2. Cell Cycle/DNA Damage Apoptosis
  3. RAD51 MDM-2/p53
  4. Solanidine

Solanidine is an orally active cholestane alkaloid. Solanidine can be isolated from potato. Solanidine decreases RAD51 and increases γH2AX and p53. Solanidine has anti-tumor effects on LLC tumors and lung cancer. Solanidine promotes breast cancer cell proliferation. Solanidine reduces neovascularization. Solanidine causes abortion in some pregnant mice.

For research use only. We do not sell to patients.

Solanidine Chemical Structure

Solanidine Chemical Structure

CAS No. : 80-78-4

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Based on 1 publication(s) in Google Scholar

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Solanidine Related Antibodies

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Description

Solanidine is an orally active cholestane alkaloid. Solanidine can be isolated from potato. Solanidine decreases RAD51 and increases γH2AX and p53. Solanidine has anti-tumor effects on LLC tumors and lung cancer. Solanidine promotes breast cancer cell proliferation. Solanidine reduces neovascularization. Solanidine causes abortion in some pregnant mice[1][2][3].

In Vitro

Solanidine (10 μM) increases the proliferation of MCF-7 human breast cancer cells in the estrogen-depleted condition[1].
Solanidine (4-8 μM; 48 h) induces DNA damage in A549 cells and reduces the migration and invasion of A549 cells under hypoxic conditions[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Solanidine Related Antibodies

Western Blot Analysis[2]

Cell Line: A549 cells
Concentration: 4 μM, 8 μM
Incubation Time: 48 h
Result: Decreased the expression of RAD51, elevated the expression of γH2AX, and increased the expression of tumor suppressor protein p53.
Inhibited the phosphorylation of ATMser1981, HIF-1αser696, and Chk2Tyr68.
In Vivo

Solanidine (2.4 mmol/kg; p.o., dietary administration; 14 days) causes hepatomegaly in non-pregnant and pregnant mice, reduces body weight gains, litter weights, and average fetus weights in pregnant mice, and leads to abortions in some pregnant mice[1].
Solanidine (4-8 μM; topical application; 7 days) reduces neovascularization in the alkali burn corneal model of rats[2].
Solanidine (10-20 mg/kg; i.p.; every other day; 6 doses) regresses LLC tumor in Balb/C female mice, reduces the number of tumor nodules, and extends the survival of animals[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss Webster mice (female, 25-36 g, timed-pregnant at 1-2 days’ gestation) pregnant mice model[1]
Dosage: 2.4 mmol/kg (in diet)
Administration: Dietary administration, 14 days
Result: Led to lower body weight gains, litter weights, and average fetus weights in pregnant mice.
Resulted in miscarriage in 5 of 24 pregnant mice.
Increased liver weight as a percentage of body weight (%LW/BW) in non-pregnant and pregnant mice.
Showed lower litter weight as a percentage of body weight (%LTW/BW).
Molecular Weight

397.64

Formula

C27H43NO
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@@]5([H])[C@H](C)[C@@]6([H])CC[C@H](C)CN6[C@]([H])5C[C@@]24[H]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 3.33 mg/mL (8.37 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5148 mL 12.5742 mL 25.1484 mL
5 mM 0.5030 mL 2.5148 mL 5.0297 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: 99.90%

SDS (557 KB)

COA (249 KB) HNMR (260 KB) RP-HPLC (237 KB) MS (80 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.5148 mL 12.5742 mL 25.1484 mL 62.8709 mL
5 mM 0.5030 mL 2.5148 mL 5.0297 mL 12.5742 mL
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Solanidine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Solanidine80-78-4RAD51MDM-2/p53cholestanealkaloidpotatospeciesSolanumdemissumacauletuberosumproliferationantitumorInhibitorinhibitorinhibit

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