1. Metabolic Enzyme/Protease PI3K/Akt/mTOR
  2. Glycosidase PI3K
  3. 1-Deoxynojirimycin

1-Deoxynojirimycin  (Synonyms: Duvoglustat)

Cat. No.: HY-14860 Purity: ≥98.0%
SDS COA Handling Instructions Technical Support

1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features.

For research use only. We do not sell to patients.

1-Deoxynojirimycin Chemical Structure

1-Deoxynojirimycin Chemical Structure

CAS No. : 19130-96-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of 1-Deoxynojirimycin:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 1
Cytotoxicity against human A549 cells measured after 48 hrs by MTT assay
Cytotoxicity against human A549 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
A549 IC50
> 1000 μM
Compound: DNJ
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 21036045]
BGC-823 IC50
> 10 μM
Compound: 1
Cytotoxicity against human BGC-823 cells measured after 48 hrs by MTT assay
Cytotoxicity against human BGC-823 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
Caco-2 IC50
0.06 μM
Compound: 1, DNJ
Inhibition of maltase in human Caco-2 cell model system after 2 hrs
Inhibition of maltase in human Caco-2 cell model system after 2 hrs
[PMID: 18595718]
HCC1937 IC50
> 10 μM
Compound: 1
Cytotoxicity against human HCC1937 cells measured after 48 hrs by MTT assay
Cytotoxicity against human HCC1937 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
HCT-116 IC50
> 10 μM
Compound: 1
Cytotoxicity against human HCT-116 cells measured after 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
HEK293 IC50
> 100 μM
Compound: dNM, 1-deoxynojirimycin
Antagonist activity at human recombinant LXRalpha expressed in HEK293 cells by luciferase reporter gene assay
Antagonist activity at human recombinant LXRalpha expressed in HEK293 cells by luciferase reporter gene assay
[PMID: 18343126]
HEK293 IC50
> 100 μM
Compound: dNM, 1-deoxynojirimycin
Antagonist activity at human recombinant LXRbeta expressed in HEK293 cells by luciferase reporter gene assay
Antagonist activity at human recombinant LXRbeta expressed in HEK293 cells by luciferase reporter gene assay
[PMID: 18343126]
HepG2 IC50
> 10 μM
Compound: 1
Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
HUVEC IC50
2 μM
Compound: 2a
Growth inhibition of HUVEC cells by MTT assay
Growth inhibition of HUVEC cells by MTT assay
[PMID: 18166456]
MCF7 IC50
> 10 μM
Compound: 1
Cytotoxicity against human MCF7 cells measured after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
MS-1 IC50
2 μM
Compound: 2a
Growth inhibition of mouse MS1 cells by MTT assay
Growth inhibition of mouse MS1 cells by MTT assay
[PMID: 18166456]
In Vivo

1-Deoxynojirimycin (Duvoglustat) (20-80 mg/kg; i.v.; daily for four weeks) shows anti-obesity effect [3].
1-Deoxynojirimycin significantly improves insulin sensitivity via activating insulin signaling PI3K/AKT pathway in skeletal muscle of db/db mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: db/db mice[3]
Dosage: 20, 40, 80 mg/kg
Administration: Intravenously; daily for four weeks
Result: Significantly reduced body weight, blood glucose and serum insulin levels; Improved glucose tolerance and insulin tolerance.
Clinical Trial
Molecular Weight

163.17

Formula

C6H13NO4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@@H](CO)NC[C@H](O)[C@H]1O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : ≥ 34 mg/mL (208.37 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.1286 mL 30.6429 mL 61.2858 mL
5 mM 1.2257 mL 6.1286 mL 12.2572 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (612.86 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.94%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.1286 mL 30.6429 mL 61.2858 mL 153.2144 mL
5 mM 1.2257 mL 6.1286 mL 12.2572 mL 30.6429 mL
10 mM 0.6129 mL 3.0643 mL 6.1286 mL 15.3214 mL
15 mM 0.4086 mL 2.0429 mL 4.0857 mL 10.2143 mL
20 mM 0.3064 mL 1.5321 mL 3.0643 mL 7.6607 mL
25 mM 0.2451 mL 1.2257 mL 2.4514 mL 6.1286 mL
30 mM 0.2043 mL 1.0214 mL 2.0429 mL 5.1071 mL
40 mM 0.1532 mL 0.7661 mL 1.5321 mL 3.8304 mL
50 mM 0.1226 mL 0.6129 mL 1.2257 mL 3.0643 mL
60 mM 0.1021 mL 0.5107 mL 1.0214 mL 2.5536 mL
80 mM 0.0766 mL 0.3830 mL 0.7661 mL 1.9152 mL
100 mM 0.0613 mL 0.3064 mL 0.6129 mL 1.5321 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
1-Deoxynojirimycin
Cat. No.:
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