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type I interferons

" in MedChemExpress (MCE) Product Catalog:

59

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3

Inhibitory Antibodies

4

Natural
Products

1

Isotope-Labeled Compounds

4

Click Chemistry

33

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-134315
    8-Nitroguanosine

    		Nucleoside Antimetabolite/Analog Others
    8-Nitroguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    8-Nitroguanosine
  • HY-152610
    3′-C-Methylguanosine

    		Nucleoside Antimetabolite/Analog Others
    3′-C-Methylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    3′-C-Methylguanosine
  • HY-152517
    8-(Methylthio)guanosine

    		Nucleoside Antimetabolite/Analog Others
    8-(Methylthio)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    8-(Methylthio)guanosine
  • HY-154332
    8-(Phenylmethoxy)guanosine

    		Nucleoside Antimetabolite/Analog Cancer
    8-(Phenylmethoxy)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    8-(Phenylmethoxy)guanosine
  • HY-152430
    8-Hydroxymethyl guanosine

    		Nucleoside Antimetabolite/Analog Cancer
    8-Hydroxymethyl guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    8-Hydroxymethyl guanosine
  • HY-137406
    1,2'-O-Dimethylguanosine

    		Nucleoside Antimetabolite/Analog Others
    1,2'-O-Dimethylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    1,2'-O-Dimethylguanosine
  • HY-154506
    N2-Phenoxyacetylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-Phenoxyacetylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-Phenoxyacetylguanosine
  • HY-152673
    9-(β-D-Xylofuranosyl)guanine

    		Nucleoside Antimetabolite/Analog Cancer
    9-(β-D-Xylofuranosyl)guanine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    9-(β-D-Xylofuranosyl)guanine
  • HY-152652
    5’(R)-C-Methylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    5’(R)-C-Methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    5’(R)-C-Methylguanosine
  • HY-154111
    8-(N-Boc-aminomethyl)guanosine

    		Nucleoside Antimetabolite/Analog Cancer
    8-(N-Boc-aminomethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    8-(N-Boc-aminomethyl)guanosine
  • HY-152742
    8-(N,N-Dimethylaminomethyl)guanosine

    		Nucleoside Antimetabolite/Analog Others
    8-(N,N-Dimethylaminomethyl)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    8-(N,N-Dimethylaminomethyl)guanosine
  • HY-152493
    3’-O-(2-Methoxyethyl)guanosine

    		Nucleoside Antimetabolite/Analog Others
    3’-O-(2-Methoxyethyl)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    3’-O-(2-Methoxyethyl)guanosine
  • HY-152991
    6-Deoxo-8-oxo-3’-deoxy-guanosine

    		Nucleoside Antimetabolite/Analog Others
    2′-Deoxy-N-(2-furanylmethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    6-Deoxo-8-oxo-3’-deoxy-guanosine
  • HY-154484
    3’-O-Me-G(iBu)-2’-phosphoramidite

    		Nucleoside Antimetabolite/Analog Cancer
    3’-O-Me-G(iBu)-2’-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    3’-O-Me-G(iBu)-2’-phosphoramidite
  • HY-154549
    3’-O-MOE-G(iBu)-2’-phosphoramidite

    		Nucleoside Antimetabolite/Analog Cancer
    3’-O-MOE-G(iBu)-2’-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    3’-O-MOE-G(iBu)-2’-phosphoramidite
  • HY-154336
    N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine
  • HY-152993
    2′-Deoxy-N-(2-furanylmethyl)guanosine

    		Nucleoside Antimetabolite/Analog Others
    2′-Deoxy-N-(2-furanylmethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    2′-Deoxy-N-(2-furanylmethyl)guanosine
  • HY-128139
    2'-C-Methylguanosine

    2'-C-beta-Methylguanosine

    		 Nucleoside Antimetabolite/Analog Others
    2'-C-Methylguanosine (2'-C-beta-Methylguanosine) is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    2'-C-Methylguanosine
  • HY-152992
    7-Cyano-7-deaza-2'-deoxy guanosine

    		Nucleoside Antimetabolite/Analog Others
    7-Cyano-7-deaza-2'-deoxy guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    7-Cyano-7-deaza-2'-deoxy guanosine
  • HY-152988
    N2-iso-Butyroyl-7'-O-DMT-morpholinoguanine

    		Nucleoside Antimetabolite/Analog Others
    N2-iso-Butyroyl-7'-O-DMT-morpholinoguanine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-iso-Butyroyl-7'-O-DMT-morpholinoguanine
  • HY-154547
    N2-iso-Butyroyl-3’-O-(methoxyethyl)guanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-iso-Butyroyl-3’-O-(methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-iso-Butyroyl-3’-O-(methoxyethyl)guanosine
  • HY-154482
    N2-iso-Butyroyl-3’-O-methylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-iso-Butyroyl-3’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-iso-Butyroyl-3’-O-methylguanosine
  • HY-154448
    3,5-Bis-O-(2,4-dichlorobenzyl)guanosine

    		Nucleoside Antimetabolite/Analog Cancer
    3,5-Bis-O-(2,4-dichlorobenzyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    3,5-Bis-O-(2,4-dichlorobenzyl)guanosine
  • HY-152797
    N4-Desmethyl-N5-Methyl wyosine

    		Nucleoside Antimetabolite/Analog Others
    N4-Desmethyl-N5-Methyl wyosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N4-Desmethyl-N5-Methyl wyosine
  • HY-152545
    N1,N2-Dimethyl-2’-O-methylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N1,N2-Dimethyl-2’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N1,N2-Dimethyl-2’-O-methylguanosine
  • HY-154606
    2'-F-2'-ara-N2-ibu-dG Phosphoramidite

    		Nucleoside Antimetabolite/Analog Cancer
    2'-F-2'-ara-N2-ibu-dG Phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    2'-F-2'-ara-N2-ibu-dG Phosphoramidite
  • HY-154350
    5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine
  • HY-W073825
    N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine
  • HY-154507
    N2-Phenoxyacetyl-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-Phenoxyacetyl-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-Phenoxyacetyl-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine
  • HY-154548
    N2-iso-Butyroyl-5’-O-DMT-3’-O-(methoxyethyl)guanosine

    		Nucleoside Antimetabolite/Analog Others
    N2-iso-Butyroyl-5’-O-DMT-3’-O-(methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-iso-Butyroyl-5’-O-DMT-3’-O-(methoxyethyl)guanosine
  • HY-152547
    N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine
  • HY-154483
    N2-iso-Butyroyl-5’-O-(4,4’-dimethoxytrityl)-3’-O-methylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-iso-Butyroyl-5’-O-(4,4’-dimethoxytrityl)-3’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-iso-Butyroyl-5’-O-(4,4’-dimethoxytrityl)-3’-O-methylguanosine
  • HY-154351
    N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite

    		Nucleoside Antimetabolite/Analog Cancer
    N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite
  • HY-154464
    N2-iso-Butyroyl-5'-O-DMT-3'-deoxy-3'-fluoroguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-iso-Butyroyl-5'-O-DMT-3'-deoxy-3'-fluoroguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
    N2-iso-Butyroyl-5'-O-DMT-3'-deoxy-3'-fluoroguanosine
  • HY-152478
    3’-β-C-Ethynylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    3’-β-C-Ethynylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . 3’-β-C-Ethynylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    3’-β-C-Ethynylguanosine
  • HY-154361
    TLR7 agonist 13

    		Nucleoside Antimetabolite/Analog Cancer
    TLR7 agonist 13 is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . TLR7 agonist 13 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    TLR7 agonist 13
  • HY-154349
    N2-iso-Butyroyl-2’-O-propargylguanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-iso-Butyroyl-2’-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . N2-iso-Butyroyl-2’-O-propargylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N2-iso-Butyroyl-2’-O-propargylguanosine
  • HY-152684
    2′-O-2-Propyn-1-ylguanosine

    		Nucleoside Antimetabolite/Analog Others
    2′-O-2-Propyn-1-ylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . 2′-O-2-Propyn-1-ylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    2′-O-2-Propyn-1-ylguanosine
  • HY-P99168
    Anifrolumab
    2 Publications Verification

    		 IFNAR Inflammation/Immunology
    Anifrolumab is a type I interferon (IFN) receptor antagonist, a human monoclonal antibody. Anifrolumab blocks the activity of type I interferon. Anifrolumab can be used in systemic lupus erythematosus (SLE) research .
    Anifrolumab
  • HY-112951
    ChX710
    2 Publications Verification

    		 STING Cancer
    ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3.
    ChX710
  • HY-W015346
    Desaminotyrosine

    3-(4-Hydroxyphenyl)propionic acid

    		 Influenza Virus Endogenous Metabolite Infection
    Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.
    Desaminotyrosine
  • HY-113469
    Cyclic GMP
    1 Publications Verification

    		 STING Endogenous Metabolite Inflammation/Immunology
    Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferon genes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators .
    Cyclic GMP
  • HY-12512
    cGAMP
    10+ Cited Publications

    Cyclic GMP-AMP; 3',3'-cGAMP

    		 STING Inflammation/Immunology
    cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .
    cGAMP
  • HY-110385
    cGAMP disodium
    10+ Cited Publications

    Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium

    		 STING Endogenous Metabolite Inflammation/Immunology
    cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .
    cGAMP disodium
  • HY-110385A
    cGAMP diammonium
    10+ Cited Publications

    Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium

    		 STING Endogenous Metabolite Inflammation/Immunology
    cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .
    cGAMP diammonium
  • HY-P99478
    Bifarcept

    		IFNAR Inflammation/Immunology
    Bifarcept is a recombinant antibody of interferon receptor type I (IFN-RI). Bifarcept can bind IFN-β and prolong its serum half-life .
    Bifarcept
  • HY-163719
    PARP7-IN-22

    		PARP Cancer
    PARP7-IN-22 (XLY-1) is a PARP7 inhibitor with an IC50 of 0.6 nM. PARP7-IN-22 (XLY-1) is orally active, enhances type I interferon signaling in vitro, restores type I interferon signaling, promotes T cell infiltration into tumor tissues, and significantly inhibits tumor growth. PARP7-IN-22 shows promise for research in the field of cancer immunotherapy .
    PARP7-IN-22
  • HY-W654000
    Cyclic GMP-13C,15N2

    Guanosine 3',5'-cyclic-13C,15N2 monophosphate

    		 Isotope-Labeled Compounds STING Endogenous Metabolite Inflammation/Immunology
    Cyclic GMP- 13C, 15N2 is 13C and 15N labeled Cyclic GMP. Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferon genes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators .
    Cyclic GMP-13C,15N2
  • HY-168219
    JMS-175-2

    		Deubiquitinase Inflammation/Immunology
    JMS-175-2 is a potent agonist of BRCC36 isopeptidase complex (BRISC), with the IC50 of 3.8 μM. JMS-175-2 plays an important role in Type I interferon-mediated diseases .
    JMS-175-2
  • HY-143321
    STING agonist-13

    		STING Cancer
    STING agonist-13 is a stimulator of interferon genes (STING) agonist, for cancer immunity via STING-mediated immune activation. STING agonist-13 can stimulate STING downstream signaling and promoting type I interferon immune responses. STING agonist-13 significantly decreases tumor volume and shows immunological memory-derived cancer inhibition .
    STING agonist-13

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