2. GPCR/G Protein Neuronal Signaling Autophagy Anti-infection
  3. Adrenergic Receptor Autophagy Bacterial
  4. Carvedilol phosphate hemihydrate

Carvedilol phosphate hemihydrate  (Synonyms: BM 14190 phosphate hemihydrate)

Cat. No.: HY-B0006A Purity: 99.94%
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Handling Instructions Technical Support

Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is a non-selective β/α-1 blocker. Carvedilol phosphate hemihydrate inhibits lipid peroxidation with an IC50 of 5 μM. Carvedilol phosphate hemihydrate is a multiple action antihypertensive agent with potential use in angina and congestive heart failure. Carvedilol phosphate hemihydrate is an autophagy inducer that inhibits the NLRP3 inflammasome.

For research use only. We do not sell to patients.

Carvedilol phosphate hemihydrate Chemical Structure

Carvedilol phosphate hemihydrate Chemical Structure

CAS No. : 610309-89-2

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Based on 8 publication(s) in Google Scholar

Other Forms of Carvedilol phosphate hemihydrate:

Carvedilol phosphate hemihydrate Related Antibodies

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Description

Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is a non-selective β/α-1 blocker[1]. Carvedilol phosphate hemihydrate inhibits lipid peroxidation with an IC50 of 5 μM. Carvedilol phosphate hemihydrate is a multiple action antihypertensive agent with potential use in angina and congestive heart failure[2]. Carvedilol phosphate hemihydrate is an autophagy inducer that inhibits the NLRP3 inflammasome[3].

IC50 & Target

β/α-1 adrenergic receptor[1]
IC50: 5 μM (lipid peroxidation)[2]
Autophagy[3]
In Vitro

Superoxide generation by activated human neutrophils in vitro is inhibited by Carvedilol with an IC50 of 28 μM. Carvedilol is shown to scavenge oxygen free radicals in a cell-free system with an IC50 of 25 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Carvedilol phosphate hemihydrate Related Antibodies
Clinical Trial
Molecular Weight

513.48

Formula

C24H26N2O4 . H3PO4 .1/2H2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(OO)=O.OC(CNCCOC1=CC=CC=C1OC)COC2=CC=CC(N3)=C2C4=C3C=CC=C4.[HH].[0.5H2O]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (194.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9475 mL 9.7375 mL 19.4750 mL
5 mM 0.3895 mL 1.9475 mL 3.8950 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9475 mL 9.7375 mL 19.4750 mL 48.6874 mL
5 mM 0.3895 mL 1.9475 mL 3.8950 mL 9.7375 mL
10 mM 0.1947 mL 0.9737 mL 1.9475 mL 4.8687 mL
15 mM 0.1298 mL 0.6492 mL 1.2983 mL 3.2458 mL
20 mM 0.0974 mL 0.4869 mL 0.9737 mL 2.4344 mL
25 mM 0.0779 mL 0.3895 mL 0.7790 mL 1.9475 mL
30 mM 0.0649 mL 0.3246 mL 0.6492 mL 1.6229 mL
40 mM 0.0487 mL 0.2434 mL 0.4869 mL 1.2172 mL
50 mM 0.0389 mL 0.1947 mL 0.3895 mL 0.9737 mL
60 mM 0.0325 mL 0.1623 mL 0.3246 mL 0.8115 mL
80 mM 0.0243 mL 0.1217 mL 0.2434 mL 0.6086 mL
100 mM 0.0195 mL 0.0974 mL 0.1947 mL 0.4869 mL
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Carvedilol phosphate hemihydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carvedilol phosphate hemihydrate610309-89-2BM 14190 phosphate hemihydrateAdrenergic ReceptorAutophagyBacterialBeta Receptorβ/α-1blockerlipidperoxidationantihypertensiveanginacongestiveheartfailureNLRP3inflammasomeInhibitorinhibitorinhibit

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