1. Signaling Pathways
  2. MAPK/ERK Pathway
    Stem Cell/Wnt
  3. ERK

ERK

ERK

Extracellular signal regulated kinases

ERKs (Extracellular-signal-regulated kinases) are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric G protein-coupled receptors, transforming agents, and carcinogens, activate the ERK pathway. In the MAPK/ERK pathway, Ras activates c-Raf, followed by mitogen-activated protein kinase kinase (abbreviated as MKK, MEK, or MAP2K) and then MAPK1/2 (below). Ras is typically activated by growth hormones through receptor tyrosine kinases and GRB2/SOS, but may also receive other signals. ERKs are known to activate many transcription factors, such as ELK1, and some downstream protein kinases. Disruption of the ERK pathway is common in cancers, especially Ras, c-Raf and receptors such as HER2.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0371
    Pachymic acid
    Inhibitor 99.94%
    Pachymic acid is a lanostrane-type triterpenoid from P. cocos. Pachymic acid inhibits Akt and ERK signaling pathways.
    Pachymic acid
  • HY-W008947
    SEW​2871
    Activator 99.53%
    SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood. SEW2871 can be used for the research of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses.
    SEW​2871
  • HY-113556
    Sappanone A
    Inhibitor 99.58%
    Sappanone A is an orally active homoisoflavone found in sappan L. Sappanone A is a PDE4 and NF-κB inhibitor with anti-inflammatory and antioxidant effect. Sappanone A induces HO-1 expression through activation of Nrf2 pathway. Sappanone A also inhibits RANKL-induced osteoclastogenesis. Sappanone A has great potential in the research of inflammation-related and cardiovascular .
    Sappanone A
  • HY-B2123
    Lactose
    Inhibitor ≥98.0%
    Lactose is a β-galactoside consisting of galactose and glucose residues,the main carbohydrate in mammalian breast milk. Lactose,a macronutrient and an inducer of host innate immune responses,possesses immune modulatory functions.
    Lactose
  • HY-N7264
    7α-Hydroxycholesterol
    99.99%
    7α-Hydroxycholesterol is a cholesterol oxide and can serve as a biomarker for oxidative stress and lipid peroxidation. 7α-Hydroxycholesterol has cytotoxic and pro-inflammatory activities. 7α-Hydroxycholesterol can also inhibit sterol synthesis and reduce the activity of HMG-CoA reductase. 7α-Hydroxycholesterol can be used in the research of diseases such as diabetes and atherosclerosis.
    7α-Hydroxycholesterol
  • HY-12056
    BIX02189
    Inhibitor 99.99%
    BIX02189 is a potent and selective MEK5 inhibitor with an IC50 of 1.5 nM. BIX02189 also inhibits ERK5 catalytic activity with an IC50 of 59 nM.
    BIX02189
  • HY-104047
    LM22B-10
    Activator 99.92%
    LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo.
    LM22B-10
  • HY-B0185A
    Lidocaine hydrochloride
    Inhibitor 99.96%
    Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor.
    Lidocaine hydrochloride
  • HY-156002
    LUNA18
    Inhibitor 99.26%
    LUNA18 is an orally-available cyclic peptide KRAS and ERK inhibitor. LUNA18 phosphorylates ERK and AKT and decreases cell proliferation in RAS-mutated cancer cells. LUNA18 exhibits RAS signal inhibition and potent anti-cancer activities through inhibiting interaction between RAS and guanine nucleotide exchange factors (GEFs) in a mouse xenograft model. LUNA18 shows significant cellular efficacy against cell lines with KRAS genetic alterations, such as colon cancer, stomach cancer, non-small cell lung cancer and pancreaticcancer.
    LUNA18
  • HY-N0498
    Nitidine chloride
    Inhibitor 99.75%
    Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway.
    Nitidine chloride
  • HY-B0444
    Maprotiline hydrochloride
    99.98%
    Maprotiline hydrochloride is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects with oral activity. Maprotiline hydrochloride induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1.
    Maprotiline hydrochloride
  • HY-111407
    MK-8353
    Inhibitor 98.13%
    MK-8353 (SCH900353) is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity.
    MK-8353
  • HY-14443
    XMD8-92
    Inhibitor 99.67%
    XMD8-92 is a potent ERK5 (BMK1)/BRD4 inhibitor with Kds of 80 and 190 nM, respectively. XMD8-92 inhibits DCAMKL2, PLK4 and TNK1 with Kds of 190, 600 and 890 nM, respectively. Anti-cancer activity.
    XMD8-92
  • HY-119272
    EF24
    Inhibitor 99.34%
    EF24, a curcumin analogue, is an NF-kB inhibitor with great anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 is active against melanoma and breast cancer cell lines with GI50 values of 0.7 μM and 0.8 μM, respectively. EF24 induces cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells and DU-145 human prostate cancer cells. EF24 increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK.
    EF24
  • HY-113772
    Inflachromene
    Inhibitor 99.88%
    Inflachromene, a microglial inhibitor, binds to HMGB1 and HMGB2 and exerts anti-inflammatory effects. Inflachromene effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage. Inflachromene can be used for the research of neuroinflammatory disorders.
    Inflachromene
  • HY-W004283
    Pentadecanoic acid
    Inhibitor ≥98.0%
    Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.
    Pentadecanoic acid
  • HY-15816A
    Ulixertinib hydrochloride
    Inhibitor 99.88%
    Ulixertinib hydrochloride (BVD-523 hydrochloride) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. Ulixertinib hydrochloride inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line.
    Ulixertinib hydrochloride
  • HY-W011727A
    Pyridoxal 5'-​phosphate monohydrate
    Activator ≥98.0%
    Pyridoxal 5'-phosphate monohydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate monohydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′‐phosphate (PMP).
    Pyridoxal 5'-​phosphate monohydrate
  • HY-17015
    Peramivir trihydrate
    98.30%
    Peramivir trihydrate (RWJ-270201 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes.
    Peramivir trihydrate
  • HY-14178
    VX-11e
    Inhibitor 99.17%
    VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK with Ki < 2 nM.
    VX-11e
Cat. No. Product Name / Synonyms Application Reactivity

ERK

ERK1

ERK2

ERK5

ERK8

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

ERK Degraders, Inhibitors & Activators
Product NameERKERK1ERK2ERK5ERK8Purity    
Yoda 1 
ERK1
ERK2
  99.98%
PD98059 
ERK1
ERK2
  99.96%
SCH772984 
ERK1, IC50: 4 nM
ERK2, IC50: 1 nM
  99.83%
Tauroursodeoxycholate
ERK
    99.93%
TBHQ
ERK
    99.89%
TERT activator-1 
ERK1
ERK2
  99.50%
β-Glycerophosphate disodium salt pentahydrate 
ERK1
ERK2
  99.81%
Ulixertinib  
ERK2, IC50: 0.3 nM (at KM ATP (60 μM))
  99.95%
Honokiol 
ERK1
ERK2
  99.90%
Astragaloside IV 
ERK1
ERK2
  99.93%
C16-PAF
ERK
    99.85%
L-Cysteine 
ERK1
ERK2
  
Tauroursodeoxycholate sodium
ERK
    98.40%
Temuterkib 
ERK1, IC50: 5 nM
ERK2, IC50: 5 nM
  99.94%
Piperlongumine 
ERK1
ERK2
  99.87%
Ravoxertinib 
ERK1, IC50: 6.1 nM
ERK2, IC50: 3.1 nM
  99.75%
β-Glycerophosphate disodium salt hydrate 
ERK1
ERK2
  ≥98.0%
Lidocaine
ERK
    99.96%
trans-Zeatin
ERK
    99.83%
Gamma-Linolenic acid 
ERK1
ERK2
  99.80%
Lysophosphatidylcholines 
ERK1
ERK2
  ≥99.0%
Fucoxanthin  
ERK2
  98.99%
FR 180204 
ERK1, Ki: 0.31 μM
ERK1, IC50: 0.51 μM
ERK2, Ki: 0.14 μM
ERK2, IC50: 0.33 μM
  99.65%
ASN007 
ERK1
ERK2
  99.70%
6-OAU
ERK
    99.91%
Pachymic acid
ERK
    99.94%
BIX02189   
ERK5, IC50: 59 nM
 99.99%
LM22B-10
ERK
    99.92%
Lidocaine hydrochloride
ERK
    99.96%
MK-8353 
ERK1, IC50: 23 nM
ERK2, IC50: 8.8 nM
  98.13%
XMD8-92   
BMK1, Kd: 80 nM
 99.67%
VX-11e  
ERK2, Ki: 2 nM
  99.17%
Peiminine 
ERK1
ERK2
  99.94%
AG126  
ERK2
  ≥98.0%
Peramivir 
ERK1
ERK2
  99.32%
AX-15836   
ERK5, IC50: 8 nM
 99.68%
ASTX029 
ERK1
ERK2
  99.86%
Broussonin E
ERK
    98.18%
Pluripotin 
ERK1, Kd: 98 nM
   98.86%
CHPG sodium salt
ERK
    99.25%
ERK1/2 inhibitor 1  
ERK2, IC50: 3.0 nM
  99.79%
Cafestol  
ERK2
  99.91%
H-Ile-Lys-Val-Ala-Val-OH 
ERK1
ERK2
  99.42%
Lidocaine (Standard)
ERK
    99.85%
Tizaterkib  
ERK2, IC50: 0.6 nM
  99.31%
CC-90003 
ERK1
ERK2
  99.71%
DEL-22379  
ERK2, IC50: 0.5 μM
  99.69%
Ravoxertinib hydrochloride 
ERK1, IC50: 6.1 nM
ERK2, IC50: 3.1 nM
  99.93%
Rineterkib 
ERK1
ERK2
  99.83%
ERK5-IN-1   
ERK5, IC50: 87 nM
 99.33%
MAP855
ERK, EC50: 5 nM
    98.48%
JWG-071   
ERK5, IC50: 88 nM
 99.15%
Methylnissolin 
ERK1
ERK2
  99.86%
XMD17-109   
ERK5, IC50: 162 nM
 99.20%
KO-947 
ERK1
ERK2
  99.61%
CK2/ERK8-IN-1    
ERK8, IC50: 0.5 μM
≥99.0%
ERK5-IN-2   
ERK5, IC50: 0.82 μM
ERK5 MEF2D, IC50: 3 μM
 98.96%
Mogrol 
ERK1
ERK2
  99.76%
CHPG
ERK
    99.51%
Magnolin 
ERK1, IC50: 87 nM
ERK2, IC50: 16.5 nM
  99.98%
β-Neo-Endorphin 
ERK1
ERK2
  99.32%
BIX02188   
ERK5, IC50: 810 nM
 99.85%
4-Methylbenzylidene camphor 
ERK1
ERK2
  99.87%
Corynoxeine 
ERK1
ERK2
  99.97%
HIOC
ERK
    99.94%
ASN007 benzenesulfonate 
ERK1
ERK2
  99.72%
Sanggenon C
ERK
    98.50%
ERK-IN-4  
ERK2, Kd: 5 μM
  99.61%
AT-533 
ERK1
ERK2
  98.86%
Myristicin
ERK
    99.89%
Loureirin B
ERK
    99.16%
Cearoin
ERK
    ≥98.0%
CKLF1-C27 
ERK1
ERK2
  98.46%
Methylthiouracil 
ERK1
ERK2
  ≥98.0%
Longdaysin  
ERK2, IC50: 52 μM
  99.83%
2,5-Dihydroxyacetophenone 
ERK1
ERK2
  99.89%
Enniatin B1
ERK
    99.34%
BAY885   
ERK5, IC50: 35 nM
 99.27%
Deltonin 
ERK1
ERK2
  99.94%
Anti-inflammatory agent 35
ERK
    99.77%
Omtriptolide
ERK
    
[Tyr8] Bradykinin 
ERK1
ERK2
  99.61%
Lidocaine hydrochloride hydrate
ERK
    99.90%
ML192 
ERK1
ERK2
  
Isoprocurcumenol
ERK
    
EVT801
ERK, IC50: 13 nM
    
SHR2415 
ERK1, IC50: 2.8 nM
ERK2, IC50: 5.9 nM
  98.63%
ERK1/2 inhibitor 9 
ERK1
ERK2
  
Syk-IN-6 
ERK1
ERK2
  
Hypothemycin 
ERK1, Ki: 8.4 μM
ERK2, Ki: 2.4 μM
  ≥98.0%
ERK5-IN-5   
ERK5
 99.05%
PT-262
ERK
    99.21%
Bohemine  
ERK2, IC50: 52 μM
  98.93%
Sugiol 
ERK1
ERK2
  99.88%
ERK2 IN-1  
ERK2, IC50: 7 nM
  
ERK-IN-2  
ERK2, IC50: 1.8 nM
  
ERK5-IN-3   
ERK5, IC50: 6 ± 1 nM
 
Aloisine A 
ERK1, IC50: 18 μM
ERK2, IC50: 22 μM
  
ZINC12409120
ERK, IC50: 5 μM
    
ERK-IN-7 
ERK1, IC50: 5 nM
ERK2, IC50: 7 nM
  
ERK1/2 inhibitor 13 
ERK1, IC50: 91.71 nM
ERK2, IC50: 97.87 nM
  
ERK-IN-2 free base  
ERK2, IC50: 1.8 nM
  
DCZ19931 
ERK1
ERK2
  
ERK-IN-8  
ERK2, IC50: ≤50 nM
  
MHJ-627   
ERK5
 
ERK2 IN-5  
ERK2, Ki: 86 nM
  
PPM-3   
ERK5, IC50: 62.4 ± 18. nM
 
Enniatin B
ERK
    99.10%
ERK2-IN-4  
ERK2, Ki: 0.006 μM
  
ERK2 allosteric-IN-1  
ERK2, IC50: 11 μM
  
CKLF1-C27 TFA 
ERK1
ERK2
  
Enniatin A1
ERK
    
Anti-inflammatory agent 31 
ERK1
ERK2
  
ERK1/2 inhibitor 10 
ERK1, IC50: 0.11 nM
ERK2, IC50: 0.8 nM
  
Myristoyl-MEK1 Derived Peptide Inhibitor 1
ERK, IC50: 13 μM (The in vivo inhibitory potency is determined in both PMA-treated NIH 3T3 cells and NGF-stimulated PC12 cells.)
 
ERK2, IC50: 10 μM (The in vitro inhibitory potency of the peptides is measured based on their ability to inhibit MEK1-mediated phosphorylation of ERK2. )
  
CXJ-2
ERK
    
MK2-IN-5 
ERK1
ERK2
  
Cudraflavone B
ERK
    
ERK5-IN-4   
ERK5
 
Anticancer agent 231 
ERK1
ERK2
  
ERK5-IN-6
ERK
    
Phenylhydroquinone 
ERK1
ERK2
  
Tizaterkib (hexanedioic acid)  
ERK2, IC50: 0.6 nM
  
Methyl helicterate 
ERK1
ERK2