Endocrinology
6-Ketoestradiol is an active metabolite of the endogenous estrogen estrone .

HY-135588

Raloxifene 6,4'-Bis-β-D-glucuronide	Drug Metabolite	Metabolic Disease
Raloxifene 6,4'-Bis-β-D-glucuronide (compound IV) is a metabolite of Raloxifene. Raloxifene is a selective estrogen receptor antagonist for the prevention of osteoporosis .

HY-B0652R

Etonogestrel (Standard) 3-Oxodesogestrel (Standard); 3-keto-Desogestrel (Standard)	Drug Metabolite Reference Standards Estrogen Receptor/ERR Progesterone Receptor Endogenous Metabolite FKBP	Endocrinology
Etonogestrel (Standard) is the analytical standard of Etonogestrel. This product is intended for research and analytical applications. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-137391

2-Bromoestradiol	Estrogen Receptor/ERR	Metabolic Disease
2-Bromoestradiol is a estrogen 2-hydroxylase inhibitor. 2-Bromoestradiol decreases irreversible binding of radiolabeled estradiol metabolite(s) to microsomal proteins .

HY-135580A

Raloxifene Bismethyl Ether hydrochloride	Drug Metabolite	Endocrinology
Raloxifene Bismethyl Ether hydrochloride is a metabolite of Raloxifene and an estrogen receptor inactive compound on which both hydroxyl groups are absent .

HY-135580

Raloxifene Bismethyl Ether	Drug Metabolite	Endocrinology
Raloxifene Bismethyl Ether is a metabolite of Raloxifene and an estrogen receptor inactive compound on which both hydroxyl groups are absent .

HY-130046

16-Epiestriol 16-epi-Estriol; 16β,17β-Estriol	Bacterial	Infection Inflammation/Immunology
16-Epiestriol is a metabolite of the endogenous estrogen estrone with antibacterial and anti-inflammatory effects[1][2][3].

HY-117153

GW7604	Estrogen Receptor/ERR	Cancer
GW7604 is an antiestrogen. GW7604 is the metabolite of GW5638, which is a high affinity estrogen receptor (ER) antagonist .

HY-W777284

Zeranol-d5 (mixture of diastereomers)	Isotope-Labeled Compounds Estrogen Receptor/ERR	Endocrinology
Zeranol-d₅ (mixture of diastereomers) is the deuterium labeled Zeranol (HY-N6709). Zeranol, a metabolite of the mycoestrogen zearalenone, is an estrogen receptor agonist. Zeranol is used as a growth promoter of livestock due to its strong estrogenic activity .

HY-D0272

2,3,4-Trihydroxybenzophenone	Estrogen Receptor/ERR	Metabolic Disease
2,3,4-Trihydroxybenzophenone is a hydroxylated benzophenone UV filter with estrogenic activity. 2,3,4-Trihydroxybenzophenone is a quorum sensing inhibitor and an EC 1.14.18.1 (tyrosinase) inhibitor. 2,3,4-Trihydroxybenzophenone is also a human urinary metabolite, a rat metabolite and a drug metabolite .

HY-135581

Raloxifene 6-glucuronide	Estrogen Receptor/ERR	Endocrinology
Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC₅₀ of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-135582

Raloxifene 4'-glucuronide	Estrogen Receptor/ERR	Endocrinology
Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC₅₀ of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-113252S2

2-Methoxyestrone-d4	Endogenous Metabolite	Inflammation/Immunology
2-Methoxyestrone-d₄ is the deuterium labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81 .

HY-W926789

(E)-GW7604	Estrogen Receptor/ERR	Metabolic Disease Cancer
(E)-GW7604 is the (E)-isomer of GW7604, an antiestrogen and a metabolite of GW5638 (HY-112746), which is a high-affinity estrogen receptor (ER) antagonist .

HY-124489

2-Hydroxyestradiol 2 Publications Verification	Endogenous Metabolite	Metabolic Disease
2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .

HY-18719B

Endoxifen hydrochloride 1 Publications Verification	Cytochrome P450 Estrogen Receptor/ERR Drug Metabolite Parasite	Cancer
Endoxifen hydrochloride is a key active metabolite of Tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen hydrochloride has the potential for breast cancer study .

HY-18719E

Endoxifen 1 Publications Verification	Cytochrome P450 Estrogen Receptor/ERR Drug Metabolite Parasite	Cancer
Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen has the potential for breast cancer study .

HY-113252S1

2-Methoxyestrone-13C6	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
2-Methoxyestrone- ¹³C₆ is the ¹³C-labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.

HY-113252S

2-Methoxyestrone-13C,d3	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
2-Methoxyestrone- ¹³C,d₃ is the ¹³C- and deuterium labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.

HY-W740212

16-Keto 17Beta-estradiol-d5	Isotope-Labeled Compounds Endogenous Metabolite	Endocrinology
16-Keto 17Beta-estradiol-d₅ is the deuterium labeled 16-Ketoestradiol (HY-W587691). 6-Ketoestradiol is an active metabolite of the endogenous estrogen estrone .

HY-130046R

16-Epiestriol (Standard) 16-epi-Estriol (Standard); 16β,17β-Estriol (Standard)	Endogenous Metabolite Reference Standards Bacterial	Infection Inflammation/Immunology
16-Epiestriol (Standard) is the analytical standard of 16-Epiestriol. This product is intended for research and analytical applications. 16-Epiestriol is a metabolite of the endogenous estrogen estrone with antibacterial and anti-inflammatory effects .

HY-135581S1

Raloxifene 6-glucuronide-d4 lithium	Isotope-Labeled Compounds Estrogen Receptor/ERR	Endocrinology
Raloxifene 6-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 6-glucuronide. Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC₅₀ of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-135582S1

Raloxifene 4'-glucuronide-d4 lithium	Isotope-Labeled Compounds Estrogen Receptor/ERR	Endocrinology
Raloxifene 4'-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 4'-glucuronide. Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC₅₀ of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-160485

G-4'G-7S	Fluorescent Dye	Endocrinology
G-4'G-7S is a endogenous metabolite of genistein (HY-14596). G-4'G-7S can be used for the research of estrogenic activity .

HY-148225

Fulvestrant 3-β-D-Glucuronide	Drug Metabolite	Cancer
Fulvestrant 3-β-D-Glucuronide, a *metabolite, is glucuronide and sulfate conjugates of Fulvestrant (HY-13636), a pure anti-estrogenic* steroid. Fulvestrant 3-β-D-Glucuronide can be used for the research of breast cancer .

HY-18719ES

Endoxifen-d5	Cytochrome P450 Estrogen Receptor/ERR Drug Metabolite Parasite	Cancer
Endoxifen-d₅ is the deuterium labeled Endoxifen. Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen has the potential for breast cancer study .

HY-135582S

Raloxifene 4'-glucuronide-d4	Estrogen Receptor/ERR Isotope-Labeled Compounds	Endocrinology
Raloxifene 4'-glucuronide-d₄ is deuterated labeled Raloxifene 4'-glucuronide (HY-135582). Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC₅₀ of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-137099A

Genistein 7-sulfate sodium	Fluorescent Dye	Endocrinology
Genistein 7-sulfate sodium is a metabolite of genistein that can reduce the activity of estrogen agonists in MCF-7 cells. Genistein 7-sulfate sodium can promote the growth of MCF-7 cells at concentrations of 10 μM and above .

HY-137099

Genistein 7-sulfate	Fluorescent Dye	Endocrinology
Genistein 7-sulfate is a metabolite of genistein that can reduce the activity of estrogen agonists in MCF-7 cells. Genistein 7-sulfate can promote the growth of MCF-7 cells at concentrations of 10 μM and above .

HY-116865

Equilenin	Endogenous Metabolite	Endocrinology Cancer
Equilenin is a B-ring unsaturated estrogen and one of the main ingredients in Premarin, a drug commonly used in estrogen replacement therapy. Equilenin can bind to estrogen receptors in the body and exert effects similar to endogenous estrogen. Equilenin can be used in estrogen replacement therapy and breast cancer research .

HY-16950A

(E/Z)-4-Hydroxytamoxifen 1 Publications Verification Afimoxifene; 4-OHT	Estrogen Receptor/ERR Adhesion G Protein-coupled Receptors (AGPCRs) Drug Metabolite	Metabolic Disease Cancer
(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity .

HY-18719BR

Endoxifen hydrochloride (Standard)	Cytochrome P450 Reference Standards Estrogen Receptor/ERR Drug Metabolite Parasite	Cancer
Endoxifen (hydrochloride) (Standard) is the analytical standard of Endoxifen (hydrochloride). This product is intended for research and analytical applications. Endoxifen hydrochloride is a key active metabolite of Tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen hydrochloride has the potential for breast cancer study[1][2].

HY-108692

Enterolactone	Apoptosis Endogenous Metabolite	Cancer
Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .

HY-N0835

(20S)-Protopanaxatriol 20(S)-APPT; g-PPT	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis	Cardiovascular Disease Endocrinology Cancer
(20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-163712

17-Epiestriol	Estrogen Receptor/ERR	Endocrinology
17-Epiestriol is an estrogen metabolite and a selective estrogen receptor (ER) β agonist. 17-epiestriol inhibits the mRNA and protein expression of the vascular cell adhesion molecule VCAM-1 induced by tumor necrosis factor α (TNFα). 17-epiestriol also inhibits TNFα-induced VCAM-1 expression and prevents NF-κB migration to the nucleus. 17-Epiestriol also induces the mRNA and protein expression of endothelial nitric oxide synthase .

HY-124489S1

2-Hydroxyestradiol-d5	Isotope-Labeled Compounds Endogenous Metabolite	Infection
2-Hydroxyestradiol-d₅ is the deuterium labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[ .

HY-124489S

2-Hydroxyestradiol-13C6	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
2-Hydroxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .

HY-124489R

2-Hydroxyestradiol (Standard)	Endogenous Metabolite	Metabolic Disease
2-Hydroxyestradiol (Standard) is the analytical standard of 2-Hydroxyestradiol. This product is intended for research and analytical applications. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .

HY-18719

Endoxifen (Z-isomer) 3 Publications Verification	Estrogen Receptor/ERR Potassium Channel	Cancer
Endoxifen Z-isomer is an oral active Tamoxifen (HY-13757A) metabolite, inducing an anti-estrogenic effect in breast cancer cells expressing ERα. Endoxifen Z-isomer inhibits hERG. This effect is concentration-dependent, with an IC₅₀ value of 1.6 μM .

HY-B0652S1

Etonogestrel-d6 3-Oxodesogestrel-d₆; 3-keto-Desogestrel-d₆	Isotope-Labeled Compounds Estrogen Receptor/ERR Progesterone Receptor Endogenous Metabolite FKBP	Endocrinology
Etonogestrel-d₆ is deuterium labeled Etonogestrel. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-108692S

Enterolactone-d6	Isotope-Labeled Compounds Apoptosis Endogenous Metabolite	Cancer
Enterolactone-d₆ is the deuterium labeled Enterolactone. Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .

HY-N10403

4-Hydroxyestradiol 1 Publications Verification 4-Hydroxy-17β-estradiol	Drug Metabolite Endogenous Metabolite	Cancer
4-Hydroxyestradiol (4-Hydroxy-17β-estradiol) is an endogenous metabolite of Estradiol (HY-B0141). 4-Hydroxyestradiol is carcinogenic and shows mutagenic activity in breast epithelial cells. 4-Hydroxyestradiol inhibits the binding of Estradiol to the estrogen receptor in a competitive manner, with a K_i of 0.48 nM .

HY-108692R

Enterolactone (Standard)	Reference Standards Apoptosis Endogenous Metabolite	Cancer
Enterolactone (Standard) is the analytical standard of Enterolactone. This product is intended for research and analytical applications. Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-129987

Estradiol 17-(β-D-Glucuronide) sodium	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite
Estradiol 17-(β-D-Glucuronide) sodium, a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans .

HY-W353102

Estradiol 17-(β-D-Glucuronide)	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite
Estradiol 17-(β-D-Glucuronide), a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans. Estradiol 17-(β-D-Glucuronide) is a high-affinity substrate for oatp organic anion transporter .

HY-B0652

Etonogestrel 3-Oxodesogestrel; 3-keto-Desogestrel	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Drug Metabolite Estrogen Receptor/ERR Progesterone Receptor Endogenous Metabolite FKBP
Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-W009300

4-Hydroxyestrone 1 Publications Verification 4-OHE1	Structural Classification Natural Products Animals Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity .

HY-113252

2-Methoxyestrone 3 Publications Verification	Structural Classification Classification of Application Fields Source classification Endocrine diseases Metabolic Disease Endogenous metabolite Monophenols Microorganisms Disease markers Phenols Nervous System Disorder Disease Research Fields Steroids	Endogenous Metabolite
2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.

HY-124489

2-Hydroxyestradiol 2 Publications Verification	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .

HY-16950A

(E/Z)-4-Hydroxytamoxifen 1 Publications Verification Afimoxifene; 4-OHT	Structural Classification Alkaloids Monophenols Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	Estrogen Receptor/ERR Adhesion G Protein-coupled Receptors (AGPCRs) Drug Metabolite
(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity .

HY-108692

Enterolactone	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Lignans Phenylpropanoids Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite
Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .

HY-W587691

16-Ketoestradiol 16-keto-17β-Estradiol	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite
6-Ketoestradiol is an active metabolite of the endogenous estrogen estrone .

HY-B0652R

Etonogestrel (Standard) 3-Oxodesogestrel (Standard); 3-keto-Desogestrel (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Drug Metabolite Reference Standards Estrogen Receptor/ERR Progesterone Receptor Endogenous Metabolite FKBP
Etonogestrel (Standard) is the analytical standard of Etonogestrel. This product is intended for research and analytical applications. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-N0835

(20S)-Protopanaxatriol 20(S)-APPT; g-PPT	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis
(20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-124489R

2-Hydroxyestradiol (Standard)	Structural Classification Source classification Phenols Polyphenols Endogenous metabolite Steroids	Endogenous Metabolite
2-Hydroxyestradiol (Standard) is the analytical standard of 2-Hydroxyestradiol. This product is intended for research and analytical applications. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .

HY-N10403

4-Hydroxyestradiol 1 Publications Verification 4-Hydroxy-17β-estradiol	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Steroids Cancer	Drug Metabolite Endogenous Metabolite
4-Hydroxyestradiol (4-Hydroxy-17β-estradiol) is an endogenous metabolite of Estradiol (HY-B0141). 4-Hydroxyestradiol is carcinogenic and shows mutagenic activity in breast epithelial cells. 4-Hydroxyestradiol inhibits the binding of Estradiol to the estrogen receptor in a competitive manner, with a K_i of 0.48 nM .

HY-108692R

Enterolactone (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Source classification Lignans Phenylpropanoids Endogenous metabolite	Reference Standards Apoptosis Endogenous Metabolite
Enterolactone (Standard) is the analytical standard of Enterolactone. This product is intended for research and analytical applications. Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .

HY-N0835R

(20S)-Protopanaxatriol (Standard) 20(S)-APPT (Standard); g-PPT (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Source classification Plants Araliaceae	Reference Standards Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis
(20S)-Protopanaxatriol (Standard) is the analytical standard of (20S)-Protopanaxatriol. This product is intended for research and analytical applications. (20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-Y0546

Benzophenone	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Photosensitizer
Benzophenone is an endogenous metabolite. Benzophenone is a photosensitizer, that absorbs UV light, transfers its energy to DNA, and triggers DNA damage. Benzophenone can be used as the fragrance enhancer, ultraviolet curing agent, additive in plastics, or the flavor ingredient. Benzophenone can also be used in the manufacturing of insecticides, agricultural chemicals, hypnotics, antihistamines, and other pharmaceuticals. Benzophenone exhibits certain carcinogenicity in mouse/rat models under long term exposure. Benzophenone exhibits estrogenic activity .

HY-145751

7α-Hydroxy-DHEA 7α-Hydroxydehydroepiandrosterone; 3β,7α-Dihydroxy-Δ5-androsten-17-one	Structural Classification Source classification Endogenous metabolite Steroids	Cytochrome P450 Mitochondrial Metabolism
7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of DHEA (HY-14650), catalyzed by intracellular steroid 7α-hydroxylases such as P450 2A1. 7α-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7α-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma .

Cat. No.	Product Name	Chemical Structure

HY-113252S2

2-Methoxyestrone-d4
2-Methoxyestrone-d₄ is the deuterium labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81 .

HY-124489S1

2-Hydroxyestradiol-d5
2-Hydroxyestradiol-d₅ is the deuterium labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[ .

HY-W777284

Zeranol-d5 (mixture of diastereomers)
Zeranol-d₅ (mixture of diastereomers) is the deuterium labeled Zeranol (HY-N6709). Zeranol, a metabolite of the mycoestrogen zearalenone, is an estrogen receptor agonist. Zeranol is used as a growth promoter of livestock due to its strong estrogenic activity .

HY-113252S1

2-Methoxyestrone-13C6
2-Methoxyestrone- ¹³C₆ is the ¹³C-labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.

HY-113252S

2-Methoxyestrone-13C,d3
2-Methoxyestrone- ¹³C,d₃ is the ¹³C- and deuterium labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.

HY-W740212

16-Keto 17Beta-estradiol-d5
16-Keto 17Beta-estradiol-d₅ is the deuterium labeled 16-Ketoestradiol (HY-W587691). 6-Ketoestradiol is an active metabolite of the endogenous estrogen estrone .

HY-135581S1

Raloxifene 6-glucuronide-d4 lithium

Raloxifene 6-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 6-glucuronide. Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC₅₀ of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-135582S1

Raloxifene 4'-glucuronide-d4 lithium

Raloxifene 4'-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 4'-glucuronide. Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC₅₀ of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-18719ES

Endoxifen-d5
Endoxifen-d₅ is the deuterium labeled Endoxifen. Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen has the potential for breast cancer study .

HY-135582S

Raloxifene 4'-glucuronide-d4

Raloxifene 4'-glucuronide-d₄ is deuterated labeled Raloxifene 4'-glucuronide (HY-135582). Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC₅₀ of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-124489S

2-Hydroxyestradiol-13C6
2-Hydroxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .

HY-B0652S1

Etonogestrel-d6
Etonogestrel-d₆ is deuterium labeled Etonogestrel. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-108692S

Enterolactone-d6
Enterolactone-d₆ is the deuterium labeled Enterolactone. Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .

HY-163712S

17-Epiestriol-d5-1

17-Epiestriol-d₅-1 is the deuterium labeled 17-Epiestriol (HY-163712). 17-Epiestriol is an estrogen metabolite and a selective estrogen receptor (ER) β agonist. 17-epiestriol inhibits the mRNA and protein expression of the vascular cell adhesion molecule VCAM-1 induced by tumor necrosis factor α (TNFα). 17-epiestriol also inhibits TNFα-induced VCAM-1 expression and prevents NF-κB migration to the nucleus. 17-Epiestriol also induces the mRNA and protein expression of endothelial nitric oxide synthase .

HY-W778286

Enterolactone-13C3
Enterolactone- ¹³C₃ is the ¹³C-labeled Enterolactone (HY-108692). Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .

HY-W009300S1

4-Hydroxyestrone-13C6
4-Hydroxyestrone- ¹³C₆ is a ¹³C-labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity .

HY-B1984S

p,p'-DDD-d8

p,p'-DDD-d₈ is the deuterium labeled p,p'-DDD[1]. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats .

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