2. Membrane Transporter/Ion Channel Neuronal Signaling JAK/STAT Signaling Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK Immunology/Inflammation
  3. nAChR JAK STAT NO Synthase
  4. α7 nAchR-JAK2-STAT3 agonist 1

α7 nAchR-JAK2-STAT3 agonist 1 

Cat. No.: HY-146066 Purity: 99.54%
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α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis.

For research use only. We do not sell to patients.

α7 nAchR-JAK2-STAT3 agonist 1 Chemical Structure

α7 nAchR-JAK2-STAT3 agonist 1 Chemical Structure

CAS No. : 2108714-20-9

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Based on 1 publication(s) in Google Scholar

Other Forms of α7 nAchR-JAK2-STAT3 agonist 1:

α7 nAchR-JAK2-STAT3 agonist 1 Related Antibodies

Top Publications Citing Use of Products

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JAK1 JAK2 JAK3 Tyk2 JAK

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STAT3 STAT5 STAT6 STAT1

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nNOS iNOS eNOS

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Description

α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis[1].

IC50 & Target

IC50: 0.32 μM (NO)[1]
Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
0.32 μM
Compound: 28
Inhibition of LPS-induced NO production in mouse RAW264.7 cells preincubated with compound for 2 hrs followed by LPS stimulation for 24 hrs by Griess reagent based assay
Inhibition of LPS-induced NO production in mouse RAW264.7 cells preincubated with compound for 2 hrs followed by LPS stimulation for 24 hrs by Griess reagent based assay
[PMID: 35576655]
Molecular Weight

426.50

Formula

C25H30O6
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(O[C@@H](CCCCC1=CC=CC=C1)CCC2=CC=C(OC(C)=O)C(OC(C)=O)=C2)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.54%

SDS (252 KB)

COA (253 KB) HNMR (144 KB) RP-HPLC (169 KB) LCMS (389 KB)

Handling Instructions (2659 KB)
References
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α7 nAchR-JAK2-STAT3 agonist 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α7 nAchR-JAK2-STAT3 agonist 12108714-20-9nAChRJAKSTATNO SynthaseNicotinic acetylcholine receptorsJanus kinaseNitric oxide synthasesNOSSepsisRAW264.7LPS-inducedCytokineInhibitorinhibitorinhibit

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