2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling NF-κB Apoptosis
  3. JAK STAT NF-κB Bcl-2 Family
  4. TM-233

TM-233 is an inhibitor of the JAK/STAT and NF-κB signaling pathways, exhibiting significant antitumor activity. TM-233 reduces the expression of the anti-apoptotic protein Mcl-1 by inhibiting the phosphorylation of JAK2 and STAT3, and regulates its transcription by directly binding to the Mcl-1 gene promoter. Additionally, TM-233 prevents the translocation of NF-κB from the cytoplasm to the nucleus by inhibiting its DNA-binding activity, thereby reducing nuclear NF-κB expression. TM-233 shows potential in overcoming Bortezomib (HY-10227) resistance and can be applied in research related to multiple myeloma.

For research use only. We do not sell to patients.

TM-233 Chemical Structure

TM-233 Chemical Structure

CAS No. : 1103745-28-3

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TM-233 Related Antibodies

Top Publications Citing Use of Products

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JAK1 JAK2 JAK3 Tyk2 JAK

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STAT3 STAT5 STAT6 STAT1

View All NF-κB Isoform Specific Products:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

View All Bcl-2 Family Isoform Specific Products:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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Description

TM-233 is an inhibitor of the JAK/STAT and NF-κB signaling pathways, exhibiting significant antitumor activity. TM-233 reduces the expression of the anti-apoptotic protein Mcl-1 by inhibiting the phosphorylation of JAK2 and STAT3, and regulates its transcription by directly binding to the Mcl-1 gene promoter. Additionally, TM-233 prevents the translocation of NF-κB from the cytoplasm to the nucleus by inhibiting its DNA-binding activity, thereby reducing nuclear NF-κB expression. TM-233 shows potential in overcoming Bortezomib (HY-10227) resistance and can be applied in research related to multiple myeloma[1].

IC50 & Target

JAK2

 

Stat-3

 

Mcl-1

 

Cellular Effect
Cell Line Type Value Description References
HL-60 IC50
0.12 μM
Compound: 18
Cytotoxicity against human HL60 cells assessed as growth inhibition after 3 days
Cytotoxicity against human HL60 cells assessed as growth inhibition after 3 days
[PMID: 25801158]
IM-9 IC50
0.23 μM
Compound: 18
Cytotoxicity against human IM9 cells assessed as growth inhibition after 3 days
Cytotoxicity against human IM9 cells assessed as growth inhibition after 3 days
[PMID: 25801158]
Molecular Weight

384.42

Formula

C25H20O4
CAS No.
SMILES

CC(OC(C1=CC=C(C=C1)OC(C)=O)C2=C3C=CC=CC3=CC4=CC=CC=C24)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TM-233 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TM-2331103745-28-3TM233TM 233JAKSTATNF-κBBcl-2 FamilyJanus kinaseNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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