2. Metabolic Enzyme/Protease GPCR/G Protein
  3. Cytochrome P450 P2Y Receptor
  4. Clopidogrel hydrogen sulfate

Clopidogrel hydrogen sulfate  (Synonyms: (S)-(+)-Clopidogrel bisulfate; (S)-(+)-Clopidogrel hydrogen sulfate)

Cat. No.: HY-17459 Purity: 99.43%
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Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor.

For research use only. We do not sell to patients.

Clopidogrel hydrogen sulfate Chemical Structure

Clopidogrel hydrogen sulfate Chemical Structure

CAS No. : 120202-66-6

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10 mM * 1 mL in DMSO
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Based on 22 publication(s) in Google Scholar

Other Forms of Clopidogrel hydrogen sulfate:

Clopidogrel hydrogen sulfate Related Antibodies

Top Publications Citing Use of Products

    Clopidogrel hydrogen sulfate purchased from MedChemExpress. Usage Cited in: Am J Transl Res. 2020 May 15;12(5):1741-1753.  [Abstract]

    Expression of MKP-5 and phosphorylated p38/MAPK in Clopidogrel-treated gastric mucosal tissues and cells. Western blot analysis show MKP-5 is decreased and negatively correlated of Clopidogrel.

    View All Cytochrome P450 Isoform Specific Products:

    View All Isoforms
    CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

    View All P2Y Receptor Isoform Specific Products:

    View All Isoforms
    P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

    • Biological Activity

    • Purity & Documentation

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    • Customer Review

    Description

    Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively[1]. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation[2]．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor[5].

    IC50 & Target[1]

    CYP2B6

    18.2 nM (IC50)

    P2Y12 Receptor

     

    CYP2C19

    524 nM (IC50)

    In Vitro

    Clopidogrel (1.5 mM;12 and 24 hours) up-regulates the expression of TRIB3 and CHOP in a concentration- and time-dependent manner, as measured by real-time PCR and Western blot analysis[3].
    Clopidogrel (1.5 mM; 24 hours) significantly induces human gastric epithelial cell (GES-1) apoptosis[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Clopidogrel hydrogen sulfate Related Antibodies

    Western Blot Analysis[3]

    Cell Line: GES-1 cells
    Concentration: 1.5 mM
    Incubation Time: 12 and 24 hours
    Result: The mRNA expression levels of both CHOP and TRIB3 were up-regulated in a concentration- and time-dependent manner.
    The protein expression levels of both CHOP and TRIB3 were up-regulated in a concentration- and time-dependent manner.

    Apoptosis Analysis[3]

    Cell Line: Gastric epithelial cell (GES-1) cells
    Concentration: 1.5 mM
    Incubation Time: 24 hours
    Result: Induced apoptosis of gastric epithelial cells．
    In Vivo

    Clopidogrel (5 mg/kg) significantly inhibits thrombus formation compared with vehicle. Acetylsalicylic acid (0.15 mg/kg) can add to the antithrombotic effect of Clopidogrel in mice; Acetylsalicylic acid (0.6 mg/kg) blunts the antithrombotic effect of Clopidogrel[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Age-matched C57BL/6J male mice weighing at least 25 g were used at 8 to 12 weeks of age[4]
    Dosage: 5 mg/kg
    Administration: Gavage treatment
    Result: Clopidogrel significantly inhibited thrombus formation compared with vehicle.
    When Clopidogrel was given in combination with 0.6 mg/kg ASA, thrombi were significantly larger than those measured with Clopidogrel alone.
    In contrast, when Clopidogrel was given in combination with 0.15 mg/kg ASA , thrombi were significantly smaller than those in mice treated with Clopidogrel and 0.6 mg/kg ASA, and smaller than those in mice given Clopidogrel alone.
    Clinical Trial
    Molecular Weight

    419.90

    Formula

    C16H18ClNO6S2
    CAS No.
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    ClC1=C([C@@H](C(OC)=O)N2CCC3=C(C=CS3)C2)C=CC=C1.O=S(O)(O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 46.7 mg/mL (111.22 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 16.67 mg/mL (39.70 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3815 mL 11.9076 mL 23.8152 mL
    5 mM 0.4763 mL 2.3815 mL 4.7630 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (4.95 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (4.95 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (119.08 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.43%

    COA (257 KB) HNMR (244 KB) LCMS (86 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 2.3815 mL 11.9076 mL 23.8152 mL 59.5380 mL
    5 mM 0.4763 mL 2.3815 mL 4.7630 mL 11.9076 mL
    10 mM 0.2382 mL 1.1908 mL 2.3815 mL 5.9538 mL
    15 mM 0.1588 mL 0.7938 mL 1.5877 mL 3.9692 mL
    20 mM 0.1191 mL 0.5954 mL 1.1908 mL 2.9769 mL
    25 mM 0.0953 mL 0.4763 mL 0.9526 mL 2.3815 mL
    30 mM 0.0794 mL 0.3969 mL 0.7938 mL 1.9846 mL
    DMSO 40 mM 0.0595 mL 0.2977 mL 0.5954 mL 1.4884 mL
    50 mM 0.0476 mL 0.2382 mL 0.4763 mL 1.1908 mL
    60 mM 0.0397 mL 0.1985 mL 0.3969 mL 0.9923 mL
    80 mM 0.0298 mL 0.1488 mL 0.2977 mL 0.7442 mL
    100 mM 0.0238 mL 0.1191 mL 0.2382 mL 0.5954 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Clopidogrel hydrogen sulfate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Clopidogrel hydrogen120202-66-6(S)-(+)-Clopidogrel bisulfate(S)-(+)-Clopidogrel hydrogenCytochrome P450P2Y ReceptorCYPsAntiplateletbloodclotCYP2B6CYP2C19antithromboticplateletaggregationInhibitorinhibitorinhibit

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