2. Search Result
Search Result
Results for "

synaptosomes

" in MedChemExpress (MCE) Product Catalog:

45

Inhibitors & Agonists

1

Peptides

6

Natural
Products

4

Isotope-Labeled Compounds

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N10772
    Albanin A

    		Calcium Channel Calmodulin Adenylate Cyclase Neurological Disease Inflammation/Immunology
    Albanin A, a flavonoid, suppresses glutamate release by decreasing Ca 2+/calmodulin/adenylate Cyclase 1 (AC1) activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity .
    Albanin A
  • HY-N2326
    (±)-Anatoxin A fumarate

    		nAChR Neurological Disease
    (±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to putative α4β2-type nAChR and α7-type nAChR in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [ 3H]-dopamine release from rat striatal synaptosomes (EC50=134 nM) .
    (±)-Anatoxin A fumarate
  • HY-108973
    CGP 15210G

    		5-HT Receptor Neurological Disease
    CGP 15210G is an inhibitor of 5-HT reuptake. CGP 15210G inhibits the uptake of radiolabelled 5-HT into rat brain synaptosomes in vitro or ex vivo .
    CGP 15210G
  • HY-123199
    Serotonin azidobenzamidine

    SABA

    		 Serotonin Transporter Neurological Disease
    Serotonin azidobenzamidine is an arylazido derivative of 5-hydroxytryptamine (HY-B1473A). Serotonin azidobenzamide competitively inhibits [3H]5-hydroxytryptamine uptake by rat cortical synaptosomes in the dark with a Ki of 130 nM .
    Serotonin azidobenzamidine
  • HY-16923A
    Crobenetine hydrochloride

    BIII-890 hydrochloride; BIII-890 CL

    		 Sodium Channel Neurological Disease
    Crobenetine hydrochloride (BIII-890 hydrochloride) is the hydrochloride form of Crobenetine (HY-16923). Crobenetine hydrochloride is a selective inhibitor for Na + channel. Crobenetine hydrochloride displaces 3HBTX from site 2 of the Na + channel (IC50=49 nM) in rat brain synaptosomes, exhibits only low binding affinity for other receptors and ion channels. Crobenetine hydrochloride protects brain tissue from the deleterious effects of focal cerebral ischemia in rodents .
    Crobenetine hydrochloride
  • HY-16923
    Crobenetine

    BIII-890; BIII-890 CL free acid

    		 Sodium Channel Neurological Disease
    Crobenetine (BIII-890), a benzomorphan derivative, is a potent, selective, and highly use-dependent Na + channel blocker. Crobenetine displaces [3H]BTX from site 2 of the Na + channel (IC50=49 nM) in rat brain synaptosomes, yet exhibits only low binding affinity for other receptors and ion channels. Crobenetine protects brain tissue from the deleterious effects of focal cerebral ischemia in rodents .
    Crobenetine
  • HY-129682
    LY125180

    		5-HT Receptor Dopamine Receptor Adrenergic Receptor Neurological Disease
    LY125180 is a serotonin uptake inhibitor. LY125180 competitively inhibits the uptake of serotonin and norepinephrine by cortical synaptosomes and of dopamine by striatal synaptosomes, with Ki values of 0.06 μM, 2.2 μM and 2.5 μM respectively .
    LY125180
  • HY-101334
    MPDC

    		GlyT Neurological Disease
    MPDC is a potent and competitive inhibitor of the Na +-dependent high-affinity glutamate transporter in forebrain synaptosomes .
    MPDC
  • HY-101334A
    MPDC hydrochloride

    		GlyT Neurological Disease
    MPDC hydrochloride is a potent and competitive inhibitor of the Na +-dependent high-affinity glutamate transporter in forebrain synaptosomes .
    MPDC hydrochloride
  • HY-101753A
    Cianopramine hydrochloride

    Cyanimipramine hydrochloride; Ro 11-2465 hydrochloride

    		 5-HT Receptor Neurological Disease
    Cianopramine hydrochloride (Cyanimipramine hydrochloride; Ro 11-2465 hydrochloride) is the hydrochloride form of Cianopramine (HY-101753). Cianopramine hydrochloride is an antidepressant, which selectively inhibits the serotonin uptake into synaptosomes .
    Cianopramine hydrochloride
  • HY-145577
    Lafadofensine

    		Monoamine Oxidase Neurological Disease
    Lafadofensine is the monoamines reuptake inhibitor. Lafadofensine has th sufficient effects after short-term administration (extracted from patent WO2006121218A1, compound 1) .
    Lafadofensine
  • HY-145577A
    Lafadofensine (D-(-)-Mandelic acid)

    		Monoamine Transporter Neurological Disease
    Lafadofensine D-(-)-Mandelic acid is the monoamines reuptake inhibitor. Lafadofensine D-(-)-Mandelic acid has sufficient effects after short-term administration .
    Lafadofensine (D-(-)-Mandelic acid)
  • HY-16934
    ML352

    		Cholinesterase (ChE) Neurological Disease
    ML352 is a noncompetitive inhibitor of the presynaptic choline transporter (CHT) with Ki values of 92 and 166 nM for HEK293 cells expressing human CHT and mouse forebrain synaptosomes, respectively .
    ML352
  • HY-B1237A
    Suloctidil hydrochloride

    		Na+/K+ ATPase Cardiovascular Disease
    Suloctidil hydrochloride hydrochloride is an active agent against on Na+/K+ ATPase activity and on membrane fluidity in rat brain synaptosomes. Suloctidil hydrochloride is currently being evaluated in many clinical trials for use in dementia and thrombotic disorders.
    Suloctidil hydrochloride
  • HY-B1237
    Suloctidil

    		Na+/K+ ATPase Cardiovascular Disease
    Suloctidil is a new drug that is currently being evaluated in many clinical trials for use in dementia and thrombotic disorders Target： Effect of suloctidil on Na+/K+ ATPase activity and on membrane fluidity in rat brain synaptosomes.
    Suloctidil
  • HY-B0696B
    Tiagabine hydrochloride hydrate

    NO050328 hydrochloride hydrate; NO328 hydrochloride hydrate; TGB hydrochloride hydrate

    		 GABA Receptor Neurological Disease
    Tiagabine hydrochloride hydrate is a potent and selective GABA uptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [ 3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively .
    Tiagabine hydrochloride hydrate
  • HY-131556
    4-Iodoamphetamine hydrochloride

    p-Iodoamphetamine hydrochloride

    		 5-HT Receptor Neurological Disease
    4-Iodoamphetamine (p-Iodoamphetamine) hydrochloride is a halogenated amphetamine featuring an iodine atom at the para position of the phenyl group. 4-Iodoamphetamine hydrochloride selectively induces serotonin release and inhibits reuptake by rat brain synaptosomes.
    4-Iodoamphetamine hydrochloride
  • HY-18610
    Diclofensine hydrochloride

    Ro 8-4650 hydrochloride

    		 Dopamine Transporter Neurological Disease
    Diclofensine hydrochloride (Ro-8-4650 hydrochloride) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.
    Diclofensine hydrochloride
  • HY-W708023
    5-APDI hydrochloride

    		5-HT Receptor Neurological Disease
    5-APDI hydrochloride is an indane with an amphetamine-like aminopropane group. 5-APDI hydrochloride inhibits the uptake of serotonin, dopamine, and norepinephrine by crude synaptosomes (IC50 values of 82 nM, 1,847 nM, and 849 nM, respectively) .
    5-APDI hydrochloride
  • HY-18610A
    Diclofensine

    Ro 8-4650

    		 Dopamine Transporter Neurological Disease
    Diclofensine(Ro-8-4650) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.
    Diclofensine
  • HY-B0696
    Tiagabine

    NO050328; NO328; TGB

    		 GABA Receptor Neurological Disease
    Tiagabine (NO050328) is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [ 3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively .
    Tiagabine
  • HY-B1287
    Citalopram hydrobromide
    Maximum Cited Publications
    7 Publications Verification

    (±)-Citalopram hydrobromide; Lu 10-171

    		 Serotonin Transporter Autophagy Neurological Disease Cancer
    Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM. Antidepressant effect .
    Citalopram hydrobromide
  • HY-158252S
    Tiagabine-d5 hydrochloride

    NO050328-d5 hydrochloride; NO328-d5 hydrochloride; TGB-d5 hydrochloride

    		 Isotope-Labeled Compounds GABA Receptor Neurological Disease
    Tiagabine-d5 (hydrochloride) is deuterium labeled Tiagabine (hydrochloride). Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [ 3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively .
    Tiagabine-d5 hydrochloride
  • HY-79635R
    Methyl indole-3-carboxylate (Standard)

    		Bacterial Infection
    Tiagabine (hydrochloride) (Standard) is the analytical standard of Tiagabine (hydrochloride). This product is intended for research and analytical applications. Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively .
    Methyl indole-3-carboxylate (Standard)
  • HY-B0696AR
    Tiagabine (hydrochloride) (Standard)

    		GABA Receptor Neurological Disease
    Tiagabine (hydrochloride) (Standard) is the analytical standard of Tiagabine (hydrochloride). This product is intended for research and analytical applications. Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively .
    Tiagabine (hydrochloride) (Standard)
  • HY-113273B
    Diadenosine pentaphosphate pentaammonium

    		Endogenous Metabolite Metabolic Disease
    Diadenosine pentaphosphate pentaammonium is an endogenous vasoactive purine dinucleotide which has been isolated from thrombocytes. Diadenosine polyphosphates (ApnA, n=2–7) have been identified as constituents of secretory vesicles such as in platelets, chromaffin cells, Torpedo synaptic terminals and brain synaptosomes .
    Diadenosine pentaphosphate pentaammonium
  • HY-113273C
    Diadenosine pentaphosphate pentalithium

    		Endogenous Metabolite Metabolic Disease
    Diadenosine pentaphosphate pentalithium is an endogenous vasoactive purine dinucleotide which has been isolated from thrombocytes. Diadenosine polyphosphates (ApnA, n=2–7) have been identified as constituents of secretory vesicles such as in platelets, chromaffin cells, Torpedo synaptic terminals and brain synaptosomes .
    Diadenosine pentaphosphate pentalithium
  • HY-B0696AS
    Tiagabine-d4 hydrochloride

    NO050328-dd4 hydrochloride; NO328-d4 hydrochloride; TGB-d4 hydrochloride

    		 GABA Receptor Isotope-Labeled Compounds Neurological Disease
    Tiagabine-d4 hydrochloride is deuterated labeled Tiagabine hydrochloride (HY-B0696A). Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [ 3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively .
    Tiagabine-d4 hydrochloride
  • HY-113273A
    Diadenosine pentaphosphate pentasodium

    		Endogenous Metabolite Metabolic Disease
    Diadenosine pentaphosphate pentasodium is an endogenous vasoactive purine dinucleotide which has been isolated from thrombocytes. Diadenosine polyphosphates (ApnA, n=2–7) have been identified as constituents of secretory vesicles such as in platelets, chromaffin cells, Torpedo synaptic terminals and brain synaptosomes .
    Diadenosine pentaphosphate pentasodium
  • HY-W008610
    GBR 12783

    		Dopamine Receptor Neurological Disease
    GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [ 3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 can improve memory performance and increase hippocampal acetylcholine release in rats .
    GBR 12783
  • HY-N6776
    Penitrem A

    		Potassium Channel Neurological Disease Cancer
    Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals .
    Penitrem A
  • HY-100968
    GBR 12783 dihydrochloride

    		Dopamine Receptor Neurological Disease
    GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [ 3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats .
    GBR 12783 dihydrochloride
  • HY-120170
    BMS-466442

    		ASCT Adrenergic Receptor Dopamine Transporter Neurological Disease
    BMS-466442 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM. BMS-466442 inhibits [ 3H] D-serine uptake into rat brain synaptosomes, with an IC50 of 400 nM. BMS-466442 can be used for schizophrenia research .
    BMS-466442
  • HY-B1287R
    Citalopram (hydrobromide) (Standard)

    (±)-Citalopram hydrobromide(Standard); Lu 10-171 (Standard)

    		 Serotonin Transporter Autophagy Neurological Disease Cancer
    Citalopram (hydrobromide) (Standard) is the analytical standard of Citalopram (hydrobromide). This product is intended for research and analytical applications. Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM. Antidepressant effect .
    Citalopram (hydrobromide) (Standard)
  • HY-B0696A
    Tiagabine hydrochloride

    NO050328 hydrochloride; NO328 hydrochloride; TGB hydrochloride

    		 GABA Receptor Trk Receptor Neurological Disease
    Tiagabine hydrochloride is an anticonvulsant agent and a selective inhibitor of the GAT-1 GABA transporter with a Ki of ∼0.1 μM. Tiagabine hydrochloride potently and selectively inhibits GABA reuptake with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in synaptosomes, neurons and glia, respectively. Tiagabine hydrochloride has neuroprotective properties .
    Tiagabine hydrochloride
  • HY-B1287S
    Citalopram-d3 hydrobromide

    (±)-Citalopram hydrobromide-d3; Lu 10-171-d3

    		 Isotope-Labeled Compounds Serotonin Transporter Autophagy Neurological Disease Cancer
    Citalopram-d3 ((±)-Citalopram-d3) hydrobromide is deuterium labeled Citalopram (hydrobromide). Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM. Antidepressant effect .
    Citalopram-d3 hydrobromide
  • HY-100838
    cis-α-(Carboxycyclopropyl)glycine

    L-CCG III

    		 EAAT Neurological Disease
    cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC50: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na +-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes .
    cis-α-(Carboxycyclopropyl)glycine
  • HY-103509
    NNC 05-2090 hydrochloride

    		GABA Receptor Neurological Disease
    NNC 05-2090 hydrochloride is a GABA uptake inhibitor and inhibitor of the β-GABA transporter (BGT-1) (IC50< /sub>: 10.6 μM). NNC 05-2090 hydrochloride also inhibits mGAT2 with a Ki value of 1.4 μM. NNC 05-2090 has anticonvulsant activity and can be used in the study of epilepsy and neurological diseases .
    NNC 05-2090 hydrochloride
  • HY-B1110
    Nomifensine
    5 Publications Verification

    (±)-Nomifensine; Nomifensin

    		 Dopamine Receptor Adrenergic Receptor Neurological Disease
    Nomifensine ((±)-Nomifensine) is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM and 830 nM, and Ki values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine shows low or ineffective binding activity to dopamine D2, α1-adrenergic, 5-HT2, and muscarinic receptors. Nomifensine has antidepressive effects .
    Nomifensine
  • HY-B1110A
    Nomifensine maleate
    5 Publications Verification

    (±)-Nomifensine maleate; Nomifensin maleate

    		 Dopamine Receptor Adrenergic Receptor Neurological Disease
    Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM and 830 nM, and Ki values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate shows low or ineffective binding activity to dopamine D2, α1-adrenergic, 5-HT2, and muscarinic receptors. Nomifensine maleate has antidepressive effects .
    Nomifensine maleate
  • HY-100769
    Hypidone hydrochloride
    1 Publications Verification

    YL0919

    		 5-HT Receptor Neurological Disease
    Hypidone hydrochloride (YL0919) is an orally active antidepressant agent with dual activity as a highly seletive 5-HT uptake blocker and an effective 5-HT1A?receptor agonist (Ki=0.19 nM). Hypidone hydrochloride inhibits the uptake of [ 3H]-5-HT into rat cerebral cortical synaptosomes and HEK293 cells with IC50s of 1.78 nM and 1.93 nM, respectively. Hypidone hydrochloride shows remarkable antidepressant effects in animal models and has the poential for the investigation of depressive disorder .
    Hypidone hydrochloride
  • HY-100928
    YS 035 hydrochloride

    		Calcium Channel Neurological Disease
    YS 035 hydrochloride is a Ca 2+ antagonist on cellular uptake and mitochondrial efflux of calcium ions. YS 035 hydrochloride inhibits Ca 2+ uptake by muscle cells and inhibits Na +/Ca 2+ exchange (Ki=28 µM). YS 035 hydrochloride is a useful tool for research on the mitochondrial Ca 2+ transport .
    YS 035 hydrochloride
  • HY-117160
    4-trans-Hydroxy-glibenclamide

    4-trans-hydroxycyclohexyl Glyburide; 4-trans-hydroxy Glibenclamide

    		 Potassium Channel Neurological Disease
    rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide (HY-15206). It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. rac-trans-4-hydroxy Glyburide inhibits glyburide binding to rat brain synaptosomes at the high and low affinity sites of SUR1/Kir6.2 with IC50 values of 0.95 and 100 nM, respectively.
    4-trans-Hydroxy-glibenclamide
  • HY-B1110S
    Nomifensine-d3 maleate

    (±)-Nomifensine-d3 maleate; Nomifensin-d3 maleate

    		 Isotope-Labeled Compounds Dopamine Receptor Adrenergic Receptor Neurological Disease
    Nomifensine-d3 ((±)-Nomifensine-d3) maleate is the deuterium labeled Nomifensine maleate (HY-B1110A). Nomifensine ((±)-Nomifensine) is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM and 830 nM, and Ki values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine shows low or ineffective binding activity to dopamine D2, α1-adrenergic, 5-HT2, and muscarinic receptors. Nomifensine has antidepressive effects .
    Nomifensine-d3 maleate
  • HY-160959
    AN317

    		nAChR Neurological Disease
    AN317 is a selective agonist for α6β2-containing nicotinic acetylcholine receptor (nAChR) with Ki of 6.2 nM and 4.1 nM, for α6/α3β2β3 receptor and α4β2 receptor, respectively. AN317 induces dopamine release in the synaptosomes of the rat striatum, enhances dopaminergic neuronal activity in substantia nigra, and exhibits protective efficacy to rat neurons against dopamine neurotoxin MPP +. AN317 exhibits good pharmacokinetic characteristics in rats. AN317 penetrates the blood-brain barrier (BB) .
    AN317

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: