2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. Adrenergic Receptor Serotonin Transporter Sodium Channel
  4. Atomoxetine hydrochloride

Atomoxetine hydrochloride  (Synonyms: Tomoxetine hydrochloride; (R)-Tomoxetine hydrochloride; LY 139603)

Cat. No.: HY-17385 Purity: 99.94%
SDS COA Handling Instructions

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Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research.

For research use only. We do not sell to patients.

Atomoxetine hydrochloride Chemical Structure

Atomoxetine hydrochloride Chemical Structure

CAS No. : 82248-59-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 110 In-stock
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Based on 4 publication(s) in Google Scholar

Other Forms of Atomoxetine hydrochloride:

Atomoxetine hydrochloride Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
0.02 μM
Compound: Atomoxetine
Inhibition of the Norepinephrine transporter (NET, SLC6A2) as assessed by GPCR-mediated changes in cell morphology using the impedance-based transporter activity through receptor activation (TRACT) assay in HEK-293 JumpIN-SLC6A2 cells
Inhibition of the Norepinephrine transporter (NET, SLC6A2) as assessed by GPCR-mediated changes in cell morphology using the impedance-based transporter activity through receptor activation (TRACT) assay in HEK-293 JumpIN-SLC6A2 cells
[PMID: 34112854]
In Vitro

Atomoxetine (Tomoxetine) (1-100 µM; 0.5-20 seconds; tsA201 cells) hydrochloride interacts with the human heart muscle sodium channel (hNav1.5) in a state and dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Atomoxetine hydrochloride Related Antibodies
In Vivo

Atomoxetine (0.3-3 mg/kg; i.p.; 0-4 hours; male Sprague-Dawley rats) hydrochlorideincreases extracellular norepinephrine and dopamine by 3-fold and increases Fos expression in the rat prefrontal cortex[1].
Atomoxetine (0.1-5 mg/kg; i.p. and p.o; for 14 days; spontaneously hypertensive rat) hydrochloride can improve behaviors associated with ADHD in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 0.3, 1 and 3 mg/kg
Administration: Intraperitoneal injection; for 4 hours
Result: Increased the number of cells expressing Fos-like immunoreactivity in PFC 3.7-fold and increased extracellular norepinephrine and dopamine by 3-fold.
Animal Model: Spontaneously hypertensive rat (SHR)[3]
Dosage: 0.1, 0.3, 1.25 and 5.0 mg/kg
Administration: Intraperitoneal injection and oral administration; for 14 days
Result: Had non-impact on the measurement of motor activity.
Clinical Trial
Molecular Weight

291.82

Formula

C17H22ClNO
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=CC=C1O[C@@H](C2=CC=CC=C2)CCNC.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (342.68 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (171.34 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4268 mL 17.1338 mL 34.2677 mL
5 mM 0.6854 mL 3.4268 mL 6.8535 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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C2

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (8.57 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (8.57 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 8.33 mg/mL (28.54 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.94%

SDS (393 KB)

COA (256 KB) LCMS (259 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.4268 mL 17.1338 mL 34.2677 mL 85.6692 mL
5 mM 0.6854 mL 3.4268 mL 6.8535 mL 17.1338 mL
10 mM 0.3427 mL 1.7134 mL 3.4268 mL 8.5669 mL
15 mM 0.2285 mL 1.1423 mL 2.2845 mL 5.7113 mL
20 mM 0.1713 mL 0.8567 mL 1.7134 mL 4.2835 mL
25 mM 0.1371 mL 0.6854 mL 1.3707 mL 3.4268 mL
30 mM 0.1142 mL 0.5711 mL 1.1423 mL 2.8556 mL
40 mM 0.0857 mL 0.4283 mL 0.8567 mL 2.1417 mL
50 mM 0.0685 mL 0.3427 mL 0.6854 mL 1.7134 mL
60 mM 0.0571 mL 0.2856 mL 0.5711 mL 1.4278 mL
80 mM 0.0428 mL 0.2142 mL 0.4283 mL 1.0709 mL
100 mM 0.0343 mL 0.1713 mL 0.3427 mL 0.8567 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Atomoxetine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atomoxetine82248-59-7Tomoxetine(R)-Tomoxetine LY 139603LY139603LY 139603LY-139603Adrenergic ReceptorSerotonin TransporterSodium ChannelBeta Receptor5-HTTSERTSLC6A4Na channelsNa+ channelsInhibitorinhibitorinhibit

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