2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. TRIA-662

TRIA-662  (Synonyms: 1-Methylnicotinamide chloride)

Cat. No.: HY-113527 Purity: 99.90%
SDS COA Handling Instructions

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TRIA-662 (1-Methylnicotinamide chloride) is an endogenous metabolite. TRIA-662 shows antithrombotic and anti-inflammatory activities.

For research use only. We do not sell to patients.

TRIA-662 Chemical Structure

TRIA-662 Chemical Structure

CAS No. : 1005-24-9

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of TRIA-662:

TRIA-662 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

TRIA-662 (1-Methylnicotinamide chloride) is an endogenous metabolite. TRIA-662 shows antithrombotic and anti-inflammatory activities[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

TRIA-662 (0.1-10 μM; 12 and 24 h) treatment shows polymerization of the G-actin[1].
TRIA-662 (0.05-0.2 μM; 1-24 h) shows anti-inflammatory activity in the endothelium[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TRIA-662 Related Antibodies

Immunofluorescence[1]

Cell Line: HMECs
Concentration: 0.1 and 10 μM
Incubation Time: 12 and 24 hours
Result: Showed polymerization of the G-actin, and strong, clearly visible, parallel F-actin fibers at 10 μM.
Clinical Trial
Molecular Weight

172.61

Formula

C7H9ClN2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[N+]1=CC=CC(C(N)=O)=C1.[Cl-]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 110 mg/mL (637.27 mM; Need ultrasonic)

DMSO : 2 mg/mL (11.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7934 mL 28.9670 mL 57.9341 mL
5 mM 1.1587 mL 5.7934 mL 11.5868 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1.25 mg/mL (7.24 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 1.25 mg/mL (7.24 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (579.34 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.90%

SDS (393 KB)

COA (247 KB) HNMR (251 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.7934 mL 28.9670 mL 57.9341 mL 144.8352 mL
5 mM 1.1587 mL 5.7934 mL 11.5868 mL 28.9670 mL
10 mM 0.5793 mL 2.8967 mL 5.7934 mL 14.4835 mL
H2O 15 mM 0.3862 mL 1.9311 mL 3.8623 mL 9.6557 mL
20 mM 0.2897 mL 1.4484 mL 2.8967 mL 7.2418 mL
25 mM 0.2317 mL 1.1587 mL 2.3174 mL 5.7934 mL
30 mM 0.1931 mL 0.9656 mL 1.9311 mL 4.8278 mL
40 mM 0.1448 mL 0.7242 mL 1.4484 mL 3.6209 mL
50 mM 0.1159 mL 0.5793 mL 1.1587 mL 2.8967 mL
60 mM 0.0966 mL 0.4828 mL 0.9656 mL 2.4139 mL
80 mM 0.0724 mL 0.3621 mL 0.7242 mL 1.8104 mL
100 mM 0.0579 mL 0.2897 mL 0.5793 mL 1.4484 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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TRIA-662 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRIA-6621005-24-91-MethylnicotinamideTRIA662TRIA 662Endogenous Metaboliteantithrombotic activityanti-inflammatory activityHMECsInhibitorinhibitorinhibit

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