2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. ADC Cytotoxin Topoisomerase
  4. (1R,9R)-Exatecan mesylate

(1R,9R)-Exatecan mesylate  (Synonyms: (1R,9R)-DX8951f)

Cat. No.: HY-13631J Purity: 99.94% ee.: 99.96%
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(1R,9R)-Exatecan mesylate((1R,9R)-DX8951f) is an isomer of Exatecan mesylate (HY-13631A). Exatecan mesylate (DX8951f) is an inhibitor of DNA topoisomerase I with an IC50 of 2.2 μM (0.975 μg/mL) and can be used in cancer research.

For research use only. We do not sell to patients.

(1R,9R)-Exatecan mesylate Chemical Structure

(1R,9R)-Exatecan mesylate Chemical Structure

CAS No. : 2938875-39-7

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Based on 1 publication(s) in Google Scholar

Other Forms of (1R,9R)-Exatecan mesylate:

(1R,9R)-Exatecan mesylate Related Antibodies

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Topoisomerase Topo I Topo II

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Description

(1R,9R)-Exatecan mesylate((1R,9R)-DX8951f) is an isomer of Exatecan mesylate (HY-13631A). Exatecan mesylate (DX8951f) is an inhibitor of DNA topoisomerase I with an IC50 of 2.2 μM (0.975 μg/mL) and can be used in cancer research[1].

IC50 & Target

Camptothecins

 

Molecular Weight

531.55

Formula

C25H26FN3O7S
CAS No.
Appearance

Solid

Color

Gray to brown

SMILES

O=S(C)(O)=O.O=C1[C@@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@H]5N)C(C)=C(F)C=C6N=C4C3=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (31.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8813 mL 9.4065 mL 18.8129 mL
5 mM 0.3763 mL 1.8813 mL 3.7626 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8813 mL 9.4065 mL 18.8129 mL 47.0323 mL
5 mM 0.3763 mL 1.8813 mL 3.7626 mL 9.4065 mL
10 mM 0.1881 mL 0.9406 mL 1.8813 mL 4.7032 mL
15 mM 0.1254 mL 0.6271 mL 1.2542 mL 3.1355 mL
20 mM 0.0941 mL 0.4703 mL 0.9406 mL 2.3516 mL
25 mM 0.0753 mL 0.3763 mL 0.7525 mL 1.8813 mL
30 mM 0.0627 mL 0.3135 mL 0.6271 mL 1.5677 mL
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(1R,9R)-Exatecan mesylate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(1R,9R)-Exatecan2938875-39-7(1R,9R)-DX8951fADC CytotoxinTopoisomeraseADC PayloadInhibitorinhibitorinhibit

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