2. MAPK/ERK Pathway
  3. MEK
  4. Tunlametinib

Tunlametinib  (Synonyms: HL-085)

Cat. No.: HY-132844 Purity: 98.25%
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Tunlametinib, an antineoplastic agent, is a MEK1/2 inhibitor.

For research use only. We do not sell to patients.

Tunlametinib Chemical Structure

Tunlametinib Chemical Structure

CAS No. : 1801756-06-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 735 In-stock
Solution
10 mM * 1 mL in DMSO USD 735 In-stock
Solid
5 mg USD 680 In-stock
10 mg USD 1100 In-stock
25 mg USD 2250 In-stock
50 mg USD 3500 In-stock
100 mg USD 5600 In-stock
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Based on 1 publication(s) in Google Scholar

Tunlametinib Related Antibodies

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Description

Tunlametinib, an antineoplastic agent, is a MEK1/2 inhibitor[1].

IC50 & Target

MEK1

 

MEK2

 

Clinical Trial
Molecular Weight

491.25

Formula

C16H12F2IN3O3S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC2=C(C(F)=C1NC3=CC=C(C=C3F)I)N=CS2)NOCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (203.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0356 mL 10.1781 mL 20.3562 mL
5 mM 0.4071 mL 2.0356 mL 4.0712 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0356 mL 10.1781 mL 20.3562 mL 50.8906 mL
5 mM 0.4071 mL 2.0356 mL 4.0712 mL 10.1781 mL
10 mM 0.2036 mL 1.0178 mL 2.0356 mL 5.0891 mL
15 mM 0.1357 mL 0.6785 mL 1.3571 mL 3.3927 mL
20 mM 0.1018 mL 0.5089 mL 1.0178 mL 2.5445 mL
25 mM 0.0814 mL 0.4071 mL 0.8142 mL 2.0356 mL
30 mM 0.0679 mL 0.3393 mL 0.6785 mL 1.6964 mL
40 mM 0.0509 mL 0.2545 mL 0.5089 mL 1.2723 mL
50 mM 0.0407 mL 0.2036 mL 0.4071 mL 1.0178 mL
60 mM 0.0339 mL 0.1696 mL 0.3393 mL 0.8482 mL
80 mM 0.0254 mL 0.1272 mL 0.2545 mL 0.6361 mL
100 mM 0.0204 mL 0.1018 mL 0.2036 mL 0.5089 mL
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Tunlametinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tunlametinib1801756-06-8HL-085HL085HL 085MEKMitogen-activated protein kinase kinaseMAPKKMAP2Ktyrosine kinaseantineoplasticInhibitorinhibitorinhibit

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