2. Anti-infection Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK
  3. Fungal Bacterial Endogenous Metabolite Antibiotic IGF-1R
  4. Sorbic acid

Sorbic acid is an effective, safe, and non-toxic food preservative. It can effectively inhibit most molds, yeasts, and certain bacteria. Sorbic acid is orally active and can enhance the growth performance of economically important animals (Duroc × Landrace × Yorkshire piglets) by activating the insulin-like growth factor system (IGF), and it can also lead to lipid accumulation by disrupting lipid clearance pathways。

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Sorbic acid Chemical Structure

Sorbic acid Chemical Structure

CAS No. : 110-44-1

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Based on 1 publication(s) in Google Scholar

Other Forms of Sorbic acid:

Sorbic acid Related Antibodies

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Description

Sorbic acid is an effective, safe, and non-toxic food preservative. It can effectively inhibit most molds, yeasts, and certain bacteria. Sorbic acid is orally active and can enhance the growth performance of economically important animals (Duroc × Landrace × Yorkshire piglets) by activating the insulin-like growth factor system (IGF), and it can also lead to lipid accumulation by disrupting lipid clearance pathways[1][2][3][4]。

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Sorbic acid (1.0 or 3 mM, 7 days, the pH of the cytoplasm and vacuole was measured between 0 and 400 minutes) inhibits the growth activity of Aspergillus niger by inducing intracellular acidification[4]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sorbic acid Related Antibodies
In Vivo

Sorbic acid (0.5-4 g/kg, orally, once daily for 42 days) can improve the growth performance of Duroc × Landrace × Yorkshire piglets by regulating IGF (Insulin-like Growth Factor) system gene expression and hormone secretion[2].
Sorbic acid (1 g/kg, p.o., once daily for 4 weeks) disrupts lipid clearance pathways in C57BL/6 mice (including decreased de novo lipogenesis, fatty acid internalization, very low-density lipoprotein (VLDL) secretion, autophagy, and β-oxidation), leading to hepatic lipid accumulation[3]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Duroc × Landrace × Yorkshire weaned piglets (21 days old)[2]
Dosage: 0.5, 2, 4 g/kg
Administration: Oral gavage (p.o.), once daliy for 42 days
Result: Significantly increased the mRNA expression of Insulin-like Growth Factor-I (IGF-I), Insulin-like Growth Factor-II (IGF-II), Insulin-like Growth Factor-I receptor (IGF-IR), and PPARα genes, as well as Insulin-like Growth Factor-I (IGF-I) secretion, while decreasing blood urea nitrogen and cortisol concentrations.
Increased average daily gain and feed conversion ratio in piglets compared to the control group.
Animal Model: C57BL/6 mice (8 weeks old) [3]
Dosage: 1 g/kg
Administration: Oral gavage, once daily for 4 weeks
Result: Increased hepatic lipid accumulation, particularly in triglycerides, fatty acids, and glycerol, but did not increase the accumulation of cholesterol esters and free cholesterol.
Decreased de novo lipogenesis, fatty acid internalization, and very low-density lipoprotein (VLDL) secretion.
Downregulated the protein expression related to autophagy and β-oxidation, including LC-3, beclin-1, autophagy-related protein 5 (ATG-5) and ATG-7, acyl-CoA synthetase long chain family member 1, carnitine palmitoyltransferase Iα, peroxisome proliferator-activated receptor α (PPARα), PPARγ, and PPARγ coactivator-1.
Molecular Weight

112.13

Formula

C6H8O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C/C=C/C=C/C(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (445.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.9182 mL 44.5911 mL 89.1822 mL
5 mM 1.7836 mL 8.9182 mL 17.8364 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (22.30 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (22.30 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 8.9182 mL 44.5911 mL 89.1822 mL 222.9555 mL
5 mM 1.7836 mL 8.9182 mL 17.8364 mL 44.5911 mL
10 mM 0.8918 mL 4.4591 mL 8.9182 mL 22.2956 mL
15 mM 0.5945 mL 2.9727 mL 5.9455 mL 14.8637 mL
20 mM 0.4459 mL 2.2296 mL 4.4591 mL 11.1478 mL
25 mM 0.3567 mL 1.7836 mL 3.5673 mL 8.9182 mL
30 mM 0.2973 mL 1.4864 mL 2.9727 mL 7.4319 mL
40 mM 0.2230 mL 1.1148 mL 2.2296 mL 5.5739 mL
50 mM 0.1784 mL 0.8918 mL 1.7836 mL 4.4591 mL
60 mM 0.1486 mL 0.7432 mL 1.4864 mL 3.7159 mL
80 mM 0.1115 mL 0.5574 mL 1.1148 mL 2.7869 mL
100 mM 0.0892 mL 0.4459 mL 0.8918 mL 2.2296 mL
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Sorbic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sorbic acid110-44-1FungalBacterialEndogenous MetaboliteAntibioticIGF-1RInsulin-like growth factor-1 receptornonpoisonousfoodpreservativemoldsyeastsbacteriaInhibitorinhibitorinhibit

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