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Pathways Recommended:	Protein Tyrosine Kinase/RTK

Results for "

tyrosine hydroxylase (TH)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Biochemical Assay Reagents (1) Calcium Channel (3) Cyclic GMP-AMP Synthase (3) ERK (3) Fungal (1) GABA Receptor (1) Imidazoline Receptor (1) Monoamine Oxidase (1) nAChR (1) NF-κB (1) Nuclear Hormone Receptor 4A/NR4A (2) Opioid Receptor (1) PKA (3)
By Research Areas:	Cardiovascular Disease (3) Infection (1) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (4)

10

Inhibitors & Agonists

1

Biochemical Assay Reagents

2

Natural
Products

2

Recombinant Proteins

Targets Recommended: Tryptophan Hydroxylase Dopamine β-hydroxylase HIF/HIF Prolyl-Hydroxylase Btk Syk DYRK Pyk2 BRK FAK FLT3 Anaplastic lymphoma kinase (ALK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Nurr1 agonist 2	Nuclear Hormone Receptor 4A/NR4A	Others
Nurr1 agonist 2 (Compound 7) is a Nurr1 agonist (EC₅₀: 0.07 μM). Nurr1 agonist 2 binds to the recombinant Nurr1 ligand binding domain (LBD) with a K_d value of 0.14 μM. Nurr1 agonist 2 increases the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2) mRNA expression .

HA-1004	Cyclic GMP-AMP Synthase PKA ERK Calcium Channel	Cardiovascular Disease Metabolic Disease
HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .

Harmane 1 Publications Verification	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor	Neurological Disease Inflammation/Immunology
Harmane is an inhibitor that binds to benzodiazepine receptors (with an IC₅₀ value of 7 μM), has an IC₅₀ of 24 μM for muscarinic acetylcholine receptors (QNB), an IC₅₀ of 2.8 μM for opioid receptors, and IC₅₀ values of 163 and 101 μM for spironolactone and serotonin, respectively. Harmane is a selective monoamine oxidase inhibitor (with IC₅₀ values of 0.5 μM for MAO A and 5 μM for MAO B). Harman inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing levodopa (L-DOPA)-induced toxicity in PC12 cells. Harmane lowers blood pressure in rats through the I1 imidazoline receptor (I1 receptor) and has antidepressant, anxiolytic, anticonvulsant, and analgesic effects. Harmane enhances the mutagenicity induced by 2-acetylaminofluorene (AAF) .

14α/β-Vindeburnol 14α/β-RU 24722	Others	Neurological Disease
14α/β-Vindeburnol (14α/β-RU 24722) a synthetic molecule derived from the eburnamine-vincamine alkaloid group, has many neuropsychopharmacological and antidepressant-like effects .

p-Fluoro-L-phenylalanine 4-Fluoro-L-phenylalanine	Biochemical Assay Reagents	Others
p-Fluoro-L-phenylalanine (4-Fluoro-L-phenylalanine) is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to the L-leucine specific receptor of Escherichia coli (K_D=0.26 μM) .

L685818	Fungal	Infection Neurological Disease
L685818 is a specific immunophilin ligand. L685818 was neuroregenerative and non-neuroprotective in primary brain cultures. L685818 protects dopaminergic neurons from toxic inhibition of MPP+ and 6-OHDA, reduces tyrosine hydroxylase (TH) loss, and promotes neuronal process regeneration. L685818 is also an antifungal reagent for Cryptococcus neoformans .

Catalpalactone	NF-κB	Inflammation/Immunology
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .

HA-1004 di(hydrochloride)	Cyclic GMP-AMP Synthase PKA ERK Calcium Channel	Cardiovascular Disease Metabolic Disease
HA-1004 dihydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 dihydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 dihydrochloride is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .

HA-1004 hydrochloride	Cyclic GMP-AMP Synthase PKA ERK Calcium Channel	Cardiovascular Disease Metabolic Disease
HA-1004 hydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 hydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein (Cyclic GMP-AMP Synthase), and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 hydrochloride an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .

Nurr1 agonist 9	Nuclear Hormone Receptor 4A/NR4A	Neurological Disease
Nurr1 agonist 9 (Compound 36) is an agonist for Nurr1 with an EC₅₀ of 0.090 µM and a K_d of 0.17 µM. Nurr1 agonist 9 activates the Nurr1 homodimer (NurRE, EC₅₀=0.094 µM) and the Nurr1-RXR heterodimer (DR5, EC₅₀=0.165 µM). Nurr1 agonist 9 induces the expression of Nurr1-regulated tyrosine hydroxylase (TH) in organoid Parkinson's Disease model. Nurr1 agonist 9 is human brain endothelial cell barrier prmeable .

Cat. No.	Product Name	Type

p-Fluoro-L-phenylalanine 4-Fluoro-L-phenylalanine	Biochemical Assay Reagents
p-Fluoro-L-phenylalanine (4-Fluoro-L-phenylalanine) is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to the L-leucine specific receptor of Escherichia coli (K_D=0.26 μM) .

Cat. No.	Product Name	Category	Target	Chemical Structure

Harmane 1 Publications Verification	Alkaloids Structural Classification other families Source classification Pyridine Alkaloids Plants Indole Alkaloids	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane is an inhibitor that binds to benzodiazepine receptors (with an IC₅₀ value of 7 μM), has an IC₅₀ of 24 μM for muscarinic acetylcholine receptors (QNB), an IC₅₀ of 2.8 μM for opioid receptors, and IC₅₀ values of 163 and 101 μM for spironolactone and serotonin, respectively. Harmane is a selective monoamine oxidase inhibitor (with IC₅₀ values of 0.5 μM for MAO A and 5 μM for MAO B). Harman inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing levodopa (L-DOPA)-induced toxicity in PC12 cells. Harmane lowers blood pressure in rats through the I1 imidazoline receptor (I1 receptor) and has antidepressant, anxiolytic, anticonvulsant, and analgesic effects. Harmane enhances the mutagenicity induced by 2-acetylaminofluorene (AAF) .

Catalpalactone	Structural Classification Natural Products Catalpa ovata G. Don Source classification Plants Bignoniaceae	NF-κB
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

	Tyrosine Hydroxylase Protein, Mouse (sf9, His) DYT14; TH; TYH dystonia 14; TYH; tyrosine 3-monooxygenase	Mouse	Sf9 insect cells
	Tyrosine hydroxylase protein is a key catalyst in the biosynthesis of catecholamines, including dopamine, norepinephrine, and epinephrine, and oversees the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa) , which is the critical and rate-limiting step pathway in synthesis.Tyrosine Hydroxylase Protein, Mouse (sf9, His) is the recombinant mouse-derived Tyrosine Hydroxylase protein, expressed by Sf9 insect cells , with N-His labeled tag.

	Tyrosine Hydroxylase Protein, Human (sf9, His) DYT14; TH; TYH dystonia 14; TYH; tyrosine 3-monooxygenase	Human	Sf9 insect cells
	Tyrosine hydroxylase is a key enzyme in the biosynthesis of catecholamines, catalyzing the conversion of L-tyrosine into L-dopa, which is the rate-limiting step in the synthesis of dopamine, norepinephrine, and epinephrine. Tyrosine is hydroxylated using tetrahydrobiopterin and oxygen. Tyrosine Hydroxylase Protein, Human (sf9, His) is the recombinant human-derived Tyrosine Hydroxylase protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Tyrosine Hydroxylase Protein, Human (sf9, His) is 496 a.a., with molecular weight of ~57.6 kDa.

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