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Humanserumalbumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Humanserumalbumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Humanserumalbumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Humanserumalbumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO −) in the vascular wall, contributing to the reduction of blood pressure .
HumanSerumAlbumin-Cy3 is a humanserumalbumin conjugated with Cy3 (Ex=554 nm; Em=568 nm). HumanSerumAlbumin-Cy3 can be used as a fluorescent marker to label or detect specific antigens, molecules or cell structures .
HumanSerumAlbumin-AF488 is a biochemical reagent conjugated to fluorescein AF488 (Ex=488 nm; Em=496 nm). HumanSerumAlbumin-AF488 can be used to label or detect specific antigens, molecules or cellular structures .
HumanSerumAlbumin-AF647 (HSA-AF647) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
Humanserumalbumin (Cell culture grade, Endotoxin<0.125 EU/mg) (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Humanserumalbumin (Cell culture grade, Endotoxin<0.125 EU/mg) exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Humanserumalbumin (Cell culture grade, Endotoxin<0.125 EU/mg) can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Humanserumalbumin (Cell culture grade, Endotoxin<0.125 EU/mg) is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, iNOS, and peroxynitrite (ONOO −) in the vascular wall, contributing to the reduction of blood pressure .
Recombinant HumanSerumAlbumin (rHSA) is an active compound and possesses an identical conformation to plasma derived HSA. Recombinant HumanSerumAlbumin (rHSA) has no difference between rHSA and plasma derived HSA. The main physiological function of Recombinant HumanSerumAlbumin (rHSA) is to regulate plasma pH and maintain plasma osmotic pressure .
HumanSerumAlbumin-APC (HSA-APC) is humanserumalbumin (HSA) labeled with allophycocyanin (APC) (HY-D1815) and can be used for fluorescent labeling and tracing experiments.
Lerodalcibep (LIB003) is a recombinant fusion protein of a PCSK9-binding domain (adnectin) and humanserumalbumin. Lerodalcibep is a Lipid-lowering agent. Lerodalcibep can be used for the research of hypercholesterolemia and cardiovascular diseases .
Sonelokimab (ALX 0761) is a trivalent bispecific nanobody composed of camel derived humanized IL-17F antibodies, IL-17A/F antibodies, and serumalbuminVHH antibodies. Sonelokimab can prolong the plasma half-life by binding to humanserumalbumin. Sonelokimab can be used for research on rheumatoid arthritis and psoriasis .
DDAO-C6 is a cridone ester derivative, highly specific fluorescence for detecting humanserumalbumin (HSA). DDAO-C6 acts as an enzymatic activatable near-infrared fluorescent probe in visually sensing endogenous lipase from gut microbes (Ex/Em=600/658 nm) .
Paclitaxel octadecanedioate (compound PTX-FA18) is comprised of Paclitaxel (HY-B0015) conjugated to 1,18-octadecanedioic acid (HY-W005178). Paclitaxel octadecanedioate mixed with humanserumalbumin (HAS) is cytotoxic to HT-1080, PANC-1, HT-29 and Hela cells (IC50s = 12, 2.48, 8.62, and 64.42 nM, respectively) .
Vobarilizumab (ALX-0061) is a humanized bispecific anti-IL-6R and anti-humanserumalbumin (ALB) monoclonal antibody (mAb) (Kd: 0.19 pM). Vobarilizumab consists of an anti-IL-6R domain and an anti-humanserumalbumin domain. Vobarilizumab can be used in the research of inflammatory autoimmune diseases, such as rheumatoid arthritis .
5-Aminofluorescein (5-AF) is a fluorescence marker, covalently bound to humanserumalbumin. The excitation wavelength is 495 nm and the emission wavelength is 535 nm .
BSPOTPE binds Humanserumalbumin (HSA) (HY-P1956), exhibits aggregation-induced emission (AIE) phenomenon. BSPOTPE shows selectivity for albumin (such as HSA and BSA), but has no obvious fluorescence response to other proteins and DNA. BSPOTPE can be used as fluorescent probe for HSA .
(R)-Duloxetine (LY248686) Hydrochloride is a napthalenyloxy-substituted amine utilized in binding studies with humanserumalbumin, and unlike its enantiomer (S)-Duloxetine, it exhibits limited efficacy as a dual serotonin and norepinephrine reuptake inhibitor (SNRI).
(E/Z)-BSPOTPE is a configurational mixture of BSPOTPE (HY-W856375). BSPOTPE can bind to humanserumalbumin (HSA) (HY-P1956) and exhibits the phenomenon of aggregation-induced emission (AIE) .
Ozoralizumab (ATN-103) is an anti-TNFα humanized antibody. Ozoralizumab is a humanized trivalent nanobody compound that consists of two anti-human TNFα nanobodies and an anti-humanserumalbumin (HSA) nanobody. Ozoralizumab can be used in research of arthritis .
Balugrastim (CG 10639) is a novel long-acting recombinant granulocyte colony-stimulating factor (G-CSF) obtained by means of a genetic fusion between recombinant humanserumalbumin and granulocyte colony-stimulating factor. Balugrastim can be used for the research of breast cancer .
MAO-B-IN-37 (Compound 37) is a derivative of TT01001 (HY-114520), and a selective inhibitor for monoamine oxidase B (MAO-B) with an IC50 of 270 nM. MAO-B-IN-37 exhibits good metabolic stability in mice microsomes and good affinity with humanserumalbumin .
CEP-40125 (RXDX-107) is a modified form of Bendamustine (HY-13567), a DNA cross-linking agent that may cause DNA damage and cell apoptosis. CEP-40125 (RXDX-107) is formed by encapsulating the alkyl ester form of Bendamustine in humanserumalbumin .
Tetrazole-C15-(N-acetylsulfamoyl)butanoic acid (Ligand 1) improves the pharmacokinetic properties of therapeutic peptides and proteins through non-covalent binding with humanserumalbumin (HSA). Tetrazole-C15-(N-acetylsulfamoyl)butanoic acid can be used for synthesis of long-acting human growth hormone (HGH) analog somapacitan .
Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-humanserumalbumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression .
Vamidothion is a polar organophosphorus insecticide and acaricide with biological activity against insects and mites. Vamidothion is degraded by humanserumalbumin (HSA) and promotes adduct formation with tyrosine residues. The phosphate amino acid adducts formed after the reaction of vamidothion with HSA are detected by liquid chromatography quadrupole-Orbitrap mass spectrometry. The metabolites of vamidothion can be used in forensic toxicology to help determine deaths caused by organophosphorus poisoning .
Levamlodipine hydrochloride (Levoamlodipine hydrochloride) is a dihydropyridine calcium channel blocker. Levamlodipine hydrochloride reduces the inflow of calcium ions by blocking L-type calcium channels on vascular smooth muscle cells, thereby leading to vasodilation, lower blood pressure and lighten the burden on the heart. Levamlodipine hydrochloride has activity to lower blood pressure and relieve angina. The binding properties of Levamlodipine hydrochloride to humanserumalbumin (HSA) contribute to the study of drug transport and release mechanisms in the body .
3,7-Dihydroxyflavone (Resogalangin) is a flavonoid phytoestrogen, which can be isolated from Adenophora species. 3,7-Dihydroxyflavone is a modulator of estrogen receptors and an inhibitor of human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase and a redox inhibitor (IC50=0.6 and 6.0 μM, respectively). 3,7-Dihydroxyflavone is a fluorescent binding substrate for humanserumalbumin (HSA) with excitation wavelengths of 370 nm (pH 7.4) and 350 nm (pH 3.5), respectively, and emission wavelength of 515 nm .
2-Iodoestradiol is a potent human sex hormone binding globulin (SHBG) ligand with a remarkably high affinity for SHBG. 2-Iodoestradiol exhibits competition for the same binding site as dihydrotestosterone in binding to human SHBG. The binding affinity constant of 2-Iodoestradiol at physiological pH and 37 degrees Celsius is 2.4 x 10(9) M-1, exceeding that for SHBG. 2-Iodoestradiol has been shown to bind to serumalbumin, but with lower affinity. The radioisotope 125I-derivative of 2-Iodoestradiol has been used to study the binding properties of human SHBG, demonstrating its potential application in biological research .
Darexaban maleate (YM150 maleate) is a direct factor Xa inhibitor with activity in preventing venous thromboembolism. The major metabolite of Darexaban maleate in humans is Darexaban glucitol, which acts pharmacologically. The glucitolation reaction of Darexaban maleate is mainly catalyzed by UGT1A9 and UGT1A10 in the human liver and intestine. The K(m) value of Darexaban maleate glucitolation in the liver is greater than 250 μM, while in the intestine it exhibits substrate inhibition kinetics with a K(m) value of 27.3 μM. The unbound K(m) value of Darexaban maleate is significantly reduced by the influence of fatty acid-free bovine serumalbumin in both HLM and UGT1A9 .
Levosemotiadil, an S-isomer of semotiadil, exhibits stronger binding affinity to humanserumalbumin (HSA) compared to its R-isomer counterpart. This study utilized high-performance frontal analysis (HPFA) to demonstrate that levosemotiadil binds approximately three times more strongly to HSA than semotiadil. The binding parameters were evaluated using Scatchard analysis, revealing specific interactions with the diazepam binding site on HSA. The presence of diazepam decreased the binding affinity of both enantiomers, while warfarin did not alter their binding characteristics. These findings highlight levosemotiadil's potential as a Ca- and Na-channel blocker with significant binding preferences for HSA, crucial for understanding its pharmacokinetics and therapeutic effects .
5-Aminofluorescein (5-AF) is a fluorescence marker, covalently bound to humanserumalbumin. The excitation wavelength is 495 nm and the emission wavelength is 535 nm .
(E/Z)-BSPOTPE is a configurational mixture of BSPOTPE (HY-W856375). BSPOTPE can bind to humanserumalbumin (HSA) (HY-P1956) and exhibits the phenomenon of aggregation-induced emission (AIE) .
DDAO-C6 is a cridone ester derivative, highly specific fluorescence for detecting humanserumalbumin (HSA). DDAO-C6 acts as an enzymatic activatable near-infrared fluorescent probe in visually sensing endogenous lipase from gut microbes (Ex/Em=600/658 nm) .
BSPOTPE binds Humanserumalbumin (HSA) (HY-P1956), exhibits aggregation-induced emission (AIE) phenomenon. BSPOTPE shows selectivity for albumin (such as HSA and BSA), but has no obvious fluorescence response to other proteins and DNA. BSPOTPE can be used as fluorescent probe for HSA .
Humanserumalbumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Humanserumalbumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Humanserumalbumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Humanserumalbumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO −) in the vascular wall, contributing to the reduction of blood pressure .
HumanSerumAlbumin-Cy3 is a humanserumalbumin conjugated with Cy3 (Ex=554 nm; Em=568 nm). HumanSerumAlbumin-Cy3 can be used as a fluorescent marker to label or detect specific antigens, molecules or cell structures .
HumanSerumAlbumin-AF488 is a biochemical reagent conjugated to fluorescein AF488 (Ex=488 nm; Em=496 nm). HumanSerumAlbumin-AF488 can be used to label or detect specific antigens, molecules or cellular structures .
HumanSerumAlbumin-AF647 (HSA-AF647) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
Humanserumalbumin (Cell culture grade, Endotoxin<0.125 EU/mg) (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Humanserumalbumin (Cell culture grade, Endotoxin<0.125 EU/mg) exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Humanserumalbumin (Cell culture grade, Endotoxin<0.125 EU/mg) can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Humanserumalbumin (Cell culture grade, Endotoxin<0.125 EU/mg) is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, iNOS, and peroxynitrite (ONOO −) in the vascular wall, contributing to the reduction of blood pressure .
HumanSerumAlbumin-APC (HSA-APC) is humanserumalbumin (HSA) labeled with allophycocyanin (APC) (HY-D1815) and can be used for fluorescent labeling and tracing experiments.
Recombinant HumanSerumAlbumin (rHSA) is an active compound and possesses an identical conformation to plasma derived HSA. Recombinant HumanSerumAlbumin (rHSA) has no difference between rHSA and plasma derived HSA. The main physiological function of Recombinant HumanSerumAlbumin (rHSA) is to regulate plasma pH and maintain plasma osmotic pressure .
Sonelokimab (ALX 0761) is a trivalent bispecific nanobody composed of camel derived humanized IL-17F antibodies, IL-17A/F antibodies, and serumalbuminVHH antibodies. Sonelokimab can prolong the plasma half-life by binding to humanserumalbumin. Sonelokimab can be used for research on rheumatoid arthritis and psoriasis .
Vobarilizumab (ALX-0061) is a humanized bispecific anti-IL-6R and anti-humanserumalbumin (ALB) monoclonal antibody (mAb) (Kd: 0.19 pM). Vobarilizumab consists of an anti-IL-6R domain and an anti-humanserumalbumin domain. Vobarilizumab can be used in the research of inflammatory autoimmune diseases, such as rheumatoid arthritis .
Ozoralizumab (ATN-103) is an anti-TNFα humanized antibody. Ozoralizumab is a humanized trivalent nanobody compound that consists of two anti-human TNFα nanobodies and an anti-humanserumalbumin (HSA) nanobody. Ozoralizumab can be used in research of arthritis .
Lerodalcibep (LIB003) is a recombinant fusion protein of a PCSK9-binding domain (adnectin) and humanserumalbumin. Lerodalcibep is a Lipid-lowering agent. Lerodalcibep can be used for the research of hypercholesterolemia and cardiovascular diseases .
Balugrastim (CG 10639) is a novel long-acting recombinant granulocyte colony-stimulating factor (G-CSF) obtained by means of a genetic fusion between recombinant humanserumalbumin and granulocyte colony-stimulating factor. Balugrastim can be used for the research of breast cancer .
Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-humanserumalbumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression .
3,7-Dihydroxyflavone (Resogalangin) is a flavonoid phytoestrogen, which can be isolated from Adenophora species. 3,7-Dihydroxyflavone is a modulator of estrogen receptors and an inhibitor of human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase and a redox inhibitor (IC50=0.6 and 6.0 μM, respectively). 3,7-Dihydroxyflavone is a fluorescent binding substrate for humanserumalbumin (HSA) with excitation wavelengths of 370 nm (pH 7.4) and 350 nm (pH 3.5), respectively, and emission wavelength of 515 nm .
The serum albumin/ALB protein has multiple binding abilities and can bind water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin, and drugs. Its main effects include regulating blood colloid osmotic pressure to achieve homeostasis. Serum Albumin/ALB Protein, Human (P.pastoris) is the recombinant human-derived Serum Albumin/ALB protein, expressed by P. pastoris , with tag free. The total length of Serum Albumin/ALB Protein, Human (P.pastoris) is 585 a.a., with molecular weight of 55-80 kDa.
The serum albumin/ALB protein has multiple binding abilities and can bind water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin, and drugs. Its main effects include regulating blood colloid osmotic pressure to achieve homeostasis. Serum Albumin/ALB Protein, Human (HEK293, His-Avi) is the recombinant human-derived Serum Albumin/ALB protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of Serum Albumin/ALB Protein, Human (HEK293, His-Avi) is 585 a.a., with molecular weight of 69-70 kDa.
The serum albumin/ALB protein has multiple binding abilities and can bind water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin, and drugs. Its main effects include regulating blood colloid osmotic pressure to achieve homeostasis. Serum Albumin/ALB Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Serum Albumin/ALB protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of Serum Albumin/ALB Protein, Human (Biotinylated, HEK293, His-Avi) is 585 a.a., with molecular weight of 69-70 kDa.
ALB; ALBU_human; albumin (32 AA); albumin (AA 34); albumin; Analbuminemia; Bisalbuminemia; Cell growth inhibiting protein 42; DKFZp779N1935; Dysalbuminemic hyperthyroxinemia; Growth inhibiting protein 20; HSA; Hyperthyroxinemia dysalbuminemic; serumalbumin.
ELISA
Human
Human Serum Albumin Antibody (YA984) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA984), targeting Human Serum Albumin. Human Serum Albumin Antibody (YA984) can be used for ELISA experiment in human background.
ALB; ALBU_human; albumin (32 AA); albumin (AA 34); albumin; Analbuminemia; Bisalbuminemia; Cell growth inhibiting protein 42; DKFZp779N1935; Dysalbuminemic hyperthyroxinemia; Growth inhibiting protein 20; HSA; Hyperthyroxinemia dysalbuminemic; serumalbumin.
WB, ELISA
Human
Human Serum Albumin Antibody (YA985) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA985), targeting Human Serum Albumin, with a predicted molecular weight of 69 kDa (observed band size: 69 kDa). Human Serum Albumin Antibody (YA985) can be used for WB, ELISA experiment in human background.
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