2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipase

Lipase

Lipase is a water-soluble enzyme that can catalyze the ester bond hydrolysis of lipids, decompose and metabolize fat molecules. Lipase is produced primarily by the pancreas and helps the body digest fats and oils. Lipase inhibitors are able to reduce the digestion and absorption of fat, thereby reducing collective caloric intake and weight loss. Lipase inhibitors are commonly used to suppress diseases such as obesity, hyperlipidemia, and pancreatitis.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-155837
    hPL-IN-2
    		Inhibitor 98.17%
    hPL-IN-2 (compound 2u) is a potent, reversible, and non-competitive inhibitor of pancreatic lipase (IC50: 1.63 μM) and can be used in anti-obesity research.
    hPL-IN-2
  • HY-N2330
    Lipstatin
    		Inhibitor
    Lipstatin is a pancreatic lipase inhibitor (IC50=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM).
    Lipstatin
  • HY-N12297
    Ciwujianoside C2
    		Activator
    Ciwujianoside C2 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C2 enhances pancreatic lipase activity in vitro.
    Ciwujianoside C2
  • HY-126938
    4-Methylumbelliferyl heptanoate
    4-Methylumbelliferyl heptanoate is a potent fluorometric substrate of lipase.
    4-Methylumbelliferyl heptanoate
  • HY-N12292
    Acanthopanaxoside A
    		Inhibitor
    Acanthopanaxoside A, a triterpenoid saponin, has pancreatic lipase inhibitory action.
    Acanthopanaxoside A
  • HY-118481
    H-Pro-Glu-OH
    H-Pro-Glu-OH is a protein secreted by pathogenic mycobacteria through the Type VII secretion system. H-Pro-Glu-OH targets LipY lipases to the cell Surface via the ESX-5 Pathway.
    H-Pro-Glu-OH
  • HY-Y1422A
    Lipase, Human Pancreas
    Lipase, Human Pancreas (Pancreatic Triacylglycerol Lipase, PL, PTL, Pancreatic Lipase) is a biological material or organic compound that can be used in life science research.
    Lipase, Human Pancreas
  • HY-121517
    URB754
    		Inhibitor
    URB754 is a potent inhibitor of the endocannabinoid-deactivating enzyme monoacylglycerol lipase (MGL) with an IC50 of 200 nM.
    URB754
  • HY-165039
    1,3-Dioleoyl-2-octanoyl glycerol
    1,3-Dioleoyl-2-octanoyl glycerol (1,3-Olein-2-caprylin) is a triacylglycerol. 1,3-Dioleoyl-2-octanoyl glycerol can be used to characterize the functionality of R. oryzae lipase for regiodistribution analysis of fats containing medium- and short-chain fatty acids.
    1,3-Dioleoyl-2-octanoyl glycerol
  • HY-Y1422J
    Lipase PS-SD
    Lipase PS-SD comes from Burkholderiacepacia and can be used for catalytic reaction.
    Lipase PS-SD
  • HY-157733
    1,2-Dioleoyl-3-behenoylglycerol
    		Inhibitor
    1,2-Dioleoyl-3-behenoylglycerol (BOO) inhibits pancreatic lipase activity. 1,2-Dioleoyl-3-behenoylglycerol prevents the deposition of visceral fat and hepatic triacylglycerol (TAG).
    1,2-Dioleoyl-3-behenoylglycerol
  • HY-N12294
    Ciwujianoside D2
    		Inhibitor
    Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro.
    Ciwujianoside D2
  • HY-N12294
    Ciwujianoside D2
    		Activator
    Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro.
    Ciwujianoside D2
  • HY-123862
    LAS195319
    		Inhibitor
    LAS195319 is an orally active and potent inhibitor against PI3Kδ with an IC50 value of 0.5 nM. LAS195319 is also a highly selective inhibitor against an extensive panel of proteins, lipid kinases and GPCRs. LAS195319 causes an inhibition of neutrophil and eosinophil infiltration. LAS195319 is promising for research of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).
    LAS195319
  • HY-138653
    Lipase Substrate
    Lipase Substrate is a substrate of lipase to detect activity.
    Lipase Substrate
  • HY-N12296
    Ciwujianoside C4
    		Activator
    Ciwujianoside C4, a saponin compound, can enhance pancreatic lipase activity in vitro.
    Ciwujianoside C4
  • HY-N8989
    (1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate
    		Inhibitor
    (1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate, isolated from the ethanol extract of Atractylodes lancea rhizome, displays significant lipase inhibition with an IC50 value of 23.9 µg/mL. Antiobesity Effect.
    (1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate
  • HY-157534
    Pancreatic lipase-IN-2
    		Inhibitor
    Pancreatic lipase-IN-2 (compound 7r) is a potent inhibitor of pancreatic lipase (PL), with the IC50 value of 2.67 μM, that has anti-obesity effect.
    Pancreatic lipase-IN-2
  • HY-155836
    hPL-IN-1
    		Inhibitor
    hPL-IN-1 (compound 2t) is a reversible inhibitor of pancreatic lipase (PL) (IC50=1.86 μM) for anti-obesity research.
    hPL-IN-1
  • HY-Y1422H
    Lipase AYS
    Lipase AYS is an immobilized lipase derived from Candida rugosa.
    Lipase AYS
Cat. No. Product Name / Synonyms Application Reactivity