WAY-267464

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WAY-267464 is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder.

For research use only. We do not sell to patients.

WAY-267464 Chemical Structure

CAS No. : 847375-16-0

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Other Forms of WAY-267464:

WAY-267464 hydrochloride Get quote

1 Publications Citing Use of MCE WAY-267464

•Sci Rep. 2024 Oct 13;14(1):23935. [Abstract]

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References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	> 10000 nM Compound: 1; WAY-267,464	Antagonist activity at human oxytocin receptor expressed in HEK293 cells assessed as inhibition of oxytocin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay Antagonist activity at human oxytocin receptor expressed in HEK293 cells assessed as inhibition of oxytocin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay	[PMID: 26741855]
HEK293	EC₅₀	> 10000 nM Compound: 1; WAY-267,464	Agonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assay Agonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assay	[PMID: 26741855]
HEK293	EC₅₀	420 nM Compound: 1; WAY-267,464	Agonist activity at human oxytocin receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assay Agonist activity at human oxytocin receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addition of Ab-Cryptate and IP1-d2 by HTRF assay	[PMID: 26741855]
HEK293	IC₅₀	613 nM Compound: 1; WAY-267,464	Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay	[PMID: 26741855]

In Vivo

WAY-267464 (i.p., 100 mg/kg) has antagonism of the memory-enhancing effects of AVP (0.005 mg/kg) on social recognition at a retention interval of 120 min^[1].
WAY-267464 (i.p., 10 and 30 mg/kg) has the antagonist effects on the arginine vasopressin Vasopressin (HY-P0049) (AVP)-induced (0.005 mg/kg) facilitation of social recognition at a retention interval of 120 min^[1].
WAY-267464 (i.p., 30 and 100 mg/kg, given alone) impairs memory at a 30 min retention interval^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar Rats (adult: 9-10 weeks; juvenile: 3-4 weeks)^[1]
Dosage:	1, 10, 30, and 100 mg/kg
Administration:	Intraperitoneal; 1, 10, 30, and 100 mg/kg
Result:	Completely prevented the AVP-induced preference for the novel over the familiar juvenile stimulus rats. Prevented the increase in preference for the novel over the familiar juvenile stimulus rat induced by AVP at 10 and 30 mg/kg, but not 1 mg/kg.

Molecular Weight

581.66

Formula

C₃₂H₃₅N₇O₄

CAS No.

847375-16-0

SMILES

O=C(N1CCN(CC2=CC(O)=CC(O)=C2)CC1)NCC3=CC=C(C(N4CC5=C(N(C)N=C5)NC6=CC=CC=C46)=O)C=C3C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Callum Hicks, et al. WAY 267,464, a non-peptide oxytocin receptor agonist, impairs social recognition memory in rats through a vasopressin 1A receptor antagonist action. Psychopharmacology (Berl). 2015 Aug;232(15):2659-67. [Content Brief]

WAY-267464 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WAY-267464847375-16-0WAY267464WAY 267464Oxytocin ReceptorOXTRoxytocin receptor (OTR)social recognition memoryvasopressin 1A receptorOxytocinVasopressinpsychiatric disordersautism spectrum disorderschizophreniasocial anxiety disorderInhibitorinhibitorinhibit

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