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Results for "

sulfhydryls

" in MedChemExpress (MCE) Product Catalog:

64

Inhibitors & Agonists

27

Fluorescent Dye

7

Biochemical Assay Reagents

1

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6

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2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-121167
    L-Albizziin

    		Glutaminase Cancer
    L-albizziin, as a sulfhydryl group reagent, is a glutamase inhibitor. L-albizziin can be used for the research of cancer .
    L-Albizziin
  • HY-164785
    TCO-PEG5-C2-Mal

    		Others Others
    TCO-PEG5-C2-Mal is a heterobifunctional linker that can be used for tetrazine ligation and sulfhydryl conjugation .
    TCO-PEG5-C2-Mal
  • HY-Y1666
    2,2′-Dipyridyl disulfide

    		Biochemical Assay Reagents Others
    2,2′-Dipyridyl disulfide is a useful reagent for the determination of sulfhydryl groups. 2,2′-Dipyridyl disulfide is a common reagent in peptide chemistry, often used in oxidation–reduction condensations to form peptide bonds or in coupling reactions to form disulfide-linked heterodimers .
    2,2′-Dipyridyl disulfide
  • HY-135233
    N-Succinimidyl-S-acetylthioacetate

    SATA

    		 Biochemical Assay Reagents Others
    N-Succinimidyl S-acetylthioacetate (SATA), a protein modification agent, introduces thiol-groups into protein molecules. N-Succinimidyl S-acetylthioacetate adds sulfhydryl groups to proteins and other amine-containing molecules in a protected form .
    N-Succinimidyl-S-acetylthioacetate
  • HY-119970
    Helenalin
    5 Publications Verification

    		 NF-κB Inflammation/Immunology Cancer
    Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .
    Helenalin
  • HY-D0843
    N-Ethylmaleimide
    15+ Cited Publications

    NEM

    		 Cathepsin Deubiquitinase Apoptosis Others
    N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC50 value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides .
    N-Ethylmaleimide
  • HY-D1260
    FM-red

    PSH-red

    		 Fluorescent Dye Neurological Disease
    FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx) .
    FM-red
  • HY-D1618
    Cyanine3 maleimide tetrafluoroborate

    		Fluorescent Dye Others
    Cyanine3 maleimide tetrafluoroborate is a specific labeling reagent for sulfhydryl groups with the λex of 550 nm and λem of 580 nm. Cyanine3 maleimide tetrafluoroborate can be used for protein and peptide labeling .
    Cyanine3 maleimide tetrafluoroborate
  • HY-119320
    Ethimidine

    Aethimidinum

    		 Biochemical Assay Reagents Cancer
    Ethimidine (Aethimidinum) can reduce the blood serum free SH (sulfhydryl) in in rats previously transplanted with sarcoma or carcinoma cells .
    Ethimidine
  • HY-D1363
    BDP R6G maleimide

    		Fluorescent Dye Others
    BDP R6G maleimide is a borodipyrromethane fluorophore with absorption and emission wavelengths similar to those of R6G rhodamine. Sulfhydryl labelling is a common protein modification where the cysteine residues in the protein allow more site-specific labelling than the NHS ester of the amine group. BDP R6G maleimide is a thiol reactive dye that reacts with thiol groups to form thioester bonds .
    BDP R6G maleimide
  • HY-D1654
    BDP 581/591 maleimide

    		Fluorescent Dye Others
    BDP 581/591 maleimide is a linker of the BDP 581/591 dye. It has a long fluorescence lifetime and can be used for fluorescence polarization assays. The maleimide group can react with thiol groups to form thioester bonds between pH 6.5 to 7.5, for the labeling of sulfhydryl groups of proteins and peptides.
    BDP 581/591 maleimide
  • HY-137791
    MMBC

    		Fluorescent Dye Others
    MMBC is a sulfhydryl-sensitive fluorophore .
    MMBC
  • HY-100216
    SPDP
    5 Publications Verification

    SPDP Crosslinker; Py-ds-Prp-OSu

    		 ADC Linker Cancer
    SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) .
    SPDP
  • HY-D2182
    Preactivated PE-Cy5 Maleimide

    		Fluorescent Dye Others
    Preactivated PE-Cy5 Maleimide is a sulfhydryl reactive dye that reacts with free sulfhydryl groups on proteins. Preactivated APC-Cy5.5 Maleimide binds easily to proteins or antibodies, and does not change the spectral characteristics of APC-Cy/YF after activation.
    Preactivated PE-Cy5 Maleimide
  • HY-D2180
    Preactivated APC-Cy5.5 Maleimide

    		Fluorescent Dye Others
    Preactivated APC-Cy5.5 Maleimide is a sulfhydryl reactive dye that reacts with free sulfhydryl groups on proteins. Preactivated APC-Cy5.5 Maleimide binds easily to proteins or antibodies, and does not change the spectral characteristics of APC-Cy/YF after activation.
    Preactivated APC-Cy5.5 Maleimide
  • HY-128925
    AMAS
    1 Publications Verification

    		 ADC Linker Cancer
    AMAS is a nonclaevable heterobifunctional crosslinker with NHS ester and maleimide groups that allows covalent conjugation of amine- and sulfhydryl-containing molecules.
    AMAS
  • HY-126493
    DM4-SPDP

    		Drug-Linker Conjugates for ADC Microtubule/Tubulin Cancer
    DM4-SPDP is a agent-linker conjugate composed of a potent antitubulin agent DM4 and a linker SMCC to make antibody agent conjugate . SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls .
    DM4-SPDP
  • HY-129500
    Zofenoprilat arginine

    		Endogenous Metabolite Cardiovascular Disease
    Zofenoprilat arginine is an antihypertensive agent that enhances the effect of bradykinin on coronary flow, particularly in the presence of sulfhydryl-containing converting enzyme inhibitors.
    Zofenoprilat arginine
  • HY-160926
    16-Oxocafestol

    		Glutathione S-transferase Cancer
    16-Oxocafestol enhances levels of glutathione S-transferase (GST) and tissue sulfhydryl in liver and in small bowel mucosa .
    16-Oxocafestol
  • HY-W698574
    Dansylamidoethyl mercaptan

    		Biochemical Assay Reagents
    Dansylamidoethyl mercaptan is a molecule that reacts with -SH groups of proteins and other sulfhydryl-containing molecules and has activity for detecting SS bonds in proteins.
    Dansylamidoethyl mercaptan
  • HY-W273281
    6,6′-Dithiodinicotinic acid

    		Biochemical Assay Reagents Others
    6,6′-Dithiodinicotinic acid is a sulfur-containing organic compound belonging to nicotinic acid derivatives, which can be used as a specific sulfhydryl blocker .
    6,6′-Dithiodinicotinic acid
  • HY-120128
    MTSEA hydrobromide

    		Biochemical Assay Reagents Neurological Disease
    MTSEA hydrobromide is a sulfhydryl-reactive compound that modifies free cysteine residues to produce a positively charged side chain approximately the size of lysine .
    MTSEA hydrobromide
  • HY-N7594
    Senecionine acetate

    O-Acetylsenecionine

    		 Mitochondrial Metabolism Others
    Senecionine acetate (O-Acetylsenecionine) is a pyrrolizidine alkaloid. Senecionine acetate inhibits the sequestration of Ca 2+ in extramitochondrial and mitochondrial compartments possibly by inactivating free sulfhydryl groups .
    Senecionine acetate
  • HY-D0975
    Sulfo-SMCC sodium
    4 Publications Verification

    		 ADC Linker Cancer
    Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
    Sulfo-SMCC sodium
  • HY-129655
    Sulfo-SMPB sodium

    		ADC Linker Cancer
    Sulfo-SMPB sodium is a non-cleavable, heterobifunctional chemical cross-linking reagent which contains N-hydroxysuccinimide (NHS) ester and maleimide groups, allowing covalent conjugation of amine- and sulfhydryl-containing molecules .
    Sulfo-SMPB sodium
  • HY-W888514
    mPEG-CHO

    mPEG-propionaldehyde

    		 Biochemical Assay Reagents Others
    mPEG-CHO (mPEG-propionaldehyde) is a polyethylene glycol (PEG) derivative with a propionaldehyde group. Propionaldehyde is a highly reactive functional group that can covalently bind to amino, sulfhydryl and other functional groups .
    mPEG-CHO
  • HY-D1869
    800CW maleimide

    		Fluorescent Dye Others
    800CW maleimide is an infrared dye that can be used for labeling molecules that contain free sulfhydryl (–SH) groups (Ex: 778 nm; Em: 796 nm). 800CW maleimide binds to plasma proteins .
    800CW maleimide
  • HY-129748
    SQ-24798

    		Carboxylesterase (CES) Others
    SQ-24,798 is a compound that inhibits carboxypeptidase B with high affinity and specificity. Its inhibitory effect may be achieved through the binding of the sulfhydryl group to the zinc ion of the enzyme and specific side chains.
    SQ-24798
  • HY-129654
    MTSES sodium

    Sodium (2-Sulfonatoethyl)methanethiosulfonate

    		 Biochemical Assay Reagents Others
    MTSES sodium (Sodium (2-Sulfonatoethyl)methanethiosulfonate) is a negatively charged, membrane-impermeable methanethiosulfonate (MTS). MTS is a compound that reacts with sulfhydryl groups to form mixed disulfide bonds and is often used to study cysteine ??residues on proteins.
    MTSES sodium
  • HY-117281S
    Moexipril-d5

    		Isotope-Labeled Compounds Angiotensin-converting Enzyme (ACE) Apoptosis Cardiovascular Disease
    Moexipril-d5 is the deuterium labeled Moexipril. Moexipril hydrochloride is a potent orally active non-sulfhydryl angiotensin converting enzyme(ACE) inhibitor, which is used for the treatment of hypertension and congestive heart failure[1][2].
    Moexipril-d5
  • HY-D1730
    AF488 NHS ester

    		Fluorescent Dye Others
    AF488 NHS ester is an amine specific fluorescence probe (Em=525 nm). AF488 NHS ester reacts with sulfhydryl groups and amines in aqueous and biological samples then change their chemical structure and fluorescence properties after derivatization .
    AF488 NHS ester
  • HY-141540
    Lactyl-CoA

    		Biochemical Assay Reagents Endogenous Metabolite Others
    Lactyl-CoA is an acyl-CoA formally condensed from the sulfhydryl group of CoA and the carboxyl group of lactic acid, also known as lactyl-CoA. Lactyl-CoA is essential for the biosynthesis of biodegradable and biocompatible lactic acid-based copolymers .
    Lactyl-CoA
  • HY-D2094
    PerCP Maleimide

    		Fluorescent Dye Inflammation/Immunology Cancer
    PerCP Maleimide is a fluorescent dye that reacts with free sulfhydryl groups on proteins. PerCP is a red fluorescence albuminous dye for immunostaining and Maleimide can be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes .
    PerCP Maleimide
  • HY-107783
    Sulfo-GMBS

    		Others Cancer
    Sulfo-GMBS is a cross-linking agent widely used in chemical modification and coupling reactions of proteins and peptides. Among the amine-sulfhydryl cross-linkers, Sulfo-GMBS generated the largest number of cross-links and covered most of the cross-links that were identified with AMAS and GMBS .
    Sulfo-GMBS
  • HY-N6773
    Cytochalasin A

    		HIV Protease Fungal Infection
    Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .
    Cytochalasin A
  • HY-E70364
    IgdE protease

    		Biochemical Assay Reagents Inflammation/Immunology
    IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage .
    IgdE protease
  • HY-D0152
    Tetramethylrhodamine-6-maleimide

    		Fluorescent Dye Others
    Tetramethylrhodamine-6-maleimide is a fluorescent dye with a reactive sulfhydryl-specific moiety is covalently coupled to this cysteine. Tetramethylrhodamine-6-maleimide can be used as labels to detect local protein motions of the fully active Na+/K+-ATPase in real time .
    Tetramethylrhodamine-6-maleimide
  • HY-157920
    Biotin-PE-maleimide

    N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine

    		 Biochemical Assay Reagents Others
    Biotin-PE-maleimide (N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine) is a bulky, membrane-impermeable, sulfhydryl-containing reagent with a relatively large molecular size. Biotin-PE-maleimide can be used for biotin labeling (such as thiol groups) and detection of proteins or other biomolecules .
    Biotin-PE-maleimide
  • HY-D0843S
    N-Ethylmaleimide-d5

    NEM-d5

    		 Cathepsin Deubiquitinase Others
    N-Ethylmaleimide-d5 is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2]. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor[3].
    N-Ethylmaleimide-d5
  • HY-148905
    p-Aminophenylmercuric acetate
    2 Publications Verification

    		 Cathepsin Infection
    p-Aminophenylmercuric acetate is an organomercurial activator of matrix metalloproteinases (MMP). P-Aminophenylmercuric acetate participates in the activation and inhibition of MMP-8 by attacking protein sulfhydryl or inducing cysteine switching reaction. p-Aminophenylmercuric acetate promotes the shedding of betacellulin precursor (pro-BTC). p-Aminophenylmercuric acetate influences the binding of agonists and antagonists to the opiate receptor .
    p-Aminophenylmercuric acetate
  • HY-D0843R
    N-Ethylmaleimide (Standard)

    		Cathepsin Deubiquitinase Apoptosis Others
    Bayogenin (Standard) is the analytical standard of Bayogenin. This product is intended for research and analytical applications. Bayogenin is an alfalfa saponin, shows moderate potency of glycogen phosphorylase inhibition .
    N-Ethylmaleimide (Standard)
  • HY-D2763
    BP Fluor 532 maleimide

    		Fluorescent Dye Others
    BP Fluor 532 maleimide is a photostable, bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 dye can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry. Maleimide is the most popular sulfhydryl-reactive group for conjugating the dye to a thiol group on a protein, oligonucleotide thiophosphate, or low molecular weight ligand. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form a stable thioether bond. The resulting conjugates exhibit brighter fluorescence and greater photostability than the conjugates of many other spectrally similar fluorophores.
    BP Fluor 532 maleimide
  • HY-D2530
    Cy5-PEG-SH (MW 3400)

    		Fluorescent Dye Others
    Cy5-PEG-SH (MW 3400) is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
    Cy5-PEG-SH (MW 3400)
  • HY-D2532
    Cy5-PEG-SH (MW 10000)

    		Fluorescent Dye Others
    Cy5-PEG-SH (MW 10000) is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
    Cy5-PEG-SH (MW 10000)
  • HY-D2529
    Cy5-PEG-SH (MW 2000)

    		Fluorescent Dye Others
    Cy5-PEG-SH (MW 2000) is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
    Cy5-PEG-SH (MW 2000)
  • HY-D1730A
    AF488 NHS ester TEA
    1 Publications Verification

    		 Fluorescent Dye Others
    AF488 NHS ester TEA is an amine specific fluorescence probe (λem=525 nm=525 nm). AF488 NHS ester reacts with sulfhydryl groups and amines in aqueous and biological samples then change their chemical structure and fluorescence properties after derivatization. AF488 exhibits the λem and λex wavelength of 520 nm and 470 nm, respectively .
    AF488 NHS ester TEA
  • HY-D2509
    Cy3-PEG-SH (MW 1000)

    		Fluorescent Dye Others
    Cy3-PEG-SH (MW 1000) is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds .
    Cy3-PEG-SH (MW 1000)
  • HY-D2531
    Cy5-PEG-SH (MW 5000)

    		Fluorescent Dye Others
    Cy5-PEG-SH (MW 5000) is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
    Cy5-PEG-SH (MW 5000)
  • HY-D2512
    Cy3-PEG-SH (MW 5000)

    		Fluorescent Dye Others
    Cy3-PEG-SH (MW 5000) is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds .
    Cy3-PEG-SH (MW 5000)
  • HY-D2556
    Cy5.5-PEG-SH (MW 1000)

    		Fluorescent Dye Others
    Cy5.5-PEG-SH (MW 1000) is a fluorescent labeling reagent that combines Cy5.5 (HY-D0924) fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) derivatives, and is suitable for molecular coupling. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds.
    Cy5.5-PEG-SH (MW 1000)

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