2. Cell Cycle/DNA Damage Epigenetics Anti-infection
  3. HDAC Parasite
  4. Apicidin

Apicidin (OSI 2040) is a fungal metabolite, acts as an orally active histone deacetylase 7/8 (HDAC7/8) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity. Apicidin can be used for cancer research.

For research use only. We do not sell to patients.

Apicidin Chemical Structure

Apicidin Chemical Structure

CAS No. : 183506-66-3

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5 mg USD 320 In-stock
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Based on 3 publication(s) in Google Scholar

Apicidin Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Apicidin (OSI 2040) is a fungal metabolite, acts as an orally active histone deacetylase 7/8 (HDAC7/8) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity. Apicidin can be used for cancer research[1][2][3][4].

IC50 & Target

HDAC7

 

HDAC8

 

In Vitro

Apicidin inhibits mammalian (HeLa) cell proliferation in vitro (50% inhibitory concentrations, 50-100 nM)[2].
Apicidin (0.1-10 μM, 24 h) inhibits the growth and the expression of HDAC in AT-84 cells dose-dependently[4].
Apicidin (1, 5 μM, 24 h) induces apoptosis and autophagy in AT-84 cells dose-dependently[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apicidin Related Antibodies
In Vivo

Apicidin (5 mg/kg, i.p., daily for 14 d) inhibits tumor growth up to 47% relative to the control group and exerts no significant systemic toxicity, including body weight changes or other apparent adverse effects[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/C mice[2].
Dosage: 2-20 mg/kg (i.p.); 25/50 mg/kg (oral).
Administration: I.P. and Oral.
Result: Demonstrated parenteral and oral efficacy against an acute strain of P. berghei in mice.
Molecular Weight

623.78

Formula

C34H49N5O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC(C(N1[C@]2([H])CCCC1)=O)[C@@H](C)CC)[C@@H](NC([C@@H](NC2=O)CCCCCC(CC)=O)=O)CC3=CN(OC)C4=C3C=CC=C4
Structure Classification
Initial Source

Toxic Fusarium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (40.08 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6031 mL 8.0156 mL 16.0313 mL
5 mM 0.3206 mL 1.6031 mL 3.2063 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.87%

COA (250 KB) LCMS (253 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6031 mL 8.0156 mL 16.0313 mL 40.0782 mL
5 mM 0.3206 mL 1.6031 mL 3.2063 mL 8.0156 mL
10 mM 0.1603 mL 0.8016 mL 1.6031 mL 4.0078 mL
15 mM 0.1069 mL 0.5344 mL 1.0688 mL 2.6719 mL
20 mM 0.0802 mL 0.4008 mL 0.8016 mL 2.0039 mL
25 mM 0.0641 mL 0.3206 mL 0.6413 mL 1.6031 mL
30 mM 0.0534 mL 0.2672 mL 0.5344 mL 1.3359 mL
40 mM 0.0401 mL 0.2004 mL 0.4008 mL 1.0020 mL
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Apicidin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apicidin183506-66-3OSI 2040OSI2040OSI-2040HDACParasiteHistone deacetylasesfungal metaboliteHDAC7HDAC8antiparasiticantiproliferativecancerAT-84Inhibitorinhibitorinhibit

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