Search Result
Results for "
siRNA delivery
" in MedChemExpress (MCE) Product Catalog:
17
Biochemical Assay Reagents
1
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-160852
-
|
|
Liposome
|
Inflammation/Immunology
|
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YSK 12C4 is an ionizable cationic lipid primarily used to enhance siRNA cellular delivery via multifunctional envelope-type nanodevices (MEND). YSK 12C4 promotes siRNA uptake and endosomal escape, effectively silencing genes in human immune cell lines .
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- HY-147087
-
|
|
Liposome
|
Cancer
|
|
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .
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- HY-145225
-
|
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Liposome
|
Others
|
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DLin-K-C3-DMA, a cationic lipid, can be used in the synthesis of nucleic acid-lipid particle to delivery of nucleic acid .
|
-
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- HY-112764
-
|
|
Liposome
|
Metabolic Disease
|
|
DMG-PEG 2000 is used?for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the?lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles .
|
-
-
- HY-145405
-
|
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Liposome
|
Others
|
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C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .
|
-
-
- HY-112251
-
D-Lin-MC3-DMA
Maximum Cited Publications
73 Publications Verification
|
Liposome
|
Cancer
|
|
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
|
-
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- HY-N1446A
-
|
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Endogenous Metabolite
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Others
|
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Glycerol Monoleate is a nontoxic, biodegradable and biocompatible, lipophilic glycerol fatty acid ester. Glycerol monooleate has hemolytic properties. glycerol monooleate is used as an emulsifier and an absorption enhancer in combination with bile salts. Glycerol Monoleate can be used in drug delivery systems and siRNA delivery in Vitro .
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-
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- HY-145796
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|
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Liposome
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Others
|
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503O13 is a degradable ionizable lipid for siRNA delivery.
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-
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- HY-141674
-
|
|
Liposome
|
Metabolic Disease
|
|
DMG-PEG is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles .
|
-
-
- HY-112764A
-
|
|
Liposome
|
Metabolic Disease
|
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DMG-PEG Excipient is used?for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG Excipient is also used for the?lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles .
|
-
-
- HY-145523
-
|
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Liposome
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Others
|
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OH-Chol is a cationic cholesterol derivative. OH-Chol can be used for siRNA delivery and gene silencing .
|
-
-
- HY-160569
-
-
-
- HY-112251A
-
|
|
Liposome
|
Cancer
|
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D-Lin-MC3-DMA Excipient, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
|
-
-
- HY-112757
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DLinDMA
1 Publications Verification
|
Liposome
|
Others
|
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DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery .
|
-
-
- HY-145799
-
5A2-SC8
1 Publications Verification
|
Liposome
|
Cancer
|
|
5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models .
|
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- HY-112772A
-
|
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Liposome
|
Others
|
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98N12-5 is a novel multi-tail ionizable lipids that has been used for efficient in vivo siRNA–delivery to the liver.
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- HY-147077
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|
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Others
|
Inflammation/Immunology
|
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Triantennary GalNAc-1 is a triantennary N-acetylgalactosamine (GalNAc) that can be conjugated to the 3' end of the sense strand of siRNA. GalNAc promotes targeted delivery of siRNA to liver cells both in vitro and in vivo [1].
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- HY-160554
-
|
|
Liposome
|
Infection
Inflammation/Immunology
|
|
C12-113 is a lipidoid delivery agent that can be used to transfect siRNA into cells. C12-113 can also be combined with other lipids to form lipid nanoparticles (LNPs) for the delivery of mRNA encoding the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice .
|
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- HY-112763
-
|
|
Liposome
|
Inflammation/Immunology
|
|
CLinDMA, a cationic lipid, can cause inflammatory response. CLinDMA can be used for the synthesis LNP201. LNP201 is a liposome assembly for systemic delivery of siRNA .
|
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- HY-163044
-
|
|
Liposome
|
Infection
|
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C12-SPM is a lipid that mediates siRNA delivery. C12-SPM has no significant cytotoxicity and can be used for research on hepatoviral diseases .
|
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- HY-159675
-
|
|
Liposome
|
Inflammation/Immunology
|
|
1-A-N is a lipid nanoparticle (LNP) used for in vivo delivery of siRNA. 1-A-N can regulate immune response by delivering siCD45 (siRNA targeting CD45) to T cells and silencing the CD45 gene .
|
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- HY-153371
-
|
|
Liposome
|
Others
|
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50-C2-C9-4tail has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo.
|
-
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- HY-P10055A
-
|
PSMA-1 TFA
|
PSMA
|
Cancer
|
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PSMA targeting peptide TFA (PSMA-1 TFA) is a PSMA targeting peptide (GRFLTGGTGRLLRIS) and can be used for targeted delivery of glucose-regulated protein (GRP)-silencing siRNAs in PCa cells .
|
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- HY-160581
-
|
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Liposome
|
Others
|
|
OH-C-Chol is a cationic liposome that serves as a siRNA delivery vehicle. OH-C-Chol (LP-C) and OH-NC-Chol (LP-NC)/siRNA complexes (lipoplexes) showed better performance than NP-C and NP-NC/siRNA complexes (nanocomplexes), respectively. ) greater gene silencing effect .
|
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- HY-148855
-
|
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Liposome
|
Others
|
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OF-C4-Deg-Lin is an ionizable lipid with varied linker lengths. OF-C4-Deg-Lin can be used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA .
|
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- HY-148701
-
|
|
Liposome
|
Cancer
|
|
mono-Pal-MTO is a palm oil-based lipid produced by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity .
|
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- HY-148702
-
|
|
Liposome
|
Cancer
|
|
di-Pal-MTO is a palm oil-based lipid produced by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity .
|
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- HY-153137
-
|
304O13
|
Liposome
|
Cancer
|
|
Tri-N-tridecyl 3-(ethyl(methyl)amino)propanoate is a biodegradable lipid prepared by the conjugate addition of alkylamines to acrylates. Tri-N-tridecyl 3-(ethyl(methyl)amino)propanoate can be used in various drug delivery systems to deliver polynucleotides, siRNA for example .
|
-
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- HY-112251S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
D-Lin-MC3-DMA- 13C3 is the 13C labeled D-Lin-MC3-DMA. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle[1][2].
|
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- HY-112758
-
|
|
Liposome
|
Others
|
|
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-147087
-
|
|
Drug Delivery
|
|
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .
|
-
- HY-145225
-
|
|
Drug Delivery
|
|
DLin-K-C3-DMA, a cationic lipid, can be used in the synthesis of nucleic acid-lipid particle to delivery of nucleic acid .
|
-
- HY-112764
-
|
|
Drug Delivery
|
|
DMG-PEG 2000 is used?for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the?lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles .
|
-
- HY-145405
-
|
|
Drug Delivery
|
|
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .
|
-
- HY-112251
-
D-Lin-MC3-DMA
Maximum Cited Publications
73 Publications Verification
|
Drug Delivery
|
|
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
|
-
- HY-112757
-
DLinDMA
1 Publications Verification
|
Drug Delivery
|
|
DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery .
|
-
- HY-145799
-
5A2-SC8
1 Publications Verification
|
Drug Delivery
|
|
5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models .
|
-
- HY-112772A
-
|
|
Drug Delivery
|
|
98N12-5 is a novel multi-tail ionizable lipids that has been used for efficient in vivo siRNA–delivery to the liver.
|
-
- HY-145796
-
|
|
Drug Delivery
|
|
503O13 is a degradable ionizable lipid for siRNA delivery.
|
-
- HY-141674
-
|
|
Drug Delivery
|
|
DMG-PEG is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles .
|
-
- HY-112763
-
|
|
Drug Delivery
|
|
CLinDMA, a cationic lipid, can cause inflammatory response. CLinDMA can be used for the synthesis LNP201. LNP201 is a liposome assembly for systemic delivery of siRNA .
|
-
- HY-153371
-
|
|
Drug Delivery
|
|
50-C2-C9-4tail has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo.
|
-
- HY-148855
-
|
|
Drug Delivery
|
|
OF-C4-Deg-Lin is an ionizable lipid with varied linker lengths. OF-C4-Deg-Lin can be used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA .
|
-
- HY-148701
-
|
|
Drug Delivery
|
|
mono-Pal-MTO is a palm oil-based lipid produced by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity .
|
-
- HY-148702
-
|
|
Drug Delivery
|
|
di-Pal-MTO is a palm oil-based lipid produced by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity .
|
-
- HY-153137
-
|
304O13
|
Drug Delivery
|
|
Tri-N-tridecyl 3-(ethyl(methyl)amino)propanoate is a biodegradable lipid prepared by the conjugate addition of alkylamines to acrylates. Tri-N-tridecyl 3-(ethyl(methyl)amino)propanoate can be used in various drug delivery systems to deliver polynucleotides, siRNA for example .
|
-
- HY-112758
-
|
|
Drug Delivery
|
|
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P10055A
-
|
PSMA-1 TFA
|
PSMA
|
Cancer
|
|
PSMA targeting peptide TFA (PSMA-1 TFA) is a PSMA targeting peptide (GRFLTGGTGRLLRIS) and can be used for targeted delivery of glucose-regulated protein (GRP)-silencing siRNAs in PCa cells .
|
-
- HY-P10514
-
|
|
Peptides
|
Others
|
|
Transportan 10 is a derivative of Transportan (HY-P1732) and is an amphiphilic cell penetrating peptide (CPP). Transportan 10 helps molecules penetrate cell membrane barriers by directly interacting with the lipid bilayer. Transportan 10 can be used in gene therapy or siRNA delivery vector research .
|
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- HY-P10520
-
|
|
Peptides
|
Others
|
|
RWmix is a synthetic cell-penetrating peptide. The secondary amphiphilic nature of RWmix promotes cellular uptake, mainly due to the alternating arrangement of arginine and tryptophan. The presence of tryptophan enhances the anchoring of the peptide to the cell membrane, thereby improving its ability to penetrate the cell membrane. RWmix can be used for gene therapy and siRNA delivery research .
|
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- HY-P10153
-
|
|
Peptides
|
Others
|
|
gH625 is a cell-penetrating viral peptide which is a part of glycoprotein H of Herpes simplex virus type I. gH625 is able to cross the cell membrane and to transport many conjugated cargoes into the cytosol. gH625 is permeable to the blood-brain barrier (BBB) and can enter the rat brain in vivo without toxic effects. gH625 can be used for siRNA delivery research .
|
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- HY-P10055
-
|
PSMA-1
|
Peptides
|
Cancer
|
|
PSMA-1 is a PSMA targeting peptide (GRFLTGGTGRLLRIS) and can be used for for targeted delivery of glucose-regulated protein (GRP)-silencing siRNAs in PCa cells.?PSMA-1 is selected and polyarginine sequences R6?or R9?were added at the C terminus to generate the CTPs. FITC labeling of the peptide with an aminohexanoic acid (Ahx) linker at the N terminus produced FITC-PSMA-1, to track PSMA binding on PCa cells .?
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-112251S
-
|
|
|
D-Lin-MC3-DMA- 13C3 is the 13C labeled D-Lin-MC3-DMA. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle[1][2].
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-147087
-
|
|
|
Cationic Lipids
|
|
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .
|
-
- HY-145225
-
|
|
|
Cationic Lipids
|
|
DLin-K-C3-DMA, a cationic lipid, can be used in the synthesis of nucleic acid-lipid particle to delivery of nucleic acid .
|
-
- HY-112764
-
|
|
|
Pegylated Lipids
|
|
DMG-PEG 2000 is used?for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the?lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles .
|
-
- HY-145405
-
|
|
|
Cationic Lipids
|
|
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .
|
-
- HY-112251
-
D-Lin-MC3-DMA
Maximum Cited Publications
73 Publications Verification
|
|
Cationic Lipids
|
|
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
|
-
- HY-145796
-
-
- HY-141674
-
|
|
|
Pegylated Lipids
|
|
DMG-PEG is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles .
|
-
- HY-112764A
-
|
|
|
Emulsifiers
Liposomal Film-forming Agents
|
|
DMG-PEG Excipient is used?for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG Excipient is also used for the?lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles .
|
-
- HY-145523
-
|
|
|
Cationic Lipids
|
|
OH-Chol is a cationic cholesterol derivative. OH-Chol can be used for siRNA delivery and gene silencing .
|
-
- HY-160569
-
|
|
|
Cationic Lipids
|
|
C14-SPM is a polyamine branched-chain lipidoid that can be used for the delivery of siRNA .
|
-
- HY-112251A
-
-
- HY-112757
-
DLinDMA
1 Publications Verification
|
|
Cationic Lipids
|
|
DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery .
|
-
- HY-145799
-
5A2-SC8
1 Publications Verification
|
|
Cationic Lipids
|
|
5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models .
|
-
- HY-112772A
-
|
|
|
Cationic Lipids
|
|
98N12-5 is a novel multi-tail ionizable lipids that has been used for efficient in vivo siRNA–delivery to the liver.
|
-
- HY-160554
-
|
|
|
Cationic Lipids
|
|
C12-113 is a lipidoid delivery agent that can be used to transfect siRNA into cells. C12-113 can also be combined with other lipids to form lipid nanoparticles (LNPs) for the delivery of mRNA encoding the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice .
|
-
- HY-112763
-
|
|
|
Cationic Lipids
|
|
CLinDMA, a cationic lipid, can cause inflammatory response. CLinDMA can be used for the synthesis LNP201. LNP201 is a liposome assembly for systemic delivery of siRNA .
|
-
- HY-163044
-
|
|
|
Cationic Lipids
|
|
C12-SPM is a lipid that mediates siRNA delivery. C12-SPM has no significant cytotoxicity and can be used for research on hepatoviral diseases .
|
-
- HY-159675
-
|
|
|
Cationic Lipids
|
|
1-A-N is a lipid nanoparticle (LNP) used for in vivo delivery of siRNA. 1-A-N can regulate immune response by delivering siCD45 (siRNA targeting CD45) to T cells and silencing the CD45 gene .
|
-
- HY-153371
-
|
|
|
Cationic Lipids
|
|
50-C2-C9-4tail has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo.
|
-
- HY-160581
-
|
|
|
Cationic Lipids
|
|
OH-C-Chol is a cationic liposome that serves as a siRNA delivery vehicle. OH-C-Chol (LP-C) and OH-NC-Chol (LP-NC)/siRNA complexes (lipoplexes) showed better performance than NP-C and NP-NC/siRNA complexes (nanocomplexes), respectively. ) greater gene silencing effect .
|
-
- HY-148855
-
|
|
|
Cationic Lipids
|
|
OF-C4-Deg-Lin is an ionizable lipid with varied linker lengths. OF-C4-Deg-Lin can be used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA .
|
-
- HY-153137
-
|
304O13
|
|
Cationic Lipids
|
|
Tri-N-tridecyl 3-(ethyl(methyl)amino)propanoate is a biodegradable lipid prepared by the conjugate addition of alkylamines to acrylates. Tri-N-tridecyl 3-(ethyl(methyl)amino)propanoate can be used in various drug delivery systems to deliver polynucleotides, siRNA for example .
|
-
- HY-112758
-
|
|
|
Cationic Lipids
|
|
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .
|
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