2. Metabolic Enzyme/Protease PI3K/Akt/mTOR Anti-infection
  3. Glucosidase PI3K Bacterial Antibiotic
  4. 1-Deoxynojirimycin hydrochloride

1-Deoxynojirimycin hydrochloride  (Synonyms: Duvoglustat hydrochloride)

Cat. No.: HY-14860A Purity: ≥98.0%
SDS COA Handling Instructions

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1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin hydrochloride suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin hydrochloride possesses antihyperglycemic, anti-obesity, and antiviral features.

For research use only. We do not sell to patients.

1-Deoxynojirimycin hydrochloride Chemical Structure

1-Deoxynojirimycin hydrochloride Chemical Structure

CAS No. : 73285-50-4

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Based on 3 publication(s) in Google Scholar

Other Forms of 1-Deoxynojirimycin hydrochloride:

1-Deoxynojirimycin hydrochloride Related Antibodies

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Description

1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin hydrochloride suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin hydrochloride possesses antihyperglycemic, anti-obesity, and antiviral features[1][2].

In Vivo

1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) (20-80 mg/kg; i.v.; daily for four weeks) shows anti-obesity effect [3].
1-Deoxynojirimycin hydrochloride significantly improves insulin sensitivity via activating insulin signaling PI3K/AKT pathway in skeletal muscle of db/db mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: db/db mice[3]
Dosage: 20, 40, 80 mg/kg
Administration: Intravenously; daily for four weeks
Result: Significantly reduced body weight, blood glucose and serum insulin levels; Improved glucose tolerance and insulin tolerance.
Clinical Trial
Molecular Weight

199.63

Formula

C6H14ClNO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@@H](CO)NC[C@H](O)[C@H]1O.[H]Cl
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (1252.32 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0093 mL 25.0463 mL 50.0927 mL
5 mM 1.0019 mL 5.0093 mL 10.0185 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (251 KB) HNMR (252 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.0093 mL 25.0463 mL 50.0927 mL 125.2317 mL
5 mM 1.0019 mL 5.0093 mL 10.0185 mL 25.0463 mL
10 mM 0.5009 mL 2.5046 mL 5.0093 mL 12.5232 mL
15 mM 0.3340 mL 1.6698 mL 3.3395 mL 8.3488 mL
20 mM 0.2505 mL 1.2523 mL 2.5046 mL 6.2616 mL
25 mM 0.2004 mL 1.0019 mL 2.0037 mL 5.0093 mL
30 mM 0.1670 mL 0.8349 mL 1.6698 mL 4.1744 mL
40 mM 0.1252 mL 0.6262 mL 1.2523 mL 3.1308 mL
50 mM 0.1002 mL 0.5009 mL 1.0019 mL 2.5046 mL
60 mM 0.0835 mL 0.4174 mL 0.8349 mL 2.0872 mL
80 mM 0.0626 mL 0.3131 mL 0.6262 mL 1.5654 mL
100 mM 0.0501 mL 0.2505 mL 0.5009 mL 1.2523 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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1-Deoxynojirimycin hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Deoxynojirimycin73285-50-4DuvoglustatGlucosidasePI3KBacterialAntibioticPhosphoinositide 3-kinasepostprandialbloodglucosediabetesantihyperglycemicanti-obesityantiviralinsulinInhibitorinhibitorinhibit

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