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melatonin receptor

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By Targets:	Melatonin Receptor (28) 5-HT Receptor (5) Apoptosis (4) Autophagy (4) Drug Metabolite (3) Endogenous Metabolite (8) Isotope-Labeled Compounds (1) Mitophagy (4) P2X Receptor (1) Sodium Channel (1) Trk Receptor (3) TRP Channel (1)
By Research Areas:	Cancer (9) Endocrinology (6) Inflammation/Immunology (5) Metabolic Disease (2) Neurological Disease (28)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Melatonin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-133113

7-Desmethyl-agomelatine 1 Publications Verification	5-HT Receptor	Neurological Disease
7-Desmethyl-agomelatine is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C .

HY-W015169

5-Methoxytryptamine O-Methylserotonin	Drug Metabolite 5-HT Receptor Endogenous Metabolite	Neurological Disease Cancer
5-Methoxytryptamine, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine is also a potent antioxidant and has radioprotective action .

HY-W015169A

5-Methoxytryptamine hydrochloride	5-HT Receptor Endogenous Metabolite	Neurological Disease Cancer
5-Methoxytryptamine hydrochloride, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine hydrochloride has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine hydrochloride is also a potent antioxidant and has radioprotective action .

HY-B0075S

Melatonin-d4 N-Acetyl-5-methoxytryptamine-d₄	Melatonin Receptor Autophagy Mitophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Melatonin-d₄ is deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4].

HY-B0075S2

Melatonin-d7 N-Acetyl-5-methoxytryptamine-d₇	Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Melatonin-d₇ is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4]. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress[5].

HY-B0075S1

Melatonin-d3 N-Acetyl-5-methoxytryptamine-d₃	Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Melatonin-d₃ is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4]. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress[5].

HY-147542

Melatonin receptor agonist 1	Melatonin Receptor	Neurological Disease
Melatonin receptor agonist 1 (compound 20c) is a potent **melatonin receptor (MT) agonist, with K_i values of 108 nM (MT₂) and 1140 nM (MT₁**) .

HY-159848

Nedemelteon	Melatonin Receptor	Neurological Disease
Nedemelteon is a **melatonin receptor** agonist .

HY-116046

GR 196429	Melatonin Receptor	Others
GR 196429 is a **melatonin receptor** agonist with some selectivity for the MT1 subtype. GR 196429 produces both sleep-promoting effects and alterations of circadian rhythm, as well as stimulating melatonin release in mice .

HY-100940

6-Chloromelatonin	Melatonin Receptor	Endocrinology
6-Chloromelatonin is a potent **melatonin receptor** agonist with greater metabolic stability than melatonin. 6-Chloromelatonin compete for [ ³H]-melatonin and 2-[ ¹²⁵I]-iodomelatonin binding to MT1 receptors (pK_i=8.9 and 9.1, respectively). 6-Chloromelatonin compete for [ ³H]-melatonin binding to MT2 receptors (pK_i=9.77) .

HY-B0075

Melatonin Maximum Cited Publications 88 Publications Verification N-Acetyl-5-methoxytryptamine	Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Melatonin is a hormone made by the pineal gland that can activates **melatonin receptor*. Melatonin* plays a role in sleep and possesses important antioxidative and anti-inflammatory properties . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .

HY-120182

GR 128107	Melatonin Receptor	Cancer
GR 128107 is a competitive **melatonin receptor** antagonist (pK_i: 9.6) .

HY-119010

UCM 549	Melatonin Receptor	Neurological Disease
UCM 549 is a **melatonin MT2 receptor** inverse agonist and a MT1 receptor antagonist .

HY-103005

Ramelteon metabolite M-II	Melatonin Receptor Drug Metabolite	Neurological Disease Endocrinology
Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC₅₀s of 208 pM, 1470 pM for human melatonin receptors (MT₁ or MT₂). Ramelteon is a selective melatonin agonist.

HY-114962

S-22153	Melatonin Receptor	Neurological Disease
S-22153 is a potent **melatonin receptor antagonist with EC₅₀ values of 19 nM, 4.6 nM for hMT₁ and hMT₂** melatonin receptor, respectively. S-22153 has K_i values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT₁, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT₂. S-22153 is a specific ligand of MT₁ and MT₂ melatonin receptors subtypes .

HY-116930

S-20928	Melatonin Receptor	Metabolic Disease
S-20928 is an antagonist for **melatonin receptor** through inhibition of binding of melatonin to its receptors. S-20928 enhances the 2-Deoxy-D-glucose (2DG) (HY-13966)-induced increase in blood glucose and glucagon levels in rats brain .

HY-107854

N-Acetyl-5-hydroxytryptamine 2 Publications Verification N-Acetylserotonin; Normelatonin; O-Demethylmelatonin	Endogenous Metabolite Trk Receptor	Neurological Disease
N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor.

HY-107628

DH97	Melatonin Receptor	Neurological Disease
DH97 is a potent and selective antagonist of MT₂ melatonin receptor, with a pK_i of 8.03 for human MT₂. DH97 shows 89- and 229-fold selectivity for human MT₂ over human mt₁ and Xenopus mel_1c receptor subtypes. DH97 can inhibit melatonin-induced enhancement of electrically-evoked responses .

HY-101176

2-Iodomelatonin 2 Publications Verification	Melatonin Receptor	Cancer
2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a K_i value of 28 pM, it is more 5-fold selective for MT₁ over MT₂ . 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues .

HY-103005S

Ramelteon metabolite M-II-d3	Melatonin Receptor Drug Metabolite	Neurological Disease Endocrinology
Ramelteon metabolite M-II-d₃ is the deuterium labeled Ramelteon metabolite M-II. Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist[1][2].

HY-100908

N-Acetyltryptamine N10-Acetyltryptamine; Nb-Acetyltryptamine; Nω-Acetyltryptamine	Melatonin Receptor	Neurological Disease
N-Acetyltryptamine is a partial agonist for melatonin receptors in the retina . N-Acetyltryptamine is also used for determination of serotonin N-acetyl transferase activity .

HY-101074

UCM 608 2-Phenylmelatonin	Melatonin Receptor	Neurological Disease Inflammation/Immunology Cancer
UCM 608 is a high affinity melatonin (MT) membrane receptor agonist. The pKi values for MT1 and MT2 are 10.7 and 10.4 .

HY-138626

ACH-000143	Melatonin Receptor	Metabolic Disease
ACH-000143 is a potent and orally active **melatonin receptor agonist, with EC₅₀** values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively .

HY-106136

TIK-301 PD-6735; LY-156735	Melatonin Receptor 5-HT Receptor	Neurological Disease
TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT₁ and MT₂ receptors agonist with K_is of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT_2B/5-HT_2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment .

HY-107854S

N-Acetyl-5-hydroxytryptamine-d3 N-Acetylserotonin-d₃; Normelatonin-d₃; O-Demethylmelatonin-d₃	Endogenous Metabolite Trk Receptor	Neurological Disease
N-Acetyl-5-hydroxytryptamine-d₃ is the deuterium labeled N-Acetyl-5-hydroxytryptamine. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor[1][2].

HY-100609

4-P-PDOT 5+ Cited Publications	Melatonin Receptor	Neurological Disease
4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist. 4-P-PDOT is >300-fold more selective for MT2 than MT1. 4-P-PDOT significantly counteracts Melatonin-mediated antioxidant effects (GSH/GSSG ratio, phospho-ERK, Nrf2 nuclear translocation, Nrf2 DNA-binding activity) .

HY-14803

Tasimelteon BMS-214778; VEC-162	Melatonin Receptor	Neurological Disease Endocrinology
Tasimelteon (BMS-214778) is an orally active and selective *dual melatonin* receptor agonist (DMRA)*. Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor* than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24) .

HY-107854R

N-Acetyl-5-hydroxytryptamine (Standard) N-Acetylserotonin (Standard); Normelatonin (Standard); O-Demethylmelatonin (Standard)	Endogenous Metabolite Trk Receptor	Neurological Disease
N-Acetyl-5-hydroxytryptamine (Standard) is the analytical standard of N-Acetyl-5-hydroxytryptamine. This product is intended for research and analytical applications. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor.

HY-101303

5-MCA-NAT	Melatonin Receptor	Others
5-MCA-NAT is a melatonin agonist that may target the melatoninMT3 receptor. 5-MCA-NAT can contract the colonic band in a concentration-dependent manner and reduce intraocular pressure (IOP) in glaucomatous monkey eyes, inhibiting the increase in IOP .

HY-14803S

Tasimelteon-d5 BMS-214778-d₅; VEC-162-d₅	Isotope-Labeled Compounds Melatonin Receptor	Neurological Disease Endocrinology
Tasimelteon-d₅ is the deuterium labeled Tasimelteon. Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24)[1][2].

HY-101358

8-M-PDOT AH-002	Melatonin Receptor	Neurological Disease
8-M-PDOT (AH-002) is a selective **melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2** over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity .

HY-14803R

Tasimelteon (Standard)	Melatonin Receptor	Neurological Disease Endocrinology
Tasimelteon (Standard) is the analytical standard of Tasimelteon. This product is intended for research and analytical applications. Tasimelteon (BMS-214778) is an orally active and selective *dual melatonin* receptor agonist (DMRA)*. Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor* than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24) .

HY-101254

Luzindole 10+ Cited Publications N-0774	Melatonin Receptor	Neurological Disease
Luzindole (N-0774) is a selective **melatonin receptor antagonist. Luzindole preferentially targets MT2 (Mel_1b) over MT1 (Mel_1a) with K_i** values of 10.2 and 158 nM for human MT2 and MT1, respectively. Luzindole suppresses experimental autoimmune encephalomyelitis (EAE), and exerts antidepressant-like activity .

HY-115861

UCM765	Others	Neurological Disease
UCM765 is a selective MT2-type melatonin receptor ligand with hypnotic, analgesic and anxiolytic activities. The partial agonist effect of UCM765 has attracted attention in pharmacological studies. By structurally modifying UCM765, its water solubility and metabolic stability can be improved, thereby increasing its bioavailability. The biological activity of UCM765 has been verified in a rat model, supporting its potential for further pharmacological studies .

HY-105285

Piromelatine Neu-P11	Melatonin Receptor 5-HT Receptor P2X Receptor TRP Channel Sodium Channel	Neurological Disease
Piromelatine (Neu-P11) is a melatonin MT₁/MT₂ receptor agonist, serotonin 5-HT_1A/5-HT_1D agonist, and serotonin 5-HT_2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities .

Cat. No.	Product Name

HY-L013

Neuronal Signaling Compound Library	2,803 compounds
Neuronal Signaling is involved in the regulation of the mechanisms of the central nervous system (CNS) such as its structure, function, genetics and physiology as well as how this can be applied to understand diseases of the nervous system. Every information processing system in the CNS is composed of neurons and glia, neurons have evolved unique capabilities for intracellular signaling (communication within the cell) and intercellular signaling (communication between cells). G protein-coupled receptors (GPCRs), including 5-HT receptor, histamine receptor, opioid receptor, etc. are the largest class of sensory proteins and are important therapeutic targets in Neuronal Signaling. Besides, Notch signaling, such as β- and γ-secretase, also plays multiple roles in the development of the CNS including regulating neural stem cell (NSC) proliferation, survival, self-renewal and differentiation. GPCR dysfunction caused by receptor mutations and environmental challenges contributes to many neurological diseases. Notch signaling in neurons, glia, and NSCs is also involved in pathological changes that occur in disorders such as stroke, Alzheimer's disease and CNS tumors. Thus, targeting Neuronal Signaling, such as notch signaling and GPCRs, can be used as therapeutic interventions for several different CNS disorders. MCE designs a unique collection of 2,803 Neuronal Signaling-related compounds that act as a useful tool for the research of neuronal regulation and neuronal diseases.

Neuronal Signaling Compound Library

2,803 compounds

Neuronal Signaling is involved in the regulation of the mechanisms of the central nervous system (CNS) such as its structure, function, genetics and physiology as well as how this can be applied to understand diseases of the nervous system. Every information processing system in the CNS is composed of neurons and glia, neurons have evolved unique capabilities for intracellular signaling (communication within the cell) and intercellular signaling (communication between cells). G protein-coupled receptors (GPCRs), including 5-HT receptor, histamine receptor, opioid receptor, etc. are the largest class of sensory proteins and are important therapeutic targets in Neuronal Signaling. Besides, Notch signaling, such as β- and γ-secretase, also plays multiple roles in the development of the CNS including regulating neural stem cell (NSC) proliferation, survival, self-renewal and differentiation. GPCR dysfunction caused by receptor mutations and environmental challenges contributes to many neurological diseases. Notch signaling in neurons, glia, and NSCs is also involved in pathological changes that occur in disorders such as stroke, Alzheimer's disease and CNS tumors. Thus, targeting Neuronal Signaling, such as notch signaling and GPCRs, can be used as therapeutic interventions for several different CNS disorders.

MCE designs a unique collection of 2,803 Neuronal Signaling-related compounds that act as a useful tool for the research of neuronal regulation and neuronal diseases.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W015169

5-Methoxytryptamine O-Methylserotonin	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Indole Alkaloids Cancer	Drug Metabolite 5-HT Receptor Endogenous Metabolite
5-Methoxytryptamine, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine is also a potent antioxidant and has radioprotective action .

HY-W015169A

5-Methoxytryptamine hydrochloride	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Indole Alkaloids Cancer	5-HT Receptor Endogenous Metabolite
5-Methoxytryptamine hydrochloride, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine hydrochloride has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine hydrochloride is also a potent antioxidant and has radioprotective action .

HY-B0075

Melatonin 85+ Cited Publications N-Acetyl-5-methoxytryptamine	Structural Classification Natural Products Other disease Neurological Disease Classification of Application Fields Anti-aging Source classification Endogenous metabolite Microorganisms Disease markers Inflammation/Immunology Disease Research Fields Cancer	Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis
Melatonin is a hormone made by the pineal gland that can activates **melatonin receptor*. Melatonin* plays a role in sleep and possesses important antioxidative and anti-inflammatory properties . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .

HY-107854

N-Acetyl-5-hydroxytryptamine 2 Publications Verification N-Acetylserotonin; Normelatonin; O-Demethylmelatonin	Alkaloids Structural Classification Monophenols Phenols Endogenous metabolite Indole Alkaloids	Endogenous Metabolite Trk Receptor
N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor.

HY-107854R

N-Acetyl-5-hydroxytryptamine (Standard) N-Acetylserotonin (Standard); Normelatonin (Standard); O-Demethylmelatonin (Standard)	Alkaloids Structural Classification Monophenols Phenols Endogenous metabolite Indole Alkaloids	Endogenous Metabolite Trk Receptor
N-Acetyl-5-hydroxytryptamine (Standard) is the analytical standard of N-Acetyl-5-hydroxytryptamine. This product is intended for research and analytical applications. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor.

Cat. No.	Product Name	Chemical Structure

HY-B0075S

Melatonin-d4
Melatonin-d₄ is deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4].

HY-B0075S2

Melatonin-d7
Melatonin-d₇ is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4]. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress[5].

Melatonin-d7

Melatonin-d₇ is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4]. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress[5].

HY-B0075S1

Melatonin-d3

Melatonin-d₃ is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4]. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress[5].

HY-103005S

Ramelteon metabolite M-II-d3
Ramelteon metabolite M-II-d₃ is the deuterium labeled Ramelteon metabolite M-II. Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist[1][2].

HY-107854S

N-Acetyl-5-hydroxytryptamine-d3
N-Acetyl-5-hydroxytryptamine-d₃ is the deuterium labeled N-Acetyl-5-hydroxytryptamine. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor[1][2].

HY-14803S

Tasimelteon-d5
Tasimelteon-d₅ is the deuterium labeled Tasimelteon. Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24)[1][2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81119

	MTNR1A Antibody MTR1A_HUMAN; melatonin receptor type 1A; melatonin receptor 1A; Mel-1A-R; Mel1a receptor; MT1; MT 1; Mel 1A R	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	MTNR1A Antibody is an unconjugated, approximately 39 kDa, rabbit-derived, anti-MTNR1A polyclonal antibody. MTNR1A Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, and predicted: chicken, dog, pig, cow, sheep, guinea pig background without labeling.

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melatonin receptor

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