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Results for "

mitochondrial calcium

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (5) Mitochondrial Metabolism (5) AMPK (1) Antibiotic (1) Apoptosis (10) Bacterial (1) Bcl-2 Family (1) CaMK (1) Caspase (1) Cyclophilin (1) Endogenous Metabolite (3) Formyl Peptide Receptor (FPR) (2) Fungal (3) Interleukin Related (1) Isotope-Labeled Compounds (3) JAK (1) Potassium Channel (2) PPAR (2) Pyroptosis (1) Reactive Oxygen Species (5) Sigma Receptor (1) SOD (1) STAT (1) Thrombopoietin Receptor (1) TNF Receptor (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (6) Infection (5) Inflammation/Immunology (7) Metabolic Disease (3) Neurological Disease (7)

By Targets:

Calcium Channel (5)

Mitochondrial Metabolism (5)

AMPK (1)

Antibiotic (1)

Apoptosis (10)

Bacterial (1)

Bcl-2 Family (1)

CaMK (1)

Caspase (1)

Cyclophilin (1)

Endogenous Metabolite (3)

Formyl Peptide Receptor (FPR) (2)

Fungal (3)

Interleukin Related (1)

Isotope-Labeled Compounds (3)

JAK (1)

Potassium Channel (2)

PPAR (2)

Pyroptosis (1)

Reactive Oxygen Species (5)

Sigma Receptor (1)

SOD (1)

STAT (1)

Thrombopoietin Receptor (1)

TNF Receptor (1)

By Research Areas:

Cancer (6)

Cardiovascular Disease (6)

Infection (5)

Inflammation/Immunology (7)

Metabolic Disease (3)

Neurological Disease (7)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Mitochondrial Metabolism Calcium Channel Mitophagy CaSR Calmodulin CRAC Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W194810

MCU-i11	Mitochondrial Metabolism	Neurological Disease Metabolic Disease
MCU-i11 is a negative regulator of the mitochondrial calcium uniporter (MCU) complex. MCU-i11 can reduce mitochondrial Ca ²⁺ uptake. MCU-i11 impairs muscle cell growth .

HY-B0926A

Sodium diatrizoate Diatrizoic acid sodium salt; Sodium amidotrizoate	Apoptosis	Inflammation/Immunology
Sodium diatrizoate (Diatrizoic acid sodium salt) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Sodium diatrizoate induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium .

HY-B0926

Diatrizoic acid Diatrizoate; Amidotrizoic acid	Apoptosis	Inflammation/Immunology
Diatrizoic acid (Diatrizoate) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Diatrizoic acid induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium .

HY-100928

YS 035 hydrochloride	Calcium Channel	Neurological Disease
YS 035 hydrochloride is a Ca ²⁺ antagonist on cellular uptake and mitochondrial efflux of calcium ions. YS 035 hydrochloride inhibits Ca ²⁺ uptake by muscle cells and inhibits Na ⁺/Ca ²⁺ exchange (K_i=28 µM). YS 035 hydrochloride is a useful tool for research on the mitochondrial Ca ²⁺ transport .

HY-P10738

N-Formyl-MMYALF	Formyl Peptide Receptor (FPR)	Infection
N-Formyl-MMYALF is a potent mitochondrial N-formyl peptide (mtFP) that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF can inhibit the FPR-1-mediated chemotactic response of polymorphonuclear leukocytes (PMNs) to bacterial peptides .

HY-150966

Antiproliferative agent-10	Mitochondrial Metabolism	Cancer
Antiproliferative agent-10 (compound 8) is an anti-tumour ruthenium(II)-tris-pyrazolylmethane complex that inhibits the growth of cancer cells by inhibiting mitochondrial calcium uptake .

HY-150969

Antiproliferative agent-12	Mitochondrial Metabolism	Cancer
Antiproliferative agent-10 (compound 1) is an anti-tumour ruthenium(II)-tris-pyrazolylmethane complex that inhibits the growth of cancer cells by inhibiting mitochondrial calcium uptake .

HY-P10738A

N-Formyl-MMYALF TFA	Formyl Peptide Receptor (FPR)	Infection
N-Formyl-MMYALF TFA is a mitochondrial N-formyl peptide that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF TFA can inhibit the FPR-1-mediated chemotactic response of PMNs to bacterial peptides .

HY-B0926R

Diatrizoic acid (Standard) Diatrizoate (Standard); Amidotrizoic acid (Standard)	Apoptosis	Inflammation/Immunology
Diatrizoic acid (Standard) is the analytical standard of Diatrizoic acid. This product is intended for research and analytical applications. Diatrizoic acid (Diatrizoate) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Diatrizoic acid induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium .

HY-B0926AR

Sodium diatrizoate (Standard)	Apoptosis	Inflammation/Immunology
Sodium diatrizoate (Standard) is the analytical standard of Sodium diatrizoate. This product is intended for research and analytical applications. Sodium diatrizoate (Diatrizoic acid sodium salt) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Sodium diatrizoate induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium .

HY-U00049B

Mioflazine di(hydrochloride)	Calcium Channel	Cardiovascular Disease Neurological Disease
Mioflazine dihydrochloride is a nucleoside transport inhibitor with sleep-improving activity. Mioflazine dihydrochloride significantly improves cardiac survival after global cardiac ischemia. Mioflazine dihydrochloride reduces the mitochondrial calcium content in guinea-pig. Mioflazine dihydrochloride does not exhibit inotropic effects during induction and nursing .

HY-U00049A

Mioflazine (di(hydrochloride) hydrate)	Calcium Channel	Cardiovascular Disease Neurological Disease
Mioflazine dihydrochloride hydrate is a nucleoside transport inhibitor with sleep-improving activity. Mioflazine dihydrochloride hydrate helps maintain the mechanical function of the left ventricle and significantly improves the heart's recovery ability after global ischemia at new temperatures. Mioflazine dihydrochloride hydrate reduces the mitochondrial calcium content in guinea-pig .

HY-N7063R

Nerol (Standard)	Reactive Oxygen Species Endogenous Metabolite Fungal Mitochondrial Metabolism Apoptosis	Infection
Nerol (Standard) is the analytical standard of Nerol. This product is intended for research and analytical applications. Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

HY-N7063

Nerol	Reactive Oxygen Species Fungal Mitochondrial Metabolism Apoptosis Endogenous Metabolite	Infection
Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

HY-N7436S

Methyl propyl disulfide-d3	Isotope-Labeled Compounds	Cancer
Methyl propyl disulfide-d₃ is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

HY-N7364S

(E)-β-Farnesene-d6 trans-β-Farnesene-d₆	Fungal Isotope-Labeled Compounds	Cancer
(E)-β-Farnesene-d₆ is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

HY-P10371

PKHB1	Reactive Oxygen Species Thrombopoietin Receptor	Inflammation/Immunology Cancer
PKHB1 is a thrombospondin-1 peptide mimic with antitumor effects. PKHB1 induces mitochondrial alterations, ROS production, intracellular Ca ²⁺ accumulation, as well calcium-dependent cell death in breast cancer cells. PKHB1 induces immune system activation through immunogenic cell death induction in breast cancer cells .

HY-109804

CORM-401 Maximum Cited Publications 10 Publications Verification	Reactive Oxygen Species	Inflammation/Immunology
CORM-401 is an oxidant-sensitive CO-releasing molecule. CORM-401 induces NO increase in the regulation of endothelial calcium signalling. CORM-401 reduces TNF-α/CHX and H2O2-induced ROS production. CORM-401 uncouples mitochondrial respiration and inhibits glycolysis .

HY-157088

C105SR	Caspase Apoptosis Cyclophilin	Others
C105SR is a cyclophilin D (CypD) inhibitor targeting to peptidyl-prolylcis-trans isomerase (PPIase). C105SR inhibits mitochondrial permeability transition opening (mPTP) with an IC ₅₀ of 5 nM. C105SR inhibits hypoxia and reoxygenation inudced hepatocyte apoptosis and increases the level of calcium retention capacity (CRC). C105SR exhibits hepaprotective effect in ischaemia-reperfusion injury (IRI) mouse model .

HY-Z0478

(-)-Limonene 1 Publications Verification (S)-(-)-Limonene	Bacterial Antibiotic CaMK	Infection Cardiovascular Disease Metabolic Disease
(-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca ²⁺) and Ca ²⁺/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture .

HY-14256

BMS-191095 1 Publications Verification	Potassium Channel	Cardiovascular Disease Neurological Disease
BMS-191095 is a selective activator of mitochondrial ATP-sensitive potassium (mitoKATP) channels. BMS-191095 inhibits human platelet aggregation by opening mitochondrial K(ATP) channels .

HY-B1899S

Taurodeoxycholic acid-d5	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis	Others
Taurodeoxycholic acid-d₅ is the deuterium labeled Taurodeoxycholic acid (HY-B1899) . Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD) .

HY-121746

GW7845	PPAR Calcium Channel Apoptosis	Cardiovascular Disease Metabolic Disease
GW7845 is an orally active non-thiazolidinedione, tyrosine-derived PPARγ agonist. GW7845 is effective at inhibiting *voltage-dependent calcium* channels (VDCC) and relaxing pressurized arteries with IC₅₀ of 3 μM by using Ba ²⁺ as the charge carrier through VDCC. GW7845-induced apoptosis** is mitochondria- and apoptosome-dependent. GW7845 induces rapid mitochondrial membrane depolarization and release of cytochrome c in primary pro-B cells and BU-11 cells .

HY-N6850

Calenduloside E 1 Publications Verification	Apoptosis Pyroptosis AMPK Bcl-2 Family JAK STAT Calcium Channel Interleukin Related TNF Receptor SOD Reactive Oxygen Species PPAR	Cardiovascular Disease Inflammation/Immunology
Calenduloside E is a pentacyclic triterpenoid saponin that can be extracted from the bark and roots of Aralia ovata, and has anti-inflammatory and anti-apoptotic activities. Calenduloside E alleviates atherosclerosis by regulating macrophage polarization, improves mitochondrial function by regulating the AMPK-SIRT3 pathway, and alleviates acute liver injury. In addition, Calenduloside E promotes the interaction between L-type calcium channels and Bcl-2 related apoptosis genes, inhibits calcium overload, and alleviates myocardial ischemia/reperfusion injury. Calenduloside E also improves non-alcoholic fatty liver disease by regulating heat shock-dependent pathways, and inhibits ROS mediated JAK1-STAT3 pathways to reduce cellular inflammatory responses .

HY-108514

(±)-PPCC hemioxalate	Sigma Receptor	Neurological Disease Cancer
(±)-PPCC hemioxalate is a compound that has the ability to regulate the activity of the sigma-1 receptor. (±)-PPCC hemioxalate can selectively bind sigma-1 protein (s1), and then activate s1 receptor leading to dissociation of s1-BIP complex to regulate ER-mitochondrial calcium signaling, which plays an important role in cell bioenergy and cell survival. (±)-PPCC hemioxalate can be used to study sigma-1 receptors in cocaine addiction, forgetting, pain, depression, Alzheimer's disease, stroke, and cancer .

HY-15208

Clamikalant sodium HMR 1098	Potassium Channel	Neurological Disease
Clamikalant sodium (HMR 1098) is an ATP-sensitive potassium (K_ATP) channel blocker. Clamikalant sodium can be used for the research of arrhythmia .

Cat. No.	Product Name

HY-L089

Mitochondria-Targeted Compound Library	1,124 compounds
Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca²⁺ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation. MCE supplies a unique collection of 1,124 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

Mitochondria-Targeted Compound Library

1,124 compounds

Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca²⁺ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation.

MCE supplies a unique collection of 1,124 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

Cat. No.	Product Name	Target	Research Area

HY-P10738

N-Formyl-MMYALF	Formyl Peptide Receptor (FPR)	Infection
N-Formyl-MMYALF is a potent mitochondrial N-formyl peptide (mtFP) that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF can inhibit the FPR-1-mediated chemotactic response of polymorphonuclear leukocytes (PMNs) to bacterial peptides .

HY-P10738A

N-Formyl-MMYALF TFA	Formyl Peptide Receptor (FPR)	Infection
N-Formyl-MMYALF TFA is a mitochondrial N-formyl peptide that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF TFA can inhibit the FPR-1-mediated chemotactic response of PMNs to bacterial peptides .

HY-P10371

PKHB1	Reactive Oxygen Species Thrombopoietin Receptor	Inflammation/Immunology Cancer
PKHB1 is a thrombospondin-1 peptide mimic with antitumor effects. PKHB1 induces mitochondrial alterations, ROS production, intracellular Ca ²⁺ accumulation, as well calcium-dependent cell death in breast cancer cells. PKHB1 induces immune system activation through immunogenic cell death induction in breast cancer cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7063

Nerol	Infection Structural Classification Natural Products Microorganisms other families Classification of Application Fields Plants Endogenous metabolite Disease Research Fields	Reactive Oxygen Species Fungal Mitochondrial Metabolism Apoptosis Endogenous Metabolite
Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

HY-Z0478

(-)-Limonene 1 Publications Verification (S)-(-)-Limonene	Cardiovascular Disease Structural Classification Other Monoterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Rutaceae Plants Citrus Disease Research Fields	Bacterial Antibiotic CaMK
(-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca ²⁺) and Ca ²⁺/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture .

HY-N6850

Calenduloside E 1 Publications Verification	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Other Diseases Aralia elata (Miq.) Seem. Plants Endogenous metabolite Disease Research Fields Araliaceae	Apoptosis Pyroptosis AMPK Bcl-2 Family JAK STAT Calcium Channel Interleukin Related TNF Receptor SOD Reactive Oxygen Species PPAR
Calenduloside E is a pentacyclic triterpenoid saponin that can be extracted from the bark and roots of Aralia ovata, and has anti-inflammatory and anti-apoptotic activities. Calenduloside E alleviates atherosclerosis by regulating macrophage polarization, improves mitochondrial function by regulating the AMPK-SIRT3 pathway, and alleviates acute liver injury. In addition, Calenduloside E promotes the interaction between L-type calcium channels and Bcl-2 related apoptosis genes, inhibits calcium overload, and alleviates myocardial ischemia/reperfusion injury. Calenduloside E also improves non-alcoholic fatty liver disease by regulating heat shock-dependent pathways, and inhibits ROS mediated JAK1-STAT3 pathways to reduce cellular inflammatory responses .

HY-N7063R

Nerol (Standard)	Infection Structural Classification Natural Products Microorganisms other families Classification of Application Fields Source classification Plants Endogenous metabolite Disease Research Fields	Reactive Oxygen Species Endogenous Metabolite Fungal Mitochondrial Metabolism Apoptosis
Nerol (Standard) is the analytical standard of Nerol. This product is intended for research and analytical applications. Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

Cat. No.	Product Name	Chemical Structure

HY-N7436S

Methyl propyl disulfide-d3
Methyl propyl disulfide-d₃ is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

HY-N7364S

(E)-β-Farnesene-d6
(E)-β-Farnesene-d₆ is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

HY-B1899S

Taurodeoxycholic acid-d5
Taurodeoxycholic acid-d₅ is the deuterium labeled Taurodeoxycholic acid (HY-B1899) . Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD) .

Taurodeoxycholic acid-d5

Taurodeoxycholic acid-d₅ is the deuterium labeled Taurodeoxycholic acid (HY-B1899) . Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD) .

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mitochondrial calcium

Inhibitors & Agonists

Screening Libraries

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NaturalProducts

Isotope-Labeled Compounds

Natural
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