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renal toxicity

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28

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6

Biochemical Assay Reagents

1

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12

Natural
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1

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-Y1091
    D-Lysine

    		Endogenous Metabolite Others
    D-Lysine is a useful raw material employed as an analog of lutenizing-hormone-releasing hormone and as a agent carrier in the form of polylysine. D-Lysine decreases renal uptake of radioactivity during scintigraphy and PRRT with low toxicity. D-Lysine not interferes with the natural amino acid metabolic balance .
    D-Lysine
  • HY-B1331
    Cyromazine

    Cyromazin; CGA-72662

    		 Endogenous Metabolite Parasite Neurological Disease Metabolic Disease
    Cyromazine (CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects. Cyromazine reduced the number of germ cells by interfering with the Ecdysone (HY-N0179) signaling pathway. Cyromazine induces renal toxicity attenuated and restored by green tea extract in rats .
    Cyromazine
  • HY-B1331R
    Cyromazine (Standard)

    Cyromazin (Standard); CGA-72662 (Standard)

    		 Reference Standards Endogenous Metabolite Parasite Neurological Disease Metabolic Disease
    Cyromazine (Standard) is the analytical standard of Cyromazine. This product is intended for research and analytical applications. Cyromazine (CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects. Cyromazine reduced the number of germ cells by interfering with the Ecdysone (HY-N0179) signaling pathway. Cyromazine induces renal toxicity attenuated and restored by green tea extract in rats .
    Cyromazine (Standard)
  • HY-149673
    XPW1

    		CDK Cancer
    XPW1 is a potent and selective CDK9 inhibitor with excellent activity against clear cell renal cell carcinoma (ccRCC) and low toxicity .
    XPW1
  • HY-108402
    Cefodizime

    		Penicillin-binding protein (PBP) Bacterial Antibiotic Infection
    Cefodizime is a third generation cephalosporin antibiotic with a broad spectrum of antibacterial activity. Cefodizime has no renal toxic effect, good tolerance and immune regulation activity, and has the potential for severe infections of the respiratory and urinary tracts .
    Cefodizime
  • HY-108402A
    Cefodizime sodium

    		Penicillin-binding protein (PBP) Bacterial Antibiotic Infection
    Cefodizime sodium is a third generation cephalosporin antibiotic with a broad spectrum of antibacterial activity. Cefodizime sodium has no renal toxic effect, good tolerance and immune regulation activity, and can be used for the research of severe infections of the respiratory and urinary tracts .
    Cefodizime sodium
  • HY-75087
    (R)-pyrrolidine-2-carboxylic acid

    (+)-(R)-Proline; (R)-(+)-Proline; (R)-2-Carboxypyrrolidine; (R)-Proline

    		 Endogenous Metabolite Metabolic Disease
    (R)-pyrrolidine-2-carboxylic acid ((+)-(R)-Proline) is a proline isomer that exhibits high renal and hepatotoxicity in rats. (R)-pyrrolidine-2-carboxylic acid can be used to study amino acid metabolism and toxicity mechanisms .
    (R)-pyrrolidine-2-carboxylic acid
  • HY-170967
    IPH10

    		Apoptosis Caspase PARP Reactive Oxygen Species (ROS) Cancer
    IPH10 is an anti-cancer agent that exhibits a strong anti-tumor effect in vivo without hepatic and renal toxicity. IPH10 can significantly increase the content of ROS, decrease the mitochondrial membrane potential, and induce apoptosis in tumor cells .
    IPH10
  • HY-108402R
    Cefodizime (Standard)

    		Penicillin-binding protein (PBP) Reference Standards Bacterial Antibiotic Infection
    Cefodizime (Standard) is the analytical standard of Cefodizime. This product is intended for research and analytical applications. Cefodizime is a third generation cephalosporin antibiotic with a broad spectrum of antibacterial activity. Cefodizime has no renal toxic effect, good tolerance and immune regulation activity, and has the potential for severe infections of the respiratory and urinary tracts .
    Cefodizime (Standard)
  • HY-108402AR
    Cefodizime sodium (Standard)

    		Penicillin-binding protein (PBP) Reference Standards Bacterial Antibiotic Infection
    Cefodizime (sodium) (Standard) is the analytical standard of Cefodizime (sodium). This product is intended for research and analytical applications. Cefodizime sodium is a third generation cephalosporin antibiotic with a broad spectrum of antibacterial activity. Cefodizime sodium has no renal toxic effect, good tolerance and immune regulation activity, and can be used for the research of severe infections of the respiratory and urinary tracts[1][2].
    Cefodizime sodium (Standard)
  • HY-121246
    Fluorofenidone
    1 Publications Verification

    AKF-PD

    		 PI3K Akt Inflammation/Immunology
    Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway .
    Fluorofenidone
  • HY-121246S
    Fluorofenidone-d3

    AKF-PD-d3

    		 Isotope-Labeled Compounds Akt PI3K Inflammation/Immunology
    Fluorofenidone-d3 is deuterium labeled Fluorofenidone. Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway .
    Fluorofenidone-d3
  • HY-13451R
    Finafloxacin (Standard)

    		Reference Standards Bacterial Antibiotic Infection
    Citric acid (Standard) is the analytical standard of Citric acid. This product is intended for research and analytical applications. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .
    Finafloxacin (Standard)
  • HY-75087R
    (R)-pyrrolidine-2-carboxylic acid (Standard)

    (+)-(R)-Proline (Standard); (R)-(+)-Proline (Standard); (R)-2-Carboxypyrrolidine (Standard); (R)-Proline (Standard)

    		 Reference Standards Endogenous Metabolite Metabolic Disease
    (R)-pyrrolidine-2-carboxylic acid (Standard) is the analytical standard of (R)-pyrrolidine-2-carboxylic acid. This product is intended for research and analytical applications. (R)-pyrrolidine-2-carboxylic acid ((+)-(R)-Proline) is a proline isomer that exhibits high renal and hepatotoxicity in rats. (R)-pyrrolidine-2-carboxylic acid can be used to study amino acid metabolism and toxicity mechanisms[1].
    (R)-pyrrolidine-2-carboxylic acid (Standard)
  • HY-121246R
    Fluorofenidone (Standard)

    		PI3K Akt Inflammation/Immunology
    Fluorofenidone (Standard) is the analytical standard of Fluorofenidone. This product is intended for research and analytical applications. Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway .
    Fluorofenidone (Standard)
  • HY-B0639
    Amifostine
    5+ Cited Publications

    WR2721

    		 MDM-2/p53 HIF/HIF Prolyl-Hydroxylase Cancer
    Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action .
    Amifostine
  • HY-150596
    CT1-3

    		Apoptosis Bcl-2 Family JNK Cancer
    CT1-3 is a potent anticancer agent. CT1-3 induces mitochondria-mediated apoptosis by regulating JNK/Bcl-2/Bax/XIAP pathway. CT1-3 suppresses the epithelial mesenchymal transition (EMT) potential of human cancer cells (HCCs) via regulating the E-cadherin/Snail axis, thus inhibits tumorigenesis. CT1-3 has a strong antitumor effect in mice model and exhibits no significant hepatic and renal toxicity .
    CT1-3
  • HY-B0639A
    Amifostine trihydrate
    5+ Cited Publications

    WR2721 trihydrate

    		 MDM-2/p53 HIF/HIF Prolyl-Hydroxylase Cancer
    Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action .
    Amifostine trihydrate
  • HY-Y1117
    Melamine
    1 Publications Verification

    		 Apoptosis TGF-β Receptor NF-κB COX NADPH Oxidase ROS Kinase Neurological Disease Inflammation/Immunology
    Melamine is an orally active inducer of Apoptosis. Melamine induces animal disease models. Melamine affects the activity of Sertoli cell and can be used for research on male reproductive function. Melamine also has neurotoxicity and nephrotoxicity. Melamine induces cognitive impairment and acute kidney injury models. Melamine can also be used to induce bladder cancer and urinary stone models .
    Melamine
  • HY-B1295
    Lithium citrate tetrahydrate
    5 Publications Verification

    Litarex tetrahydrate

    		 Apoptosis Endogenous Metabolite Bacterial Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    Lithium citrate (Litarex) tetrahydrate is a natural preservative and food tartness enhancer. Lithium citrate tetrahydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Lithium citrate tetrahydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Lithium citrate tetrahydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
    Lithium citrate tetrahydrate
  • HY-N1428
    Citric acid
    Maximum Cited Publications
    16 Publications Verification

    		 Apoptosis Endogenous Metabolite Bacterial Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
    Citric acid
  • HY-N1428R
    Citric acid (standard)
    3 Publications Verification

    		 Reference Standards Apoptosis Endogenous Metabolite Bacterial Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    Citric acid (Standard) is the analytical standard of Citric acid (HY-N1428). This product is intended for research and analytical applications. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
    Citric acid (standard)
  • HY-W009156
    Citric acid tripotassium hydrate
    5 Publications Verification

    Potassium citrate monohydrate

    		 Apoptosis Endogenous Metabolite Bacterial Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    Citric acid tripotassium hydrate (Potassium citrate monohydrate) is a natural preservative and food tartness enhancer. Citric acid tripotassium hydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid tripotassium hydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid tripotassium hydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
    Citric acid tripotassium hydrate
  • HY-B2201
    Citric acid trisodium
    5+ Cited Publications

    Sodium citrate; Trisodium citrate anhydrous

    		 Apoptosis Endogenous Metabolite Bacterial Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    Citric acid trisodium (Sodium citrate) is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
    Citric acid trisodium
  • HY-N1428A
    Citric acid monohydrate
    3 Publications Verification

    		 Apoptosis Endogenous Metabolite Bacterial Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
    Citric acid monohydrate
  • HY-W008606
    Sodium citrate monobasic

    Citric acid monosodium salt

    		 Apoptosis Endogenous Metabolite Bacterial Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    Sodium citrate monobasic (Citric acid monosodium salt) is a natural preservative and food tartness enhancer. Sodium citrate monobasic induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Sodium citrate monobasic cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Sodium citrate monobasic is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
    Sodium citrate monobasic
  • HY-N1428AR
    Citric acid monohydrate (Standard)

    		Reference Standards Endogenous Metabolite Apoptosis Bacterial Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    Citric acid monohydrate (Standard) is the analytical standard of Citric acid monohydrate (HY-N1428A). This product is intended for research and analytical applications. Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
    Citric acid monohydrate (Standard)
  • HY-131384
    8,11,14-Eicosatriynoic acid

    8,11,14-Icosatriynoic acid

    		 COX Others
    8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization . 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    8,11,14-Eicosatriynoic acid

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