Sonlicromanol hydrochloride (Synonyms: KH176 hydrochloride)

Name: Sonlicromanol hydrochloride
Brand: MedChemExpress
SKU: HY-120332
Rating: 4.5 (1 reviews)

Cat. No.: HY-120332 Purity: 99.85%: FAQs
Data Sheet SDS COA Handling Instructions

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Sonlicromanol (KH176) hydrochloride, a chemical entity derivative of Trolox, is a blood-brain barrier permeable ROS-redox modulator. Sonlicromanol (KH176) hydrochloride is used in the study for mitochondrial disorders.

For research use only. We do not sell to patients.

Sonlicromanol hydrochloride Chemical Structure

CAS No. : 2162149-24-6

Size	Price	Stock	Quantity
5 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1650	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2600	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3900	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Sonlicromanol hydrochloride:

Sonlicromanol Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vivo

Sonlicromanol (KH176) hydrochloride maintains microstructural coherence in the brain of Ndufs4^−/− mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Ndufs4^−/− mice (Leigh Disease model)^[1].
Dosage:	10 mg/kg.
Administration:	IP, daily (PD14-PD45, 32 days).
Result:	Significantly improve rotarod and gait performance and reduced the degeneration of retinal ganglion cells. Resulted in statistically significantly higher FA values in the external capsule and a similar trend was found in the cerebral peduncle.

Clinical Trial

Molecular Weight

368.90

Formula

C₁₉H₂₉ClN₂O₃

CAS No.

2162149-24-6

Appearance

Solid

Color

White to yellow

SMILES

CC1=C(C(C)=C2CC[C@@](C(N[C@@H]3CCCNC3)=O)(OC2=C1C)C)O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 170 mg/mL (460.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 100 mg/mL (271.08 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7108 mL	13.5538 mL	27.1076 mL
5 mM	0.5422 mL	2.7108 mL	5.4215 mL
10 mM	0.2711 mL	1.3554 mL	2.7108 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (13.55 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.
Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 4.25 mg/mL (11.52 mM); Clear solution

This protocol yields a clear solution of ≥ 4.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (42.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 3

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 4.25 mg/mL (11.52 mM); Clear solution

This protocol yields a clear solution of ≥ 4.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (42.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.85%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (247 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Ria de Haas, et al. Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease. Sci Rep. 2017 Sep 15;7(1):11733. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.7108 mL	13.5538 mL	27.1076 mL	67.7690 mL
	5 mM	0.5422 mL	2.7108 mL	5.4215 mL	13.5538 mL
	10 mM	0.2711 mL	1.3554 mL	2.7108 mL	6.7769 mL
	15 mM	0.1807 mL	0.9036 mL	1.8072 mL	4.5179 mL
	20 mM	0.1355 mL	0.6777 mL	1.3554 mL	3.3885 mL
	25 mM	0.1084 mL	0.5422 mL	1.0843 mL	2.7108 mL
	30 mM	0.0904 mL	0.4518 mL	0.9036 mL	2.2590 mL
	40 mM	0.0678 mL	0.3388 mL	0.6777 mL	1.6942 mL
	50 mM	0.0542 mL	0.2711 mL	0.5422 mL	1.3554 mL
	60 mM	0.0452 mL	0.2259 mL	0.4518 mL	1.1295 mL
	80 mM	0.0339 mL	0.1694 mL	0.3388 mL	0.8471 mL
	100 mM	0.0271 mL	0.1355 mL	0.2711 mL	0.6777 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Sonlicromanol hydrochloride Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sonlicromanol2162149-24-6KH176KH 176KH-176Reactive Oxygen SpeciesOXPHOSLeighdiseaseganglionmtDNAInhibitorinhibitorinhibit

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Sonlicromanol hydrochloride (Synonyms: KH176 hydrochloride)

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Complete Stock Solution Preparation Table

Sonlicromanol hydrochloride Related Classifications

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