1-Deoxynojirimycin (Synonyms: Duvoglustat)

Name: 1-Deoxynojirimycin
Brand: MedChemExpress
SKU: HY-14860
Rating: 5.0 (3 reviews)

Cat. No.: HY-14860 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features.

For research use only. We do not sell to patients.

1-Deoxynojirimycin Chemical Structure

CAS No. : 19130-96-2

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of 1-Deoxynojirimycin:

Deoxymannojirimycin hydrochloride Get quote
1-Deoxynojirimycin hydrochloride Get quote
1-Deoxynojirimycin (Standard) Get quote

3 Publications Citing Use of MCE 1-Deoxynojirimycin

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All PI3K Isoform Specific Products:

View All Isoforms

PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 10 μM Compound: 1	Cytotoxicity against human A549 cells measured after 48 hrs by MTT assay Cytotoxicity against human A549 cells measured after 48 hrs by MTT assay	[PMID: 33979163]
A549	IC₅₀	> 1000 μM Compound: DNJ	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 21036045]
BGC-823	IC₅₀	> 10 μM Compound: 1	Cytotoxicity against human BGC-823 cells measured after 48 hrs by MTT assay Cytotoxicity against human BGC-823 cells measured after 48 hrs by MTT assay	[PMID: 33979163]
Caco-2	IC₅₀	0.06 μM Compound: 1, DNJ	Inhibition of maltase in human Caco-2 cell model system after 2 hrs Inhibition of maltase in human Caco-2 cell model system after 2 hrs	[PMID: 18595718]
HCC1937	IC₅₀	> 10 μM Compound: 1	Cytotoxicity against human HCC1937 cells measured after 48 hrs by MTT assay Cytotoxicity against human HCC1937 cells measured after 48 hrs by MTT assay	[PMID: 33979163]
HCT-116	IC₅₀	> 10 μM Compound: 1	Cytotoxicity against human HCT-116 cells measured after 48 hrs by MTT assay Cytotoxicity against human HCT-116 cells measured after 48 hrs by MTT assay	[PMID: 33979163]
HEK293	IC₅₀	> 100 μM Compound: dNM, 1-deoxynojirimycin	Antagonist activity at human recombinant LXRalpha expressed in HEK293 cells by luciferase reporter gene assay Antagonist activity at human recombinant LXRalpha expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 18343126]
HEK293	IC₅₀	> 100 μM Compound: dNM, 1-deoxynojirimycin	Antagonist activity at human recombinant LXRbeta expressed in HEK293 cells by luciferase reporter gene assay Antagonist activity at human recombinant LXRbeta expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 18343126]
HepG2	IC₅₀	> 10 μM Compound: 1	Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay	[PMID: 33979163]
HUVEC	IC₅₀	2 μM Compound: 2a	Growth inhibition of HUVEC cells by MTT assay Growth inhibition of HUVEC cells by MTT assay	[PMID: 18166456]
MCF7	IC₅₀	> 10 μM Compound: 1	Cytotoxicity against human MCF7 cells measured after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells measured after 48 hrs by MTT assay	[PMID: 33979163]
MS-1	IC₅₀	2 μM Compound: 2a	Growth inhibition of mouse MS1 cells by MTT assay Growth inhibition of mouse MS1 cells by MTT assay	[PMID: 18166456]

In Vivo

1-Deoxynojirimycin (Duvoglustat) (20-80 mg/kg; i.v.; daily for four weeks) shows anti-obesity effect ^[3].
1-Deoxynojirimycin significantly improves insulin sensitivity via activating insulin signaling PI3K/AKT pathway in skeletal muscle of db/db mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	db/db mice^[3]
Dosage:	20, 40, 80 mg/kg
Administration:	Intravenously; daily for four weeks
Result:	Significantly reduced body weight, blood glucose and serum insulin levels; Improved glucose tolerance and insulin tolerance.

Clinical Trial

Molecular Weight

163.17

Formula

C₆H₁₃NO₄

CAS No.

19130-96-2

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@@H](CO)NC[C@H](O)[C@H]1O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : ≥ 34 mg/mL (208.37 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.1286 mL	30.6429 mL	61.2858 mL
5 mM	1.2257 mL	6.1286 mL	12.2572 mL
10 mM	0.6129 mL	3.0643 mL	6.1286 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (612.86 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.94%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (248 KB) RP-HPLC (195 KB)

Handling Instructions (2659 KB)

References

[1]. Gao K, et al. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing. Molecules. 2016 Nov 23;21(11). pii: E1600. [Content Brief]

[2]. Chaluntorn Vichasilp,et al. Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction. LWT - Food Science and Technology. Volume 45, Issue 2, March 2012, Pages 226-232

[3]. Liu Q, et al. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice. Molecules. 2015 Dec 4;20(12):21700-14. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.1286 mL	30.6429 mL	61.2858 mL	153.2144 mL
	5 mM	1.2257 mL	6.1286 mL	12.2572 mL	30.6429 mL
	10 mM	0.6129 mL	3.0643 mL	6.1286 mL	15.3214 mL
	15 mM	0.4086 mL	2.0429 mL	4.0857 mL	10.2143 mL
	20 mM	0.3064 mL	1.5321 mL	3.0643 mL	7.6607 mL
	25 mM	0.2451 mL	1.2257 mL	2.4514 mL	6.1286 mL
	30 mM	0.2043 mL	1.0214 mL	2.0429 mL	5.1071 mL
	40 mM	0.1532 mL	0.7661 mL	1.5321 mL	3.8304 mL
	50 mM	0.1226 mL	0.6129 mL	1.2257 mL	3.0643 mL
	60 mM	0.1021 mL	0.5107 mL	1.0214 mL	2.5536 mL
	80 mM	0.0766 mL	0.3830 mL	0.7661 mL	1.9152 mL
	100 mM	0.0613 mL	0.3064 mL	0.6129 mL	1.5321 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

1-Deoxynojirimycin Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Deoxynojirimycin19130-96-2DuvoglustatGlycosidasePI3KPhosphoinositide 3-kinasepostprandialbloodglucosediabetesantihyperglycemicanti-obesityantiviralinsulinInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

1-Deoxynojirimycin (Synonyms: Duvoglustat)

Customer Review

Other Forms of 1-Deoxynojirimycin:

1-Deoxynojirimycin Related Antibodies

3 Publications Citing Use of MCE 1-Deoxynojirimycin

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All PI3K Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

1-Deoxynojirimycin Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report