2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Melanocortin Receptor
  5. Melanocortin Receptor Isoform

Melanocortin Receptor

 

Melanocortin Receptor Related Products (73):

Cat. No. Product Name Effect Purity
  • HY-18678A
    Bremelanotide Acetate
    		Agonist 99.98%
    Bremelanotide Acetate (PT-141 Acetate), a synthetic peptide analogue of α-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R for the treatment of sexual dysfunction.
  • HY-107139
    JNJ-10229570
    		Antagonist ≥98.0%
    JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively.
  • HY-P1726
    MSG606
    		Antagonist 98.25%
    MSG606 is a selective MC1R (melanocortin 1 receptor) antagonist and can be used for the research of neuroprotective effects.
  • HY-109114
    Dersimelagon
    		Agonist 98.66%
    Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon shows good affinity for hMC1R and hMC4R with Ki values of 2.26, 32.9 nM, respectively. Dersimelagon can be used for the research of skin pigmentation.
  • HY-11029
    SNT-207707
    		Inhibitor 99.51%
    SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor.
  • HY-118930A
    MK-0493 hydrochloride
    		Agonist 98.76%
    MK-0493 hydrochloride is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake.
  • HY-148349A
    (2R,2R)-PF-07258669
    		Antagonist
    (2R,2R)-PF-07258669 is a MC4R (melanocortin 4 receptor) antagonist. (2R,2R)-PF-07258669 can be used in the study of regulating appetite and energy expenditure.
  • HY-109114A
    Dersimelagon phosphate
    		Agonist
    Dersimelagon phosphate is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon phosphate shows good affinity for hMC1R and hMC4R with Ki values of 2.26, 32.9 nM, respectively. Dersimelagon phosphate can be used for the research of skin pigmentation.
  • HY-11030A
    SNT-207858 free base
    		Antagonist 98.82%
    SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
  • HY-B1456A
    Fenoprofen
    		Agonist 99.72%
    Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID). Fenoprofen can be used to to relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. Fenoprofen is an allosteric enhancer for melanocortin receptors. Fenoprofen also increases ERK1/2 activation.
  • HY-148349
    PF-07258669
    		Antagonist 98.44%
    PF-07258669 is a melanocortin-4 receptor (MC4) antagonist. PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa.
  • HY-P3561A
    Agouti-related Protein (AGRP) (83-132) Amide (human) (TFA)
    		Inhibitor
    Agouti-related Protein (AGRP) (83-132) Amide (human) TFA is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the melanocortin-4 receptor (MC4R) to increase food intake.
  • HY-P5971A
    TCMCB07 TFA
    		Antagonist 99.69%
    TCMCB07 TFA, a cyclic nonapeptide peptide, is an orally active and brain-penetrant melanocortin receptor 4 (MC4R) antagonist. TCMCB07 TFA plays an important role in cachexia.
  • HY-P5971
    TCMCB07
    		Antagonist 99.24%
    TCMCB07, a cyclic nonapeptide peptide, is an orally active and brain-penetrant melanocortin receptor 4 (MC4R) antagonist. TCMCB07 plays an important role in cachexia.
  • HY-P5247
    Palmitoyl tetrapeptide-20
    		Activator 99.67%
    Palmitoyl tetrapeptide-20 (PTP20) is a biomimetic peptide that is an agonist for α-MSH. Palmitoyl tetrapeptide-20 can protect follicular melanocytes and activate melanogenesis by enhancing catalase expression.
  • HY-124740
    ML00253764
    		Antagonist 99.70%
    ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity.
  • HY-P1558
    ACTH (11-24)
    		Antagonist 99.65%
    ACTH (11-24) is an adrenocorticotropic hormone (ACTH) receptor antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system.
  • HY-153660
    Bivamelagon
    		Agonist 99.50%
    MC-4R Agonist 2 (Example 1) is a MC4R agonist. MC-4R Agonist 2 can be used in the study of obesity, diabetes, inflammation, and erectile dysfunction.
  • HY-P1208
    PG-931
    		Agonist 99.81%
    PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo.
  • HY-P1210A
    Lys-γ3-MSH(human) TFA
    Lys-γ3-MSH(human) TFA is a melanocortin peptide derived from the C-terminal of the fragment of pro-opiomelanocortin (POMC). Lys-γ3-MSH(human) TFA potentiates the steroidogenic response of the rat adrenal to adrenocorticotrophin (ACTH). Lys-γ3-MSH(human) TFA is a potent stimulator of lipolysis with an apparent EC50 of 3.56 nM. Lys-γ3-MSH(human) TFA can activate hormone sensitive lipase (HSL) and Perilipin A resulting in lipolysis.