Search Result

Results for "

temperatures

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) ADC Linker (4) Adrenergic Receptor (1) Antibiotic (2) Apoptosis (4) Aryl Hydrocarbon Receptor (1) Autophagy (1) Bacterial (10) Biochemical Assay Reagents (30) Bombesin Receptor (1) Calcium Channel (2) Caspase (2) CFTR (1) DNA/RNA Synthesis (2) Drug Derivative (1) Drug Intermediate (1) Drug Isomer (3) Drug Metabolite (6) Endogenous Metabolite (16) Fatty Acid Synthase (FASN) (1) Fluorescent Dye (17) G-quadruplex (1) HCV (1) HIV (1) HSP (1) Isotope-Labeled Compounds (7) JAK (2) Microtubule/Tubulin (1) MMP (1) NF-κB (2) Parasite (1) PARP (3) Phosphodiesterase (PDE) (2) PI3K (2) Potassium Channel (1) Prostaglandin Receptor (1) PSMA (1) Radionuclide-Drug Conjugates (RDCs) (1) Ser/Thr Protease (5) Telomerase (1) TRP Channel (3)
By Research Areas:	Cancer (10) Cardiovascular Disease (3) Endocrinology (1) Infection (12) Inflammation/Immunology (7) Metabolic Disease (8) Neurological Disease (11)
Click Chemistry:	TCO (1) Azide (1) Tetrazine (3) Alkynes (2)

118

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136171

Antidepressant agent 1	Drug Derivative	Neurological Disease
Antidepressant agent 1 is a pyrazidole-halogeno-derivative with antidepressant effects. Antidepressant agent 1 also can be used to increase body temperature .

HY-156262

DEPC-Treated Water	Biochemical Assay Reagents	Others
DEPC-Treated Water is ultrapure water that has been sterilized by high temperature and high pressure and does not contain nuclease. It can avoid contamination by non-specific endonucleases and exonucleases and does not affect RNase activity .

HY-144820

JO146	Ser/Thr Protease	Infection
JO146 is a Chlamydia trachomatis high temperature requirement A (CtHtrA) protease inhibitor with IC₅₀s of 21.86 and 1.15 μM for CtHtrA and human neutrophil elastase (HNE), respectively. JO146 can be used to inhibits bacterial infections .

HY-144867

CCT245232	HSP	Cancer
CCT245232 is a potent inhibitor of heat shock factor 1 (HSF1). HSF1 is the master regulator of the heat shock response, in which multiple genes are induced in response to temperature increase and other stresses. CCT245232 has the potential for the research of proliferative diseases, such as cancer (extracted from patent WO2015049535A1) .

HY-135555

5-Carboxamidotryptamine 5-CT	5-HT Receptor	Neurological Disease
5-Carboxamidotryptamine (5-CT) is a 5-HT_1A, 5-HT_1B, 5-HT_1D, 5-HT_5A, 5-HT₇ receptor agonist . 5-Carboxamidotryptamine has a K_i value of 4.6 nM for cloned human 5-HT_5A receptor. 5-Carboxamidotryptamine causes a dose-dependent reduction in rectal temperature of mice .

HY-E70124B

Esterase, Bacillus stearothermophilus	Biochemical Assay Reagents	Metabolic Disease
Esterase, Bacillus stearothermophilus is a carboxylate hydrolase. Esterase, Bacillus stearothermophilus has a higher temperature stability .

HY-12547

Betonicine Achilleine	Bacterial	Infection
Betonicine (Achilleine), an alkaloid, has cell protectant activity. Betonicine protects Bacillus subtilis against extremes in osmolarity and growth temperatures .

HY-D0015A

Cresol Red sodium	Fluorescent Dye	Others
Cresol Red sodium is a triarylmethane dye. Cresol Red sodium can be used for indicating pH, temperatures and salinities .

HY-147181

1,3-Di-(2-pyrenyl)propane	Fluorescent Dye	Others
1,3-Di-(2-pyrenyl)propane is a fluorescent indicator. 1,3-Di-(2-pyrenyl)propane can be used in fluidity of bacterial membrane lipids monitored by intramolecular excimerization. 1,3-Di-(2-pyrenyl)propane shows temperature dependence of fluorescence lifetime distributions .

HY-D1545

Violamine R Acid Violet 9	Fluorescent Dye	Others
Violamine R (Acid Violet 9) is a potent fluorophore. Violamine R shows environment and temperature-dependent photoluminescence (PL) intermittency in poly(vinyl alcohol) (PVOH) and potassium acid phthalate (KAP). Violamine R can be used to measure the temperatures spanning the glass-transition temperature (Tg) of the polymer host by the fluorescence intermittency or blinking in poly(vinyl alcohol) (PVA) .

HY-D0267

Quinaldine red	Fluorescent Dye	Others
Quinaldine red is a fluorescent probe for determining the melting temperature (Tm) of proteins .

HY-E70400

Thermostable T7 RNA Polymerase	DNA/RNA Synthesis	Others
Thermostable T7 RNA Polymerase is a thermostable version of T7 RNA Polymerase (HY-E70090). Compared with T7 RNA Polymerase, it has high temperature resistance and stable activity. T7 RNA polymerase is a polymerase expressed by Escherichia coli from the RNA polymerase gene of T7 bacteriophage. T7 RNA polymerase is highly specific and involved in in vitro transcription (IVT) of mRNA. In the presence of Mg ²⁺, T7 RNA polymerase only uses the single-stranded or double-stranded DNA containing the T7 promoter sequence as a template, and uses NTP as a substrate to synthesize RNA complementary to the single-stranded DNA downstream of the promoter .

HY-N6600

Octadecane	Biochemical Assay Reagents	Others
Octadecane is an alkane that is used to store thermal energy at ambient temperature as a phase change material .

HY-104061

AMG8788	TRP Channel	Others
AMG8788 is a potent, selective, orally active antagonist of TRPM8 with an IC₅₀ of 63.2 nM .

HY-104062

AMG9678	TRP Channel	Others
AMG9678 is a potent, selective, orally active antagonist of TRPM8 with an IC₅₀ of 31.2 nM .

HY-D1422

ER Thermo Yellow BDNCA-346	Fluorescent Dye
ER Thermo Yellow is an endoplasmic reticulum-targeted temperature-visible fluorescent probe with high sensitivity (3.9%/°C).

HY-W088074A

Chromium(III)oxide, 99.9% trace metals basis	Biochemical Assay Reagents	Others
Chromium(III)oxide, 99.9% trace metals basis is an important refractory material with its high melting point temperature and oxidation resistance .

HY-125678

Jasmine lactone	Others	Others
Jasmine lactone, a volatile substance produced by plants under stress, has a strong odor and is known for its unique jasmine-like floral and fruity scent which is very popular in tea, especially in oolong and black tea. The biosynthesis mechanism of Jasmine lactone in tea is regulated by various stresses, including mechanical damage and low temperature stress. Continuous mechanical damage and low temperature and mechanical damage can enhance the accumulation of Jasmine lactone in tea .

HY-W012954B

TMA chloride, for molecular biology, 99%(T) Tetramethylammonium chloride, for molecular biology, 99%(T)	Biochemical Assay Reagents	Others
TMA chloride, for molecular biology, 99%(T) (Tetramethylammonium chloride, for molecular biology, 99%(T)) can increase the specificity of hybridization and raise the DNA denaturation temperature in PCR.

HY-D1005A24

Poloxamer 402 (L122) PEG-PPG-PEG, 5000 (Average)	Biochemical Assay Reagents	Others
Poloxamer 402 L122 (PEG-PPG-PEG, 5000 Averag) is a synthetic triblock copolymer of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO). Poloxamer 402 L122 forms thermoreversible gel, which remains fluid at room temperature but becomes more viscous gel at body temperature. Poloxamer 402 L122 is utilized in drug delivery, tissue regeneration and generation of micellar system .

HY-165037

1,2-Dimyristoyl-3-eicosapentaenoyl-rac-glycerol MME; 1,2-Myristin-3-eicosapentaenoin; 14:0/14:0/20:5-TG	Drug Isomer	Others
1,2-Dimyristoyl-3-eicosapentaenoyl-rac-glycerol (MME) is a compound that is studied as a triglyceride isomer in algae, and its isomer ratio changes with culture temperature.

HY-128476

Sodium Tartrate	Biochemical Assay Reagents	Others
Sodium Tartrate is a pH-Regulating agent with antioxidant activity. Sodium Tartrate is particularly effective retarding hydrolysis while heating at high temperatures, resulting in increase of acid values (AVs) of vegetable oils .

HY-Y0842B

Formamide (deionizde) Methanamide (deionizde); Formimidic acid (deionizde)	Biochemical Assay Reagents	Others
Formamide (deionizde) is a clear liquid amide derived from formic acid. Formamide (deionizde) allows for the denaturation and renaturation of nucleic acids at room temperature, ranging from 15-50% .

HY-N6600S

Octadecane-d38	Isotope-Labeled Compounds	Others
Octadecane-d₃₈ is the deuterium labeled Octadecane[1]. Octadecane is an alkane that is used to store thermal energy at ambient temperature as a phase change material[2].

HY-W099535

Lithium dodecyl sulfate	Biochemical Assay Reagents	Others
Lithium dodecyl sulfate is an anionic detergent and surfactant that can be used in place of SDS for electrophoresis under low temperatures. Lithium dodecyl sulfate can be used for synthesis of nanomaterials and chromatography .

HY-119936

GLPG2451	CFTR Autophagy	Inflammation/Immunology
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC₅₀ of 11.1 nM .

HY-141720

4-(2,4,4-Trimethylpentan-2-yl)benzene-PEG4-OH	HCV	Others
4-(2,4,4-Trimethylpentan-2-yl)benzene-PEG4-OH, a nonionic surfactant with a low hydrophile-lypophile balance (HLB) value and dispersible in aqueous solution at room temperature, has a Krafft point above the room temperature. 4-(2,4,4-Trimethylpentan-2-yl)benzene-PEG4-OH has the potential for the research of the hepatitis C virus (HCV) .

HY-W888515

mPEG-PCL	Biochemical Assay Reagents	Others
mPEG-PCL is a biodegradable, biocompatible, and semi-crystalline copolymer having a very low glass transition temperature. mPEG-PCL can be used as synthetic material for biomedical and drug delivery .

HY-E70380

Endopeptidase, arctic marine microbial ArcticZymes Proteinase	Biochemical Assay Reagents	Others
Endopeptidase, arctic marine microbial (ArcticZymes Proteinase), a proteinase, is used for the digestion of chromatin, thus releasing naked DNA. As it is thermolable, it can be inactivated at temperatures compatible with RNA integrity and DNA as double strands .

HY-N4072

6''-O-Acetylglycitin 2 Publications Verification	Others	Metabolic Disease
6''-O-Acetylglycitin, a acetyl glucoside, is one of the isoflavone isomer in soybeans, shows various extents of content reduction dependent on storage temperature, packaging condition, and its isoflavone isomer kind .

HY-W048502

8-Mercaptoadenosine 8-Thioadenosine	Drug Intermediate	Others
8-Mercaptoadenosine is a nucleoside derivative that can be synthesized in DMF-aqueous solution at room temperature using NaSH via the corresponding 8-bromo compounds, and it is an intermediate in the synthesis of the substrate for RNA pyrophosphorylase .

HY-W010929

PYR14-TFSI	Biochemical Assay Reagents	Others
PYR14-TFSI is a room temperature ionic liquid (RTIL) with a wide electrochemical window (5.5V) and a high viscosity, making it a useful candidate for electrochemical energy applications .

HY-B2220B

Thermostable cellulase (recombinant)	Endogenous Metabolite	Others
Thermostable cellulase (recombinant) is a heat-stable cellulose enzyme expressed in hyperthermophilic bacteria. Thermostable cellulase (recombinant) can hydrolyze cellulose biomass into fermentable sugars at high temperatures, which can be used for biofuel production .

HY-P99629

Galegenimab FHTR 2163; RG 6147; RO 7171009	Ser/Thr Protease	Neurological Disease
Galegenimab (FHTR 2163; RG 6147; RO 7171009), an anti-High-temperature requirement A1 (HTRA1) antibody fragment. Galegenimab can be used for age-related macular degeneration (AMD) research .

HY-W040263

TAPS sodium TAPS Na	Biochemical Assay Reagents	Others
TAPS sodium is a biological buffer that protects the structural integrity of lysozyme bacteria and prevents them from thermal denaturation at high temperatures. A pKa of 8.1 for TAPS results in half-maximal connexin channel activity .

HY-131545

Parogrelil NT-702 free base; NT-702 free base	Phosphodiesterase (PDE)	Others
Parogrelil (NT-702 free base) is a compound with intermittent claudication inhibitory activity that inhibits PDE3, inhibits platelet aggregation and vasoconstriction, and improves walking distance and plantar surface temperature in a rat experimental model.

HY-150137

Iomeprol	Biochemical Assay Reagents	Others
Iomeprol is a nonionic X-ray contrast agent with low osmotic pressure, stable chemical properties, and can withstand high temperature sterilization. Iomeprol can be widely used in vascular, body cavity, and gastrointestinal angiography examinations .

HY-D1144

Acid blue 260	Fluorescent Dye
Acid blue 260 is an azo dye whose staining effect is effectively removed by multi-walled carbon nanotubes (MWCNTs). At 298 K, the adsorption capacity of MWCNT is 233.34 mg/g; and increases with the increase of dye concentration and temperature.

HY-W105731

1,10-Diiododecane Decamethylene diiodide	Endogenous Metabolite	Others
1,10-Diiododecane (Decamethylene diiodide) serves as a crosslinking reagent for tetrabutylammonium polygalacturonic acid and acts as an alkylating agent in the synthesis of both symmetrical and unsymmetrical bis-cryptophanes, in addition to being utilized for the production of decane at a temperature of 20°C.

HY-120396

LY 293284	5-HT Receptor	Neurological Disease
LY 293284 is a potent and selective 5-HT1A receptor agonist. LY 293284 results in a significant drop in core temperature and consumes more food in cholestasis rat induced by bile duct resection .

HY-150754

FtsZ-IN-4	Bacterial	Infection
FtsZ-IN-4 is an orally active FtsZ (*filamenting temperature-sensitive mutant Z*) inhibitor, exhibits excellent antibacterial activity. FtsZ-IN-4 shows good pharmaceutical properties with low cytotoxicity (CC₅₀ >20 μg/mL) .

HY-W015003

9-Ethylcarbazole N-Ethylcarbazole	Biochemical Assay Reagents	Others
9-Ethylcarbazole (N-Ethylcarbazole) serves as a hydrogen storage material. The introduction of nitrogen (N) into 9-ethylcarbazole can reduce the endothermic nature of the reaction and decrease the dehydrogenation temperature, thereby facilitating the process of hydrogen storage and release .

HY-D0877

TAPS	Biochemical Assay Reagents	Others
TAPS is a biological buffer, remain lysozyme native structure intact and prevents thermal denaturation against high temperatures. TAPS exhibits pK_a value of 8.1, while the half-maximum values of connexin channel activity is 8.5 (pH) .

HY-P2467

Biotin-TAT (47-57)	Fluorescent Dye	Metabolic Disease
Biotin-TAT (47-57), a biotin tagged TAT, is a transactivator of transcription. Biotin-TAT (47-57) is one of the most widely used protein transduction domains (PTDs) into different primary cells is ATP- and temperature-dependent, indicating the involvement of endocytosis .

HY-125374A

Larotaxel dihydrate XRP9881 dihydrate	Microtubule/Tubulin	Cancer
Larotaxel (dihydrate) (XRP9881 (dihydrate)), a new taxane compound prepared by partial synthesis from 10-deacetyl baccatin III, is active against tumors .

HY-156301

Methyltetrazine-amido-PEG8-amine Trifluoroacetate	Biochemical Assay Reagents	Others
Methyltetrazine-amido-PEG8-amine Trifluoroacetate is a heterobifunctional linker containing a terminal methyltetrazine, which can react with TCO-containing compounds without the catalysis of Cu or elevated temperatures, and terminal amine, which reacts with NHS ester specifically and efficiently. The PEG spacer enhances water solubility.

HY-U00049A

Mioflazine (di(hydrochloride) hydrate)	Calcium Channel	Cardiovascular Disease Neurological Disease
Mioflazine dihydrochloride hydrate is a nucleoside transport inhibitor with sleep-improving activity. Mioflazine dihydrochloride hydrate helps maintain the mechanical function of the left ventricle and significantly improves the heart's recovery ability after global ischemia at new temperatures. Mioflazine dihydrochloride hydrate reduces the mitochondrial calcium content in guinea-pig .

HY-157808

Antibacterial agent 185	Bacterial	Infection
Antibacterial agent 185 (compound IP-01) is a potent antibacterial agent. Antibacterial agent 185 inhibits filamentous temperature-sensitive mutant Z (FtsZ) polymerization and bundling by increasing GTP hydrolysis. Antibacterial agent 185 inhibits Streptococcus pneumoniae and shows narrow-spectrum activity .

HY-W795031

Arsenobetaine	Bacterial	Infection
Arsenobetaine is an organoarsenical and a compatible solute that has been found in various marine animals, such as lobsters and crabs, as well as terrestrial organisms, including earthworms and lichens. Arsenobetaine is protective against B. subtilis cell death induced by high osmolarity or extreme temperatures when used at a concentration of 1 mM .

HY-111219

Parogrelil hydrochloride NM-702; NT-702	Phosphodiesterase (PDE)	Others
Parogrelil (hydrochloride) (NM-702) is a phosphodiesterase inhibitor with activity in inhibiting intermittent claudication. Parogrelil (hydrochloride) selectively inhibits PDE3, inhibits human platelet aggregation in vitro and rat aortic contraction, and improves walking distance and plantar surface temperature in the rat femoral artery ligation model, with better effects than cilostazol.

Cat. No.	Product Name

HY-L022M

FDA-Approved Drug Library Mini

3,097 compounds

New drug development is a time-consuming and high-cost process. Drug repurposing (also called drug repositioning, reprofiling or re‑tasking) offers various advantages over developing an entirely new drug for a given indication. First, the risk of failure is lower. Second, the time frame for drug development can be reduced. Third, less investment is needed. Approved drugs have identified bioactivities, good pharmacokinetic characteristics and safety which are suitable for drug repurposing.

MCE owns a unique collection of 3,097 approved compounds which have been completed extensive preclinical and clinical studies and have well-characterized bioactivities, safety and bioavailability properties. The package of this library is 96-well microplate with peelable foil seal, which makes the screening process easier and faster.

HY-L166

Ion Channel Compound Library

1,371 compounds

Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important.

MCE designs a unique collection of 1,371 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Cat. No.	Product Name	Type

HY-D1422

ER Thermo Yellow BDNCA-346	Fluorescent Dyes/Probes
ER Thermo Yellow is an endoplasmic reticulum-targeted temperature-visible fluorescent probe with high sensitivity (3.9%/°C).

HY-128692

Lucifer Yellow CH dilithium salt

1 Publications Verification

Fluorescent Dyes/Probes

Lucifer Yellow CH dilithium salt is a high-intensity fluorescent probe containing free hydrazyl groups. Lucifer Yellow CH can react with fatty aldehydes at room temperature. Lucifer Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Lucifer yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .

HY-W127715

Lucifer Yellow CH dipotassium salt

1 Publications Verification

Fluorescent Dyes/Probes

Lucifer Yellow CH dipotassium is a high-intensity fluorescent probe containing free hydrazyl groups. Lucifer Yellow CH can react with fatty aldehydes at room temperature. Lucifer Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Lucifer yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .

HY-D0015A

Cresol Red sodium	Dyes
Cresol Red sodium is a triarylmethane dye. Cresol Red sodium can be used for indicating pH, temperatures and salinities .

HY-D1545

Violamine R

Acid Violet 9

Dyes

Violamine R (Acid Violet 9) is a potent fluorophore. Violamine R shows environment and temperature-dependent photoluminescence (PL) intermittency in poly(vinyl alcohol) (PVOH) and potassium acid phthalate (KAP). Violamine R can be used to measure the temperatures spanning the glass-transition temperature (Tg) of the polymer host by the fluorescence intermittency or blinking in poly(vinyl alcohol) (PVA) .

HY-D1144

Acid blue 260	Dyes
Acid blue 260 is an azo dye whose staining effect is effectively removed by multi-walled carbon nanotubes (MWCNTs). At 298 K, the adsorption capacity of MWCNT is 233.34 mg/g; and increases with the increase of dye concentration and temperature.

HY-D2769

Oregon green 488 azide Difluorocarboxyfluorescein azide, 6-isomer	Fluorescent Dyes/Probes
Oregon green 488 azide (Difluorocarboxyfluorescein azide, 6-isomer) is a bright, green-fluorescent azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.

HY-D2744

BP Fluor 488 TCO

Fluorescent Dyes/Probes

BP Fluor 488 TCO reacts with tetrazines to produce a stable, covalent linkage, also referred to as the inverse-electron demand Diels-Alder cycloaddition reaction. This reaction is extremely fast (k > 800 M-1 s-1), selective, biocompatible, and does not require Cu-catalyst or elevated temperatures. Such excellent reaction rate constants are unparalleled by any other bioorthogonal reaction pair described to date.

HY-W800695

BP Fluor 405 DBCO

Fluorescent Dyes/Probes

BP Fluor 405 DBCO is a blue-fluorescent dye that often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. BP Fluor 405 DBCO reacts with azides via a copper-free click chemistry reaction to form a stable triazole and does not require a Cu-catalyst or elevated temperatures.

HY-W800692

BP Fluor 350 azide

Fluorescent Dyes/Probes

BP Fluor 350 Azide is a blue-fluorescent, azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures. BP Fluor 350 is a water-soluble, moderately photostable, blue-fluorescent probe optimally excited by the 350 nm laser line. It is routinely used for generation of stable signal in imaging and flow cytometry. The brightness and photostability of blue dyes are best suited to direct imaging of high-abundance targets.

HY-W800699

BP Fluor 430 DBCO

Fluorescent Dyes/Probes

BP Fluor 430 DBCO reacts with azides via a copper-free click chemistry reaction to form a stable triazole and does not require a Cu-catalyst or elevated temperatures. In applications where the presence of copper is a concern, BP Fluor 430 DBCO is an ideal alternative to copper requiring fluorescent alkynes. BP Fluor 430 is a bright, photostable, green-fluorescent probe optimally excited near its absorption maximum at 432 nm. Its emission peak at 539 nm is pH independent over a wide pH range. BP Fluor DBCO reagent is not suitable for staining intracellular components of fixed and permeabilized cells due to high backgrounds.

HY-W800696

BP Fluor 430 azide

Fluorescent Dyes/Probes

BP Fluor 430 Azide is a water-soluble, green-fluorescent, azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require a Cu-catalyst or elevated temperatures. BP Fluor 430 is a bright, photostable, green-fluorescent probe with excitation near its absorption maximum at 432 nm and emission maximum at 539 nm. This probe is water soluble and pH-insensitive from pH 4 to pH 10. A next generation probe, BP Fluor 430 Picolyl Azide, is also available for detection of low abundance alkyne-tagged biomolecules.

HY-W800702

BP Fluor 555 azide

Fluorescent Dyes/Probes

BP Fluor 555 Azide is a water-soluble, bright orange-fluorescent dye with excitation ideally suited for the 532 nm or 555 nm laser lines and visualized with TRITC (tetramethylrhodamine) filter sets. BP Fluor 555 conjugates of antibodies, peptides, and proteins are pH insensitive from pH 4 to pH 10. AF 555 conjugates ideally suited for detection of low abundance targets. BP Fluor 555 Azide can be reacted with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures. The brightness and photostability of this dye are best suited to direct imaging of low-abundance targets.

HY-W800701

BP Fluor 546 DBCO

Fluorescent Dyes/Probes

BP Fluor 546 DBCO is an azide-reactive probe that can be used for imaging azide-tagged biomolecules via a copper-free click reaction. The DBCO moiety reacts with azides to form a stable triazole and does not require a Cu-catalyst or elevated temperatures. In applications where the presence of copper is a concern, BP Fluor 546 DBCO is an ideal alternative to copper-requiring fluorescent alkynes. BP Fluor 546 is a water-soluble, pH-insensitive (from pH 4-10), orange-fluorescent dye with absorption and emission maxima at 554 and 570 nm, respectively. It can be used with the 488 nm and 532 nm laser lines. BP Fluor 546 dye conjugates to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, which are often used for generating stable signals in imaging and flow cytometry.

Cat. No.	Product Name	Type

HY-156262

DEPC-Treated Water	Gene Sequencing and Synthesis
DEPC-Treated Water is ultrapure water that has been sterilized by high temperature and high pressure and does not contain nuclease. It can avoid contamination by non-specific endonucleases and exonucleases and does not affect RNase activity .

HY-D0267

Quinaldine red	Indicators
Quinaldine red is a fluorescent probe for determining the melting temperature (Tm) of proteins .

HY-W088074A

Chromium(III)oxide, 99.9% trace metals basis	Cell Assay Reagents
Chromium(III)oxide, 99.9% trace metals basis is an important refractory material with its high melting point temperature and oxidation resistance .

HY-Y0842B

Formamide (deionizde) Methanamide (deionizde); Formimidic acid (deionizde)	Co-solvents
Formamide (deionizde) is a clear liquid amide derived from formic acid. Formamide (deionizde) allows for the denaturation and renaturation of nucleic acids at room temperature, ranging from 15-50% .

HY-W099535

Lithium dodecyl sulfate	Biochemical Assay Reagents
Lithium dodecyl sulfate is an anionic detergent and surfactant that can be used in place of SDS for electrophoresis under low temperatures. Lithium dodecyl sulfate can be used for synthesis of nanomaterials and chromatography .

HY-W010929

PYR14-TFSI	Biochemical Assay Reagents
PYR14-TFSI is a room temperature ionic liquid (RTIL) with a wide electrochemical window (5.5V) and a high viscosity, making it a useful candidate for electrochemical energy applications .

HY-D0877

TAPS	Buffer Reagents
TAPS is a biological buffer, remain lysozyme native structure intact and prevents thermal denaturation against high temperatures. TAPS exhibits pK_a value of 8.1, while the half-maximum values of connexin channel activity is 8.5 (pH) .

HY-W012954B

TMA chloride, for molecular biology, 99%(T) Tetramethylammonium chloride, for molecular biology, 99%(T)	Surfactants
TMA chloride, for molecular biology, 99%(T) (Tetramethylammonium chloride, for molecular biology, 99%(T)) can increase the specificity of hybridization and raise the DNA denaturation temperature in PCR.

HY-D1005A24

Poloxamer 402 (L122)

PEG-PPG-PEG, 5000 (Average)

Co-solvents

Poloxamer 402 L122 (PEG-PPG-PEG, 5000 Averag) is a synthetic triblock copolymer of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO). Poloxamer 402 L122 forms thermoreversible gel, which remains fluid at room temperature but becomes more viscous gel at body temperature. Poloxamer 402 L122 is utilized in drug delivery, tissue regeneration and generation of micellar system .

HY-W040263

TAPS sodium TAPS Na	Buffer Reagents
TAPS sodium is a biological buffer that protects the structural integrity of lysozyme bacteria and prevents them from thermal denaturation at high temperatures. A pKa of 8.1 for TAPS results in half-maximal connexin channel activity .

HY-W011060

Cryptand 2.2.2 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane	Biochemical Assay Reagents
Cryptand 2.2.2 is a metal ion chelator that can be used as a reducing agent and stabilizer to prepare nanoparticles. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn ²⁺, Co ²⁺, Ni ²⁺, Cu ²⁺) .

HY-W011060R

Cryptand 2.2.2 (Standard)

Biochemical Assay Reagents

Cryptand 2.2.2 (Standard) is the analytical standard of Cryptand 2.2.2. This product is intended for research and analytical applications. Cryptand 2.2.2 is a metal ion chelator that can be used as a reducing agent and stabilizer to prepare nanoparticles. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn2+, Co2+, Ni2+, Cu2+) .

HY-W001952

6-Bromo-2-naphthol

Biochemical Assay Reagents

6-Bromo-2-naphthol is an RTP (real-time polymerase chain reaction) probe capable of real-time monitoring of PCR reactions and quantification of specific nucleic acid sequences. 6-Bromo-2-naphthol phosphoresces at room temperature. RTP probes are a type of small DNA or RNA sequence labeled with fluorescent dyes and quencher molecules and can be widely used for gene expression analysis, SNP genotyping and pathogen detection .

HY-W250146

Locust bean gum, from Ceratonia siliqua seeds

Locust bean gum, Polysaccharide>75%, 5000-6500 mPa·S

Biochemical Assay Reagents

Locust bean gum is a natural polysaccharide derived from the seeds of the carob tree. It is commonly used as a thickening, stabilizing and gelling agent in a variety of foods, including dairy, baked goods and meat products. Locust bean gum has several properties suitable for these applications, including high water retention capacity, ability to form stable gels at low temperatures, and resistance to acidic conditions. Additionally, it can be used as a dietary fiber supplement due to its potential health benefits, including improving digestion and lowering cholesterol levels.

HY-W782399

CORM-A1

Sodium boranocarbonate

Biochemical Assay Reagents

CORM-A1 (Sodium boranocarbonate) is a water-soluble carbon monoxide (CO) releasing molecule that facilitates the investigation of CO's impact on cellular systems. As CO is generated from heme degradation by the enzyme heme oxygenase, it serves as a crucial gaseous signaling mediator in mammalian cells. CORM-A1 not only exhibits anti-oxidant and anti-inflammatory properties but also regulates CO release in a manner dependent on pH and temperature, promoting mild vasorelaxation and hypotension. Furthermore, CORM-A1 has been shown to provide cytoprotection in primary cultures of astrocytes under oxidative stress while also enhancing autophagy due to its boron-containing composition.

Cat. No.	Product Name	Target	Research Area

HY-P2467

Biotin-TAT (47-57)	Fluorescent Dye	Metabolic Disease
Biotin-TAT (47-57), a biotin tagged TAT, is a transactivator of transcription. Biotin-TAT (47-57) is one of the most widely used protein transduction domains (PTDs) into different primary cells is ATP- and temperature-dependent, indicating the involvement of endocytosis .

HY-P10267

Neuromedin (B-30)	Bombesin Receptor	Neurological Disease Inflammation/Immunology
Neuromedin B-30 is the neuropeptide, which is orignally isolated from porcine brain and spinal cord. , and may exhibit activity in stimulating smooth-muscle. Neuromedin B causes local vasodilation, increases vascular permeability and local hyperalgesia, thereby participating in neurogenic inflammation. Neuromedin B regulates appetite, body temperature, and behavioral responses to stress. Neuromedin B is also involved in regulating smooth muscle contraction and secretory function in the gastrointestinal tract .

Cat. No.	Product Name

HY-E0224

0.5 mL Storage Tube

0.5 mL Storage Tube, Three-Code Tube, External Thread with Screw Cap, Compatible with SBS- 96-Well Racks. This product is made from high-quality PP material, suitable for ultra-low temperature storage, with excellent weather resistance. Free from DNase and RNase, and can be sterilized by irradiation. The bottom of the tube features a unique QR code, while the side wall has a 1D linear barcode and directly readable numeric code, all three codes are identical and unique. The codes are laser-etched, scratch-resistant, not easy to fall off, and have high contrast for easy reading. The accompanying tube rack (HY-E0225) is made of the same material as the tube, effectively preventing uneven expansion issues during freeze-thaw cycles.

Cat. No.	Product Name	Target	Research Area

HY-P99629

Galegenimab FHTR 2163; RG 6147; RO 7171009	Ser/Thr Protease	Neurological Disease
Galegenimab (FHTR 2163; RG 6147; RO 7171009), an anti-High-temperature requirement A1 (HTRA1) antibody fragment. Galegenimab can be used for age-related macular degeneration (AMD) research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4072

6''-O-Acetylglycitin 2 Publications Verification	Monophenols Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Phenols Metabolic Disease Plants Disease Research Fields Isoflavones	Others
6''-O-Acetylglycitin, a acetyl glucoside, is one of the isoflavone isomer in soybeans, shows various extents of content reduction dependent on storage temperature, packaging condition, and its isoflavone isomer kind .

HY-Z0283

Benzamide Benzenecarboxamide; Phenylamide	Structural Classification Alkaloids Human Gut Microbiota Metabolites Classification of Application Fields Other Alkaloids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite PARP
Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .

HY-W010155

Tryptophol Indole-3-ethanol	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis Caspase Bacterial
Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces Apoptosis and cleavage of caspase-8. Tryptophol inhibits *Cunninghamella blakesleeana* biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy .

HY-N1964

Gibberellic acid 1 Publications Verification Gibberellin A3	Structural Classification Microorganisms Classification of Application Fields Gibberellins Rutaceae Other Diseases Plants Phytohormone Disease Research Fields Citrus reticulata Blanco Agricultural Research	Others
Gibberellic Acid is named after the fungus Gibberella fujikuroi. Gibberellic Acid regulates processes in plant development and growth, including seed development and germination, stem and root growth, cell division, and flowering time. Gibberellic Acid also improves plant response to growth stress caused by various environmental stresses, such as cold stress, drought stress, heavy metal stress, etc. Gibberellic Acid also causes increased lipid peroxidation and fluctuations in the antioxidant defense system in rats .

HY-12547

Betonicine Achilleine	Structural Classification Alkaloids Labiatae Source classification Pyridine Alkaloids Plants Petroselinum crispum (Mill.) Fuss	Bacterial
Betonicine (Achilleine), an alkaloid, has cell protectant activity. Betonicine protects Bacillus subtilis against extremes in osmolarity and growth temperatures .

HY-125678

Jasmine lactone	Structural Classification Natural Products Oleaceae Ketones, Aldehydes, Acids Source classification Jasminum sambac (L.) Aiton Plants	Others
Jasmine lactone, a volatile substance produced by plants under stress, has a strong odor and is known for its unique jasmine-like floral and fruity scent which is very popular in tea, especially in oolong and black tea. The biosynthesis mechanism of Jasmine lactone in tea is regulated by various stresses, including mechanical damage and low temperature stress. Continuous mechanical damage and low temperature and mechanical damage can enhance the accumulation of Jasmine lactone in tea .

HY-N1369R

Menthol (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Labiatae Source classification Erythrina poeppigiana Plants Endogenous metabolite	Calcium Channel
Menthol (Standard) is the analytical standard of Menthol. This product is intended for research and analytical applications. Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

HY-Z0283R

Benzamide (Standard)	Structural Classification Alkaloids Human Gut Microbiota Metabolites Other Alkaloids Source classification Endogenous metabolite	Endogenous Metabolite PARP
Benzamide (Standard) is the analytical standard of Benzamide. This product is intended for research and analytical applications. Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .

HY-N1964R

Gibberellic acid (Standard) Gibberellin A3 (Standard)	Structural Classification Microorganisms Classification of Application Fields Gibberellins Source classification Rutaceae Other Diseases Plants Phytohormone Disease Research Fields Citrus reticulata Blanco Agricultural Research	Others
Gibberellic acid (Standard) is the analytical standard of Gibberellic acid. This product is intended for research and analytical applications. Gibberellic Acid is named after the fungus Gibberella fujikuroi. Gibberellic Acid regulates processes in plant development and growth, including seed development and germination, stem and root growth, cell division, and flowering time. Gibberellic Acid also improves plant response to growth stress caused by various environmental stresses, such as cold stress, drought stress, heavy metal stress, etc. Gibberellic Acid also causes increased lipid peroxidation and fluctuations in the antioxidant defense system in rats .

HY-W010155R

Tryptophol (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite Apoptosis Caspase Bacterial
Tryptophol (Standard) is an analytical standard for Tryptophol. This product is intended for use in research and analytical applications.Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces Apoptosis and cleavage of caspase-8. Tryptophol inhibits *Cunninghamella blakesleeana* biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy .

HY-N2515

Ginsenoside Rk1 Maximum Cited Publications 6 Publications Verification	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	NF-κB PI3K JAK Apoptosis
Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .

HY-B2132

Tryptamine 1 Publications Verification 3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine	Alkaloids Structural Classification Microorganisms Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Indole Alkaloids	Endogenous Metabolite 5-HT Receptor Aryl Hydrocarbon Receptor
Tryptamine is a selective, blood-brain-penetrating 5-HT4 receptor agonist (EC50=1-3 mM) and an endogenous ligand of the aryl hydrocarbon receptor (AHR) (Kd=10-50 nM). Tryptamine promotes intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs) and accelerates gastrointestinal motility. Tryptamine regulates Th17/Treg balance to inhibit neuroinflammation, competitively binds to 5-HT receptors to regulate central nervous system activity, and participates in temperature regulation and spinal reflex regulation as a neuromodulator. Tryptamine can be used to study intestinal motility disorders such as functional constipation, and has shown significant efficacy in multiple sclerosis models .

HY-N2515R

Ginsenoside Rk1 (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Source classification Plants Araliaceae	NF-κB PI3K JAK Apoptosis
Ginsenoside Rk1 (Standard) is the analytical standard of Ginsenoside Rk1. This product is intended for research and analytical applications. Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .

Cat. No.	Product Name	Chemical Structure

HY-133675S

Mono(5-carboxy-2-ethylpentyl) phthalate-d4

Mono(5-carboxy-2-ethylpentyl) phthalate-d₄ (MECPP-d₄) is a deuterium labeled Mono(5-carboxy-2-ethylpentyl) phthalate (HY-133675). Mono(5-carboxy-2-ethylpentyl) phthalate (MECPP) is a metabolite of Di-(2-ethylhexyl) phthalate (DEHP). Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking .

HY-133677S

Mono(2-ethyl-5-hydroxyhexyl) phthalate-d4

Mono(2-ethyl-5-hydroxyhexyl) phthalate-d₄ (MEHHP-d₄) is a deuterium labeled Mono(2-ethyl-5-hydroxyhexyl) phthalate (HY-133677). Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) is an oxidative metabolite of Di(2-ethylhexyl) phthalate (DEHP). Mono(2-ethyl-5-hydroxyhexyl) phthalate may protective sperm DNA damage. Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking .

HY-N6600S

Octadecane-d38
Octadecane-d₃₈ is the deuterium labeled Octadecane[1]. Octadecane is an alkane that is used to store thermal energy at ambient temperature as a phase change material[2].

HY-W711852

Benzamide-d5

Benzamide-d₅ (Benzenecarboxamide-d₅) is deuterium labeled Benzamide. Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .

HY-N9484S

Menthofuran-13C2

Menthofuran- ¹³C₂ is ¹³C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

HY-133676S

Mono(2-ethyl-5-oxohexyl) phthalate-d4

Mono(2-ethyl-5-oxohexyl) phthalate-d₄ is a deuterium labeled Mono(2-ethyl-5-oxohexyl) phthalate (HY-133676). Mono(2-ethyl-5-oxohexyl) phthalate is an oxidative metabolite of Di(2-ethylhexyl) phthalate (DEHP). Mono(2-ethyl-5-oxohexyl) phthalate may protective sperm DNA damage. Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking .

HY-W700491

AalphaC-15N3

AalphaC- ¹⁵N₃ (2-Amino-α-carboline- ¹⁵N₃) is ¹⁵N labeled AalphaC. AalphaC (AαC) is a potential carcinogen with carcinogenic activity. AalphaC is an important biomarker in tobacco smoke and is associated with tobacco smoke exposure. Urinary concentrations of AalphaC are significantly higher in dedicated smokers than in non-smokers, indicating its importance in monitoring tobacco exposure. AalphaC levels increase significantly with increasing serum nicotine levels, indicating its close relationship with tobacco use. In addition, consuming high-temperature cooked beef significantly increases the amount of AalphaC in urine, while consuming vegetables is associated with a decrease in AalphaC concentrations. Smoking half a pack of cigarettes is associated with a significant increase in the amount of AalphaC, which further confirms the biological activity of AalphaC and its association with dietary habits .

Cat. No.	Product Name		Classification

HY-156301

Methyltetrazine-amido-PEG8-amine Trifluoroacetate		Tetrazine
Methyltetrazine-amido-PEG8-amine Trifluoroacetate is a heterobifunctional linker containing a terminal methyltetrazine, which can react with TCO-containing compounds without the catalysis of Cu or elevated temperatures, and terminal amine, which reacts with NHS ester specifically and efficiently. The PEG spacer enhances water solubility.

HY-151691

Trisulfo-Cy3 Methyltetrazine		Tetrazine
Trisulfo-Cy3 Methyltetrazine is a click chemistry reagent containing an methyltetrazine group. Methyltetrazine-activated Cy3 probe reacts with TCO-containing compounds via an Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require Cu-catalyst or elevated temperatures .

HY-D2769

Oregon green 488 azide Difluorocarboxyfluorescein azide, 6-isomer		Azide
Oregon green 488 azide (Difluorocarboxyfluorescein azide, 6-isomer) is a bright, green-fluorescent azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.

HY-D2744

BP Fluor 488 TCO		TCO
BP Fluor 488 TCO reacts with tetrazines to produce a stable, covalent linkage, also referred to as the inverse-electron demand Diels-Alder cycloaddition reaction. This reaction is extremely fast (k > 800 M-1 s-1), selective, biocompatible, and does not require Cu-catalyst or elevated temperatures. Such excellent reaction rate constants are unparalleled by any other bioorthogonal reaction pair described to date.

HY-151837

H-L-Phe(4-NH-Poc)-OH hydrochloride		Alkynes
H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent containing an azide group. Used as a modified Phe or Tyr analogue in protein and peptide biosynthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported . H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-151824

Boc-L-Phe(4-NH-Poc)-OH		Alkynes
Boc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent containing an azide group. Used as an orthogonally protected building block in peptide synthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported . Boc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-151833

Methyltetrazine-amido-N-bis(PEG4-acid)		Tetrazine
Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent containing an azide group. Methyltetrazine-amido-N-bis(PEG4-acid) is a PEG derivative that contains a methyltetrazine group and two acid groups. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. PEG linker increases the water solubility of the compound. Reagent grade, for research use only . Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

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