Sodium oleate (Synonyms: Oleic acid sodium; 9-cis-Octadecenoic acid sodium; 9Z-Octadecenoic acid sodium)

Name: Sodium oleate
Brand: MedChemExpress
SKU: HY-N1446B
Rating: 5.0 (40 reviews)

Cat. No.: HY-N1446B Purity: 98.27%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium. Sodium oleate is a Na⁺/K⁺ ATPase activator.

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Sodium oleate Chemical Structure

CAS No. : 143-19-1

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Based on 40 publication(s) in Google Scholar

Other Forms of Sodium oleate:

37 Publications Citing Use of MCE Sodium oleate

Proliferation Assay

Cell Viability Assay

: Sodium oleate purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2024 Aug 12;42(8):1386-1400.e8. [Abstract]; Oleic acid (50 μM; 1-4 d) significantly promotes viability in CRC cells (HCT116, HT-29, DLD-1).

: Sodium oleate purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2024 Aug 12;42(8):1386-1400.e8. [Abstract]; Oleic acid (50 μM) significantly promotes the proliferation of colorectal cancer (CRC) cells (HCT116, HT-29).

: Sodium oleate purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2024 Jan;13(1):e12401. [Abstract]; Oleic acid (500-1000 μM; 24 h) significantly inhibits the activity of ARPE-19 cells.

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Description

Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium^[1]. Sodium oleate is a Na⁺/K⁺ ATPase activator^[2].

IC₅₀ & Target

Na⁺/K⁺ ATPase^[2]

In Vitro

Oleic acid is the most common monounsaturated fatty acids (FA) in human adipocytes and other tissues. Oleic acid prompts cell proliferation and migration in high metastatic cancer cells via enhancing β-oxidation mediated by AMPK activation. Oleic acid inhibits cancer cell growth and survival in low metastatic carcinoma cells, such as gastric carcinoma SGC7901 and breast carcinoma MCF-7 cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

304.44

Formula

C₁₈H₃₃NaO₂

CAS No.

143-19-1

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCC/C=C\CCCCCCCC(O[Na])=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (82.12 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2847 mL	16.4236 mL	32.8472 mL
5 mM	0.6569 mL	3.2847 mL	6.5694 mL
10 mM	0.3285 mL	1.6424 mL	3.2847 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 9.09 mg/mL (29.86 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Purity & Documentation

Purity: 98.27%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (238 KB) RP-HPLC (245 KB)

Handling Instructions (2659 KB)

References

[1]. Li S, et al. High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner. PLoS One. 2014 May 13;9(5):e97330. [Content Brief]

[2]. Jack-Hays MG, et al. Activation of Na+/K(+)-ATPase by fatty acids, acylglycerols, and related amphiphiles: structure-activity relationship. Biochim Biophys Acta. 1996 Feb 21;1279(1):43-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.2847 mL	16.4236 mL	32.8472 mL	82.1180 mL
	5 mM	0.6569 mL	3.2847 mL	6.5694 mL	16.4236 mL
	10 mM	0.3285 mL	1.6424 mL	3.2847 mL	8.2118 mL
	15 mM	0.2190 mL	1.0949 mL	2.1898 mL	5.4745 mL
	20 mM	0.1642 mL	0.8212 mL	1.6424 mL	4.1059 mL
	25 mM	0.1314 mL	0.6569 mL	1.3139 mL	3.2847 mL
	30 mM	0.1095 mL	0.5475 mL	1.0949 mL	2.7373 mL
	40 mM	0.0821 mL	0.4106 mL	0.8212 mL	2.0529 mL
	50 mM	0.0657 mL	0.3285 mL	0.6569 mL	1.6424 mL
	60 mM	0.0547 mL	0.2737 mL	0.5475 mL	1.3686 mL
	80 mM	0.0411 mL	0.2053 mL	0.4106 mL	1.0265 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Sodium oleate Related Classifications

Keywords:

Sodium oleate143-19-1Oleic acid9-cis-Octadecenoic acid9Z-Octadecenoic acidNa+/K+ ATPaseApoptosisSodium potassium pumpmonounsaturatedATPaseInhibitorinhibitorinhibit

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Sodium oleate (Synonyms: Oleic acid sodium; 9-cis-Octadecenoic acid sodium; 9Z-Octadecenoic acid sodium)

Customer Review

Other Forms of Sodium oleate:

37 Publications Citing Use of MCE Sodium oleate

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•Related Screening Libraries:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Sodium oleate Related Classifications

Keywords:

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