Allyl methyl trisulfide

Name: Allyl methyl trisulfide
Brand: MedChemExpress
SKU: HY-134900
Rating: 4.5 (1 reviews)

Cat. No.: HY-134900 Purity: 40.00%: FAQs
Data Sheet SDS COA Handling Instructions

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Allyl methyl trisulfide is a volatile organic compound and a component of garlic (Allium sativum L.) essential oil, which has antibacterial, antioxidant and antitumor activities.

For research use only. We do not sell to patients.

Allyl methyl trisulfide Chemical Structure

CAS No. : 34135-85-8

Size	Price	Stock	Quantity
100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Allyl methyl trisulfide is a volatile organic compound and a component of garlic (Allium sativum L.) essential oil, which has antibacterial, antioxidant and antitumor activities^[1].

In Vivo

Allyl methyl trisulfide (AMS) (50-200 mg/kg, orally, daily, 30 days) has protective effect in STZ-induced hyperglycemia rats. It can lead to a significant decrease in the expression of blood glucose and pro-inflammatory markers TNF-α, IL-6, and NF-κB p65, while increasing plasma insulin levels, and has some antioxidant activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (170-190 g)^[1]
Dosage:	50, 100 and 200 mg/kg
Administration:	orally in the daily morning for 30 days
Result:	Enhanced body, organ weight and reduced food, water intake. Dose-dependently decreased plasma glucose and enhanced insulin. Attenuated the oxidative stress stimulated by STZ in hepatocytes. Increased activity of hepatotoxicity markers AST, ALT and ALP. Significantly downregulated the expression of pro-inflammatory proteins, cytokines (TNF-α and IL-6) and transcription factors (NF-κB p65).

Molecular Weight

152.30

Formula

C₄H₈S₃

CAS No.

34135-85-8

Appearance

Liquid

Color

Colorless to light yellow

SMILES

CSSSCC=C

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 200 mg/mL (1313.20 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.5660 mL	32.8299 mL	65.6599 mL
5 mM	1.3132 mL	6.5660 mL	13.1320 mL
10 mM	0.6566 mL	3.2830 mL	6.5660 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (32.83 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 40.00%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (242 KB)

Handling Instructions (2659 KB)

References

[1]. Kathiroli Sujithra, et al. Allyl methyl sulfide, an organosulfur compound alleviates hyperglycemia mediated hepatic oxidative stress and inflammation in streptozotocin - induced experimental rats. Biomed Pharmacother. 2018 Nov;107:292-302. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.5660 mL	32.8299 mL	65.6599 mL	164.1497 mL
	5 mM	1.3132 mL	6.5660 mL	13.1320 mL	32.8299 mL
	10 mM	0.6566 mL	3.2830 mL	6.5660 mL	16.4150 mL
	15 mM	0.4377 mL	2.1887 mL	4.3773 mL	10.9433 mL
	20 mM	0.3283 mL	1.6415 mL	3.2830 mL	8.2075 mL
	25 mM	0.2626 mL	1.3132 mL	2.6264 mL	6.5660 mL
	30 mM	0.2189 mL	1.0943 mL	2.1887 mL	5.4717 mL
	40 mM	0.1641 mL	0.8207 mL	1.6415 mL	4.1037 mL
	50 mM	0.1313 mL	0.6566 mL	1.3132 mL	3.2830 mL
	60 mM	0.1094 mL	0.5472 mL	1.0943 mL	2.7358 mL
	80 mM	0.0821 mL	0.4104 mL	0.8207 mL	2.0519 mL
	100 mM	0.0657 mL	0.3283 mL	0.6566 mL	1.6415 mL