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Results for "

pigmentation

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

1

Biochemical Assay Reagents

3

Peptides

6

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-159107
    2-MNG

    2-Mercaptonicotinoyl glycine

    		 Others Others
    2-MNG (2-Mercaptonicotinoyl glycine) is an inhibitor for melanogenesis with an average IC50 of 49.5μM in normal human melanocytes. 2-MNG binds to melanin precursors, prevents the incorporation into growing melanin, and thereby inhibits the synthesis of eumelanin and pheomelanin. 2-MNG can be used in research about skin pigmentation .
    2-MNG
  • HY-N12267
    N,N′-Diferuloylputrescine

    (E/Z)-Terrestribisamide

    		 Melanocortin Receptor Metabolic Disease
    N,N′-Diferuloylputrescine ((E/Z)-Terrestribisamide) is a inhibitor of pigmentation with 57% reduction. N,N′-Diferuloylputrescine significantly reduces the protein level of MITF. N,N′-Diferuloylputrescine has strong antioxidant activities as radical scavengers against reactive oxygen species .
    N,N′-Diferuloylputrescine
  • HY-109114
    Dersimelagon

    MT-7117

    		 Melanocortin Receptor Metabolic Disease
    Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon shows good affinity for hMC1R and hMC4R with Ki values of 2.26, 32.9 nM, respectively. Dersimelagon can be used for the research of skin pigmentation .
    Dersimelagon
  • HY-P0097A
    Nonapeptide-1 acetate salt
    2 Publications Verification

    Melanostatine-5 acetate salt

    		 Melanocortin Receptor Metabolic Disease Endocrinology Cancer
    Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). Nonapeptide-1 acetate salt is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively). Nonapeptide-1 acetate salt inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .
    Nonapeptide-1 acetate salt
  • HY-P0097
    Nonapeptide-1
    2 Publications Verification

    Melanostatine-5

    		 Melanocortin Receptor Metabolic Disease Endocrinology Cancer
    Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively). Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .
    Nonapeptide-1
  • HY-121889
    FQ

    		Tyrosinase Inflammation/Immunology
    FQ is a tyrosinase inhibitor that effectively inhibits the diphenolase activity of mushroom tyrosinase (IC50=120 μM). FQ can be used in the study of pigmentation .
    FQ
  • HY-109114A
    Dersimelagon phosphate

    MT-7117 phosphate

    		 Melanocortin Receptor Metabolic Disease
    Dersimelagon phosphate is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon phosphate shows good affinity for hMC1R and hMC4R with Ki values of 2.26, 32.9 nM, respectively. Dersimelagon phosphate can be used for the research of skin pigmentation .
    Dersimelagon phosphate
  • HY-161969
    Tyrosinase-IN-34

    		Tyrosinase Cancer
    Tyrosinase-IN-34 (compound 5a) is a human tyrosinase inhibitor (IC50: 3.5 μM) with the potential to control melanogenesis and pigmentation .
    Tyrosinase-IN-34
  • HY-20074
    (+)-Pinanediol

    (1S,2S,3R,5S)-(+)-Pinanediol

    		 Biochemical Assay Reagents Others
    (+)-Pinanediol ((1S,2S,3R,5S)-(+)-Pinanediol) is a potent inducer of melanin production. In S91 cells, it acts by inducing higher levels of pigmentation and nitric oxide (NO) synthesis .
    (+)-Pinanediol
  • HY-W068430
    5,7-Dimethoxy-2,2-dimethylchromene

    		Others Others
    5,7-Dimethoxy-2,2-dimethylchromene is a synthetic precocenoid, has potential insect control function. 5,7-Dimethoxy-2,2-dimethylchromene induces loss of pigmentation in hatching larvae of shield bug (Eurgaster integriceps) .
    5,7-Dimethoxy-2,2-dimethylchromene
  • HY-P5247
    Palmitoyl tetrapeptide-20

    PTP20

    		 Melanocortin Receptor Metabolic Disease Inflammation/Immunology
    Palmitoyl tetrapeptide-20 (PTP20) is a biomimetic peptide that is an agonist for α-MSH. Palmitoyl tetrapeptide-20 can protect follicular melanocytes and activate melanogenesis by enhancing catalase expression .
    Palmitoyl tetrapeptide-20
  • HY-W015591
    Mandelic acid

    (±)-Mandelic acid; DL-Mandelic acid

    		 Bacterial Endogenous Metabolite Infection
    Mandelic acid ((±)-Mandelic acid), an alpha-hydroxycarboxylic acid, has been widely used as an intermediate of pharmaceutical and fine chemicals. Mandelic acid shows antimicrobial activity and has been used for the research of urinary tract infections and vaginal trichomoniasis. Mandelic acid exhibits high sperm-immobilizing activity and low vaginal irritation .
    Mandelic acid
  • HY-W015591R
    Mandelic acid (Standard)

    		Bacterial Endogenous Metabolite Infection
    Mandelic acid (Standard) is the analytical standard of Mandelic acid. This product is intended for research and analytical applications. Mandelic acid ((±)-Mandelic acid), an alpha-hydroxycarboxylic acid, has been widely used as an intermediate of pharmaceutical and fine chemicals. Mandelic acid shows antimicrobial activity and has been used for the research of urinary tract infections and vaginal trichomoniasis. Mandelic acid exhibits high sperm-immobilizing activity and low vaginal irritation .
    Mandelic acid (Standard)
  • HY-N3773
    Dodoviscin A

    		Tyrosinase Cancer
    Dodoviscin A is a pigmentation-altering agent, which can be isolated from the aerial parts of Dodonaea viscosa. Dodoviscin A inhibits melanin production in B16-F10 melanoma cells. Dodoviscin A suppresses mushroom tyrosinase activity, and tyrosinase activity induced by 3-isobutyl-1-methylxanthine. Dodoviscin A also inhibits the phorphosylation of cAMP response element binding protein, induced by 3-isobutyl-1-methylxanthine and forskolin .
    Dodoviscin A
  • HY-N0113A
    Hordenine sulfate

    Ordenina sulfate; Peyocactine sulfate

    		 Antibiotic Others
    Hordenine sulfate (Ordenina sulfate) is an active compound extracted from malted barley that has melanin-inhibiting activity. Hordenine sulfate significantly reduced melanin content and reduced intracellular cAMP levels. Hordenine sulfate inhibits the expression of proteins related to melanogenesis, including microblind transcription factor (MITF), tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2. Therefore, Hordenine sulfate can be used as an active ingredient to inhibit pigmentation .
    Hordenine sulfate

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