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Results for "

oxime

" in MedChemExpress (MCE) Product Catalog:

44

Inhibitors & Agonists

6

Biochemical Assay Reagents

6

Natural
Products

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0778
    Milbemycin oxime
    1 Publications Verification

    		 Antibiotic Parasite Infection
    Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .
    Milbemycin oxime
  • HY-121035
    7BIO

    7-Bromoindirubin-3-oxime

    		 CDK GSK-3 Neurological Disease
    7BIO (7-Bromoindirubin-3-Oxime) is the derivate of indirubin. 7BIO (7-Bromoindirubin-3-Oxime) has inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β). 7BIO (7-Bromoindirubin-3-Oxime) inhibits Aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, activation of astrocytes and microglia, and attenuates Aβ oligomer-induced cognitive impairments in mice [1].
    7BIO
  • HY-139254
    Indirubin-3′-oxime

    IDR3O; I3O

    		 CDK GSK-3 JNK Neurological Disease
    Indirubin-3′-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes .
    Indirubin-3′-oxime
  • HY-W008840
    Propan-2-one oxime

    		Biochemical Assay Reagents Others
    Propan-2-one oxime is a kind of biological materials or organic compounds that are widely used in life science research .
    Propan-2-one oxime
  • HY-B0778R
    Milbemycin oxime (Standard)

    		Antibiotic Parasite Infection
    Milbemycin oxime (Standard) is the analytical standard of Milbemycin oxime. This product is intended for research and analytical applications. Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .
    Milbemycin oxime (Standard)
  • HY-157224
    Zearalanone carboxymethoxyl oxime

    		Others Others
    Zearalanone carboxymethoxyl oxime is a hapten that binds to the free amine on BSA .
    Zearalanone carboxymethoxyl oxime
  • HY-118793
    Inosine oxime

    6-Hydroxyadenosine

    		 Endogenous Metabolite Others
    Inosine oxime (6-Hydroxyadenosine) is an endogenous metabolite in the course of cell metabolism by cytochrome P450, by oxidative stress or by deviating nucleotide biosynthesis. Inosine oxime has toxic and mutagenic for procaryotic and eucaryotic cells .
    Inosine oxime
  • HY-135194R
    Risperidone E-oxime (Standard)

    		Drug Metabolite Others
    Risperidone E-oxime (Standard) is the analytical standard of Risperidone E-oxime. This product is intended for research and analytical applications. Risperidone E-oxime is an impurity of Risperidone . Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively .
    Risperidone E-oxime (Standard)
  • HY-W145605
    D-Glucosamine oxime hydrochloride

    		Biochemical Assay Reagents Others
    D-Glucosamine Oxime Hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    D-Glucosamine oxime hydrochloride
  • HY-138074
    Milbemycin A4 oxime

    5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime

    		 Parasite Infection
    Milbemycin A4 oxime is a derivative of milbemycin A4 (Item No. 17155) and a component of Milbemycin Oxime (HY-B0778), compounds that both have insecticidal and nematocidal activity. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae of the heartworm D. immitis in naturally infested dogs. It inhibits the growth of clinical isolates of C. glabrata with MIC80 values ranging from 16 to greater than 32 μg/mL.1 Milbemycin A4 oxime (2.5 μg/mL) blocks efflux of Fluconazole (HY-B0101) from a clinical isolate of C. glabrata, but not from a strain lacking the efflux pumps CgCDR1 and PDH1, and reduces the MICs of fluconazole and 4-nitroquinoline 1-oxide in wild-type C. glabrata. It enhances adriamycin-induced inhibition of cell growth, as well as increases the intracellular accumulation of adriamycin and the P-glycoprotein substrate Rhodamine 123 (HY-D0816), in adriamycin-resistant, but not -sensitive, MCF-7 breast cancer cells in a concentration-dependent manner.
    Milbemycin A4 oxime
  • HY-135325
    4-Hydroxyacetophenone oxime

    		Drug Metabolite Inflammation/Immunology
    4-Hydroxyacetophenone oxime is an impurity of Acetaminophen (Paracetamol). Acetaminophen is a potent cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2) inhibitor, and used antipyretic and analgesic agent .
    4-Hydroxyacetophenone oxime
  • HY-168548
    pAF-Oxime-PEG4-OH

    		ADC Linker Cancer
    pAF-Oxime-PEG4-OH serves as a linker for Opadotina (HY-147248) and can be utilized in the preparation of antibody-drug conjugates (ADCs) .
    pAF-Oxime-PEG4-OH
  • HY-135194
    Risperidone E-oxime

    		Drug Metabolite Others
    Risperidone E-oxime is an impurity of Risperidone . Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively .
    Risperidone E-oxime
  • HY-10580
    GSK 3 Inhibitor IX
    Maximum Cited Publications
    11 Publications Verification

    6-Bromoindirubin-3'-oxime; BIO; MLS 2052

    		 GSK-3 CDK Apoptosis Cancer
    GSK 3 Inhibitor IX (6-Bromoindirubin-3'-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex with IC50s of 5 nM/320 nM/80 nM for (GSK-3α/β)/CDK1/CDK5, respectively.
    GSK 3 Inhibitor IX
  • HY-146981
    α-Glucosidase-IN-3

    		Glucosidase Inflammation/Immunology
    α-Glucosidase-IN-3 is an oleanolic acid (OA) oxime ester derivativ eagainst α-glucosidase(IC50=0.35 µM) and α-amylase.
    α-Glucosidase-IN-3
  • HY-157047
    Anticancer agent 171

    		Others Cancer
    Anticancer agent 171 (Compound 6a) is an oxime analogue. Anticancer agent 171 has anticancer activity against HCT116 cells with an IC50 value of 3.43 μM. Anticancer agent 171 can be used for the research of cancer .
    Anticancer agent 171
  • HY-146984
    α-Amylase-IN-2

    		Glucosidase Inflammation/Immunology
    α-Glucosidase-IN-3 is an oleanolic acid (OA) oxime ester derivative against α-glucosidase (IC50=1.28 µM) and α-amylase (IC50=3.8 µM) .
    α-Amylase-IN-2
  • HY-W343384
    Methyl 4,6-O-benzylidene-2-deoxy-α-D-erythro-hexopyranosid-3-ulose oxime

    		Biochemical Assay Reagents
    Methyl 4, 6-O-Benzylidene-2-deoxy-α-d-Erythro-Hexopyranosid-3-ulose oxime is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology .
    Methyl 4,6-O-benzylidene-2-deoxy-α-D-erythro-hexopyranosid-3-ulose oxime
  • HY-162022
    BTA-188

    		Enterovirus Virus Protease Infection
    BTA-188, a pyridazinyl oxime ether, is an orally active, potent inhibitor of rhinoviruses (HRV) and enterovirus (EV) 71 in vitro. BTA-188 inhibits HRV-2 replication with an IC50 of 0.8 nM and an IC90 of 11 nM. BTA-188 inhibits enterovirus with an IC50 of 82 and an IC90 of 109 nM. BTA-188 is a potential chemotherapeutic agent for infections caused by the viruses in the Picornaviridae .
    BTA-188
  • HY-116656
    Oximino oxamyl

    Oxamyl oxime

    		 Others Others
    Oximino oxamyl is an active compound.
    Oximino oxamyl
  • HY-U00283
    Falintolol, (Z)-

    		Adrenergic Receptor Endocrinology
    Falintolol, (Z)-, a new β-adrenergic antagonist, is characterized by the presence of an oxime function.
    Falintolol, (Z)-
  • HY-156399
    KR-27425

    		Endogenous Metabolite Neurological Disease
    AChE activator 1 (compound 13) is a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase(AChE) .
    KR-27425
  • HY-19807
    Indirubin-3'-monoxime
    3 Publications Verification

    Indirubin-3'-oxime

    		 GSK-3 CDK Lipoxygenase Cancer
    Indirubin-3'-monoxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC50s of 22 nM and 7.8-10 µM, respectively; Indirubin-3'-monoxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC50s of 100 and 180 nM.
    Indirubin-3'-monoxime
  • HY-157532
    AChE-IN-55

    		Cholinesterase (ChE) Others
    AChE-IN-55, 1,2,3-Triazole oxime derivative, is an inhibitor of AChE(4.8 μM) .
    AChE-IN-55
  • HY-163397
    Antibacterial agent 196

    		Fungal Infection
    Antibacterial agent 196 (compound 6b) is a coumarin derivative containing oxime ether structure, and shows antifungal activity, with the EC50 of 0.46 μg/mL against Rhizoctonia solani .
    Antibacterial agent 196
  • HY-158321
    SDH-IN-15

    		Fungal Succinate Dehydrogenase Infection
    SDH-IN-15 (Compound 5e) is an inhibitor of succinate dehydrogenase (SDH) (IC50=2.04 μM). SDH-IN-15 has significant antifungal activity. SDH-IN-15 blocks the mitochondrial respiratory chain of the fungus through inhibition of SDH, resulting in fungal death .
    SDH-IN-15
  • HY-W011108
    Obidoxime dichloride

    		Cholinesterase (ChE) Neurological Disease
    Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride reactivates sarin-inhibited acetylcholinesterase (AChE) and reduces acute toxicity of sarin-evaluated .
    Obidoxime dichloride
  • HY-B1200
    Pralidoxime chloride

    2-PAM chloride

    		 Cholinesterase (ChE) Neurological Disease
    Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning .
    Pralidoxime chloride
  • HY-B1738
    Pralidoxime

    		Cholinesterase (ChE) Neurological Disease
    Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning .
    Pralidoxime
  • HY-B1738A
    Pralidoxime iodide

    		Cholinesterase (ChE) Neurological Disease
    Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning .
    Pralidoxime iodide
  • HY-B1738B
    Pralidoxime methanesulfonate

    		Cholinesterase (ChE) Neurological Disease
    Pralidoxime methanesulfonate is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime methanesulfonate reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime methanesulfonate is an antidote for organophosphate poisoning .
    Pralidoxime methanesulfonate
  • HY-W012898
    Dimethylglyoxime

    Biacetyl dioxime

    		 Biochemical Assay Reagents Others
    Dimethylglyoxime (Biacetyl dioxime) belongs to the class of oximes and consists of two acetyl groups attached to a nitrogen atom, which in turn is attached to another nitrogen atom through a diimine bond. Dimethylglyoxime is a specific chelator of Ni that inhibits or slows the aggregation of Aβ peptides in vitro .
    Dimethylglyoxime
  • HY-B1200R
    Pralidoxime chloride (Standard)

    		Cholinesterase (ChE) Neurological Disease
    Pralidoxime (chloride) (Standard) is the analytical standard of Pralidoxime (chloride). This product is intended for research and analytical applications. Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning .
    Pralidoxime chloride (Standard)
  • HY-153263
    (Aminooxy)acetamide-Val-Cit-PAB-MMAE

    		Drug-Linker Conjugates for ADC Cancer
    (Aminooxy)acetamide-Val-Cit-PAB-MMAE (MMAE 5) is an intermediate used in the synthetic preparation of drug-linker conjugates for ADC. (Aminooxy)acetamide-Val-Cit-PAB-MMAE is conjugated to polyamide via oxime bond formation to form MMAE polyamide conjugate. Then MMAE polyamide conjugate can be conjugated to Trastuzumab, to make ADC .
    (Aminooxy)acetamide-Val-Cit-PAB-MMAE
  • HY-U00085
    Itameline

    RU 47213

    		 Cholinesterase (ChE) Neurological Disease
    Itameline (RU 47213) is a prodrug with oral and long-lasting cholinergic activity. Itameline is a novel tetrahydropyridine-oxime that is cleaved in vivo to form an active metabolite, RU 35963. RU 35963 is a muscarinic receptor agonist that is nonselective with respect to receptor subtypes. Itameline possesses the capacity to reduce memory deficits induced by an impairment of cholinergic transmission in the rat .
    Itameline
  • HY-163297
    Antifungal agent 90

    		Fungal Infection
    Antifungal agent 90 (Compound 7n) is an antifungal agent that inhibits ergosterol biosynthesis. Antifungal agent 90 showed excellent antifungal activity against Valsa mali and Botrytis cinerea with EC50 values respectively. 4.26 and 1.41 μg/mL .
    Antifungal agent 90
  • HY-W440884
    DSPE-PEG-Ald (MW 3400)

    		Biochemical Assay Reagents Others
    DSPE-PEG-Ald, MW 3400 is a self-assemble polyPEG which spontaneously forms lipid bilayer in water. The polymer can be used to prepare nanoparticles or liposomse as a targeted drug carrier, such as mRNA vaccine. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond. Reagent grade, for research use only.
    DSPE-PEG-Ald (MW 3400)
  • HY-W440883
    DSPE-PEG-Ald, MW 2000

    		Liposome Others
    DSPE-PEG-Ald, MW 2000 is a phospholipid polyPEG which can self-assemble to form lipid bilayer in aqueous solution. The polymer can be used to prepare liposome as a drug delivery vehicle for administration of drugs or nutrients, such as mRNA vaccines. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond. Reagent grade, for research use only.
    DSPE-PEG-Ald, MW 2000
  • HY-W440885
    DSPE-PEG-Ald (MW 5000)

    		Biochemical Assay Reagents Others
    DSPE-PEG-Ald, MW 5000 is a phospholipid PEG polymer which can self-assemble spontaneously in water with their hydrophilic heads oriented toward the water (micelles). The polymer can be used to prepare liposome as a drug nanocarrier for administration of nutrients and therapeutic drugs, such as lipid nanoparticles in mRNA or DNA vaccines. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond. Reagent grade, for research use only.
    DSPE-PEG-Ald (MW 5000)
  • HY-146116
    Antifungal agent 32

    		Fungal Infection
    Antifungal agent 32 (compound 1a) is a potent antifungal agent. Antifungal agent 32 inhibits Candida albicans filamentation and biofilm formation. Antifungal agent 32 inhibits the morphological switching of Candida albicans and its adherence to epithelial cells. Antifungal agent 32 can be used for Candida albicans infections research .
    Antifungal agent 32
  • HY-129476
    L-Canaline

    		Parasite Endogenous Metabolite Infection Cancer
    L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. L-Canaline has anticancer and antiproliferative effects .
    L-Canaline
  • HY-N2150
    Psammaplin A

    		HDAC DNA Methyltransferase DNA/RNA Synthesis Bacterial Infection Cancer
    Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A ia a highly potent and selective DAC1 inhibitor with an IC50 of 0.9 nM. Psammaplin A possess the antimicrobial effect on the Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Antitumor Activity .
    Psammaplin A
  • HY-155137
    CHBO4

    		Monoamine Oxidase Reactive Oxygen Species Neurological Disease
    CHBO4 is a potent, reversible, competitive, and selective hMAO-B inhibitor with an IC50 value of 0.031 μM in CHBO subseries and an Ki value of 0.010 ± 0.005 μM. CHBO4 reduce cell damage by scavenging intracellular reactive oxygen species (ROS). CHBO4 can be used for Parkinson's Disease (PD) research .
    CHBO4
  • HY-103441
    JNJ28871063 hydrochloride

    		EGFR Cancer
    JNJ28871063 hydrochloride is an orally active, highly selective and ATP competitive pan-ErbB kinase inhibitor with IC50 values of 22 nM, 38 nM, and 21 nM for ErbB1, ErbB2, and ErbB4, respectively. JNJ28871063 hydrochloride inhibits phosphorylation of functionally important tyrosine residues in both EGFR and ErbB2. JNJ28871063 hydrochloride crosses the blood-brain barrier and has antitumor activity in human tumor xenograft models that overexpress EGFR and ErbB2 .
    JNJ28871063 hydrochloride

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