Search Result

Results for "

psychiatric disorder

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (9) Autophagy (2) Biochemical Assay Reagents (1) Carbonic Anhydrase (1) Casein Kinase (1) Cholinesterase (ChE) (1) Cytochrome P450 (2) Dopamine Receptor (6) Endogenous Metabolite (4) GABA Receptor (3) GPR6 (1) GPR88 (1) GSK-3 (2) iGluR (7) mAChR (9) mGluR (1) nAChR (4) Neurokinin Receptor (1) Neurotensin Receptor (2) Oxytocin Receptor (2) Phosphodiesterase (PDE) (2) Potassium Channel (2) Serotonin Transporter (1) Sodium Channel (3)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (62)

By Targets:

5-HT Receptor (9)

Autophagy (2)

Biochemical Assay Reagents (1)

Carbonic Anhydrase (1)

Casein Kinase (1)

Cholinesterase (ChE) (1)

Cytochrome P450 (2)

Dopamine Receptor (6)

Endogenous Metabolite (4)

GABA Receptor (3)

GPR6 (1)

GPR88 (1)

GSK-3 (2)

iGluR (7)

mAChR (9)

mGluR (1)

nAChR (4)

Neurokinin Receptor (1)

Neurotensin Receptor (2)

Oxytocin Receptor (2)

Phosphodiesterase (PDE) (2)

Potassium Channel (2)

Serotonin Transporter (1)

Sodium Channel (3)

By Research Areas:

Cancer (3)

Cardiovascular Disease (2)

Endocrinology (1)

Inflammation/Immunology (2)

Metabolic Disease (2)

Neurological Disease (62)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0339

Primidone 2 Publications Verification	Sodium Channel	Neurological Disease
Primidone is a potent anticonvulsant agent of the barbiturate class. Primidone is a neuronal voltage-gated sodium channel (VGSC) blocker and can be used for the study of epilepsy, essential tremor, and Psychiatric disorders .

HY-116076

S-15535	5-HT Receptor	Neurological Disease
S-15535 is a highly selective 5-HT_1A receptor ligand. S-15535 is an antagonist of postsynaptic 5-HT_1A receptors and an agonist of presynaptic 5-HT_1A receptors. S-15535 can be used in research on psychiatric disorders, such as anti-anxiety .

HY-124607B

BRD3731 1 Publications Verification	GSK-3	Neurological Disease Metabolic Disease
BRD3731 is a selective GSK3β inhibitor, with IC₅₀s of 15 nM and 215 nM for GSK3β and GSK3α, respectively. BRD3731 is potentail for the research of post-traumatic stress disorder (PTSD), psychiatric disorder, diabetes, and neurodegenerative disorders .

HY-148325

α7 Nicotinic receptor agonist-1	nAChR	Neurological Disease
α7 Nicotinic receptor agonist-1 (Preparation 5) is an α7 nAChR agonist. α7 Nicotinic receptor agonist-1 can be used in studies of psychiatric disorders (such as schizophrenia, manic or hypomanic depression and anxiety disorders) and intellectual disorders (such as alzheimer's disease, learning deficits, cognitive deficits, attention deficits, memory loss, lewy body dementia and attention deficit hyperactivity disorder) .

HY-110175

CX614	iGluR	Neurological Disease
CX614 is a positive variant modulator of AMPA receptors that enhances excitatory postsynaptic potentials (amplitude and duration) by blocking and slowing the inactivation of responses to glutamate and automatically evokes excitatory postsynaptic currents in neuronal cultures. CX614 can be used in the study of psychiatric disorders such as depression .

HY-A0243

Aceprometazine 1664CB; Acepromethazine	Others	Neurological Disease
Aceprometazine (1664CB) is an orally active antipsychotic. Aceprometazine can be used in the study of psychiatric disorders, such as depression .

HY-131287

MGS0028	mGluR	Neurological Disease
MGS0028 is a selective metabotropic glutamate 2/3 (mGlu2/3) receptor agonist. MGS0028 can be used for psychiatric disorders research .

HY-146076

5-HT6/5-HT2A receptor ligand-1	5-HT Receptor	Neurological Disease
5-HT6/5-HT2A receptor ligand-1 (compound 33) is a dual 5-HT₆/5-HT_2A receptor antagonist, with a K_i of 2 nM and 11 nM, respectively. 5-HT6/5-HT2A receptor ligand-1 has the potential for neurological and psychiatric disorders research .

HY-141495A

Razpipadon (-)-PW0464	Dopamine Receptor	Neurological Disease
Razpipadon ((-)-PW0464), an aromatic compound, is a dopamine receptor partial agonist. Razpipadon can be used in the study of dopamine D1 ligand-mediated related psychiatric disorders .

HY-15522

WAY-267464	Oxytocin Receptor	Neurological Disease
WAY-267464 is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder .

HY-18078

PQ-10	Phosphodiesterase (PDE)	Neurological Disease
PQ-10 is a potent inhibitor of Phosphodiesterase 10A (PDE10A) with IC₅₀ andED₅₀ of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia .

HY-161511

LPH-5	5-HT Receptor	Neurological Disease
LPH-5 is a selective 5-HT2A receptor agonist (EC₅₀=190 nM). LPH-5 works by selectively activating the 5-HT2A receptor, which may be involved in regulating mood, perception, and other central nervous system functions associated with the 5-HT2A receptor. LPH-5 can be used to further explore the 5-HT2A receptor in psychiatric disorders, including depression, anxiety, and substance abuse disorders .

HY-16716

Basmisanil 1 Publications Verification RG1662; RO5186582	GABA Receptor	Neurological Disease
Basmisanil (RG1662) is a highly selective orally active α subunit-containing GABAA receptors (GABAAα5) negative allosteric modulator (NAMs). Basmisanil can inhibit GABAA-α5 with a K_i value of 5 nM and IC₅₀ value of 8 nM, respectively. Basmisanil can be used for the research of multiple cognitive and psychiatric disorders .

HY-101490

PDE1-IN-2	Phosphodiesterase (PDE)	Neurological Disease
PDE1-IN-2 is a PDE1 inhibitor extracted from patent WO2016/55618 A1, example 31. PDE1-IN-2 has IC₅₀ values of 6 nM, 140 nM and 164 nM for PDE1C, PDE1B and PDE1A, respectvely. PDE1-IN-2 is developed for the research of neurodegenerative disorders and psychiatric disorders .

HY-U00021

Clothixamide Clotixamide	Others	Neurological Disease
Clothixamide is a thiazide derivative. It is used to treat psychiatric disorders.

HY-153530

LI-2242	Others	Neurological Disease Metabolic Disease
LI-2242 is an inositol hexakisphosphate kinase (IP6K) inhibitor. LI-2242 has inhibition effect for IP6K1, IP6K2, IP6K3 and IPMK with IC₅₀ values of 31 nM, 42 nM, 8.7 nM and 1944 nM, respectively. LI-2242 can be used for thew research of type II diabetes, obesity, metabolic complications, venous thrombosis, and psychiatric disorders .

HY-107664A

SR 142948 dihydrochloride	Neurotensin Receptor	Neurological Disease
SR 142948 dihydrochloride is an orally active and selective non-peptide neurotensin receptor (NT) antagonist with IC₅₀s of 1.19 nM, 0.32 nM, 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, respectively. SR 142948 dihydrochloride antagonizes NT-induced inositol monophosphate formation in HT-29 cells with an IC₅₀ of 3.9 nM. SR 142948 dihydrochloride blocks hypothermia, analgesia and steering behavior induced by NT in vivo. SR 142948 dihydrochloride shows blood-brain permeability and can be used in study of psychiatric disorders .

HY-101841

LY 2033298	mAChR	Neurological Disease
LY 2033298 is a selective positive allosteric modulator of the muscarinic M₄ receptor. LY 2033298 can be used in the study of psychiatric disorders .

HY-159689

Cloroperone	5-HT Receptor	Neurological Disease
Cloroperone is a 5-HT₂ receptor inhibitor with a K_i value of 4.5 nM. Cloroperone can be used in research on psychiatric disorders .

HY-107693

SSR 146977 hydrochloride	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
SSR 146977 hydrochloride is a potent and selective antagonist of the tachykinin NK₃ receptor. SSR 146977 hydrochloride can be used in the study of psychiatric disorders and airway inflammation .

HY-W250174

Lithium 3,5-diiodosalicylate 3,5-Diiodosalicylic acid lithium salt	Biochemical Assay Reagents	Others
Lithium 3,5-diiodosalicylate is a compound used in the study of bipolar disorder and other psychiatric disorders. It contains lithium and a salicylate. Lithium 3,5-diiodosalicylate works by affecting the levels of certain neurotransmitters in the brain, including dopamine and serotonin.

HY-108679

WAY-267464 hydrochloride	Oxytocin Receptor	Neurological Disease
WAY-267464 hydrochloride is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 hydrochloride can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 hydrochloride can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder .

HY-B0339S

Primidone-d5	Sodium Channel	Neurological Disease
Primidone-d₅ is the deuterium labeled Primidone. Primidone is a potent anticonvulsant agent of the barbiturate class. Primidone is a neuronal voltage-gated sodium channel (VGSC) blocker and can be used for the study of epilepsy, essential tremor, and Psychiatric disorders[1].

HY-109164

Zelquistinel AGN-241751; GATE-251	iGluR	Neurological Disease
Zelquistinel (AGN-241751) is a N-methyl-D-aspartate (NMDA) receptor partial agonist used for the research of depression, anxiety and other related psychiatric disorders .

HY-10814

CP-810123	nAChR	Neurological Disease
CP-810123 is a brain-permeable agonist of α7 nAChR for the research of cognitive impairment associated with psychiatric or neurological disorders such as schizophrenia and Alzheimer's disease .

HY-155989

GSK3-IN-4	GSK-3	Neurological Disease
GSK3-IN-4 (compound 0715) is a potent GSK3 inhibitor. GSK3-IN-4 can be used for psychiatric disorder research .

HY-103429

Quinelorane dihydrochloride LY163502	Dopamine Receptor	Neurological Disease
Quinelorane dihydrochloride (LY163502) is a potent dopamine D3/D2 receptor agonist. Quinelorane has the potential for neurological and psychiatric disorders research .

HY-139580

Plazinemdor CAD-9303	iGluR	Neurological Disease
Plazinemdor is a N-methyl-D-aspartate(NMDA) receptor positive allosteric modulator. Plazinemdor can be uses in the research of psychiatric, neurological, and neurodevelopmental disorders, as well as diseases of the nervous system ..

HY-163096

GPR88 agonist 3	GPR88	Neurological Disease
GPR88 agonist 3 (compound 20) is a GPR88 agonist 3, with an EC₅₀ of 204 nM. GPR88 agonist 3 can be used for psychiatric and neurodegenerative disorders research .

HY-B0762S

Acetyl-L-carnitine-d3 hydrochloride O-Acetyl-L-carnitine-d₃ (hydrochloride)	Endogenous Metabolite	Neurological Disease
Acetyl-L-carnitine-d₃ (hydrochloride) is the deuterium labeled Acetyl-L-carnitine hydrochloride. Acetyl-L-carnitine hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine found in the body. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and exibits anti-stress-related psychiatric disorders[1].

HY-B0762S1

Acetyl-L-carnitine-d3-1 hydrochloride O-Acetyl-L-carnitine-d₃-1 (hydrochloride)	Endogenous Metabolite	Neurological Disease
Acetyl-L-carnitine-d₃-1 (hydrochloride) is the deuterium labeled Acetyl-L-carnitine hydrochloride. Acetyl-L-carnitine hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine found in the body. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and exibits anti-stress-related psychiatric disorders[1].

HY-156817

TNIK-IN-6	Others	Neurological Disease
TNIK-IN-6 (Compound 9) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK) and , with IC₅₀ of 0.93 μM, that plays important roles in neurological and psychiatric disorders .

HY-168537

LB-102	Dopamine Receptor 5-HT Receptor	Neurological Disease
LB-102 is an orally active inhibitor of dopamine D₂, D₃, and 5-HT7 receptors, which can be used in research on schizophrenia and other psychiatric disorders .

HY-B0762

Acetyl-L-carnitine hydrochloride 2 Publications Verification O-Acetyl-L-carnitine hydrochloride; ALCAR hydrochloride	Endogenous Metabolite	Neurological Disease Cancer
Acetyl-L-carnitine (O-Acetyl-L-carnitine) hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine found in the body. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and exibits anti-stress-related psychiatric disorders .

HY-134661

(S)-CVN424	GPR6	Neurological Disease
(S)-CVN424 is a potent G-Protein-Coupled Receptor 6 (GPR6) modulator. (S)-CVN424 has the potential for a variety of neurological and psychiatric disorders research, including Parkinson's disease .

HY-B1487

Procyclidine hydrochloride Tricyclamol hydrochloride; (±)-Procyclidine hydrochloride	iGluR mAChR	Neurological Disease
Procyclidine (Tricyclamol, (±)-Procyclidine) hydrochloride , an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine hydrochloride can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy .

HY-B1487A

Procyclidine Tricyclamol; (±)-Procyclidine	mAChR iGluR	Neurological Disease
Procyclidine (Tricyclamol; (±)-Procyclidine), an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy .

HY-B0339R

Primidone (Standard) 2 Publications Verification	Sodium Channel	Neurological Disease
Primidone (Standard) is the analytical standard of Primidone. This product is intended for research and analytical applications. Primidone is a potent anticonvulsant agent of the barbiturate class. Primidone is a neuronal voltage-gated sodium channel (VGSC) blocker and can be used for the study of epilepsy, essential tremor, and Psychiatric disorders .

HY-169162

hBChE-IN-3	Carbonic Anhydrase Cholinesterase (ChE)	Neurological Disease
hBChE-IN-3 (compound 30) is a combination of carbonic anhydrase (CA) activator and cholinesterase (ChE) inhibitor with IC50 values of 7.4 and 1.9 nM for AchE and BchE, respectively. hBChE-IN-3 can be used in the study of neurodegeneration and psychiatric disorders .

HY-13204

Biperiden hydrochloride KL 373 hydrochloride	mAChR	Neurological Disease
Biperiden (KL 373) hydrochloride is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden hydrochloride has the potential for the research of Parkinson's disease and other related psychiatric disorders .

HY-13204A

Biperiden KL 373	mAChR	Neurological Disease
Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders .

HY-100783B

Bicuculline methobromide (+)-Bicuculline methobromide; d-Bicuculline methobromide	GABA Receptor	Neurological Disease
Bicuculline methobromide is a selective GABAA Receptor antagonist with an IC₅₀ value of 3 μM. Bicuculline methobromide induces clonic tonic convulsions in mammals and can also be used to block Ca ²⁺ activated potassium channels. Bicuculline methobromide can be used in studies of epilepsy and other related psychiatric disorders .

HY-13999

NSI-189	Others	Neurological Disease
NSI-189, benzylpiperizine-aminiopyridine, is a multi-domain neurogenic compound with brain-therapeutic properties. NSI-189 can stimulate neurogenesis of human hippocampus-derived neural stem cells in vitro and stimulates neurogenesis in murine hippocampus in vivo. NSI-189 can be used for the research of psychiatric disorders .

HY-137790

Bicuculline methochloride 20+ Cited Publications (+)-Bicuculline methochloride; d-Bicuculline methochloride	GABA Receptor	Neurological Disease
Bicuculline ((+)-Bicuculline; d-Bicuculline) methochloride is a selective GABAA receptor antagonist with an IC₅₀ value of 3 μM. Bicuculline methochloride induces clonic tonic convulsions in mammals and can also be used to block Ca ²⁺ activated potassium channels. Bicuculline methochloride can be used in studies of epilepsy and other related psychiatric disorders .

HY-B1487R

Procyclidine hydrochloride (Standard)	iGluR mAChR	Neurological Disease
Procyclidine (hydrochloride) (Standard) is the analytical standard of Procyclidine (hydrochloride). This product is intended for research and analytical applications. Procyclidine (Tricyclamol, (±)-Procyclidine) hydrochloride , an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine hydrochloride can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy .

HY-13204AR

Biperiden (Standard)	mAChR	Neurological Disease
Biperiden (Standard) is the analytical standard of Biperiden. This product is intended for research and analytical applications. Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders .

HY-19733

Lumateperone tosylate ITI-007 tosylate	5-HT Receptor Dopamine Receptor	Neurological Disease
Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone tosylate has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia .

HY-13204B

Biperiden lactate KL 373 lactate	mAChR	Neurological Disease
Biperiden (KL 373) lactate is an orally active non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors. Biperiden (KL 373) lactate inhibits acetylcholine and enhances dopamine signaling in the central nervous system. Biperiden (KL 373) lactate has the potential for the research of Parkinson's disease and other related psychiatric disorders .

HY-13204R

Biperiden hydrochloride (Standard) KL 373 hydrochloride (Standard)	mAChR	Neurological Disease
Biperiden (hydrochloride) (Standard) is the analytical standard of Biperiden (hydrochloride). This product is intended for research and analytical applications. Biperiden (KL 373) hydrochloride is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden hydrochloride has the potential for the research of Parkinson's disease and other related psychiatric disorders .

HY-12152

PNU-120596 1 Publications Verification NSC 216666	nAChR	Neurological Disease Inflammation/Immunology
PNU-120596 (NSC 216666) is a potent and selective α7 nAChR positive allosteric modulator (PMA) with an EC₅₀ of 216 nM. PNU-120596 is inactive against α4β2, α3β4, and α9α10 nAChRs. PNU-120596 has the potential for psychiatric and neurological disorders research .

Cat. No.	Product Name	Type

HY-W250174

Lithium 3,5-diiodosalicylate 3,5-Diiodosalicylic acid lithium salt	Biochemical Assay Reagents
Lithium 3,5-diiodosalicylate is a compound used in the study of bipolar disorder and other psychiatric disorders. It contains lithium and a salicylate. Lithium 3,5-diiodosalicylate works by affecting the levels of certain neurotransmitters in the brain, including dopamine and serotonin.

Cat. No.	Product Name	Target	Research Area

HY-P6292

KS-133	Peptides	Neurological Disease
KS-133 is a selective and potent antagonist of vasoactive intestinal peptide receptor 2 (VIPR2), with the IC₅₀ values of 24.8 nM and 500 nM in Ca influx assay and cAMP assay. KS-133 plays an important role in schizophrenia research .

HY-P6292A

KS-133 TFA	Peptides	Neurological Disease
KS-133 TFA is a selective and potent antagonist of vasoactive intestinal peptide receptor 2 (VIPR2), with the IC₅₀ values of 24.8 nM and 500 nM in Ca influx assay and cAMP assay. KS-133 TFA plays an important role in schizophrenia research .

Cat. No.	Product Name	Category	Target	Chemical Structure