2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. TCMCB07

TCMCB07, a cyclic nonapeptide peptide, is an orally active and brain-penetrant melanocortin receptor 4 (MC4R) antagonist. TCMCB07 plays an important role in cachexia.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

TCMCB07 Chemical Structure

TCMCB07 Chemical Structure

CAS No. : 1456699-27-6

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5 mg USD 150 In-stock
10 mg USD 240 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of TCMCB07:

TCMCB07 Related Antibodies

Top Publications Citing Use of Products

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MC1R MC3R MC2R MC4R MC5R

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Description

TCMCB07, a cyclic nonapeptide peptide, is an orally active and brain-penetrant melanocortin receptor 4 (MC4R) antagonist. TCMCB07 plays an important role in cachexia[1].

Molecular Weight

1230.46

Formula

C63H87N15O11
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-Nle-c[Asp-Pro-D-Nal(2')-Arg-Trp-Lys]-dVal-dPro-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (81.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8127 mL 4.0635 mL 8.1270 mL
5 mM 0.1625 mL 0.8127 mL 1.6254 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8127 mL 4.0635 mL 8.1270 mL 20.3176 mL
5 mM 0.1625 mL 0.8127 mL 1.6254 mL 4.0635 mL
10 mM 0.0813 mL 0.4064 mL 0.8127 mL 2.0318 mL
15 mM 0.0542 mL 0.2709 mL 0.5418 mL 1.3545 mL
20 mM 0.0406 mL 0.2032 mL 0.4064 mL 1.0159 mL
25 mM 0.0325 mL 0.1625 mL 0.3251 mL 0.8127 mL
30 mM 0.0271 mL 0.1355 mL 0.2709 mL 0.6773 mL
40 mM 0.0203 mL 0.1016 mL 0.2032 mL 0.5079 mL
50 mM 0.0163 mL 0.0813 mL 0.1625 mL 0.4064 mL
60 mM 0.0135 mL 0.0677 mL 0.1355 mL 0.3386 mL
80 mM 0.0102 mL 0.0508 mL 0.1016 mL 0.2540 mL
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TCMCB07 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCMCB071456699-27-6TCMCB 07TCMCB-07Melanocortin ReceptorMC ReceptorMC4R antagonistCachexianonapeptide peptideorally activebrain-penetrantInhibitorinhibitorinhibit

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