2. Autophagy NF-κB
  3. Autophagy Keap1-Nrf2
  4. Selenomethionine

Selenomethionine  (Synonyms: Seleno-DL-methionine; DL-Selenomethionine)

Cat. No.: HY-B1000 Purity: 99.86%
SDS COA Handling Instructions Technical Support

Selenomethionine is a naturally occurring amino acid containing selenium that has oral activity and is a common natural food source. Selenomethionine has antitumor activity.

For research use only. We do not sell to patients.

Selenomethionine Chemical Structure

Selenomethionine Chemical Structure

CAS No. : 1464-42-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
50 mg In-stock
100 mg In-stock
500 mg In-stock
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5 g   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Selenomethionine:

Selenomethionine Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Selenomethionine is a naturally occurring amino acid containing selenium that has oral activity and is a common natural food source. Selenomethionine has antitumor activity[1][2][3].

In Vitro

Selenomethionine (50 μM, 12 h) decreases the hatchability and glutathione consumption of Japanese rice embryos, but does not affect selenium accumulation[1].
Selenomethionine (45-135 μM, 24 h) inhibits the growth of MCF-7/S breast cancer, DU-145 prostate cancer cells and UAC-375 melanoma cells in a dose-dependent manner[2].
Selenomethionine (25-500 μM, 24 h) inhibits TBHP-induced oxidative stress and mitochondrial division by activating the Nrf2 pathway, thereby inhibiting the apoptosis of nucleus pulposus cells (NPCs) and improving intervertebral disc degeneration (IDD)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Selenomethionine Related Antibodies

Western Blot Analysis[3]

Cell Line: NPCs
Concentration: 25, 50, 75, 100, 150, 300, and 500 μM
Incubation Time: 24 h
Result: Downregulated of cleaved-caspase 9, cleaved-caspase 3 and upregulated of Bax and Bcl-2.
Reduced the expression levels of DRP1, MFF, and Fis1, upregulated the expression levels of OPA1, Mfn1, and Mfn2.
In Vivo

Selenomethionine (2 mg/kg/day, gavage for 4 weeks) can improve the degenerative performance in the acupuncturally-induced rat IDD model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: IDD Rat Model[3]
Dosage: 2mg/kg/day
Administration: i.g
Result: Reduced NP size, collapsed disc height, significant loss of cells, and dense ECM.
Decreased the levels of Nrf2 and collagen II amd increased the expression level of MMP13.
Clinical Trial
Molecular Weight

196.11

Formula

C5H11NO2Se
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C(N)CC[Se]C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 12.5 mg/mL (63.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0992 mL 25.4962 mL 50.9923 mL
5 mM 1.0198 mL 5.0992 mL 10.1985 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (50.99 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.86%

SDS (728 KB)

COA (244 KB) RP-HPLC (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.0992 mL 25.4962 mL 50.9923 mL 127.4808 mL
5 mM 1.0198 mL 5.0992 mL 10.1985 mL 25.4962 mL
10 mM 0.5099 mL 2.5496 mL 5.0992 mL 12.7481 mL
15 mM 0.3399 mL 1.6997 mL 3.3995 mL 8.4987 mL
20 mM 0.2550 mL 1.2748 mL 2.5496 mL 6.3740 mL
25 mM 0.2040 mL 1.0198 mL 2.0397 mL 5.0992 mL
30 mM 0.1700 mL 0.8499 mL 1.6997 mL 4.2494 mL
40 mM 0.1275 mL 0.6374 mL 1.2748 mL 3.1870 mL
50 mM 0.1020 mL 0.5099 mL 1.0198 mL 2.5496 mL
60 mM 0.0850 mL 0.4249 mL 0.8499 mL 2.1247 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Selenomethionine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Selenomethionine1464-42-2Seleno-DL-methionine DL-SelenomethionineAutophagyKeap1-Nrf2Inhibitorinhibitorinhibit

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