2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. (1R)-AZD-1480

(1R)-AZD-1480 is the (1R) chiral isomer of AZD-1480, an ATP competitive JAK1 and JAK2 inhibitor.

For research use only. We do not sell to patients.

(1R)-AZD-1480 Chemical Structure

(1R)-AZD-1480 Chemical Structure

CAS No. : 935666-99-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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10 mg In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (1R)-AZD-1480:

(1R)-AZD-1480 Related Antibodies

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Description

(1R)-AZD-1480 is the (1R) chiral isomer of AZD-1480, an ATP competitive JAK1 and JAK2 inhibitor[1].

Molecular Weight

348.77

Formula

C14H14ClFN8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=C(N=C(N=C1)N[C@H](C)C2=NC=C(C=N2)F)NC3=NNC(C)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (286.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8672 mL 14.3361 mL 28.6722 mL
5 mM 0.5734 mL 2.8672 mL 5.7344 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8672 mL 14.3361 mL 28.6722 mL 71.6805 mL
5 mM 0.5734 mL 2.8672 mL 5.7344 mL 14.3361 mL
10 mM 0.2867 mL 1.4336 mL 2.8672 mL 7.1680 mL
15 mM 0.1911 mL 0.9557 mL 1.9115 mL 4.7787 mL
20 mM 0.1434 mL 0.7168 mL 1.4336 mL 3.5840 mL
25 mM 0.1147 mL 0.5734 mL 1.1469 mL 2.8672 mL
30 mM 0.0956 mL 0.4779 mL 0.9557 mL 2.3893 mL
40 mM 0.0717 mL 0.3584 mL 0.7168 mL 1.7920 mL
50 mM 0.0573 mL 0.2867 mL 0.5734 mL 1.4336 mL
60 mM 0.0478 mL 0.2389 mL 0.4779 mL 1.1947 mL
80 mM 0.0358 mL 0.1792 mL 0.3584 mL 0.8960 mL
100 mM 0.0287 mL 0.1434 mL 0.2867 mL 0.7168 mL
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(1R)-AZD-1480 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(1R)-AZD-1480935666-99-2JAKJanus kinasechiral isomerAZD-1480Inhibitorinhibitorinhibit

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