2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. (1R)-AZD-1480

(1R)-AZD-1480 is the (1R) chiral isomer of AZD-1480, an ATP competitive JAK1 and JAK2 inhibitor.

For research use only. We do not sell to patients.

(1R)-AZD-1480 Chemical Structure

(1R)-AZD-1480 Chemical Structure

CAS No. : 935666-99-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 471 In-stock
Solution
10 mM * 1 mL in DMSO USD 496 In-stock
Solid
5 mg USD 451 In-stock
10 mg USD 750 In-stock
25 mg USD 1505 In-stock
50 mg USD 2500 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (1R)-AZD-1480:

(1R)-AZD-1480 Related Antibodies

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JAK1 JAK2 JAK3 Tyk2 JAK

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Description

(1R)-AZD-1480 is the (1R) chiral isomer of AZD-1480, an ATP competitive JAK1 and JAK2 inhibitor[1].

Molecular Weight

348.77

Formula

C14H14ClFN8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=C(N=C(N=C1)N[C@H](C)C2=NC=C(C=N2)F)NC3=NNC(C)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (286.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8672 mL 14.3361 mL 28.6722 mL
5 mM 0.5734 mL 2.8672 mL 5.7344 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8672 mL 14.3361 mL 28.6722 mL 71.6805 mL
5 mM 0.5734 mL 2.8672 mL 5.7344 mL 14.3361 mL
10 mM 0.2867 mL 1.4336 mL 2.8672 mL 7.1680 mL
15 mM 0.1911 mL 0.9557 mL 1.9115 mL 4.7787 mL
20 mM 0.1434 mL 0.7168 mL 1.4336 mL 3.5840 mL
25 mM 0.1147 mL 0.5734 mL 1.1469 mL 2.8672 mL
30 mM 0.0956 mL 0.4779 mL 0.9557 mL 2.3893 mL
40 mM 0.0717 mL 0.3584 mL 0.7168 mL 1.7920 mL
50 mM 0.0573 mL 0.2867 mL 0.5734 mL 1.4336 mL
60 mM 0.0478 mL 0.2389 mL 0.4779 mL 1.1947 mL
80 mM 0.0358 mL 0.1792 mL 0.3584 mL 0.8960 mL
100 mM 0.0287 mL 0.1434 mL 0.2867 mL 0.7168 mL
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(1R)-AZD-1480 Related Classifications

Help & FAQs
  • How should lyophilized recombinant proteins be reconstituted and stored?

    1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss. 2. Taking 10 μg as an example, first add 20 μL of reconstituted solution provided by MCE and use a pipette to gently resuspend the lyophilized protein until it is fully dissolved.. (For most proteins, the reconstitution solution we provide is sterile water. If a diluent other than water is required, it will be indicated in the product's Certificate of Analysis (COA).). 3. Add an additional 80 μL of buffer/culture medium containing carrier protein (either 0.1% BSA, 5% HSA, 10% FBS, or 5% trehalose), and then use a pipette to gently mix until uniform. The final concentration is should not be lower than 100 μg/mL. 4. Aliquot at least 20 μL per tube. 5. After aliquoting, store it frozen at a temperature ranging from -20ºC to -80ºC, and it can be preserved for 3 to 6 months.

  • How should solution-form recombinant proteins be stored?

    1. The product can be stored in its original form and diluted as needed upon use. 2. Alternatively, dilute with a buffer/culture medium containing a carrier protein (either 0.1% BSA, 5% HSA, 10% FBS, or 5% alginate), mix well by pipetting, and ensure that

  • Why is it necessary to add carrier proteins?

    Carrier proteins are commonly added to enhance the stability of recombinant proteins, preventing them from adhering to the walls of the container during freezing or thawing processes. Plastic tubes have a certain adsorptive capacity for proteins, which may lead to difficulty in separating the protein from the tube walls, resulting in a decrease in the actual concentration of the protein in the solution and thus affecting its activity. To minimize such losses, it is recommended to add a commonly used carrier protein solution prior to the long-term storage of recombinant protein products.

  • Carrier protein types and options?

    In cases where the carrier protein is not expected to influence the experimental outcomes, an appropriate carrier protein, such as 0.1% BSA (Bovine Serum Albumin), 5% HSA (Human Serum Albumin), 10% FBS (Fetal Bovine Serum), or 5% trehalose, can be incorpo

Keywords:

(1R)-AZD-1480935666-99-2JAKJanus kinasechiral isomerAZD-1480Inhibitorinhibitorinhibit

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