2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Vemtoberant

Vemtoberant  (Synonyms: APD418)

Cat. No.: HY-148804 Purity: 99.08%
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Vemtoberant is an β3 Adrenergic Receptor antagonist. Vemtoberant can be used for research of β3 adrenergic receptor-mediated disorder, such as, heart failure.

For research use only. We do not sell to patients.

Vemtoberant Chemical Structure

Vemtoberant Chemical Structure

CAS No. : 2169905-68-2

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1 mg USD 200 In-stock
5 mg USD 500 In-stock
10 mg USD 800 In-stock
25 mg USD 1600 In-stock
50 mg USD 2400 In-stock
100 mg USD 3600 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Vemtoberant:

Vemtoberant Related Antibodies

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α adrenergic receptor β adrenergic receptor

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Description

Vemtoberant is an β3 Adrenergic Receptor antagonist. Vemtoberant can be used for research of β3 adrenergic receptor-mediated disorder, such as, heart failure[1][2].

Clinical Trial
Molecular Weight

619.75

Formula

C29H37N3O8S2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CS(C1=CC=CC(OC[C@@H](O)CN[C@@H]2CC3(OC2)CCN(CC3)S(=O)(C4=CN(CC)C5=CC=CC=C5C4=O)=O)=C1)(=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (403.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6136 mL 8.0678 mL 16.1355 mL
5 mM 0.3227 mL 1.6136 mL 3.2271 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6136 mL 8.0678 mL 16.1355 mL 40.3388 mL
5 mM 0.3227 mL 1.6136 mL 3.2271 mL 8.0678 mL
10 mM 0.1614 mL 0.8068 mL 1.6136 mL 4.0339 mL
15 mM 0.1076 mL 0.5379 mL 1.0757 mL 2.6893 mL
20 mM 0.0807 mL 0.4034 mL 0.8068 mL 2.0169 mL
25 mM 0.0645 mL 0.3227 mL 0.6454 mL 1.6136 mL
30 mM 0.0538 mL 0.2689 mL 0.5379 mL 1.3446 mL
40 mM 0.0403 mL 0.2017 mL 0.4034 mL 1.0085 mL
50 mM 0.0323 mL 0.1614 mL 0.3227 mL 0.8068 mL
60 mM 0.0269 mL 0.1345 mL 0.2689 mL 0.6723 mL
80 mM 0.0202 mL 0.1008 mL 0.2017 mL 0.5042 mL
100 mM 0.0161 mL 0.0807 mL 0.1614 mL 0.4034 mL
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Vemtoberant Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vemtoberant2169905-68-2APD418APD 418APD-418Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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