Tasipimidine sulfate

Name: Tasipimidine sulfate
Brand: MedChemExpress
SKU: HY-109075A
Rating: 4.5 (1 reviews)

Cat. No.: HY-109075A Purity: 99.46%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tasipimidine sulfate is an orally active and selective α2A-adrenoceptor agonist with a pEC₅₀ of 7.57 against human α2A-adrenoceptor. Tasipimidine sulfate can be used for situational anxiety and fear research.

For research use only. We do not sell to patients.

Tasipimidine sulfate Chemical Structure

CAS No. : 1465908-73-9

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 600	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1150	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1800	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2850	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Tasipimidine sulfate:

Tasipimidine Get quote

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

human α2A-adrenoceptor

7.57 (pEC₅₀)

rodent α2D-adrenoceptor

6.56 (pEC₅₀)

human α2C-adrenoceptor

6.29 (pEC₅₀)

human α2B-adrenoceptor

6.00 (pEC₅₀)

Molecular Weight

330.36

Formula

C₁₃H₁₈N₂O₆S

CAS No.

1465908-73-9

Appearance

Solid

Color

White to off-white

SMILES

O=S(O)(O)=O.COC1=CC=CC2=C1CCOC2C3=NCCN3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (378.38 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0270 mL	15.1350 mL	30.2700 mL
5 mM	0.6054 mL	3.0270 mL	6.0540 mL
10 mM	0.3027 mL	1.5135 mL	3.0270 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (6.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (6.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.46%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (251 KB) HNMR (257 KB) LCMS (258 KB)

Handling Instructions (2659 KB)

References

[1]. Lehtimäki J, et al. Tasipimidine-the pharmacological profile of a novel orally active selective α2A-adrenoceptor agonist. Eur J Pharmacol. 2022 May 15;923:174949. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0270 mL	15.1350 mL	30.2700 mL	75.6750 mL
	5 mM	0.6054 mL	3.0270 mL	6.0540 mL	15.1350 mL
	10 mM	0.3027 mL	1.5135 mL	3.0270 mL	7.5675 mL
	15 mM	0.2018 mL	1.0090 mL	2.0180 mL	5.0450 mL
	20 mM	0.1514 mL	0.7568 mL	1.5135 mL	3.7838 mL
	25 mM	0.1211 mL	0.6054 mL	1.2108 mL	3.0270 mL
	30 mM	0.1009 mL	0.5045 mL	1.0090 mL	2.5225 mL
	40 mM	0.0757 mL	0.3784 mL	0.7568 mL	1.8919 mL
	50 mM	0.0605 mL	0.3027 mL	0.6054 mL	1.5135 mL
	60 mM	0.0505 mL	0.2523 mL	0.5045 mL	1.2613 mL
	80 mM	0.0378 mL	0.1892 mL	0.3784 mL	0.9459 mL
	100 mM	0.0303 mL	0.1514 mL	0.3027 mL	0.7568 mL