2. GPCR/G Protein
  3. Oxytocin Receptor
  4. WAY-267464

WAY-267464 is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder.

For research use only. We do not sell to patients.

WAY-267464 Chemical Structure

WAY-267464 Chemical Structure

CAS No. : 847375-16-0

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Description

WAY-267464 is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder[1].

In Vivo

WAY-267464 (i.p., 100 mg/kg) has antagonism of the memory-enhancing effects of AVP (0.005 mg/kg) on social recognition at a retention interval of 120 min[1].
WAY-267464 (i.p., 10 and 30 mg/kg) has the antagonist effects on the arginine vasopressin Vasopressin (HY-P0049) (AVP)-induced (0.005 mg/kg) facilitation of social recognition at a retention interval of 120 min[1].
WAY-267464 (i.p., 30 and 100 mg/kg, given alone) impairs memory at a 30 min retention interval[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar Rats (adult: 9-10 weeks; juvenile: 3-4 weeks)[1]
Dosage: 1, 10, 30, and 100 mg/kg
Administration: Intraperitoneal; 1, 10, 30, and 100 mg/kg
Result: Completely prevented the AVP-induced preference for the novel over the familiar juvenile stimulus rats.
Prevented the increase in preference for the novel over the familiar juvenile stimulus rat induced by AVP at 10 and 30 mg/kg, but not 1 mg/kg.
Molecular Weight

581.66

Formula

C32H35N7O4
CAS No.
SMILES

O=C(N1CCN(CC2=CC(O)=CC(O)=C2)CC1)NCC3=CC=C(C(N4CC5=C(N(C)N=C5)NC6=CC=CC=C46)=O)C=C3C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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WAY-267464 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

WAY-267464847375-16-0WAY267464WAY 267464Oxytocin ReceptorOXTRoxytocin receptor (OTR)social recognition memoryvasopressin 1A receptorOxytocinVasopressinpsychiatric disordersautism spectrum disorderschizophreniasocial anxiety disorderInhibitorinhibitorinhibit

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