2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 5'-DMT-3'-TBDMS-Bz-rA

5'-DMT-3'-TBDMS-Bz-rA is a nucleoside with protective and modification effects.

For research use only. We do not sell to patients.

5'-DMT-3'-TBDMS-Bz-rA Chemical Structure

5'-DMT-3'-TBDMS-Bz-rA Chemical Structure

CAS No. : 81256-88-4

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Based on 1 publication(s) in Google Scholar

5'-DMT-3'-TBDMS-Bz-rA Related Antibodies

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Description

5'-DMT-3'-TBDMS-Bz-rA is a nucleoside with protective and modification effects.

Molecular Weight

787.97

Formula

C44H49N5O7Si
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@H](N5C6=NC=NC(NC(C7=CC=CC=C7)=O)=C6N=C5)O4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (126.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2691 mL 6.3454 mL 12.6908 mL
5 mM 0.2538 mL 1.2691 mL 2.5382 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (3.17 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.19%

COA (263 KB) HNMR (320 KB) RP-HPLC (447 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2691 mL 6.3454 mL 12.6908 mL 31.7271 mL
5 mM 0.2538 mL 1.2691 mL 2.5382 mL 6.3454 mL
10 mM 0.1269 mL 0.6345 mL 1.2691 mL 3.1727 mL
15 mM 0.0846 mL 0.4230 mL 0.8461 mL 2.1151 mL
20 mM 0.0635 mL 0.3173 mL 0.6345 mL 1.5864 mL
25 mM 0.0508 mL 0.2538 mL 0.5076 mL 1.2691 mL
30 mM 0.0423 mL 0.2115 mL 0.4230 mL 1.0576 mL
40 mM 0.0317 mL 0.1586 mL 0.3173 mL 0.7932 mL
50 mM 0.0254 mL 0.1269 mL 0.2538 mL 0.6345 mL
60 mM 0.0212 mL 0.1058 mL 0.2115 mL 0.5288 mL
80 mM 0.0159 mL 0.0793 mL 0.1586 mL 0.3966 mL
100 mM 0.0127 mL 0.0635 mL 0.1269 mL 0.3173 mL
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5'-DMT-3'-TBDMS-Bz-rA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5'-DMT-3'-TBDMS-Bz-rA81256-88-4Nucleoside Antimetabolite/AnalogInhibitorinhibitorinhibit

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