2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling Apoptosis
  3. JAK Apoptosis
  4. ZT55

ZT55 is an orally active and highly-selective JAK2 inhibitor with an IC50 value of 0.031 μM. ZT55 inhibits the proliferation of JAK2V617F-expressing HEL cell lines and induces apoptosis and cycle arrest. ZT-55 also effectively inhibits the growth of HEL xenograft tumours in a mice model. ZT-55 can be used in studies of myeloproliferative neoplasms, polycythemia vera and primary thrombocythemia.

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ZT55 Chemical Structure

ZT55 Chemical Structure

CAS No. : 2138488-38-5

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ZT55 Related Antibodies

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Description

ZT55 is an orally active and highly-selective JAK2 inhibitor with an IC50 value of 0.031 μM. ZT55 inhibits the proliferation of JAK2V617F-expressing HEL cell lines and induces apoptosis and cycle arrest. ZT-55 also effectively inhibits the growth of HEL xenograft tumours in a mice model. ZT-55 can be used in studies of myeloproliferative neoplasms, polycythemia vera and primary thrombocythemia[1].

IC50 & Target[1]

JAK2

0.031 μM (IC50)

In Vitro

ZT55 (0-100 μM; 48 h) inhibits the proliferation of JAK2V617F (+) HEL cells in a concentration-dependent manner (IC50=18.05 μM)[1].
ZT55 (12.5, 25, 50 μM; 24, 48, 72 h) inhibits the cell viability and induces apoptosis of HEL cells in a concentration- and time-dependent manner[1].
ZT55 (12.5, 25, 50 μM; 24 h) arrests HEL cells in the G2/M phase in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZT55 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HEL cells (JAK2V617F(+))
Concentration: 0-100 μM
Incubation Time: 48 h
Result: Significantly inhibited proliferation in a concentration-dependent manner (IC50=18.05 μM).

Cell Viability Assay[1]

Cell Line: HEL cells
Concentration: 12.5, 25, 50 μM
Incubation Time: 24, 48, 72 h
Result: Inhibited viability of HEL cells in a concentration- and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: HEL cells (JAK2V617F(+))
Concentration: 0-100 μM
Incubation Time: 24, 48, 72 h
Result: Induced cell apoptosis in a concentration- and time-dependent manner.

Cell Cycle Analysis[1]

Cell Line: HEL cells (JAK2V617F(+))
Concentration: 0-100 μM
Incubation Time: 24, 48, 72 h
Result: Significantly increased the number of HEL cells in the G2/M phase in a concentration-dependent manner.
In Vivo

ZT55 (100 mg/kg; p.o; once a day for 2 weeks) drastically attenuates the growth of subcutaneous HEL tumors in nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female, athymic BALB/c nude mice (6 to 8-week-old; JAK2V617F xenograft model)[1].
Dosage: 100 mg/kg
Administration: Oral administration; once a day for 2 weeks
Result: Induced marked reductions in tumor volume.
Molecular Weight

296.32

Formula

C17H16N2O3
CAS No.
SMILES

O=C(NC1=CC=CC=C1OC)CC2=CN(O)C3=C2C=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZT55 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZT552138488-38-5ZT 55ZT-55JAKApoptosisJanus kinaseMPNmyeloproliferative neoplasmspolycythemia vera and primary thrombocythemiaHEL cellsInhibitorinhibitorinhibit

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